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Volumn 56, Issue 2, 2013, Pages 311-322

Functional relevance of genes implicated by obesity genome-wide association study signals for human adipocyte biology

Author keywords

Adipocyte; Adipogenesis; BDNF; GWAS; MTCH2; NEGR1; Obesity; SGBS; TMEM18

Indexed keywords

BRAIN DERIVED NEUROTROPHIC FACTOR; CELL PROTEIN; DEXAMETHASONE; INSULIN; MITOCHONDRIAL CARRIER HOMOLOGUE 2 PROTEIN; NEURONAL GROWTH REGULATOR PROTEIN; NIEMANN PICK DISEASE TYPE C1 PROTEIN; PHOSPHOTRIESTERASE RELATED PROTEIN; SH2B ADAPTOR PROTEIN 1; SMALL INTERFERING RNA; TRANSCRIPTION FACTOR MAF; TRANSMEMBRANE PROTEIN 18; UNCLASSIFIED DRUG; CARRIER PROTEIN; GLYCOSYLPHOSPHATIDYLINOSITOL ANCHORED PROTEIN; MAF PROTEIN, HUMAN; MEMBRANE PROTEIN; MTCH2 PROTEIN, HUMAN; NEGR1 PROTEIN, HUMAN; NERVE CELL ADHESION MOLECULE; NPC1 PROTEIN, HUMAN; PTER PROTEIN, HUMAN; SH2B1 PROTEIN, HUMAN; SIGNAL TRANSDUCING ADAPTOR PROTEIN; TMEM18 PROTEIN, HUMAN; TRANSCRIPTION FACTOR C MAF;

EID: 84878795484     PISSN: 0012186X     EISSN: 14320428     Source Type: Journal    
DOI: 10.1007/s00125-012-2773-0     Document Type: Article
Times cited : (74)

References (50)
  • 1
    • 59149097625 scopus 로고    scopus 로고
    • Genome-wide association study for early-onset and morbid adult obesity identifies three new risk loci in European populations
    • 19151714 10.1038/ng.301 1:CAS:528:DC%2BD1MXntFGktg%3D%3D
    • Meyre D, Delplanque J, Chèvre JC et al (2009) Genome-wide association study for early-onset and morbid adult obesity identifies three new risk loci in European populations. Nat Genet 41:157-159
    • (2009) Nat Genet , vol.41 , pp. 157-159
    • Meyre, D.1    Delplanque, J.2    Chèvre, J.C.3
  • 2
    • 58149163141 scopus 로고    scopus 로고
    • Genome-wide association yields new sequence variants at seven loci that associate with measures of obesity
    • 19079260 10.1038/ng.274 1:CAS:528:DC%2BD1cXhsV2hsrjO
    • Thorleifsson G, Walters GB, Gudbjartsson DF et al (2009) Genome-wide association yields new sequence variants at seven loci that associate with measures of obesity. Nat Genet 41:18-24
    • (2009) Nat Genet , vol.41 , pp. 18-24
    • Thorleifsson, G.1    Walters, G.B.2    Gudbjartsson, D.F.3
  • 3
    • 58149163142 scopus 로고    scopus 로고
    • Six new loci associated with body mass index highlight a neuronal influence on body weight regulation
    • 19079261 10.1038/ng.287 1:CAS:528:DC%2BD1cXhsV2hsrnK
    • Willer CJ, Speliotes EK, Loos RJ et al (2009) Six new loci associated with body mass index highlight a neuronal influence on body weight regulation. Nat Genet 41:25-34
    • (2009) Nat Genet , vol.41 , pp. 25-34
    • Willer, C.J.1    Speliotes, E.K.2    Loos, R.J.3
  • 4
    • 64349105205 scopus 로고    scopus 로고
    • Identification and importance of brown adipose tissue in adult humans
    • 19357406 10.1056/NEJMoa0810780 1:CAS:528:DC%2BD1MXltlSqsro%3D
    • Cypess AM, Lehman S, Williams G et al (2009) Identification and importance of brown adipose tissue in adult humans. N Engl J Med 360:1509-1517
    • (2009) N Engl J Med , vol.360 , pp. 1509-1517
    • Cypess, A.M.1    Lehman, S.2    Williams, G.3
  • 5
    • 84858285593 scopus 로고    scopus 로고
    • Dysfunction of lipid sensor GPR120 leads to obesity in both mouse and human
    • 22343897 10.1038/nature10798 1:CAS:528:DC%2BC38XisVKru74%3D
    • Ichimura A, Hirasawa A, Poulain-Godefroy O et al (2012) Dysfunction of lipid sensor GPR120 leads to obesity in both mouse and human. Nature 483:350-354
    • (2012) Nature , vol.483 , pp. 350-354
    • Ichimura, A.1    Hirasawa, A.2    Poulain-Godefroy, O.3
  • 6
    • 84856011484 scopus 로고    scopus 로고
    • Metagenomic systems biology of the human gut microbiome reveals topological shifts associated with obesity and inflammatory bowel disease
    • 22184244 10.1073/pnas.1116053109 1:CAS:528:DC%2BC38Xht1ensbc%3D
    • Greenblum S, Turnbaugh PJ, Borenstein E (2012) Metagenomic systems biology of the human gut microbiome reveals topological shifts associated with obesity and inflammatory bowel disease. Proc Natl Acad Sci USA 109:594-599
    • (2012) Proc Natl Acad Sci USA , vol.109 , pp. 594-599
    • Greenblum, S.1    Turnbaugh, P.J.2    Borenstein, E.3
  • 7
    • 80054911514 scopus 로고    scopus 로고
    • Forming functional fat: A growing understanding of adipocyte differentiation
    • 21952300 10.1038/nrm3198 1:CAS:528:DC%2BC3MXht1anu7%2FN
    • Cristancho AG, Lazar MA (2011) Forming functional fat: a growing understanding of adipocyte differentiation. Nat Rev Mol Cell Biol 12:722-734
    • (2011) Nat Rev Mol Cell Biol , vol.12 , pp. 722-734
    • Cristancho, A.G.1    Lazar, M.A.2
  • 8
    • 0035129323 scopus 로고    scopus 로고
    • Characterization of a human pre-adipocyte cell strain with high capacity for adipose differentiation
    • 11244452 10.1038/sj.ijo.0801520 1:STN:280:DC%2BD38%2Fgs1GitQ%3D%3D
    • Wabitsch M, Brenner RE, Melzner I et al (2001) Characterization of a human pre-adipocyte cell strain with high capacity for adipose differentiation. Int J Obes Relat Metab Disord 25:8-15
    • (2001) Int J Obes Relat Metab Disord , vol.25 , pp. 8-15
    • Wabitsch, M.1    Brenner, R.E.2    Melzner, I.3
  • 9
    • 26444479396 scopus 로고    scopus 로고
    • Adiponectin expression in humans is dependent on differentiation of adipocytes and down-regulated by humoral serum components of high molecular weight
    • 16202386 10.1016/j.bbrc.2005.09.064
    • Körner A, Wabitsch M, Seidel B et al (2005) Adiponectin expression in humans is dependent on differentiation of adipocytes and down-regulated by humoral serum components of high molecular weight. Biochem Biophys Res Commun 337:540-550
    • (2005) Biochem Biophys Res Commun , vol.337 , pp. 540-550
    • Körner, A.1    Wabitsch, M.2    Seidel, B.3
  • 10
    • 0032013007 scopus 로고    scopus 로고
    • The effect of glucose concentration on insulin-induced 3 T3-L1 adipose cell differentiation
    • 9545023 1:CAS:528:DyaK1cXktlOjsL0%3D
    • Gagnon A, Sorisky A (1998) The effect of glucose concentration on insulin-induced 3 T3-L1 adipose cell differentiation. Obes Res 6:157-163
    • (1998) Obes Res , vol.6 , pp. 157-163
    • Gagnon, A.1    Sorisky, A.2
  • 11
    • 0023919926 scopus 로고
    • Insulin-like growth factor-I is an essential regulator of the differentiation of 3 T3-L1 adipocytes
    • 2967822 1:CAS:528:DyaL1cXksV2itLc%3D
    • Smith PJ, Wise LS, Berkowitz R, Wan C, Rubin CS (1988) Insulin-like growth factor-I is an essential regulator of the differentiation of 3 T3-L1 adipocytes. J Biol Chem 263:9402-9408
    • (1988) J Biol Chem , vol.263 , pp. 9402-9408
    • Smith, P.J.1    Wise, L.S.2    Berkowitz, R.3    Wan, C.4    Rubin, C.S.5
  • 12
    • 0035076381 scopus 로고    scopus 로고
    • Effect of dexamethasone on adipocyte differentiation markers and tumour necrosis factor-alpha expression in human PAZ6 cells
    • 11317672 10.1007/s001250051630 1:CAS:528:DC%2BD3MXhsFCms70%3D
    • Zilberfarb V, Siquier K, Strosberg AD, Issad T (2001) Effect of dexamethasone on adipocyte differentiation markers and tumour necrosis factor-alpha expression in human PAZ6 cells. Diabetologia 44:377-386
    • (2001) Diabetologia , vol.44 , pp. 377-386
    • Zilberfarb, V.1    Siquier, K.2    Strosberg, A.D.3    Issad, T.4
  • 13
    • 0019427350 scopus 로고
    • Pharmacological characterizations of adrenergic receptors in human adipocytes
    • 6257762 10.1172/JCI110055 1:CAS:528:DyaL3MXps1KgsA%3D%3D
    • Burns TW, Langley PE, Terry BE et al (1981) Pharmacological characterizations of adrenergic receptors in human adipocytes. J Clin Invest 67:467-475
    • (1981) J Clin Invest , vol.67 , pp. 467-475
    • Burns, T.W.1    Langley, P.E.2    Terry, B.E.3
  • 14
    • 34347233419 scopus 로고    scopus 로고
    • Serum retinol-binding protein is more highly expressed in visceral than in subcutaneous adipose tissue and is a marker of intra-abdominal fat mass
    • 17618858 10.1016/j.cmet.2007.06.002
    • Kloting N, Graham TE, Berndt J et al (2007) Serum retinol-binding protein is more highly expressed in visceral than in subcutaneous adipose tissue and is a marker of intra-abdominal fat mass. Cell Metab 6:79-87
    • (2007) Cell Metab , vol.6 , pp. 79-87
    • Kloting, N.1    Graham, T.E.2    Berndt, J.3
  • 15
    • 67651216024 scopus 로고    scopus 로고
    • NRXN3 is a novel locus for waist circumference: A genome-wide association study from the CHARGE Consortium
    • 19557197 10.1371/journal.pgen.1000539
    • Heard-Costa NL, Zillikens MC, Monda KL et al (2009) NRXN3 is a novel locus for waist circumference: a genome-wide association study from the CHARGE Consortium. PLoS Genet 5:e1000539
    • (2009) PLoS Genet , vol.5 , pp. 1000539
    • Heard-Costa, N.L.1    Zillikens, M.C.2    Monda, K.L.3
  • 16
    • 67651236725 scopus 로고    scopus 로고
    • Genome-wide association scan meta-analysis identifies three loci influencing adiposity and fat distribution
    • 19557161 10.1371/journal.pgen.1000508
    • Lindgren CM, Heid IM, Randall JC et al (2009) Genome-wide association scan meta-analysis identifies three loci influencing adiposity and fat distribution. PLoS Genet 5:e1000508
    • (2009) PLoS Genet , vol.5 , pp. 1000508
    • Lindgren, C.M.1    Heid, I.M.2    Randall, J.C.3
  • 17
    • 64549158008 scopus 로고    scopus 로고
    • Replication and extension of genome-wide association study results for obesity in 4923 adults from northern Sweden
    • 19164386 10.1093/hmg/ddp041
    • Renström F, Payne F, Nordström A et al (2009) Replication and extension of genome-wide association study results for obesity in 4923 adults from northern Sweden. Hum Mol Genet 18:1489-1496
    • (2009) Hum Mol Genet , vol.18 , pp. 1489-1496
    • Renström, F.1    Payne, F.2    Nordström, A.3
  • 18
    • 79958140016 scopus 로고    scopus 로고
    • Impact of metabolic regulators on the expression of the obesity associated genes FTO and NAMPT in human pre-adipocytes and adipocytes
    • 21687707 10.1371/journal.pone.0019526 1:CAS:528:DC%2BC3MXns1yis7Y%3D
    • Friebe D, Löffler D, Schönberg M et al (2011) Impact of metabolic regulators on the expression of the obesity associated genes FTO and NAMPT in human pre-adipocytes and adipocytes. PLoS One 6:e19526
    • (2011) PLoS One , vol.6 , pp. 19526
    • Friebe, D.1    Löffler, D.2    Schönberg, M.3
  • 19
    • 67649875640 scopus 로고    scopus 로고
    • Loss-of-function mutation in the dioxygenase-encoding FTO gene causes severe growth retardation and multiple malformations
    • 19559399 10.1016/j.ajhg.2009.06.002 1:CAS:528:DC%2BD1MXhtVeltL7P
    • Boissel S, Reish O, Proulx K et al (2009) Loss-of-function mutation in the dioxygenase-encoding FTO gene causes severe growth retardation and multiple malformations. Am J Hum Genet 85:106-111
    • (2009) Am J Hum Genet , vol.85 , pp. 106-111
    • Boissel, S.1    Reish, O.2    Proulx, K.3
  • 20
    • 67349211789 scopus 로고    scopus 로고
    • Inactivation of the Fto gene protects from obesity
    • 19234441 10.1038/nature07848 1:CAS:528:DC%2BD1MXitFKltb4%3D
    • Fischer J, Koch L, Emmerling C et al (2009) Inactivation of the Fto gene protects from obesity. Nature 458:894-898
    • (2009) Nature , vol.458 , pp. 894-898
    • Fischer, J.1    Koch, L.2    Emmerling, C.3
  • 21
    • 0028134706 scopus 로고
    • Localization of the melanocortin-4 receptor (MC4-R) in neuroendocrine and autonomic control circuits in the brain
    • 7854347 10.1210/me.8.10.1298 1:CAS:528:DyaK2cXmvFeiurY%3D
    • Mountjoy KG, Mortrud MT, Low MJ, Simerly RB, Cone RD (1994) Localization of the melanocortin-4 receptor (MC4-R) in neuroendocrine and autonomic control circuits in the brain. Mol Endocrinol 8:1298-1308
    • (1994) Mol Endocrinol , vol.8 , pp. 1298-1308
    • Mountjoy, K.G.1    Mortrud, M.T.2    Low, M.J.3    Simerly, R.B.4    Cone, R.D.5
  • 22
    • 0030889192 scopus 로고    scopus 로고
    • Targeted disruption of the melanocortin-4 receptor results in obesity in mice
    • 9019399 10.1016/S0092-8674(00)81865-6 1:CAS:528:DyaK2sXltF2nsg%3D%3D
    • Huszar D, Lynch CA, Fairchild-Huntress V et al (1997) Targeted disruption of the melanocortin-4 receptor results in obesity in mice. Cell 88:131-141
    • (1997) Cell , vol.88 , pp. 131-141
    • Huszar, D.1    Lynch, C.A.2    Fairchild-Huntress, V.3
  • 23
    • 77955274518 scopus 로고    scopus 로고
    • PPARgamma in adipocyte differentiation and metabolism - Novel insights from genome-wide studies
    • 20542036 10.1016/j.febslet.2010.06.010 1:CAS:528:DC%2BC3cXps1Wmtr8%3D
    • Siersbaek R, Nielsen R, Mandrup S (2010) PPARgamma in adipocyte differentiation and metabolism - novel insights from genome-wide studies. FEBS Lett 584:3242-3249
    • (2010) FEBS Lett , vol.584 , pp. 3242-3249
    • Siersbaek, R.1    Nielsen, R.2    Mandrup, S.3
  • 24
    • 25844491778 scopus 로고    scopus 로고
    • Plasma visfatin concentrations and fat depot-specific mRNA expression in humans
    • 16186392 10.2337/diabetes.54.10.2911 1:CAS:528:DC%2BD2MXhtV2rs7%2FN
    • Berndt J, Klöting N, Kralisch S et al (2005) Plasma visfatin concentrations and fat depot-specific mRNA expression in humans. Diabetes 54:2911-2916
    • (2005) Diabetes , vol.54 , pp. 2911-2916
    • Berndt, J.1    Klöting, N.2    Kralisch, S.3
  • 25
    • 49649114875 scopus 로고    scopus 로고
    • Transmembrane protein 18 enhances the tropism of neural stem cells for glioma cells
    • 18559506 10.1158/0008-5472.CAN-07-5291 1:CAS:528:DC%2BD1cXnt1aqtLs%3D
    • Jurvansuu J, Zhao Y, Leung DSY et al (2008) Transmembrane protein 18 enhances the tropism of neural stem cells for glioma cells. Cancer Res 68:4614-4622
    • (2008) Cancer Res , vol.68 , pp. 4614-4622
    • Jurvansuu, J.1    Zhao, Y.2    Leung, D.S.Y.3
  • 26
    • 77952405825 scopus 로고    scopus 로고
    • Two new loci for body-weight regulation identified in a joint analysis of genome-wide association studies for early-onset extreme obesity in French and German study groups
    • 20421936 10.1371/journal.pgen.1000916
    • Scherag A, Dina C, Hinney A et al (2010) Two new loci for body-weight regulation identified in a joint analysis of genome-wide association studies for early-onset extreme obesity in French and German study groups. PLoS Genet 6:e1000916
    • (2010) PLoS Genet , vol.6 , pp. 1000916
    • Scherag, A.1    Dina, C.2    Hinney, A.3
  • 27
    • 78049337953 scopus 로고    scopus 로고
    • Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index
    • 20935630 10.1038/ng.686 1:CAS:528:DC%2BC3cXht1KmsL%2FN
    • Speliotes EK, Willer CJ, Berndt SI et al (2010) Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index. Nat Genet 42:937-948
    • (2010) Nat Genet , vol.42 , pp. 937-948
    • Speliotes, E.K.1    Willer, C.J.2    Berndt, S.I.3
  • 28
    • 79952182383 scopus 로고    scopus 로고
    • Potential therapeutic uses of BDNF in neurological and psychiatric disorders
    • 21358740 10.1038/nrd3366 1:CAS:528:DC%2BC3MXisFemsbo%3D
    • Nagahara AH, Tuszynski MH (2011) Potential therapeutic uses of BDNF in neurological and psychiatric disorders. Nat Rev Drug Discov 10:209-219
    • (2011) Nat Rev Drug Discov , vol.10 , pp. 209-219
    • Nagahara, A.H.1    Tuszynski, M.H.2
  • 29
    • 85027958110 scopus 로고    scopus 로고
    • Weighing in the role of BDNF in the central control of eating behavior
    • 22012072 10.1007/s12035-011-8212-2 1:CAS:528:DC%2BC3MXhsFOjt7bK
    • Cordeira J, Rios M (2011) Weighing in the role of BDNF in the central control of eating behavior. Mol Neurobiol 44:441-448
    • (2011) Mol Neurobiol , vol.44 , pp. 441-448
    • Cordeira, J.1    Rios, M.2
  • 30
    • 0038392755 scopus 로고    scopus 로고
    • Brain-derived neurotrophic factor regulates energy balance downstream of melanocortin-4 receptor
    • 12796784 10.1038/nn1073 1:CAS:528:DC%2BD3sXkvVKmtLg%3D
    • Xu B, Goulding EH, Zang K et al (2003) Brain-derived neurotrophic factor regulates energy balance downstream of melanocortin-4 receptor. Nat Neurosci 6:736-742
    • (2003) Nat Neurosci , vol.6 , pp. 736-742
    • Xu, B.1    Goulding, E.H.2    Zang, K.3
  • 31
    • 37549055474 scopus 로고    scopus 로고
    • Selective deletion of Bdnf in the ventromedial and dorsomedial hypothalamus of adult mice results in hyperphagic behavior and obesity
    • 18160634 10.1523/JNEUROSCI.3308-07.2007 1:CAS:528:DC%2BD1cXktVCqug%3D%3D
    • Unger TJ, Calderon GA, Bradley LC, Sena-Esteves M, Rios M (2007) Selective deletion of Bdnf in the ventromedial and dorsomedial hypothalamus of adult mice results in hyperphagic behavior and obesity. J Neurosci 27:14265-14274
    • (2007) J Neurosci , vol.27 , pp. 14265-14274
    • Unger, T.J.1    Calderon, G.A.2    Bradley, L.C.3    Sena-Esteves, M.4    Rios, M.5
  • 32
    • 33748741883 scopus 로고    scopus 로고
    • Serum brain-derived neurotrophic factor concentrations in lean and overweight children and adolescents
    • 16787984 10.1210/jc.2006-0658 1:CAS:528:DC%2BD28Xpslajur0%3D
    • El Gharbawy AH, Adler-Wailes DC, Mirch MC et al (2006) Serum brain-derived neurotrophic factor concentrations in lean and overweight children and adolescents. J Clin Endocrinol Metab 91:3548-3552
    • (2006) J Clin Endocrinol Metab , vol.91 , pp. 3548-3552
    • El Gharbawy, A.H.1    Adler-Wailes, D.C.2    Mirch, M.C.3
  • 33
    • 34447127251 scopus 로고    scopus 로고
    • Brain-derived neurotrophic factor (BDNF) and type 2 diabetes
    • 17151862 10.1007/s00125-006-0537-4 1:CAS:528:DC%2BD2sXitlSksw%3D%3D
    • Krabbe KS, Nielsen AR, Krogh-Madsen R et al (2007) Brain-derived neurotrophic factor (BDNF) and type 2 diabetes. Diabetologia 50:431-438
    • (2007) Diabetologia , vol.50 , pp. 431-438
    • Krabbe, K.S.1    Nielsen, A.R.2    Krogh-Madsen, R.3
  • 34
    • 0034653422 scopus 로고    scopus 로고
    • BDNF regulates eating behavior and locomotor activity in mice
    • 10716929 10.1093/emboj/19.6.1290 1:CAS:528:DC%2BD3cXit1GmsLg%3D
    • Kernie SG, Liebl DJ, Parada LF (2000) BDNF regulates eating behavior and locomotor activity in mice. EMBO J 19:1290-1300
    • (2000) EMBO J , vol.19 , pp. 1290-1300
    • Kernie, S.G.1    Liebl, D.J.2    Parada, L.F.3
  • 35
    • 77953121576 scopus 로고    scopus 로고
    • MTCH2/MIMP is a major facilitator of tBID recruitment to mitochondria
    • 20436477 10.1038/ncb2057 1:CAS:528:DC%2BC3cXmslShur4%3D
    • Zaltsman Y, Shachnai L, Yivgi-Ohana N et al (2010) MTCH2/MIMP is a major facilitator of tBID recruitment to mitochondria. Nat Cell Biol 12:553-562
    • (2010) Nat Cell Biol , vol.12 , pp. 553-562
    • Zaltsman, Y.1    Shachnai, L.2    Yivgi-Ohana, N.3
  • 36
    • 80053519280 scopus 로고    scopus 로고
    • MTCH2 in human white adipose tissue and obesity
    • 21795451 10.1210/jc.2010-3050
    • Kulyté A, Rydén M, Mejhert N et al (2011) MTCH2 in human white adipose tissue and obesity. J Clin Endocrinol Metab 96:E1661-E1165
    • (2011) J Clin Endocrinol Metab , vol.96
    • Kulyté, A.1    Rydén, M.2    Mejhert, N.3
  • 37
    • 84856246018 scopus 로고    scopus 로고
    • Expression of new loci associated with obesity in diet-induced obese rats: From genetics to physiology
    • 10.1038/oby.2011.236 1:CAS:528:DC%2BC38XhsFCmt7w%3D
    • Gutierrez-Aguilar R, Kim DH, Woods SC, Seeley RJ (2012) Expression of new loci associated with obesity in diet-induced obese rats: from genetics to physiology. Obes (Silver Spring) 20:306-312
    • (2012) Obes (Silver Spring) , vol.20 , pp. 306-312
    • Gutierrez-Aguilar, R.1    Kim, D.H.2    Woods, S.C.3    Seeley, R.J.4
  • 38
    • 0032801844 scopus 로고    scopus 로고
    • Role of PPAR gamma in regulating adipocyte differentiation and insulin-responsive glucose uptake
    • 10842659 10.1111/j.1749-6632.1999.tb07792.x 1:CAS:528: DC%2BD3cXhsFOnsQ%3D%3D
    • Hamm JK, el Jack AK, Pilch PF, Farmer SR (1999) Role of PPAR gamma in regulating adipocyte differentiation and insulin-responsive glucose uptake. Ann NY Acad Sci 892:134-145
    • (1999) Ann NY Acad Sci , vol.892 , pp. 134-145
    • Hamm, J.K.1    El Jack, A.K.2    Pilch, P.F.3    Farmer, S.R.4
  • 39
    • 0030977450 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor gene expression in human tissues. Effects of obesity, weight loss, and regulation by insulin and glucocorticoids
    • 9153284 10.1172/JCI119424 1:CAS:528:DyaK2sXjsVGqtro%3D
    • Vidal-Puig AJ, Considine RV, Jimenez-Linan M et al (1997) Peroxisome proliferator-activated receptor gene expression in human tissues. Effects of obesity, weight loss, and regulation by insulin and glucocorticoids. J Clin Invest 99:2416-2422
    • (1997) J Clin Invest , vol.99 , pp. 2416-2422
    • Vidal-Puig, A.J.1    Considine, R.V.2    Jimenez-Linan, M.3
  • 40
    • 0033583077 scopus 로고    scopus 로고
    • Characterization of a novel rat brain glycosylphosphatidylinositol- anchored protein (Kilon), a member of the IgLON cell adhesion molecule family
    • 10075727 10.1074/jbc.274.12.8224 1:CAS:528:DyaK1MXitFSrsLw%3D
    • Funatsu N, Miyata S, Kumanogoh H et al (1999) Characterization of a novel rat brain glycosylphosphatidylinositol-anchored protein (Kilon), a member of the IgLON cell adhesion molecule family. J Biol Chem 274:8224-8230
    • (1999) J Biol Chem , vol.274 , pp. 8224-8230
    • Funatsu, N.1    Miyata, S.2    Kumanogoh, H.3
  • 41
    • 47649105358 scopus 로고    scopus 로고
    • IgLON cell adhesion molecule Kilon is a crucial modulator for synapse number in hippocampal neurons
    • 18602091 10.1016/j.brainres.2008.05.069 1:CAS:528:DC%2BD1cXptVWjs70%3D
    • Hashimoto T, Yamada M, Maekawa S, Nakashima T, Miyata S (2008) IgLON cell adhesion molecule Kilon is a crucial modulator for synapse number in hippocampal neurons. Brain Res 1224:1-11
    • (2008) Brain Res , vol.1224 , pp. 1-11
    • Hashimoto, T.1    Yamada, M.2    Maekawa, S.3    Nakashima, T.4    Miyata, S.5
  • 42
    • 84855710418 scopus 로고    scopus 로고
    • Differential coexpression analysis of obesity-associated networks in human subcutaneous adipose tissue
    • 10.1038/ijo.2011.22 1:CAS:528:DC%2BC38XntF2mug%3D%3D
    • Walley AJ, Jacobson P, Falchi M et al (2012) Differential coexpression analysis of obesity-associated networks in human subcutaneous adipose tissue. Int J Obes (Lond) 36:137-147
    • (2012) Int J Obes (Lond) , vol.36 , pp. 137-147
    • Walley, A.J.1    Jacobson, P.2    Falchi, M.3
  • 43
    • 77957825249 scopus 로고    scopus 로고
    • Maf promotes osteoblast differentiation in mice by mediating the age-related switch in mesenchymal cell differentiation
    • 20877012 10.1172/JCI42528 1:CAS:528:DC%2BC3cXht1GgtLbP
    • Nishikawa K, Nakashima T, Takeda S et al (2010) Maf promotes osteoblast differentiation in mice by mediating the age-related switch in mesenchymal cell differentiation. J Clin Invest 120:3455-3465
    • (2010) J Clin Invest , vol.120 , pp. 3455-3465
    • Nishikawa, K.1    Nakashima, T.2    Takeda, S.3
  • 44
    • 25144523930 scopus 로고    scopus 로고
    • Identification of SH2-B as a key regulator of leptin sensitivity, energy balance, and body weight in mice
    • 10.1016/j.cmet.2005.07.004 1:CAS:528:DC%2BD2MXps12ht7o%3D
    • Ren D, Li M, Duan C, Rui L (2005) Identification of SH2-B as a key regulator of leptin sensitivity, energy balance, and body weight in mice. Cell Metabol 2:95-104
    • (2005) Cell Metabol , vol.2 , pp. 95-104
    • Ren, D.1    Li, M.2    Duan, C.3    Rui, L.4
  • 45
    • 4344581405 scopus 로고    scopus 로고
    • Disruption of the SH2-B gene causes age-dependent insulin resistance and glucose intolerance
    • 15314154 10.1128/MCB.24.17.7435-7443.2004 1:CAS:528:DC%2BD2cXntVKhtb4%3D
    • Duan C, Yang H, White MF, Rui L (2004) Disruption of the SH2-B gene causes age-dependent insulin resistance and glucose intolerance. Mol Cell Biol 24:7435-7443
    • (2004) Mol Cell Biol , vol.24 , pp. 7435-7443
    • Duan, C.1    Yang, H.2    White, M.F.3    Rui, L.4
  • 46
    • 33846822094 scopus 로고    scopus 로고
    • Neuronal SH2B1 is essential for controlling energy and glucose homeostasis
    • 17235396 10.1172/JCI29417 1:CAS:528:DC%2BD2sXhs1Oqtrw%3D
    • Ren D, Zhou Y, Morris D, Li M, Li Z, Rui L (2007) Neuronal SH2B1 is essential for controlling energy and glucose homeostasis. J Clin Invest 117:397-406
    • (2007) J Clin Invest , vol.117 , pp. 397-406
    • Ren, D.1    Zhou, Y.2    Morris, D.3    Li, M.4    Li, Z.5    Rui, L.6
  • 47
    • 34249909505 scopus 로고    scopus 로고
    • The National Niemann-Pick C1 disease database: Report of clinical features and health problems
    • 17497724 10.1002/ajmg.a.31735
    • Garver WS, Francis GA, Jelinek D et al (2007) The National Niemann-Pick C1 disease database: report of clinical features and health problems. Am J Med Genet A 143A:1204-1211
    • (2007) Am J Med Genet A , vol.143 , pp. 1204-1211
    • Garver, W.S.1    Francis, G.A.2    Jelinek, D.3
  • 48
    • 78650527923 scopus 로고    scopus 로고
    • Npc1 haploinsufficiency promotes weight gain and metabolic features associated with insulin resistance
    • 21036943 10.1093/hmg/ddq466 1:CAS:528:DC%2BC3cXhs1WgtbrL
    • Jelinek D, Millward V, Birdi A, Trouard TP, Heidenreich RA, Garver WS (2011) Npc1 haploinsufficiency promotes weight gain and metabolic features associated with insulin resistance. Hum Mol Genet 20:312-321
    • (2011) Hum Mol Genet , vol.20 , pp. 312-321
    • Jelinek, D.1    Millward, V.2    Birdi, A.3    Trouard, T.P.4    Heidenreich, R.A.5    Garver, W.S.6
  • 49
    • 55449112450 scopus 로고    scopus 로고
    • High-resolution mapping of expression-QTLs yields insight into human gene regulation
    • 18846210 10.1371/journal.pgen.1000214
    • Veyrieras JB, Kudaravalli S, Kim SY et al (2008) High-resolution mapping of expression-QTLs yields insight into human gene regulation. PLoS Genet 4:e1000214
    • (2008) PLoS Genet , vol.4 , pp. 1000214
    • Veyrieras, J.B.1    Kudaravalli, S.2    Kim, S.Y.3
  • 50
    • 77956857406 scopus 로고    scopus 로고
    • The small molecule phenamil is a modulator of adipocyte differentiation and PPARgamma expression
    • 20519739 10.1194/jlr.M008490 1:CAS:528:DC%2BC3cXhtVOltr%2FL
    • Park KW, Waki H, Choi SP, Park KM, Tontonoz P (2010) The small molecule phenamil is a modulator of adipocyte differentiation and PPARgamma expression. J Lipid Res 51:2775-2784
    • (2010) J Lipid Res , vol.51 , pp. 2775-2784
    • Park, K.W.1    Waki, H.2    Choi, S.P.3    Park, K.M.4    Tontonoz, P.5


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