-
1
-
-
14844334627
-
Appetite control
-
Wynne K., Stanley S., McGowan B., Bloom S. Appetite control. Journal of Endocrinology 2005, 184:291-318.
-
(2005)
Journal of Endocrinology
, vol.184
, pp. 291-318
-
-
Wynne, K.1
Stanley, S.2
McGowan, B.3
Bloom, S.4
-
2
-
-
0036627597
-
Multiple neural systems controlling food intake and body weight
-
Berthoud H.R. Multiple neural systems controlling food intake and body weight. Neuroscience & Biobehavioral Reviews 2002, 26:393-428.
-
(2002)
Neuroscience & Biobehavioral Reviews
, vol.26
, pp. 393-428
-
-
Berthoud, H.R.1
-
3
-
-
34248200002
-
Peripheral tissue-brain interactions in the regulation of food intake
-
López M., Tovar S., Vázquez M.J., Williams L.M., Diéguez C. Peripheral tissue-brain interactions in the regulation of food intake. Proceedings of the Nutrition Society 2007, 66:131-155.
-
(2007)
Proceedings of the Nutrition Society
, vol.66
, pp. 131-155
-
-
López, M.1
Tovar, S.2
Vázquez, M.J.3
Williams, L.M.4
Diéguez, C.5
-
5
-
-
77249131674
-
Hypothalamic nutrient sensing in the control of energy homeostasis
-
Blouet C., Schwartz G.J. Hypothalamic nutrient sensing in the control of energy homeostasis. Behavioural Brain Research 2010, 209:1-12.
-
(2010)
Behavioural Brain Research
, vol.209
, pp. 1-12
-
-
Blouet, C.1
Schwartz, G.J.2
-
6
-
-
79960932903
-
Hypothalamic control of lipid metabolism: focus on leptin, ghrelin and melanocortins
-
Diéguez C., Vazquez M.J., Romero A., López M., Nogueiras R. Hypothalamic control of lipid metabolism: focus on leptin, ghrelin and melanocortins. Neuroendocrinology 2011, 94:1-11.
-
(2011)
Neuroendocrinology
, vol.94
, pp. 1-11
-
-
Diéguez, C.1
Vazquez, M.J.2
Romero, A.3
López, M.4
Nogueiras, R.5
-
7
-
-
12344277552
-
Diabetes, obesity, and the brain
-
Schwartz M.W., Porte D. Diabetes, obesity, and the brain. Science 2005, 307:375-379.
-
(2005)
Science
, vol.307
, pp. 375-379
-
-
Schwartz, M.W.1
Porte, D.2
-
8
-
-
78649753017
-
Leptin rapidly improves glucose homeostasis in obese mice by increasing hypothalamic insulin sensitivity
-
Koch C., Augustine R.A., Steger J., Ganjam G.K., Benzler J., Pracht C., et al. Leptin rapidly improves glucose homeostasis in obese mice by increasing hypothalamic insulin sensitivity. Journal of Neuroscience 2010, 30:16180-16187.
-
(2010)
Journal of Neuroscience
, vol.30
, pp. 16180-16187
-
-
Koch, C.1
Augustine, R.A.2
Steger, J.3
Ganjam, G.K.4
Benzler, J.5
Pracht, C.6
-
9
-
-
77449144768
-
Divergent regulation of energy expenditure and hepatic glucose production by insulin receptor in agouti-related protein and POMC neurons
-
Lin H.V., Plum L., Ono H., Gutiérrez-Juárez R., Shanabrough M., Borok E., et al. Divergent regulation of energy expenditure and hepatic glucose production by insulin receptor in agouti-related protein and POMC neurons. Diabetes 2010, 59:337-346.
-
(2010)
Diabetes
, vol.59
, pp. 337-346
-
-
Lin, H.V.1
Plum, L.2
Ono, H.3
Gutiérrez-Juárez, R.4
Shanabrough, M.5
Borok, E.6
-
10
-
-
36048955043
-
The central melanocortin system directly controls peripheral lipid metabolism
-
Nogueiras R., Wiedmer P., Perez-Tilve D., Veyrat-Durebex C., Keogh J.M., Sutton G.M., et al. The central melanocortin system directly controls peripheral lipid metabolism. Journal of Clinical Investigation 2007, 117:3475-3488.
-
(2007)
Journal of Clinical Investigation
, vol.117
, pp. 3475-3488
-
-
Nogueiras, R.1
Wiedmer, P.2
Perez-Tilve, D.3
Veyrat-Durebex, C.4
Keogh, J.M.5
Sutton, G.M.6
-
11
-
-
77954107681
-
Melanocortin signaling in the CNS directly regulates circulating cholesterol
-
Perez-Tilve D., Hofmann S.M., Basford J., Nogueiras R., Pfluger P.T., Patterson J.T., et al. Melanocortin signaling in the CNS directly regulates circulating cholesterol. Nature Neuroscience 2010, 13:877-882.
-
(2010)
Nature Neuroscience
, vol.13
, pp. 877-882
-
-
Perez-Tilve, D.1
Hofmann, S.M.2
Basford, J.3
Nogueiras, R.4
Pfluger, P.T.5
Patterson, J.T.6
-
12
-
-
84860573203
-
Hypothalamic neuropeptide Y (NPY) controls hepatic VLDL-triglyceride secretion in rats via the sympathetic nervous system
-
Bruinstroop E., Pei L., Ackermans M.T., Foppen E., Borgers A.J., Kwakkel J., Alkemade A., Fliers E., Kalsbeek A. Hypothalamic neuropeptide Y (NPY) controls hepatic VLDL-triglyceride secretion in rats via the sympathetic nervous system. Diabetes 2012, 61:1043-1050.
-
(2012)
Diabetes
, vol.61
, pp. 1043-1050
-
-
Bruinstroop, E.1
Pei, L.2
Ackermans, M.T.3
Foppen, E.4
Borgers, A.J.5
Kwakkel, J.6
Alkemade, A.7
Fliers, E.8
Kalsbeek, A.9
-
14
-
-
79960202841
-
Type 2 diabetes across generations: from pathophysiology to prevention and management
-
Nolan C.J., Damm P., Prentki M. Type 2 diabetes across generations: from pathophysiology to prevention and management. Lancet 2011, 378:169-181.
-
(2011)
Lancet
, vol.378
, pp. 169-181
-
-
Nolan, C.J.1
Damm, P.2
Prentki, M.3
-
16
-
-
64649104158
-
Banting Lecture. From the triumvirate to the ominous octet: a new paradigm for the treatment of type 2 diabetes mellitus
-
DeFronzo R.A. Banting Lecture. From the triumvirate to the ominous octet: a new paradigm for the treatment of type 2 diabetes mellitus. Diabetes 2009, 58:773-795.
-
(2009)
Diabetes
, vol.58
, pp. 773-795
-
-
DeFronzo, R.A.1
-
17
-
-
79953735981
-
Dissociation of lipotoxicity and glucotoxicity in a mouse model of obesity associated diabetes: role of forkhead box O1 (FOXO1) in glucose-induced beta cell failure
-
Kluth O., Mirhashemi F., Scherneck S., Kaiser D., Kluge R., Neschen S., et al. Dissociation of lipotoxicity and glucotoxicity in a mouse model of obesity associated diabetes: role of forkhead box O1 (FOXO1) in glucose-induced beta cell failure. Diabetologia 2011, 54:605-616.
-
(2011)
Diabetologia
, vol.54
, pp. 605-616
-
-
Kluth, O.1
Mirhashemi, F.2
Scherneck, S.3
Kaiser, D.4
Kluge, R.5
Neschen, S.6
-
18
-
-
0032953097
-
Heritability of type II (non-insulin-dependent) diabetes mellitus and abnormal glucose tolerance-a population-based twin study
-
Poulsen P., Kyvik K.O., Vaag A., Beck-Nielsen H. Heritability of type II (non-insulin-dependent) diabetes mellitus and abnormal glucose tolerance-a population-based twin study. Diabetologia 1999, 42:139-145.
-
(1999)
Diabetologia
, vol.42
, pp. 139-145
-
-
Poulsen, P.1
Kyvik, K.O.2
Vaag, A.3
Beck-Nielsen, H.4
-
19
-
-
12144273136
-
Heritability of insulin secretion, peripheral and hepatic insulin action, and intracellular glucose partitioning in young and old Danish twins
-
Poulsen P., Levin K., Petersen I., Christensen K., Beck-Nielsen H., Vaag A. Heritability of insulin secretion, peripheral and hepatic insulin action, and intracellular glucose partitioning in young and old Danish twins. Diabetes 2005, 54:275-283.
-
(2005)
Diabetes
, vol.54
, pp. 275-283
-
-
Poulsen, P.1
Levin, K.2
Petersen, I.3
Christensen, K.4
Beck-Nielsen, H.5
Vaag, A.6
-
20
-
-
0041813673
-
Twin study of genetic and environmental influences on glucose tolerance and indices of insulin sensitivity and secretion
-
Schousboe K., Visscher P.M., Henriksen J.E., Hopper J.L., Sørensen T.I., Kyvik K.O. Twin study of genetic and environmental influences on glucose tolerance and indices of insulin sensitivity and secretion. Diabetologia 2003, 46:1276-1283.
-
(2003)
Diabetologia
, vol.46
, pp. 1276-1283
-
-
Schousboe, K.1
Visscher, P.M.2
Henriksen, J.E.3
Hopper, J.L.4
Sørensen, T.I.5
Kyvik, K.O.6
-
21
-
-
33749017409
-
The human obesity gene map: the 2005 update
-
Rankinen T., Zuberi A., Chagnon Y.C., Weisnagel S.J., Argyropoulos G., Walts B., et al. The human obesity gene map: the 2005 update. Obesity (Silver Spring) 2006, 14:529-644.
-
(2006)
Obesity (Silver Spring)
, vol.14
, pp. 529-644
-
-
Rankinen, T.1
Zuberi, A.2
Chagnon, Y.C.3
Weisnagel, S.J.4
Argyropoulos, G.5
Walts, B.6
-
22
-
-
78649842241
-
Genomics, type 2 diabetes, and obesity
-
McCarthy M.I. Genomics, type 2 diabetes, and obesity. New England Journal of Medicine 2010, 363:2339-2350.
-
(2010)
New England Journal of Medicine
, vol.363
, pp. 2339-2350
-
-
McCarthy, M.I.1
-
23
-
-
84862909349
-
Five years of GWAS discovery
-
Visscher P.M., Brown M.A., McCarthy M.I., Yang J. Five years of GWAS discovery. American Journal of Human Genetics 2012, 90:7-24.
-
(2012)
American Journal of Human Genetics
, vol.90
, pp. 7-24
-
-
Visscher, P.M.1
Brown, M.A.2
McCarthy, M.I.3
Yang, J.4
-
24
-
-
84872232296
-
Meta-analysis investigating associations between healthy diet and fasting glucose and insulin levels and modification by loci associated with glucose homeostasis in data from 15 cohorts
-
Nettleton J.A., Hivert M.F., Lemaitre R.N., McKeown N.M., Mozaffarian D., Tanaka T., et al. Meta-analysis investigating associations between healthy diet and fasting glucose and insulin levels and modification by loci associated with glucose homeostasis in data from 15 cohorts. American Journal of Epidemiology 2013, 177:103-115.
-
(2013)
American Journal of Epidemiology
, vol.177
, pp. 103-115
-
-
Nettleton, J.A.1
Hivert, M.F.2
Lemaitre, R.N.3
McKeown, N.M.4
Mozaffarian, D.5
Tanaka, T.6
-
25
-
-
77951623073
-
Crystal structure of the FTO protein reveals basis for its substrate specificity
-
Han Z., Niu T., Chang J., Lei X., Zhao M., Wang Q., Cheng W., Wang J., Feng Y., Chai J. Crystal structure of the FTO protein reveals basis for its substrate specificity. Nature 2010, 464:1205-1209.
-
(2010)
Nature
, vol.464
, pp. 1205-1209
-
-
Han, Z.1
Niu, T.2
Chang, J.3
Lei, X.4
Zhao, M.5
Wang, Q.6
Cheng, W.7
Wang, J.8
Feng, Y.9
Chai, J.10
-
26
-
-
67349211789
-
Inactivation of the Fto gene protects from obesity
-
Fischer J., Koch L., Emmerling C., Vierkotten J., Peters T., Brüning J.C., Rüther U. Inactivation of the Fto gene protects from obesity. Nature 2009, 458:894-898.
-
(2009)
Nature
, vol.458
, pp. 894-898
-
-
Fischer, J.1
Koch, L.2
Emmerling, C.3
Vierkotten, J.4
Peters, T.5
Brüning, J.C.6
Rüther, U.7
-
27
-
-
84873735640
-
Role for the obesity-related FTO gene in the cellular sensing of amino acids
-
Gulati P., Cheung M.K., Antrobus R., Church C.D., Harding H.P., Tung Y.C., et al. Role for the obesity-related FTO gene in the cellular sensing of amino acids. Proceedings of the National Academy of Sciences of the United States of America 2013, 110:2557-2562.
-
(2013)
Proceedings of the National Academy of Sciences of the United States of America
, vol.110
, pp. 2557-2562
-
-
Gulati, P.1
Cheung, M.K.2
Antrobus, R.3
Church, C.D.4
Harding, H.P.5
Tung, Y.C.6
-
28
-
-
84880916638
-
The fat mass and obesity associated gene (Fto) regulates activity of the dopaminergic midbrain circuitry
-
Hess M.E., Hess S., Meyer K.D., Verhagen L.A., Koch L., Brönneke H.S., et al. The fat mass and obesity associated gene (Fto) regulates activity of the dopaminergic midbrain circuitry. Nature Neuroscience 2013, 16:1042-1048.
-
(2013)
Nature Neuroscience
, vol.16
, pp. 1042-1048
-
-
Hess, M.E.1
Hess, S.2
Meyer, K.D.3
Verhagen, L.A.4
Koch, L.5
Brönneke, H.S.6
-
29
-
-
79952305733
-
Inverse association of the obesity predisposing FTO rs9939609 genotype with alcohol consumption and risk for alcohol dependence
-
Sobczyk-Kopciol A., Broda G., Wojnar M., Kurjata P., Jakubczyk A., Klimkiewicz A., et al. Inverse association of the obesity predisposing FTO rs9939609 genotype with alcohol consumption and risk for alcohol dependence. Addiction 2011, 106:739-748.
-
(2011)
Addiction
, vol.106
, pp. 739-748
-
-
Sobczyk-Kopciol, A.1
Broda, G.2
Wojnar, M.3
Kurjata, P.4
Jakubczyk, A.5
Klimkiewicz, A.6
-
30
-
-
0041624549
-
Transgenic mice expressing green fluorescent protein under the control of the melanocortin-4 receptor promoter
-
Liu H., Kishi T., Roseberry A.G., Cai X., Lee C.E., Montez J.M., Friedman J.M., Elmquist J.K. Transgenic mice expressing green fluorescent protein under the control of the melanocortin-4 receptor promoter. Journal of Neuroscience 2003, 23:7143-7154.
-
(2003)
Journal of Neuroscience
, vol.23
, pp. 7143-7154
-
-
Liu, H.1
Kishi, T.2
Roseberry, A.G.3
Cai, X.4
Lee, C.E.5
Montez, J.M.6
Friedman, J.M.7
Elmquist, J.K.8
-
31
-
-
84874046819
-
Melanocortin 4 receptor distribution in the human hypothalamus
-
Siljee J.E., Unmehopa U.A., Kalsbeek A., Swaab D.F., Fliers E., Alkemade A. Melanocortin 4 receptor distribution in the human hypothalamus. European Journal of Endocrinology 2013, 168:361-369.
-
(2013)
European Journal of Endocrinology
, vol.168
, pp. 361-369
-
-
Siljee, J.E.1
Unmehopa, U.A.2
Kalsbeek, A.3
Swaab, D.F.4
Fliers, E.5
Alkemade, A.6
-
32
-
-
84889087307
-
The melanocortin-4 receptor as target for obesity treatment: a systematic review of emerging pharmacological therapeutic options
-
([Epub ahead of print])
-
Fani L., Bak S., Delhanty P., van Rossum E.F., van den Akker E.L. The melanocortin-4 receptor as target for obesity treatment: a systematic review of emerging pharmacological therapeutic options. International Journal of Obesity (London) 2013, ([Epub ahead of print]).
-
(2013)
International Journal of Obesity (London)
-
-
Fani, L.1
Bak, S.2
Delhanty, P.3
van Rossum, E.F.4
van den Akker, E.L.5
-
33
-
-
0028300331
-
A molecular model for the genetic and phenotypic characteristics of the mouse lethal yellow (Ay) mutation
-
Michaud E.J., Bultman S.J., Klebig M.L., van Vugt M.J., Stubbs L.J., Russell L.B., Woychik R.P. A molecular model for the genetic and phenotypic characteristics of the mouse lethal yellow (Ay) mutation. Proceedings of the National Academy of Sciences of the United States of America 1994, 91:2562-2566.
-
(1994)
Proceedings of the National Academy of Sciences of the United States of America
, vol.91
, pp. 2562-2566
-
-
Michaud, E.J.1
Bultman, S.J.2
Klebig, M.L.3
van Vugt, M.J.4
Stubbs, L.J.5
Russell, L.B.6
Woychik, R.P.7
-
34
-
-
0030764741
-
Antagonism of central melanocortin receptors in vitro and in vivo by Agouti-related protein
-
Ollmann M.M., Wilson B.D., Yang Y.K., Kerns J.A., Chen Y., Gantz I., Barsh G.S. Antagonism of central melanocortin receptors in vitro and in vivo by Agouti-related protein. Science 1997, 278:135-138.
-
(1997)
Science
, vol.278
, pp. 135-138
-
-
Ollmann, M.M.1
Wilson, B.D.2
Yang, Y.K.3
Kerns, J.A.4
Chen, Y.5
Gantz, I.6
Barsh, G.S.7
-
35
-
-
0030893647
-
Hypothalamic expression of ART, a novel gene related to agouti, is up-regulated in obese and diabetic mutant mice
-
Shutter J.R., Graham M., Kinsey A.C., Scully S., Luthy R., Stark K.L. Hypothalamic expression of ART, a novel gene related to agouti, is up-regulated in obese and diabetic mutant mice. Genes & Development 1997, 11:593-602.
-
(1997)
Genes & Development
, vol.11
, pp. 593-602
-
-
Shutter, J.R.1
Graham, M.2
Kinsey, A.C.3
Scully, S.4
Luthy, R.5
Stark, K.L.6
-
36
-
-
0035810771
-
Agouti-related protein functions as an inverseagonist at a constitutively active brain melanocortin-4 receptor
-
Haskell-Luevano C., Monck E.K. Agouti-related protein functions as an inverseagonist at a constitutively active brain melanocortin-4 receptor. Regulatory Peptides 2001, 99:1-7.
-
(2001)
Regulatory Peptides
, vol.99
, pp. 1-7
-
-
Haskell-Luevano, C.1
Monck, E.K.2
-
37
-
-
0035130843
-
AgRP(83-132) acts as an inverse agonist on the human-melanocortin-4 receptor
-
Nijenhuis W.A., Oosterom J., Adan R.A. AgRP(83-132) acts as an inverse agonist on the human-melanocortin-4 receptor. Molecular Endocrinology 2001, 15:164-171.
-
(2001)
Molecular Endocrinology
, vol.15
, pp. 164-171
-
-
Nijenhuis, W.A.1
Oosterom, J.2
Adan, R.A.3
-
38
-
-
38449087113
-
In vivo evidence for inverse agonism of Agouti-related peptide in the central nervous system of proopiomelanocortin-deficient mice
-
Tolle V., Low M.J. In vivo evidence for inverse agonism of Agouti-related peptide in the central nervous system of proopiomelanocortin-deficient mice. Diabetes 2008, 57:86-94.
-
(2008)
Diabetes
, vol.57
, pp. 86-94
-
-
Tolle, V.1
Low, M.J.2
-
39
-
-
0038389438
-
Alpha-MSH and desacetyl-alpha-MSH signaling through melanocortin receptors
-
Mountjoy K.G., Wu C.S., Cornish J., Callon K.E. alpha-MSH and desacetyl-alpha-MSH signaling through melanocortin receptors. Annals of the New York Academy of Sciences 2003, 994:58-65.
-
(2003)
Annals of the New York Academy of Sciences
, vol.994
, pp. 58-65
-
-
Mountjoy, K.G.1
Wu, C.S.2
Cornish, J.3
Callon, K.E.4
-
40
-
-
39749193898
-
Backbone cyclic peptidomimetic melanocortin-4 receptor agonist as a novel orally administrated drug lead for treating obesity
-
Hess S., Linde Y., Ovadia O., Safrai E., Shalev D.E., Swed A., et al. Backbone cyclic peptidomimetic melanocortin-4 receptor agonist as a novel orally administrated drug lead for treating obesity. Journal of Medicinal Chemistry 2008, 51:1026-1034.
-
(2008)
Journal of Medicinal Chemistry
, vol.51
, pp. 1026-1034
-
-
Hess, S.1
Linde, Y.2
Ovadia, O.3
Safrai, E.4
Shalev, D.E.5
Swed, A.6
-
41
-
-
33846191084
-
Melanocortins and agouti-related protein modulate the excitability of two arcuate nucleus neuron populations by alteration of resting potassium conductances
-
Smith M.A., Hisadome K., Al-Qassab H., Heffron H., Withers D.J., Ashford M.L. Melanocortins and agouti-related protein modulate the excitability of two arcuate nucleus neuron populations by alteration of resting potassium conductances. Journal of Physiology - London 2007, 578:425-438.
-
(2007)
Journal of Physiology - London
, vol.578
, pp. 425-438
-
-
Smith, M.A.1
Hisadome, K.2
Al-Qassab, H.3
Heffron, H.4
Withers, D.J.5
Ashford, M.L.6
-
42
-
-
0030889192
-
Targeted disruption of the melanocortin-4 receptor results in obesity in mice
-
Huszar D., Lynch C.A., Fairchild-Huntress V., Dunmore J.H., Fang Q., Berkemeier L.R., et al. Targeted disruption of the melanocortin-4 receptor results in obesity in mice. Cell 1997, 88:131-141.
-
(1997)
Cell
, vol.88
, pp. 131-141
-
-
Huszar, D.1
Lynch, C.A.2
Fairchild-Huntress, V.3
Dunmore, J.H.4
Fang, Q.5
Berkemeier, L.R.6
-
43
-
-
0034981271
-
Melanocortin-4 receptor is required for acute homeostatic responses to increased dietary fat
-
Butler A.A., Marks D.L., Fan W., Kuhn C.M., Bartolome M., Cone R.D. Melanocortin-4 receptor is required for acute homeostatic responses to increased dietary fat. Nature Neuroscience 2001, 4:605-611.
-
(2001)
Nature Neuroscience
, vol.4
, pp. 605-611
-
-
Butler, A.A.1
Marks, D.L.2
Fan, W.3
Kuhn, C.M.4
Bartolome, M.5
Cone, R.D.6
-
44
-
-
0031662163
-
A frameshift mutation in human MC4R is associated with a dominant form of obesity
-
Vaisse C., Clement K., Guy-Grand B., Froguel P. A frameshift mutation in human MC4R is associated with a dominant form of obesity. Nature Genetics 1998, 20:113-114.
-
(1998)
Nature Genetics
, vol.20
, pp. 113-114
-
-
Vaisse, C.1
Clement, K.2
Guy-Grand, B.3
Froguel, P.4
-
45
-
-
0031668219
-
A frameshift mutation in MC4R associated with dominantly inherited human obesity
-
Yeo G.S., Farooqi I.S., Aminian S., Halsall D.J., Stanhope R.G., O'Rahilly S. A frameshift mutation in MC4R associated with dominantly inherited human obesity. Nature Genetics 1998, 20:111-112.
-
(1998)
Nature Genetics
, vol.20
, pp. 111-112
-
-
Yeo, G.S.1
Farooqi, I.S.2
Aminian, S.3
Halsall, D.J.4
Stanhope, R.G.5
O'Rahilly, S.6
-
46
-
-
84881145144
-
Eating behaviour in obese patients with melanocortin-4 receptor mutations: a literature review
-
Valette M., Bellisle F., Carette C., Poitou C., Dubern B., Paradis G., et al. Eating behaviour in obese patients with melanocortin-4 receptor mutations: a literature review. International Journal of Obesity (London) 2013, 37:1027-1035.
-
(2013)
International Journal of Obesity (London)
, vol.37
, pp. 1027-1035
-
-
Valette, M.1
Bellisle, F.2
Carette, C.3
Poitou, C.4
Dubern, B.5
Paradis, G.6
-
47
-
-
84866724514
-
Association between common polymorphism near the MC4R gene and obesity risk: a systematic review and meta-analysis
-
Xi B., Chandak G.R., Shen Y., Wang Q., Zhou D. Association between common polymorphism near the MC4R gene and obesity risk: a systematic review and meta-analysis. PLoS One 2012, 7:e45731.
-
(2012)
PLoS One
, vol.7
-
-
Xi, B.1
Chandak, G.R.2
Shen, Y.3
Wang, Q.4
Zhou, D.5
-
48
-
-
49649114875
-
Transmembrane protein 18 enhances the tropism of neural stem cells for glioma cells
-
Jurvansuu J., Zhao Y., Leung D.S., Boulaire J., Yu Y.H., Ahmed S., Wang S. Transmembrane protein 18 enhances the tropism of neural stem cells for glioma cells. Cancer Research 2008, 68:4614-4622.
-
(2008)
Cancer Research
, vol.68
, pp. 4614-4622
-
-
Jurvansuu, J.1
Zhao, Y.2
Leung, D.S.3
Boulaire, J.4
Yu, Y.H.5
Ahmed, S.6
Wang, S.7
-
49
-
-
77952288486
-
The obesity gene, TMEM18, is of ancient origin, found in majority of neuronal cells in all major brain regions and associated with obesity in severely obese children
-
Almén M.S., Jacobsson J.A., Shaik J.H., Olszewski P.K., Cedernaes J., Alsiö J., et al. The obesity gene, TMEM18, is of ancient origin, found in majority of neuronal cells in all major brain regions and associated with obesity in severely obese children. BMC Medical Genetics 2010, 11:58.
-
(2010)
BMC Medical Genetics
, vol.11
, pp. 58
-
-
Almén, M.S.1
Jacobsson, J.A.2
Shaik, J.H.3
Olszewski, P.K.4
Cedernaes, J.5
Alsiö, J.6
-
50
-
-
84878795484
-
Functional relevance of genes implicated by obesity genome-wide association study signals for human adipocyte biology
-
Bernhard F., Landgraf K., Klöting N., Berthold A., Büttner P., Friebe D., et al. Functional relevance of genes implicated by obesity genome-wide association study signals for human adipocyte biology. Diabetologia 2013, 56:311-322.
-
(2013)
Diabetologia
, vol.56
, pp. 311-322
-
-
Bernhard, F.1
Landgraf, K.2
Klöting, N.3
Berthold, A.4
Büttner, P.5
Friebe, D.6
-
51
-
-
58149163142
-
Six new loci associated with body mass index highlight a neuronal influence on body weight regulation
-
Willer C.J., Speliotes E.K., Loos R.J., Li S., Lindgren C.M., Heid I.M., et al. Six new loci associated with body mass index highlight a neuronal influence on body weight regulation. Nature Genetics 2009, 41:25-34.
-
(2009)
Nature Genetics
, vol.41
, pp. 25-34
-
-
Willer, C.J.1
Speliotes, E.K.2
Loos, R.J.3
Li, S.4
Lindgren, C.M.5
Heid, I.M.6
-
52
-
-
0030900696
-
Stabilization of beta-catenin by genetic defects in melanoma cell lines
-
Rubinfeld B., Robbins P., El-Gamil M., Albert I., Porfiri E., Polakis P. Stabilization of beta-catenin by genetic defects in melanoma cell lines. Science 1997, 275:1790-1792.
-
(1997)
Science
, vol.275
, pp. 1790-1792
-
-
Rubinfeld, B.1
Robbins, P.2
El-Gamil, M.3
Albert, I.4
Porfiri, E.5
Polakis, P.6
-
53
-
-
77958468040
-
Molecular function of TCF7L2: consequences of TCF7L2 splicing for molecular function and risk for type 2 diabetes
-
Hansson O., Zhou Y., Renström E., Osmark P. Molecular function of TCF7L2: consequences of TCF7L2 splicing for molecular function and risk for type 2 diabetes. Current Diabetes Reports 2010, 10:444-451.
-
(2010)
Current Diabetes Reports
, vol.10
, pp. 444-451
-
-
Hansson, O.1
Zhou, Y.2
Renström, E.3
Osmark, P.4
-
55
-
-
84866107559
-
Abnormal glucose tolerance and insulin secretion in pancreas-specific Tcf7l2-null mice
-
da Silva Xavier G., Mondragon A., Sun G., Chen L., McGinty J.A., French P.M., Rutter G.A. Abnormal glucose tolerance and insulin secretion in pancreas-specific Tcf7l2-null mice. Diabetologia 2012, 55:2667-2676.
-
(2012)
Diabetologia
, vol.55
, pp. 2667-2676
-
-
da Silva Xavier, G.1
Mondragon, A.2
Sun, G.3
Chen, L.4
McGinty, J.A.5
French, P.M.6
Rutter, G.A.7
-
56
-
-
84866890442
-
TCF7L2 modulates glucose homeostasis by regulating CREB- and FoxO1-dependent transcriptional pathway in the liver
-
Oh K.J., Park J., Kim S.S., Oh H., Choi C.S., Koo S.H. TCF7L2 modulates glucose homeostasis by regulating CREB- and FoxO1-dependent transcriptional pathway in the liver. PLoS Genetics 2012, 8:e1002986.
-
(2012)
PLoS Genetics
, vol.8
-
-
Oh, K.J.1
Park, J.2
Kim, S.S.3
Oh, H.4
Choi, C.S.5
Koo, S.H.6
-
57
-
-
0027504874
-
Identification of two mPPAR related receptors and evidence for the existence of five subfamily members
-
Chen F., Law S.W., O'Malley B.W. Identification of two mPPAR related receptors and evidence for the existence of five subfamily members. Biochemical and Biophysical Research Communications 1993, 29(196):671-677.
-
(1993)
Biochemical and Biophysical Research Communications
, vol.29
, Issue.196
, pp. 671-677
-
-
Chen, F.1
Law, S.W.2
O'Malley, B.W.3
-
58
-
-
0027278522
-
Positive regulation of the peroxisomal beta-oxidation pathway by fatty acids through activation of peroxisome proliferator-activated receptors (PPAR)
-
Dreyer C., Keller H., Mahfoudi A., Laudet V., Krey G., Wahli W. Positive regulation of the peroxisomal beta-oxidation pathway by fatty acids through activation of peroxisome proliferator-activated receptors (PPAR). Biology of the Cell 1993, 77:67-76.
-
(1993)
Biology of the Cell
, vol.77
, pp. 67-76
-
-
Dreyer, C.1
Keller, H.2
Mahfoudi, A.3
Laudet, V.4
Krey, G.5
Wahli, W.6
-
59
-
-
84877329207
-
PPARγ signaling and metabolism: the good, the bad and the future
-
Ahmadian M., Suh J.M., Hah N., Liddle C., Atkins A.R., Downes M., Evans R.M. PPARγ signaling and metabolism: the good, the bad and the future. Nature Medicine 2013, 19:557-566.
-
(2013)
Nature Medicine
, vol.19
, pp. 557-566
-
-
Ahmadian, M.1
Suh, J.M.2
Hah, N.3
Liddle, C.4
Atkins, A.R.5
Downes, M.6
Evans, R.M.7
-
62
-
-
0036203360
-
Novel insulin sensitizers: pharmacogenomic aspects
-
Otto C., Lehrke M., Göke B. Novel insulin sensitizers: pharmacogenomic aspects. Pharmacogenomics 2002, 3:99-116.
-
(2002)
Pharmacogenomics
, vol.3
, pp. 99-116
-
-
Otto, C.1
Lehrke, M.2
Göke, B.3
-
64
-
-
1842452946
-
Gene variants, insulin resistance, and dyslipidaemia
-
Laakso M. Gene variants, insulin resistance, and dyslipidaemia. Current Opinion in Lipidology 2004, 115-120.
-
(2004)
Current Opinion in Lipidology
, pp. 115-120
-
-
Laakso, M.1
-
66
-
-
0037269223
-
The genetics of neonatal hyperinsulinism
-
Fournet J.C., Junien C. The genetics of neonatal hyperinsulinism. Hormone Research 2003, 59(Suppl 1):30-34.
-
(2003)
Hormone Research
, vol.59
, Issue.SUPPL 1
, pp. 30-34
-
-
Fournet, J.C.1
Junien, C.2
-
67
-
-
84865756318
-
Amino acid properties may be useful in predicting clinical outcome in patients with Kir6.2 neonatal diabetes
-
Fraser C.S., Rubio-Cabezas O., Littlechild J.A., Ellard S., Hattersley A.T., Flanagan S.E. Amino acid properties may be useful in predicting clinical outcome in patients with Kir6.2 neonatal diabetes. European Journal of Endocrinology 2012, 167:417-421.
-
(2012)
European Journal of Endocrinology
, vol.167
, pp. 417-421
-
-
Fraser, C.S.1
Rubio-Cabezas, O.2
Littlechild, J.A.3
Ellard, S.4
Hattersley, A.T.5
Flanagan, S.E.6
-
69
-
-
63249118012
-
Replication study of candidate genes associated with type 2 diabetes based on genome-wide screening
-
Tabara Y., Osawa H., Kawamoto R., Onuma H., Shimizu I., Miki T., et al. Replication study of candidate genes associated with type 2 diabetes based on genome-wide screening. Diabetes 2009, 58:493-498.
-
(2009)
Diabetes
, vol.58
, pp. 493-498
-
-
Tabara, Y.1
Osawa, H.2
Kawamoto, R.3
Onuma, H.4
Shimizu, I.5
Miki, T.6
-
70
-
-
84862777036
-
Meta-analysis identifies common variants associated with body mass index in east Asians
-
Wen W., Cho Y.S., Zheng W., Dorajoo R., Kato N., Qi L., et al. Meta-analysis identifies common variants associated with body mass index in east Asians. Nature Genetics 2012, 44:307-311.
-
(2012)
Nature Genetics
, vol.44
, pp. 307-311
-
-
Wen, W.1
Cho, Y.S.2
Zheng, W.3
Dorajoo, R.4
Kato, N.5
Qi, L.6
-
71
-
-
84878720938
-
A meta-analysis identifies new loci associated with body mass index in individuals of African ancestry
-
Monda K.L., Chen G.K., Taylor K.C., Palmer C., Edwards T.L., Lange L.A., et al. A meta-analysis identifies new loci associated with body mass index in individuals of African ancestry. Nature Genetics 2013, 45:690-696.
-
(2013)
Nature Genetics
, vol.45
, pp. 690-696
-
-
Monda, K.L.1
Chen, G.K.2
Taylor, K.C.3
Palmer, C.4
Edwards, T.L.5
Lange, L.A.6
-
72
-
-
77954162542
-
Use of genome-wide expression data to mine the "Gray Zone" of GWA studies leads to novel candidate obesity genes
-
Naukkarinen J., Surakka I., Pietiläinen K.H., Rissanen A., Salomaa V., Ripatti S., Wichmann H.E., Kaprio J., Taskinen M.R., Peltonen L., et al. Use of genome-wide expression data to mine the "Gray Zone" of GWA studies leads to novel candidate obesity genes. PLoS Genetics 2010, 6:e1000976.
-
(2010)
PLoS Genetics
, vol.6
-
-
Naukkarinen, J.1
Surakka, I.2
Pietiläinen, K.H.3
Rissanen, A.4
Salomaa, V.5
Ripatti, S.6
Wichmann, H.E.7
Kaprio, J.8
Taskinen, M.R.9
Peltonen, L.10
-
73
-
-
84878569025
-
Genome-wide SNP and CNV analysis identifies common and low-frequency variants associated with severe early-onset obesity
-
Wheeler E., Huang N., Bochukova E.G., Keogh J.M., Lindsay S., Garg S., et al. Genome-wide SNP and CNV analysis identifies common and low-frequency variants associated with severe early-onset obesity. Nature Genetics 2013, 45:513-517.
-
(2013)
Nature Genetics
, vol.45
, pp. 513-517
-
-
Wheeler, E.1
Huang, N.2
Bochukova, E.G.3
Keogh, J.M.4
Lindsay, S.5
Garg, S.6
-
74
-
-
78049337953
-
Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index
-
Speliotes E.K., Willer C.J., Berndt S.I., Monda K.L., Thorleifsson G., Jackson A.U., et al. Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index. Nature Genetics 2010, 42:937-948.
-
(2010)
Nature Genetics
, vol.42
, pp. 937-948
-
-
Speliotes, E.K.1
Willer, C.J.2
Berndt, S.I.3
Monda, K.L.4
Thorleifsson, G.5
Jackson, A.U.6
-
75
-
-
76249116215
-
A new highly penetrant form of obesity due to deletions on chromosome 16p112
-
Walters R.G., Jacquemont S., Valsesia A., de Smith A.J., Martinet D., Andersson J., et al. A new highly penetrant form of obesity due to deletions on chromosome 16p112. Nature 2010, 463:671-675.
-
(2010)
Nature
, vol.463
, pp. 671-675
-
-
Walters, R.G.1
Jacquemont, S.2
Valsesia, A.3
de Smith, A.J.4
Martinet, D.5
Andersson, J.6
-
76
-
-
84906329061
-
Molecular genetic aspects of weight regulation
-
Hebebrand J., Hinney A., Knoll N., Volckmar A.L., Scherag A. Molecular genetic aspects of weight regulation. Deutsches Aerzteblatt International 2013, 110:338-344.
-
(2013)
Deutsches Aerzteblatt International
, vol.110
, pp. 338-344
-
-
Hebebrand, J.1
Hinney, A.2
Knoll, N.3
Volckmar, A.L.4
Scherag, A.5
-
77
-
-
80053920983
-
Mirror extreme BMI phenotypes associated with gene dosage at the chromosome 16p112. locus
-
Jacquemont S., Reymond A., Zufferey F., Harewood L., Walters R.G., Kutalik Z., et al. Mirror extreme BMI phenotypes associated with gene dosage at the chromosome 16p112. locus. Nature 2011, 478:97-102.
-
(2011)
Nature
, vol.478
, pp. 97-102
-
-
Jacquemont, S.1
Reymond, A.2
Zufferey, F.3
Harewood, L.4
Walters, R.G.5
Kutalik, Z.6
-
78
-
-
84889095376
-
-
The Wellcome Trust. Ten years on, Wellcome Trust launches study of 10 000 human genomes in UK (accessed 22.6.12)
-
The Wellcome Trust. Ten years on, Wellcome Trust launches study of 10 000 human genomes in UK (accessed 22.6.12). http://www.wellcome.ac.uk/News/Media-office/Press-releases/2010/%20WTX060061.htm.
-
-
-
-
79
-
-
34249929950
-
Development of diabetes in obese, insulin-resistant mice: essential role of dietary carbohydrate in beta cell destruction
-
Jürgens H.S., Neschen S., Ortmann S., Scherneck S., Schmolz K., Schüler G., et al. Development of diabetes in obese, insulin-resistant mice: essential role of dietary carbohydrate in beta cell destruction. Diabetologia 2007, 50:1481-1489.
-
(2007)
Diabetologia
, vol.50
, pp. 1481-1489
-
-
Jürgens, H.S.1
Neschen, S.2
Ortmann, S.3
Scherneck, S.4
Schmolz, K.5
Schüler, G.6
-
80
-
-
33645776248
-
Hyperphagia, lower body temperature, and reduced running wheel activity precede development of morbid obesity in New Zealand obese mice
-
Jürgens H.S., Schürmann A., Kluge R., Ortmann S., Klaus S., Joost H.G., Tschöp M.H. Hyperphagia, lower body temperature, and reduced running wheel activity precede development of morbid obesity in New Zealand obese mice. Physiological Genomics 2006, 25:234-241.
-
(2006)
Physiological Genomics
, vol.25
, pp. 234-241
-
-
Jürgens, H.S.1
Schürmann, A.2
Kluge, R.3
Ortmann, S.4
Klaus, S.5
Joost, H.G.6
Tschöp, M.H.7
-
81
-
-
0017349397
-
Laboratory animals exhibiting obesity and diabetes syndromes
-
Herberg L., Coleman D.L. Laboratory animals exhibiting obesity and diabetes syndromes. Metabolism 1997, 26:59-99.
-
(1997)
Metabolism
, vol.26
, pp. 59-99
-
-
Herberg, L.1
Coleman, D.L.2
-
83
-
-
0034434695
-
Quantitative trait loci for obesity and insulin resistance (Nob1, Nob2) and their interaction with the leptin receptor allele (LeprA720T/T1044I) in New Zealand obese mice
-
Kluge R., Giesen K., Bahrenberg G., Plum L., Ortlepp J.R., Joost H.G. Quantitative trait loci for obesity and insulin resistance (Nob1, Nob2) and their interaction with the leptin receptor allele (LeprA720T/T1044I) in New Zealand obese mice. Diabetologia 2000, 43:1565-1572.
-
(2000)
Diabetologia
, vol.43
, pp. 1565-1572
-
-
Kluge, R.1
Giesen, K.2
Bahrenberg, G.3
Plum, L.4
Ortlepp, J.R.5
Joost, H.G.6
-
84
-
-
55049131588
-
Tbc1d1 mutation in lean mouse strain confers leanness and protects from diet-induced obesity
-
Chadt A., Leicht K., Deshmukh A., Jiang L.Q., Scherneck S., Bernhardt U., et al. Tbc1d1 mutation in lean mouse strain confers leanness and protects from diet-induced obesity. Nature Genetics 2008, 40:1354-1359.
-
(2008)
Nature Genetics
, vol.40
, pp. 1354-1359
-
-
Chadt, A.1
Leicht, K.2
Deshmukh, A.3
Jiang, L.Q.4
Scherneck, S.5
Bernhardt, U.6
-
85
-
-
84884692647
-
Conventional knockout of Tbc1d1 in mice impairs insulin- and AICAR-stimulated glucose uptake in skeletal muscle
-
Dokas J., Chadt A., Nolden T., Himmelbauer H., Zierath J.R., Joost H.G., Al-Hasani H. Conventional knockout of Tbc1d1 in mice impairs insulin- and AICAR-stimulated glucose uptake in skeletal muscle. Endocrinology 2013, 154:3502-3514.
-
(2013)
Endocrinology
, vol.154
, pp. 3502-3514
-
-
Dokas, J.1
Chadt, A.2
Nolden, T.3
Himmelbauer, H.4
Zierath, J.R.5
Joost, H.G.6
Al-Hasani, H.7
-
86
-
-
33748745768
-
TBC1D1 is a candidate for a severe obesity gene and evidence for a gene/gene interaction in obesity predisposition
-
Stone S., Abkevich V., Russell D.L., Riley R., Timms K., Tran T., et al. TBC1D1 is a candidate for a severe obesity gene and evidence for a gene/gene interaction in obesity predisposition. Human Molecular Genetics 2006, 15:2709-2720.
-
(2006)
Human Molecular Genetics
, vol.15
, pp. 2709-2720
-
-
Stone, S.1
Abkevich, V.2
Russell, D.L.3
Riley, R.4
Timms, K.5
Tran, T.6
-
87
-
-
44849112532
-
R125W coding variant in TBC1D1 confers risk for familial obesity and contributes to linkage on chromosome 4p14 in the French population
-
Meyre D., Farge M., Lecoeur C., Proenca C., Durand E., Allegaert F., et al. R125W coding variant in TBC1D1 confers risk for familial obesity and contributes to linkage on chromosome 4p14 in the French population. Human Molecular Genetics 2008, 17:1798-1802.
-
(2008)
Human Molecular Genetics
, vol.17
, pp. 1798-1802
-
-
Meyre, D.1
Farge, M.2
Lecoeur, C.3
Proenca, C.4
Durand, E.5
Allegaert, F.6
-
88
-
-
33748980248
-
Diabetic modifier QTLs identified in F2 intercrosses between Akita and A/J mice
-
Takeshita S., Moritani M., Kunika K., Inoue H., Itakura M. Diabetic modifier QTLs identified in F2 intercrosses between Akita and A/J mice. Mammalian Genome 2006, 17:927-940.
-
(2006)
Mammalian Genome
, vol.17
, pp. 927-940
-
-
Takeshita, S.1
Moritani, M.2
Kunika, K.3
Inoue, H.4
Itakura, M.5
-
89
-
-
84871187647
-
Bhlhe40, a potential diabetic modifier gene on Dbm1 locus, negatively controls myocyte fatty acid oxidation
-
Takeshita S., Suzuki T., Kitayama S., Moritani M., Inoue H., Itakuram M. Bhlhe40, a potential diabetic modifier gene on Dbm1 locus, negatively controls myocyte fatty acid oxidation. Genes & Genetic Systems 2012, 87:253-264.
-
(2012)
Genes & Genetic Systems
, vol.87
, pp. 253-264
-
-
Takeshita, S.1
Suzuki, T.2
Kitayama, S.3
Moritani, M.4
Inoue, H.5
Itakuram, M.6
-
90
-
-
67650269847
-
Characterization of Nob3, a major quantitative trait locus for obesity and hyperglycemia on mouse chromosome 1
-
Vogel H., Nestler M., Rüschendorf F., Block M.D., Tischer S., Kluge R., et al. Characterization of Nob3, a major quantitative trait locus for obesity and hyperglycemia on mouse chromosome 1. Physiological Genomics 2009, 38:226-232.
-
(2009)
Physiological Genomics
, vol.38
, pp. 226-232
-
-
Vogel, H.1
Nestler, M.2
Rüschendorf, F.3
Block, M.D.4
Tischer, S.5
Kluge, R.6
-
91
-
-
84865072344
-
Loss of function of Ifi202b by a microdeletion on chromosome 1 of C57BL/6J mice suppresses 11β-hydroxysteroid dehydrogenase type 1 expression and development of obesity
-
Vogel H., Scherneck S., Kanzleiter T., Benz V., Kluge R., Stadion M., et al. Loss of function of Ifi202b by a microdeletion on chromosome 1 of C57BL/6J mice suppresses 11β-hydroxysteroid dehydrogenase type 1 expression and development of obesity. Human Molecular Genetics 2012, 21:3845-3857.
-
(2012)
Human Molecular Genetics
, vol.21
, pp. 3845-3857
-
-
Vogel, H.1
Scherneck, S.2
Kanzleiter, T.3
Benz, V.4
Kluge, R.5
Stadion, M.6
-
92
-
-
84889101105
-
Identification of a loss-of-function mutation in Ube2l6 associated with obesity resistance
-
Marcelin G., Liu S.M., Schwartz G.J., Chua S.C. Identification of a loss-of-function mutation in Ube2l6 associated with obesity resistance. Diabetes 2013, 62:2784-2795.
-
(2013)
Diabetes
, vol.62
, pp. 2784-2795
-
-
Marcelin, G.1
Liu, S.M.2
Schwartz, G.J.3
Chua, S.C.4
-
93
-
-
33745260655
-
Positional cloning of Sorcs1, a type 2 diabetes quantitative trait locus
-
Clee S.M., Yandell B.S., Schueler K.M., Rabaglia M.E., Richards O.C., Raines S.M., et al. Positional cloning of Sorcs1, a type 2 diabetes quantitative trait locus. Nature Genetics 2006, 38:688-693.
-
(2006)
Nature Genetics
, vol.38
, pp. 688-693
-
-
Clee, S.M.1
Yandell, B.S.2
Schueler, K.M.3
Rabaglia, M.E.4
Richards, O.C.5
Raines, S.M.6
-
94
-
-
34347389636
-
SORCS1: a novel human type 2 diabetes susceptibility gene suggested by the mouse
-
Goodarzi M.O., Lehman D.M., Taylor K.D., Guo X., Cui J., Quiñones M.J., et al. SORCS1: a novel human type 2 diabetes susceptibility gene suggested by the mouse. Diabetes 2007, 56:1922-1929.
-
(2007)
Diabetes
, vol.56
, pp. 1922-1929
-
-
Goodarzi, M.O.1
Lehman, D.M.2
Taylor, K.D.3
Guo, X.4
Cui, J.5
Quiñones, M.J.6
-
95
-
-
80055076208
-
Positional cloning of a type 2 diabetes quantitative trait locus; tomosyn-2, a negative regulator of insulin secretion
-
Bhatnagar S., Oler A.T., Rabaglia M.E., Stapleton D.S., Schueler K.L., Truchan N.A., et al. Positional cloning of a type 2 diabetes quantitative trait locus; tomosyn-2, a negative regulator of insulin secretion. PLoS Genetics 2011, 7:e1002323.
-
(2011)
PLoS Genetics
, vol.7
-
-
Bhatnagar, S.1
Oler, A.T.2
Rabaglia, M.E.3
Stapleton, D.S.4
Schueler, K.L.5
Truchan, N.A.6
-
96
-
-
48249083457
-
Positional cloning of Lisch-Like, a candidate modifier of susceptibility to type 2 diabetes in mice
-
Dokmanovic-Chouinard M., Chung W.K., Chevre J.C., Watson E., Yonan J., Wiegand B., et al. Positional cloning of Lisch-Like, a candidate modifier of susceptibility to type 2 diabetes in mice. PLoS Genetis 2008, 4:e1000137.
-
(2008)
PLoS Genetis
, vol.4
-
-
Dokmanovic-Chouinard, M.1
Chung, W.K.2
Chevre, J.C.3
Watson, E.4
Yonan, J.5
Wiegand, B.6
-
97
-
-
68249127301
-
Positional cloning of zinc finger domain transcription factor Zfp69, a candidate gene for obesity-associated diabetes contributed by mouse locus Nidd/SJL
-
Scherneck S., Nestler M., Vogel H., Blüher M., Block M.D., Berriel Diaz M., et al. Positional cloning of zinc finger domain transcription factor Zfp69, a candidate gene for obesity-associated diabetes contributed by mouse locus Nidd/SJL. PLoS Genetics 2009, 5:e1000541.
-
(2009)
PLoS Genetics
, vol.5
-
-
Scherneck, S.1
Nestler, M.2
Vogel, H.3
Blüher, M.4
Block, M.D.5
Berriel Diaz, M.6
-
101
-
-
77956913463
-
Personalized epigenomic signatures that are stable over time and covary with body mass index
-
Feinberg A., Irizarry R., Fradin D., Aryee M.J., Murakami P., Aspelund T., Eiriksdottir G., Harris T.B., Launer L., Gudnason V., Fallin M.D. Personalized epigenomic signatures that are stable over time and covary with body mass index. Science Translational Medicine 2010, 2:1-16.
-
(2010)
Science Translational Medicine
, vol.2
, pp. 1-16
-
-
Feinberg, A.1
Irizarry, R.2
Fradin, D.3
Aryee, M.J.4
Murakami, P.5
Aspelund, T.6
Eiriksdottir, G.7
Harris, T.B.8
Launer, L.9
Gudnason, V.10
Fallin, M.D.11
-
102
-
-
84863986133
-
Functions of DNA methylation: islands, start sites, gene bodies and beyond
-
Jones P.A. Functions of DNA methylation: islands, start sites, gene bodies and beyond. Nature Reviews Genetics 2012, 13:484-492.
-
(2012)
Nature Reviews Genetics
, vol.13
, pp. 484-492
-
-
Jones, P.A.1
-
103
-
-
84863889319
-
In vivo control of CpG and non-CpG DNA methylation by DNA methyltransferases
-
Arand J., Spieler D., Karius T., Branco M.R., Meilinger D., Meissner A., Jenuwein T., Xu G., Leonhardt H., Wolf V., Walter J. In vivo control of CpG and non-CpG DNA methylation by DNA methyltransferases. PLoS Genetics 2012, 8:e1002750.
-
(2012)
PLoS Genetics
, vol.8
-
-
Arand, J.1
Spieler, D.2
Karius, T.3
Branco, M.R.4
Meilinger, D.5
Meissner, A.6
Jenuwein, T.7
Xu, G.8
Leonhardt, H.9
Wolf, V.10
Walter, J.11
-
104
-
-
69149087790
-
Non-CpG methylation of the PGC-1alpha promoter through DNMT3B controls mitochondrial density
-
Barrès R., Osler M.E., Yan J., Rune A., Fritz T., Caidahl K., Krook A., Zierath J.R. Non-CpG methylation of the PGC-1alpha promoter through DNMT3B controls mitochondrial density. Cell Metabolism 2009, 10:189-198.
-
(2009)
Cell Metabolism
, vol.10
, pp. 189-198
-
-
Barrès, R.1
Osler, M.E.2
Yan, J.3
Rune, A.4
Fritz, T.5
Caidahl, K.6
Krook, A.7
Zierath, J.R.8
-
105
-
-
79953197543
-
Hypermethylation of hepatic glucokinase and L-type pyruvate kinase promoters in high-fat diet-induced obese Rats
-
Jiang M., Zhang Y., Liu M., Lan M.S., Fei J., Fan W., Gao X., Lu D. Hypermethylation of hepatic glucokinase and L-type pyruvate kinase promoters in high-fat diet-induced obese Rats. Endocrinology 2011, 152:1284-1289.
-
(2011)
Endocrinology
, vol.152
, pp. 1284-1289
-
-
Jiang, M.1
Zhang, Y.2
Liu, M.3
Lan, M.S.4
Fei, J.5
Fan, W.6
Gao, X.7
Lu, D.8
-
106
-
-
84885953389
-
Diet-dependent alterations of hepatic Scd1 expression are accompanied by differences in promoter methylation
-
([Epub ahead of print])
-
Schwenk R.W., Jonas W., Ernst S.B., Kammel A., Jähnert M., Schürmann A. Diet-dependent alterations of hepatic Scd1 expression are accompanied by differences in promoter methylation. Hormone and Metabolic Research 2013, ([Epub ahead of print]).
-
(2013)
Hormone and Metabolic Research
-
-
Schwenk, R.W.1
Jonas, W.2
Ernst, S.B.3
Kammel, A.4
Jähnert, M.5
Schürmann, A.6
-
107
-
-
84866052921
-
Hepatic lipid accumulation alters global histone h3 lysine 9 and 4 trimethylation in the peroxisome proliferator-activated receptor alpha network
-
Jun H.-J., Kim J., Hoang M.-H., Lee S.-J. Hepatic lipid accumulation alters global histone h3 lysine 9 and 4 trimethylation in the peroxisome proliferator-activated receptor alpha network. PloS One 2012, 7:e44345.
-
(2012)
PloS One
, vol.7
-
-
Jun, H.-J.1
Kim, J.2
Hoang, M.-H.3
Lee, S.-J.4
-
108
-
-
77958596171
-
Chronic high-fat diet in fathers programs β-cell dysfunction in female rat offspring
-
Ng S., Lin R., Laybutt R., Barres R., Owens J., Morris M. Chronic high-fat diet in fathers programs β-cell dysfunction in female rat offspring. Nature 2010, 467:963-966.
-
(2010)
Nature
, vol.467
, pp. 963-966
-
-
Ng, S.1
Lin, R.2
Laybutt, R.3
Barres, R.4
Owens, J.5
Morris, M.6
-
109
-
-
40049102090
-
Inheritance of an epigenetic mark: the CpG DNA methyltransferase 1 is required for de novo establishment of a complex pattern of non-CpG methylation
-
Grandjean V., Yaman R., Cuzin F., Rassoulzadegan M. Inheritance of an epigenetic mark: the CpG DNA methyltransferase 1 is required for de novo establishment of a complex pattern of non-CpG methylation. PloS One 2007, 2:e1136.
-
(2007)
PloS One
, vol.2
-
-
Grandjean, V.1
Yaman, R.2
Cuzin, F.3
Rassoulzadegan, M.4
-
110
-
-
70350313230
-
Maternal high-fat diet promotes body length increases and insulin insensitivity in second-generation mice
-
Dunn G.A., Bale T.L. Maternal high-fat diet promotes body length increases and insulin insensitivity in second-generation mice. Endocrinology 2009, 150:4999-5009.
-
(2009)
Endocrinology
, vol.150
, pp. 4999-5009
-
-
Dunn, G.A.1
Bale, T.L.2
-
111
-
-
79960114901
-
Offspring of mothers fed a high fat diet display hepatic cell cycle inhibition and associated changes in gene expression and DNA methylation
-
Dudley K.J., Sloboda D.M., Connor K.L., Beltrand J., Vickers M.H. Offspring of mothers fed a high fat diet display hepatic cell cycle inhibition and associated changes in gene expression and DNA methylation. Cell Cycle 2011, 6:e21662.
-
(2011)
Cell Cycle
, vol.6
-
-
Dudley, K.J.1
Sloboda, D.M.2
Connor, K.L.3
Beltrand, J.4
Vickers, M.H.5
-
112
-
-
79955096234
-
Maternal diet and aging alter the epigenetic control of a promoter-enhancer interaction at the Hnf4a gene in rat pancreatic islets
-
Sandovici I., Smith N.H., Dekker M., Ackers-Johnson M., Uribe-Lewis S. Maternal diet and aging alter the epigenetic control of a promoter-enhancer interaction at the Hnf4a gene in rat pancreatic islets. Proceedings of the National Academy of Sciences of the United States of America 2011, 108:5449-5454.
-
(2011)
Proceedings of the National Academy of Sciences of the United States of America
, vol.108
, pp. 5449-5454
-
-
Sandovici, I.1
Smith, N.H.2
Dekker, M.3
Ackers-Johnson, M.4
Uribe-Lewis, S.5
-
113
-
-
84873804024
-
Direct control of hepatic glucose production by interleukin-13 in mice
-
Stanya K.J., Jacobi D., Liu S., Bhargava P., Dai L., Gangl M.R., Inouye K., Barlow J.L., Ji Y., Mizgerd J.P., Qi L., Shi H., Mckenzie A.N.J., Lee C. Direct control of hepatic glucose production by interleukin-13 in mice. Journal of Clinical Investigation 2013, 123:261-271.
-
(2013)
Journal of Clinical Investigation
, vol.123
, pp. 261-271
-
-
Stanya, K.J.1
Jacobi, D.2
Liu, S.3
Bhargava, P.4
Dai, L.5
Gangl, M.R.6
Inouye, K.7
Barlow, J.L.8
Ji, Y.9
Mizgerd, J.P.10
Qi, L.11
Shi, H.12
Mckenzie, A.N.J.13
Lee, C.14
-
114
-
-
84863334811
-
Increased DNA methylation and decreased expression of PDX-1 in pancreatic islets from patients with type 2 diabetes
-
Yang B.T., Dayeh T.A., Volkov P.A., Kirkpatrick C.L., Malmgren S., Jing X., Renström E., Wollheim C.B., Nitert M.D., Ling C. Increased DNA methylation and decreased expression of PDX-1 in pancreatic islets from patients with type 2 diabetes. Molecular Endocrinology (Baltimore, Md.) 2012, 26:1-10.
-
(2012)
Molecular Endocrinology (Baltimore, Md.)
, vol.26
, pp. 1-10
-
-
Yang, B.T.1
Dayeh, T.A.2
Volkov, P.A.3
Kirkpatrick, C.L.4
Malmgren, S.5
Jing, X.6
Renström, E.7
Wollheim, C.B.8
Nitert, M.D.9
Ling, C.10
-
115
-
-
84880335165
-
DNA methylation of the glucagon-like peptide 1 receptor (GLP1R) in human pancreatic islets
-
Hall E., Dayeh T., Kirkpatrick C.L., Wollheim C.B., Dekker Nitert M., Ling C. DNA methylation of the glucagon-like peptide 1 receptor (GLP1R) in human pancreatic islets. BMC Medical Genetics 2013, 14:76.
-
(2013)
BMC Medical Genetics
, vol.14
, pp. 76
-
-
Hall, E.1
Dayeh, T.2
Kirkpatrick, C.L.3
Wollheim, C.B.4
Dekker Nitert, M.5
Ling, C.6
-
116
-
-
78650446334
-
Paternally induced transgenerational environmental reprogramming of metabolic gene expression in mammals
-
Carone B.R., Fauquier L., Habib N., Shea J.M., Hart C.E., Li R., Bock C., Li C., Gu H., Zamore P.D., Meissner A., Weng Z., Hofmann H.A., Friedman N., Rando O.J. Paternally induced transgenerational environmental reprogramming of metabolic gene expression in mammals. Cell 2010, 143:1084-1096.
-
(2010)
Cell
, vol.143
, pp. 1084-1096
-
-
Carone, B.R.1
Fauquier, L.2
Habib, N.3
Shea, J.M.4
Hart, C.E.5
Li, R.6
Bock, C.7
Li, C.8
Gu, H.9
Zamore, P.D.10
Meissner, A.11
Weng, Z.12
Hofmann, H.A.13
Friedman, N.14
Rando, O.J.15
-
117
-
-
20444411948
-
Dietary protein restriction of pregnant rats induces and folic acid supplementation prevents epigenetic modification of hepatic gene expression in the offspring
-
Lillycrop K.A., Phillips E.S., Jackson A.A., Hanson M.A., Burdge G.C. Dietary protein restriction of pregnant rats induces and folic acid supplementation prevents epigenetic modification of hepatic gene expression in the offspring. Journal of Nutrition 2005, 1382-1386.
-
(2005)
Journal of Nutrition
, pp. 1382-1386
-
-
Lillycrop, K.A.1
Phillips, E.S.2
Jackson, A.A.3
Hanson, M.A.4
Burdge, G.C.5
-
118
-
-
84889093638
-
-
Piyathilake C.J., Celedonio J.E., Macaluso M., Bell W.C., Grizzle W.E. NIH Public Access 2009, 24:94-99.
-
(2009)
NIH Public Access
, vol.24
, pp. 94-99
-
-
Piyathilake, C.J.1
Celedonio, J.E.2
Macaluso, M.3
Bell, W.C.4
Grizzle, W.E.5
-
119
-
-
84863189292
-
Expression of DNA methyltransferases in the mouse uterus during early pregnancy and susceptibility to dietary folate deficiency
-
Ding Y.B., He J.L., Liu X.Q., Chen X.M., Long C.L., Wang Y.X. Expression of DNA methyltransferases in the mouse uterus during early pregnancy and susceptibility to dietary folate deficiency. Reproduction (Cambridge, England) 2012, 144:91-100.
-
(2012)
Reproduction (Cambridge, England)
, vol.144
, pp. 91-100
-
-
Ding, Y.B.1
He, J.L.2
Liu, X.Q.3
Chen, X.M.4
Long, C.L.5
Wang, Y.X.6
-
120
-
-
84874289975
-
Maternal diet supplemented with methyl-donors protects against atherosclerosis in F1 ApoE(-/-) mice
-
Delaney C., Garg S.K., Fernandes C., Hoeltzel M., Allen R.H., Stabler S., Yung R. Maternal diet supplemented with methyl-donors protects against atherosclerosis in F1 ApoE(-/-) mice. PloS One 2013, 8:e56253.
-
(2013)
PloS One
, vol.8
-
-
Delaney, C.1
Garg, S.K.2
Fernandes, C.3
Hoeltzel, M.4
Allen, R.H.5
Stabler, S.6
Yung, R.7
-
121
-
-
77957258099
-
Maternal high-fat diet alters methylation and gene expression of dopamine and opioid-related genes
-
Vucetic Z., Kimmel J., Totoki K., Hollenbeck E., Reyes T.M. Maternal high-fat diet alters methylation and gene expression of dopamine and opioid-related genes. Endocrinology 2010, 151:4756-4764.
-
(2010)
Endocrinology
, vol.151
, pp. 4756-4764
-
-
Vucetic, Z.1
Kimmel, J.2
Totoki, K.3
Hollenbeck, E.4
Reyes, T.M.5
-
122
-
-
84877055098
-
Methyl donor supplementation blocks the adverse effects of maternal high fat diet on offspring physiology
-
Carlin J., George R., Reyes T.M. Methyl donor supplementation blocks the adverse effects of maternal high fat diet on offspring physiology. PloS One 2013, 8:e63549.
-
(2013)
PloS One
, vol.8
-
-
Carlin, J.1
George, R.2
Reyes, T.M.3
-
123
-
-
84868295000
-
Food-induced brain responses and eating behaviour
-
Smeets P.A., Charbonnier L., van Meer F., van der Laan L.N., Spetter M.S. Food-induced brain responses and eating behaviour. Proceedings of the Nutrition Society 2012, 71:511-520.
-
(2012)
Proceedings of the Nutrition Society
, vol.71
, pp. 511-520
-
-
Smeets, P.A.1
Charbonnier, L.2
van Meer, F.3
van der Laan, L.N.4
Spetter, M.S.5
-
124
-
-
0033781030
-
Hypothalamic dopamine and serotonin in the regulation of food intake
-
Meguid M.M., Fetissov S.O., Varma M., Sato T., Zhang L., Laviano A., Rossi-Fanelli F. Hypothalamic dopamine and serotonin in the regulation of food intake. Nutrition (Burbank, Los Angeles County, California) 2000, 16:843-857.
-
(2000)
Nutrition (Burbank, Los Angeles County, California)
, vol.16
, pp. 843-857
-
-
Meguid, M.M.1
Fetissov, S.O.2
Varma, M.3
Sato, T.4
Zhang, L.5
Laviano, A.6
Rossi-Fanelli, F.7
-
125
-
-
78650752631
-
Reward, dopamine and the control of food intake: implications for obesity
-
Volkow N., Wang G., Baler R. Reward, dopamine and the control of food intake: implications for obesity. Trends in Cognitive Sciences 2011, 15:37-46.
-
(2011)
Trends in Cognitive Sciences
, vol.15
, pp. 37-46
-
-
Volkow, N.1
Wang, G.2
Baler, R.3
-
126
-
-
0041422625
-
Feeding-induced dopamine release in dorsal striatum correlates with meal pleasantness ratings in healthy human volunteers
-
Small D.M., Jones-Gotman M., Dagher A. Feeding-induced dopamine release in dorsal striatum correlates with meal pleasantness ratings in healthy human volunteers. Neuroimage 2003, 19:1709-1715.
-
(2003)
Neuroimage
, vol.19
, pp. 1709-1715
-
-
Small, D.M.1
Jones-Gotman, M.2
Dagher, A.3
-
127
-
-
28444442694
-
Corticostriatal-hypothalamic circuitry and food motivation: integration of energy, action and reward
-
Kelley A.E., Baldo B.A., Pratt W.E., Will M.J. Corticostriatal-hypothalamic circuitry and food motivation: integration of energy, action and reward. Physiology & Behavior 2005, 86:773-795.
-
(2005)
Physiology & Behavior
, vol.86
, pp. 773-795
-
-
Kelley, A.E.1
Baldo, B.A.2
Pratt, W.E.3
Will, M.J.4
-
128
-
-
64549162774
-
High-fat diet decreases tyrosine hydroxylase mRNA expression irrespective of obesity susceptibility in mice
-
Li Y., South T., Han M., Chen J., Wang R., Huang X.F. High-fat diet decreases tyrosine hydroxylase mRNA expression irrespective of obesity susceptibility in mice. Brain Research 2009, 1268:181-189.
-
(2009)
Brain Research
, vol.1268
, pp. 181-189
-
-
Li, Y.1
South, T.2
Han, M.3
Chen, J.4
Wang, R.5
Huang, X.F.6
-
129
-
-
84857918896
-
Epigenetic dysregulation of the dopamine system in diet-induced obesity
-
Vucetic Z., Carlin J.L., Totoki K., Reyes T.M. Epigenetic dysregulation of the dopamine system in diet-induced obesity. Journal of Neurochemistry 2012, 120:891-898.
-
(2012)
Journal of Neurochemistry
, vol.120
, pp. 891-898
-
-
Vucetic, Z.1
Carlin, J.L.2
Totoki, K.3
Reyes, T.M.4
-
130
-
-
78649842241
-
Genomics, type 2 diabetes, and obesity
-
McCarthy M.I. Genomics, type 2 diabetes, and obesity. New England Journal of Medicine 2010, 363:2339-2350.
-
(2010)
New England Journal of Medicine
, vol.363
, pp. 2339-2350
-
-
McCarthy, M.I.1
-
131
-
-
84866686337
-
Synaptic plasticity in neuronal circuits regulating energy balance
-
Zeltser L.M., Seeley R.J., Tschöp M.H. Synaptic plasticity in neuronal circuits regulating energy balance. Nature Neuroscience 2012, 15:1336-1342.
-
(2012)
Nature Neuroscience
, vol.15
, pp. 1336-1342
-
-
Zeltser, L.M.1
Seeley, R.J.2
Tschöp, M.H.3
-
132
-
-
70350674919
-
Hypothalamic proopiomelanocortin promoter methylation becomes altered by early overfeeding: an epigenetic model of obesity and the metabolic syndrome
-
Plagemann A., Harder T., Brunn M., Harder A., Roepke K., Wittrock-staar M., Ziska T., Schellong K., Rodekamp E., Melchior K., Dudenhausen J.W. Hypothalamic proopiomelanocortin promoter methylation becomes altered by early overfeeding: an epigenetic model of obesity and the metabolic syndrome. Journal of Physiology 2009, 20:4963-4976.
-
(2009)
Journal of Physiology
, vol.20
, pp. 4963-4976
-
-
Plagemann, A.1
Harder, T.2
Brunn, M.3
Harder, A.4
Roepke, K.5
Wittrock-staar, M.6
Ziska, T.7
Schellong, K.8
Rodekamp, E.9
Melchior, K.10
Dudenhausen, J.W.11
-
133
-
-
84859226938
-
An Alu element-associated hypermethylation variant of the POMC gene is associated with childhood obesity
-
Kuehnen P., Mischke M., Wiegand S., Sers C., Horsthemke B., Lau S., Keil T., Lee Y.-A., Grueters A., Krude H. An Alu element-associated hypermethylation variant of the POMC gene is associated with childhood obesity. PLoS Genetics 2012, 8:e1002543.
-
(2012)
PLoS Genetics
, vol.8
-
-
Kuehnen, P.1
Mischke, M.2
Wiegand, S.3
Sers, C.4
Horsthemke, B.5
Lau, S.6
Keil, T.7
Lee, Y.-A.8
Grueters, A.9
Krude, H.10
-
134
-
-
84878929919
-
IGF2 methylation is associated with lipid profile in obese children
-
Deodati A., Inzaghi E., Liguori A., Puglianiello A., Germani D., Brufani C., Fintini D., Cappa M., Barbetti F., Cianfarani S. IGF2 methylation is associated with lipid profile in obese children. Hormone Research in Paediatrics 2013, 79:361-367.
-
(2013)
Hormone Research in Paediatrics
, vol.79
, pp. 361-367
-
-
Deodati, A.1
Inzaghi, E.2
Liguori, A.3
Puglianiello, A.4
Germani, D.5
Brufani, C.6
Fintini, D.7
Cappa, M.8
Barbetti, F.9
Cianfarani, S.10
-
135
-
-
84875041053
-
Fatty acid binding protein 3 (fabp3) is associated with insulin, lipids and cardiovascular phenotypes of the metabolic syndrome through epigenetic modifications in a northern European family population
-
Zhang Y., Kent J.W., Lee A., Cerjak D., Ali O., Diasio R., Olivier M., Blangero J., Carless M.A., Kissebah A.H. Fatty acid binding protein 3 (fabp3) is associated with insulin, lipids and cardiovascular phenotypes of the metabolic syndrome through epigenetic modifications in a northern European family population. BMC Medical Genomics 2013, 6:9.
-
(2013)
BMC Medical Genomics
, vol.6
, pp. 9
-
-
Zhang, Y.1
Kent, J.W.2
Lee, A.3
Cerjak, D.4
Ali, O.5
Diasio, R.6
Olivier, M.7
Blangero, J.8
Carless, M.A.9
Kissebah, A.H.10
-
136
-
-
84878769670
-
Differential DNA methylation patterns between high and low responders to a weight loss intervention in overweight or obese adolescents: the EVASYON study
-
Moleres A., Campión J., Milagro F.I., Marcos A., Campoy C., Garagorri J.M., Gómez-Martínez S., Martínez J.A., Azcona-Sanjulián M.C., Martí A. Differential DNA methylation patterns between high and low responders to a weight loss intervention in overweight or obese adolescents: the EVASYON study. FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology 2013, 27:2504-2512.
-
(2013)
FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
, vol.27
, pp. 2504-2512
-
-
Moleres, A.1
Campión, J.2
Milagro, F.I.3
Marcos, A.4
Campoy, C.5
Garagorri, J.M.6
Gómez-Martínez, S.7
Martínez, J.A.8
Azcona-Sanjulián, M.C.9
Martí, A.10
-
137
-
-
84858055958
-
Acute exercise remodels promoter methylation in human skeletal muscle
-
Barrès R., Yan J., Egan B., Treebak J.T., Rasmussen M., Fritz T., Caidahl K., Krook A., O'Gorman D.J., Zierath J.R. Acute exercise remodels promoter methylation in human skeletal muscle. Cell Metabolism 2012, 15:405-411.
-
(2012)
Cell Metabolism
, vol.15
, pp. 405-411
-
-
Barrès, R.1
Yan, J.2
Egan, B.3
Treebak, J.T.4
Rasmussen, M.5
Fritz, T.6
Caidahl, K.7
Krook, A.8
O'Gorman, D.J.9
Zierath, J.R.10
-
138
-
-
84879678934
-
A six months exercise intervention influences the genome-wide DNA methylation pattern in human adipose tissue
-
Rönn T., Volkov P., Davegårdh C., Dayeh T. A six months exercise intervention influences the genome-wide DNA methylation pattern in human adipose tissue. PLoS Genetics 2013, 9:e1003572.
-
(2013)
PLoS Genetics
, vol.9
-
-
Rönn, T.1
Volkov, P.2
Davegårdh, C.3
Dayeh, T.4
|