Frontal affinity chromatography with MS detection of the ligand binding domain of PPARγ receptor: Ligand affinity screening and stereoselective ligand-macromolecule interaction

Journal of Chromatography A

Volumn 1232, Issue , 2012, Pages 84-92

  Calleri, E ^a   Fracchiolla, G ^b   Montanari, R ^c   Pochetti, G ^c   Lavecchia, A ^d   Loiodice, F ^b   Laghezza, A ^b   Piemontese, L ^b   Massolini, G ^a   Temporini, C ^a  

^a UNIVERSITY OF PAVIA   (Italy)

^b UNIVERSITY OF BARI   (Italy)

^c CNR   (Italy)

^d UNIVERSITY OF NAPLES FEDERICO II   (Italy)

Author keywords

Binding assay; Enantioselective binding; FAC MS; HPAC; Immobilized PPAR receptor; Ligand affinity screening

Indexed keywords

ADIPOCYTES; AMINOPROPYL SILICA; BINDING ASSAYS; BINDING STUDIES; CARDIO-VASCULAR DISEASE; DIRECT IMPACT; DYSLIPIDEMIAS; ELUTION EXPERIMENTS; ENANTIOSELECTIVE; ENANTIOSELECTIVE BINDING; FAC-MS; FIBRATES; FRONTAL AFFINITY CHROMATOGRAPHIES; HPAC; IMMOBILIZATION CHEMISTRY; IMMOBILIZATION CONDITIONS; ISOFORMS; LIGAND AFFINITY; LIGAND BINDING DOMAIN; MS DETECTION; NUCLEAR RECEPTORS; PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR; RELATIVE BINDING AFFINITY; SILICA COLUMN; STEREO-SELECTIVE; TYPE-2 DIABETES;

AFFINITY CHROMATOGRAPHY; BINDING ENERGY; CAPILLARITY; CYTOLOGY; DIAGNOSIS; DISEASES; ENANTIOSELECTIVITY; MASS SPECTROMETRY; SILICA; STEREOCHEMISTRY; STEREOSELECTIVITY; TRANSCRIPTION FACTORS;

LIGANDS;

AMINOPROPYL SILICA PARTICLE; FIBRIC ACID DERIVATIVE; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; SILICA GEL; UNCLASSIFIED DRUG;

ADIPOCYTE; ANALYTICAL EQUIPMENT; ARTICLE; ATHEROSCLEROSIS; BINDING AFFINITY; CARDIOVASCULAR DISEASE; CELL FUNCTION; CHIRALITY; CHROMATOGRAPHY; CONCENTRATION (PARAMETERS); DISEASE ASSOCIATION; DISSOCIATION CONSTANT; DYSLIPIDEMIA; ELUTION; ENANTIOSELECTIVITY; FRONTAL AFFINITY CHROMATOGRAPHY; HUMAN; HUMAN CELL; LIGAND BINDING; MACROPHAGE; MASS SPECTROMETRY; MUSCLE; NON INSULIN DEPENDENT DIABETES MELLITUS; OPEN TUBULAR CAPILLARY; PRIORITY JOURNAL; PROCESS OPTIMIZATION; PROTEIN DOMAIN; PROTEIN FUNCTION; PROTEIN IMMOBILIZATION; STEREOCHEMISTRY; VALIDATION PROCESS;

BINDING SITES; CHROMATOGRAPHY, AFFINITY; DRUG DISCOVERY; HEP G2 CELLS; HUMANS; IMMOBILIZED PROTEINS; LIGANDS; MACROMOLECULAR SUBSTANCES; MASS SPECTROMETRY; PPAR GAMMA; STEREOISOMERISM;

EID: 84858070063     PISSN: 00219673     EISSN: 18733778     Source Type: Journal    
DOI: 10.1016/j.chroma.2011.10.037     Document Type: Article

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