Continuous Flow immobilized enzyme reactor-tandem mass spectrometry for screening of AChE inhibitors in complex mixtures

Analytical Chemistry

Volumn 83, Issue 13, 2011, Pages 5230-5236

  Forsberg, Erica M ^a   Green, James R A ^a   Brennan, John D ^a  

^a MCMASTER UNIVERSITY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ABSORBANCES; ACETYLCHOLINESTERASE; AUTOMATED INJECTION; BIOACTIVE COMPOUNDS; BIOACTIVES; COMPLEX MIXTURE; COMPOUND COLLECTIONS; CONTINUOUS FLOWS; ELLMAN REAGENT; ENZYME REACTORS; FUNCTIONAL SCREENING; IMMOBILIZED ENZYME; IMMOBILIZED ENZYME REACTORS; MOLECULE MIXTURES; MONOLITHIC COLUMNS; MONOLITHIC SILICA; NANO-LC; RAPID SCREENING; ROBUST PERFORMANCE; SCREENING ASSAYS; TWO-CHANNEL;

ENZYME ACTIVITY; MASS SPECTROMETRY; SILICA;

MIXTURES;

ACETYLCHOLINESTERASE; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; IMMOBILIZED ENZYME;

ARTICLE; COMPARATIVE STUDY; DRUG EFFECT; DRUG MIXTURE; IC 50; METHODOLOGY; REPRODUCIBILITY; TANDEM MASS SPECTROMETRY; VALIDATION STUDY;

ACETYLCHOLINESTERASE; ANGIOTENSIN-CONVERTING ENZYME INHIBITORS; COMPLEX MIXTURES; ENZYMES, IMMOBILIZED; INHIBITORY CONCENTRATION 50; REPRODUCIBILITY OF RESULTS; TANDEM MASS SPECTROMETRY;

EID: 79960005373     PISSN: 00032700     EISSN: None     Source Type: Journal    
DOI: 10.1021/ac200534t     Document Type: Article

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