메뉴 건너뛰기




Volumn 15, Issue 2, 2004, Pages 115-120

Gene variants, insulin resistance, and dyslipidaemia

Author keywords

Dyslipidaemia; Hepatic lipase; Insulin receptor substrate; Insulin sensitivity; LDL size; PC 1; PPAR 2

Indexed keywords

FATTY ACID BINDING PROTEIN; INSULIN; INSULIN RECEPTOR SUBSTRATE 1; INSULIN RECEPTOR SUBSTRATE 2; LIPOPROTEIN; LIVER TRIACYLGLYCEROL LIPASE; LOW DENSITY LIPOPROTEIN; MEMBRANE PROTEIN; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA 2; PROTEIN PC 1; UNCLASSIFIED DRUG;

EID: 1842452946     PISSN: 09579672     EISSN: None     Source Type: Journal    
DOI: 10.1097/00041433-200404000-00004     Document Type: Review
Times cited : (43)

References (37)
  • 1
    • 0024160877 scopus 로고
    • Banting lecture 1988. Role of insulin resistance in human disease
    • Reaven GM. Banting lecture 1988. Role of insulin resistance in human disease. Diabetes 1988; 37:1595-1607.
    • (1988) Diabetes , vol.37 , pp. 1595-1607
    • Reaven, G.M.1
  • 2
    • 0036615436 scopus 로고    scopus 로고
    • Molecular insights into insulin action and secretion
    • Rhodes CJ, White MF. Molecular insights into insulin action and secretion. Eur J Clin Invest 2002; 32 (Suppl. 3):3-13.
    • (2002) Eur J Clin Invest , vol.32 , Issue.3 SUPPL. , pp. 3-13
    • Rhodes, C.J.1    White, M.F.2
  • 3
    • 0141506880 scopus 로고    scopus 로고
    • Epidemic obesity and the metabolic syndrome
    • Haffner SM, Taegtmeyer H. Epidemic obesity and the metabolic syndrome. Circulation 2003; 108:1541-1545.
    • (2003) Circulation , vol.108 , pp. 1541-1545
    • Haffner, S.M.1    Taegtmeyer, H.2
  • 4
    • 0141730248 scopus 로고    scopus 로고
    • The metabolic syndrome. More than the sum of its parts?
    • Reilly MP, Rader DJ. The metabolic syndrome. More than the sum of its parts? Circulation 2003; 108:1546-1551. This study reviews the past and current definition of the metabolic syndrome.
    • (2003) Circulation , vol.108 , pp. 1546-1551
    • Reilly, M.P.1    Rader, D.J.2
  • 5
    • 2542507751 scopus 로고    scopus 로고
    • Insulin resistance syndrome predicts coronary heart disease events in elderly nondiabetic men
    • Lempiäinen P, Mykkänen L, Pyörälä K, et al. Insulin resistance syndrome predicts coronary heart disease events in elderly nondiabetic men. Circulation 1999; 100:123-128.
    • (1999) Circulation , vol.100 , pp. 123-128
    • Lempiäinen, P.1    Mykkänen, L.2    Pyörälä, K.3
  • 6
    • 0034002064 scopus 로고    scopus 로고
    • Cardiovascular risk factors clustering with endogenous hyperinsulinaemia predict death from coronary heart disease in patients with type II diabetes
    • Lehto S, Rönnemaa T, Pyörälä K, Laakao M. Cardiovascular risk factors clustering with endogenous hyperinsulinaemia predict death from coronary heart disease in patients with type II diabetes. Diabetologia 2000; 43:148-155.
    • (2000) Diabetologia , vol.43 , pp. 148-155
    • Lehto, S.1    Rönnemaa, T.2    Pyörälä, K.3    Laakao, M.4
  • 7
    • 0042767042 scopus 로고    scopus 로고
    • Minimal model-based insulin sensitivity has greater heritability and a different genetic basis than homeostasis model assessment or fasting insulin
    • Bergman RN, Zaccaro D, Watanabe RM, et al. Minimal model-based insulin sensitivity has greater heritability and a different genetic basis than homeostasis model assessment or fasting insulin. Diabetes 2003; 52:2168-2174. An excellent study comparing estimates based on fasting insulin, the HOMA index, and the insulin sensitivity index evaluated by the minimal model in a large number of subjects from the insulin Resistance and Atherosclerosis Study.
    • (2003) Diabetes , vol.52 , pp. 2168-2174
    • Bergman, R.N.1    Zaccaro, D.2    Watanabe, R.M.3
  • 8
    • 84910110212 scopus 로고    scopus 로고
    • The insulin resistance syndrome: Impact on lipoprotein metabolism and atherothrombosis
    • Ginsberg HN, Huang LS. The insulin resistance syndrome: impact on lipoprotein metabolism and atherothrombosis. J Cardiovasc Risk 2000; 7:325-331.
    • (2000) J Cardiovasc Risk , vol.7 , pp. 325-331
    • Ginsberg, H.N.1    Huang, L.S.2
  • 9
    • 0035217903 scopus 로고    scopus 로고
    • The Q121K PC-1 variant and obesity have additive and independent effects in causing insulin resistance
    • Frititta L, Baratta R, Spampinato D, et al. The Q121K PC-1 variant and obesity have additive and independent effects in causing insulin resistance. J Clin Endocrinol Metab 2001; 86:5888-5891.
    • (2001) J Clin Endocrinol Metab , vol.86 , pp. 5888-5891
    • Frititta, L.1    Baratta, R.2    Spampinato, D.3
  • 10
    • 0041808862 scopus 로고    scopus 로고
    • The K121Q polymorphism of the PC-1 gene is associated with insulin resistance but not with dyslipidemia
    • Kubaszek A, Pihlajamäki J, Karhapää P, et al. The K121Q polymorphism of the PC-1 gene is associated with insulin resistance but not with dyslipidemia. Diabetes Care 2003; 26:464-467. This study gives evidence that the effects of PC-1 on insulin action are probably present only in skeletal muscle.
    • (2003) Diabetes Care , vol.26 , pp. 464-467
    • Kubaszek, A.1    Pihlajamäki, J.2    Karhapää, P.3
  • 11
    • 0036772369 scopus 로고    scopus 로고
    • Effects of the Pro12Ala polymorphism of the peroxisome proliferator-activated receptor gamma-2 gene on adiposity, insulin sensitivity and lipid profile in the Spanish population
    • Gonzales Sanchez JL, Serrano Rios M, Fernandez Perez C, et al. Effects of the Pro12Ala polymorphism of the peroxisome proliferator-activated receptor gamma-2 gene on adiposity, insulin sensitivity and lipid profile in the Spanish population. Eur J Endocrinol 2002; 147:495-501.
    • (2002) Eur J Endocrinol , vol.147 , pp. 495-501
    • Gonzales Sanchez, J.L.1    Serrano Rios, M.2    Fernandez Perez, C.3
  • 12
    • 0029893417 scopus 로고    scopus 로고
    • A common amino acid polymorphism in insulin receptor substrate-1 causes impaired insulin signaling. Evidence from transfection studies
    • Almind K, Inoue G, Pedersen O, Kahn CR. A common amino acid polymorphism in insulin receptor substrate-1 causes impaired insulin signaling. Evidence from transfection studies. J Clin Invest 1996; 97:2569-2575.
    • (1996) J Clin Invest , vol.97 , pp. 2569-2575
    • Almind, K.1    Inoue, G.2    Pedersen, O.3    Kahn, C.R.4
  • 13
    • 0037622751 scopus 로고    scopus 로고
    • The Arg972 variant in insulin receptor substrate-1 is associated with an atherogenic profile in offspring of type 2 diabetic patient
    • Marini MA, Frontoni S, Mineo D, et al. The Arg972 variant in insulin receptor substrate-1 is associated with an atherogenic profile in offspring of type 2 diabetic patient. J Clin Endocrinol Metab 2003; 88:3368-3371. A comprehensive study on the significance of the common variant in the IRS-1 gene on glucose metabolism, lipids and lipoproteins, and markers of early atherosclerosis.
    • (2003) J Clin Endocrinol Metab , vol.88 , pp. 3368-3371
    • Marini, M.A.1    Frontoni, S.2    Mineo, D.3
  • 14
    • 0035084073 scopus 로고    scopus 로고
    • The G972R variant of the insulin receptor substrate-1 (IRS-1) gene, body fat distribution and insulin resistance
    • Baroni MG, Arca M, Sentinelli F, et al. The G972R variant of the insulin receptor substrate-1 (IRS-1) gene, body fat distribution and insulin resistance. Diabetologia 2001; 44:367-372.
    • (2001) Diabetologia , vol.44 , pp. 367-372
    • Baroni, M.G.1    Arca, M.2    Sentinelli, F.3
  • 15
    • 0036710280 scopus 로고    scopus 로고
    • IRS proteins and the common path to diabetes
    • White MF. IRS proteins and the common path to diabetes. Am J Physiol Endocrinol Metab 2002; 283:E413-E422. An excellent review on the early insulin signalling pathway.
    • (2002) Am J Physiol Endocrinol Metab , vol.283
    • White, M.F.1
  • 16
    • 0035432254 scopus 로고    scopus 로고
    • New amino acid substitutions in the IRS-2 gene in Finnish and Chinese subjects with late-onset type 2 diabetes
    • Wang H, Rissanen J, Miettinen R, et al. New amino acid substitutions in the IRS-2 gene in Finnish and Chinese subjects with late-onset type 2 diabetes. Diabetes 2001; 50:1949-1951.
    • (2001) Diabetes , vol.50 , pp. 1949-1951
    • Wang, H.1    Rissanen, J.2    Miettinen, R.3
  • 17
    • 0037238412 scopus 로고    scopus 로고
    • Polymorphisms of the insulin receptor substrate-2 in patients with type 2 diabetes
    • D'Alfonso R, Marini MA, Frittitta L, et al. Polymorphisms of the insulin receptor substrate-2 in patients with type 2 diabetes. J Clin Endocrinol Metab 2003; 88:317-322. This in-vivo and in-vitro study indicates that the common variant (Gly1057Asp) of the IRS-2 gene does not associate with insulin resistance, insulin secretion, or IRS-2 function in fibroblasts from carriers of this polymorphism. No defect in IRS-2 expression, insulin-stimulated phosphorylation, or binding to the p85 subunit of phosphatidylinositol 3-kinase was found.
    • (2003) J Clin Endocrinol Metab , vol.88 , pp. 317-322
    • D'Alfonso, R.1    Marini, M.A.2    Frittitta, L.3
  • 18
    • 0038645828 scopus 로고    scopus 로고
    • The metabolic syndrome: Peroxisome proliferator-activated receptor γ and its therapeutic modulation
    • Gurnell M, Savage DB, Chatterjee KK, O'Rahilly S. The metabolic syndrome: peroxisome proliferator-activated receptor γ and its therapeutic modulation. J Clin Endocrinol Metab 2003; 88:2412-2421. A comprehensive review on nuclear receptors (PPAR), their association with the metabolic syndrome and their therapeutic modulation.
    • (2003) J Clin Endocrinol Metab , vol.88 , pp. 2412-2421
    • Gurnell, M.1    Savage, D.B.2    Chatterjee, K.K.3    O'Rahilly, S.4
  • 19
    • 0038327846 scopus 로고    scopus 로고
    • PPAR agonists in the treatment of insulin resistance and associated arterial disease
    • Camejo G. PPAR agonists in the treatment of insulin resistance and associated arterial disease. Int J Clin Pract (Suppl.) 2003; 134:36-44.
    • (2003) Int J Clin Pract (Suppl.) , vol.134 , pp. 36-44
    • Camejo, G.1
  • 20
    • 0037900979 scopus 로고    scopus 로고
    • Minireview: Lipid metabolism, metabolic diseases, and peroxisome proliferator-activated receptors
    • Lee C-H, Olson P, Evans RM. Minireview: lipid metabolism, metabolic diseases, and peroxisome proliferator-activated receptors. Endocrinology 2003; 144:2201-2207. A review on the effects of peroxisome proliferator-activated receptors PPAR-α, PPAR-γ, and PPAR-δ, on glucose and lipid metabolism. Therapeutic aspects are also discussed.
    • (2003) Endocrinology , vol.144 , pp. 2201-2207
    • Lee, C.-H.1    Olson, P.2    Evans, R.M.3
  • 21
    • 0031595923 scopus 로고    scopus 로고
    • A Pro12Ala substitution in PPARgamma2 associated with decreased receptor activity, lower body mass index and improved insulin sensitivity
    • Deeb SS, Fajas L, Nemoto M, et al. A Pro12Ala substitution in PPARgamma2 associated with decreased receptor activity, lower body mass index and improved insulin sensitivity. Nat Genet 1998; 20:284-287.
    • (1998) Nat Genet , vol.20 , pp. 284-287
    • Deeb, S.S.1    Fajas, L.2    Nemoto, M.3
  • 22
    • 0033624575 scopus 로고    scopus 로고
    • The common PPARgamma Pro12Ala polymorphism is associated with decreased risk of type 2 diabetes
    • Altshuler D, Hirschhorn JN, Klannemark M, et al. The common PPARgamma Pro12Ala polymorphism is associated with decreased risk of type 2 diabetes. Nat Genet 2000; 26:76-80.
    • (2000) Nat Genet , vol.26 , pp. 76-80
    • Altshuler, D.1    Hirschhorn, J.N.2    Klannemark, M.3
  • 23
    • 0036329369 scopus 로고    scopus 로고
    • Association of ths Pro12Ala polymorphism in the PPAR-gamma2 gene with 3-year incidence of type 2 diabetes and body weight change in the Finnish Diabetes Prevention Study
    • Lindi VI, Uusitupa MI, Lindströn J, et al. for the Finnish Diabetes Prevention Study Group. Association of ths Pro12Ala polymorphism in the PPAR-gamma2 gene with 3-year incidence of type 2 diabetes and body weight change in the Finnish Diabetes Prevention Study. Diabetes 2002; 51:2581-2586. The Finnish Diabetes Prevention Study showed that the Pro12Ala polymorphism has a very strong interaction with life-style changes, implying a crucial role of the gene-environment interaction in the risk of type 2 diabetes.
    • (2002) Diabetes , vol.51 , pp. 2581-2586
    • Lindi, V.I.1    Uusitupa, M.I.2    Lindströn, J.3
  • 24
    • 0036303247 scopus 로고    scopus 로고
    • The effects of the Pro12Ala polymorphism of the peroxisome proliferator-activated receptor-gamma2 gene on insulin sensitivity and insulin metabolism interact with size at birth
    • Eriksson J, Lindi V, Uusitupa M, et al. The effects of the Pro12Ala polymorphism of the peroxisome proliferator-activated receptor-gamma2 gene on insulin sensitivity and insulin metabolism interact with size at birth. Diabetes 2002; 51:2321-2324.
    • (2002) Diabetes , vol.51 , pp. 2321-2324
    • Eriksson, J.1    Lindi, V.2    Uusitupa, M.3
  • 25
    • 0141886852 scopus 로고    scopus 로고
    • The effects of the Pro12Ala polymorphism of the PPAR-gamma2 gene on lipid metabolism interact with body size at birth
    • Eriksson J, Lindi V, Uusitupa M, et al. The effects of the Pro12Ala polymorphism of the PPAR-gamma2 gene on lipid metabolism interact with body size at birth. Clin Genet 2003; 64:366-370. This study showed that the 12Ala allele was associated with lipid and lipoprotein levels only among those who had a low birthweight.
    • (2003) Clin Genet , vol.64 , pp. 366-370
    • Eriksson, J.1    Lindi, V.2    Uusitupa, M.3
  • 26
    • 0344944629 scopus 로고    scopus 로고
    • Evidence for genetic epistasis in human insulin resistance: The combined effect of PC-1 (K121Q) and PPARgamma2 (P12A) polymorphisms
    • Baratta R, Di Paola R, Spampinato D, et al. Evidence for genetic epistasis in human insulin resistance: the combined effect of PC-1 (K121Q) and PPARgamma2 (P12A) polymorphisms. J Mol Med 2003; 81(11):718-23. This original study demonstrates a gene-gene interaction with respect to common polymorphisms in the PC-1 and PPAR-γ2 genes.
    • (2003) J Mol Med , vol.81 , Issue.11 , pp. 718-723
    • Baratta, R.1    Di Paola, R.2    Spampinato, D.3
  • 27
    • 0034107017 scopus 로고    scopus 로고
    • Hepatic lipase deficiency decreases the selective uptake of HDL-cholesteryl esters in vivo
    • Lambert G, Amar MJ, Martin P, et al. Hepatic lipase deficiency decreases the selective uptake of HDL-cholesteryl esters in vivo. J Lipid Res 2000; 41:667-672.
    • (2000) J Lipid Res , vol.41 , pp. 667-672
    • Lambert, G.1    Amar, M.J.2    Martin, P.3
  • 28
    • 0037195149 scopus 로고    scopus 로고
    • Dietary fat intake determines the effect of a common polymorphism in the hepatic lipase gene promoter on high-density lipoprotein metabolism. Evidence of a strong dose effect in this gene-nutrient interaction in the Framingham Study
    • Ordovas JM, Corella D, Demissie S, et al. Dietary fat intake determines the effect of a common polymorphism in the hepatic lipase gene promoter on high-density lipoprotein metabolism. Evidence of a strong dose effect in this gene-nutrient interaction in the Framingham Study. Circulation 2002; 106:2315-2321. A very important study demonstrating a gene-nutrient interaction with respect to a variant in the promoter region of the hepatic lipase gene.
    • (2002) Circulation , vol.106 , pp. 2315-2321
    • Ordovas, J.M.1    Corella, D.2    Demissie, S.3
  • 29
    • 0346739933 scopus 로고    scopus 로고
    • Fatty acid binding protein-2 gene variants and insulin resistance: Gene and gene-environment interaction effects
    • Weiss EP, Brown MD, Shuldiner AR, Hagberg JM. Fatty acid binding protein-2 gene variants and insulin resistance: gene and gene-environment interaction effects. Physiol Genom 2002; 10:145-157. A comprehensive review particularly on the Ala54Thr polymorphism of the fatty acid binding protein 2 gene. The review concentrates particularly on the interaction between behavioural and environmental factors and the Ala54Thr polymorphism.
    • (2002) Physiol Genom , vol.10 , pp. 145-157
    • Weiss, E.P.1    Brown, M.D.2    Shuldiner, A.R.3    Hagberg, J.M.4
  • 30
    • 0028940934 scopus 로고
    • An amino acid substitution in the human intestinal fatty acid binding protein is associated with increased fatty acid binding, increased fat oxidation, and insulin resistance
    • Baier LJ, Sacchettini JC, Knowler WC, et al. An amino acid substitution in the human intestinal fatty acid binding protein is associated with increased fatty acid binding, increased fat oxidation, and insulin resistance. J Clin Invest 1995; 95:1281-1287.
    • (1995) J Clin Invest , vol.95 , pp. 1281-1287
    • Baier, L.J.1    Sacchettini, J.C.2    Knowler, W.C.3
  • 31
    • 0035403711 scopus 로고    scopus 로고
    • Association of the Ala54Thr polymorphism in the intestinal fatty acid-binding protein with 2-h post-challenge insulin levels in the Framingham Offspring Study
    • Galluzzi JR, Cupples LA, Meigs JB, et al. Association of the Ala54Thr polymorphism in the intestinal fatty acid-binding protein with 2-h post-challenge insulin levels in the Framingham Offspring Study. Diabetes Care 2001; 24:1161-1166.
    • (2001) Diabetes Care , vol.24 , pp. 1161-1166
    • Galluzzi, J.R.1    Cupples, L.A.2    Meigs, J.B.3
  • 32
    • 0031709728 scopus 로고    scopus 로고
    • Postprandial lipemic response is modified by the polymorphism at codon 54 of the fatty acid-binding protein 2 gene
    • Ågren JJ, Valve R, Vidgren H, et al. Postprandial lipemic response is modified by the polymorphism at codon 54 of the fatty acid-binding protein 2 gene. Arterioscler Thromb Vasc Biol 1998; 18:1606-1610.
    • (1998) Arterioscler Thromb Vasc Biol , vol.18 , pp. 1606-1610
    • Ågren, J.J.1    Valve, R.2    Vidgren, H.3
  • 33
    • 0029151577 scopus 로고
    • Prospective study of small LDLs as a risk factor for non-insulin dependent diabetes mellitus in elderly men and women
    • Austin MA, Mykkänen L, Kuusisto J, et al. Prospective study of small LDLs as a risk factor for non-insulin dependent diabetes mellitus in elderly men and women. Circulation 1995; 92:1770-1778.
    • (1995) Circulation , vol.92 , pp. 1770-1778
    • Austin, M.A.1    Mykkänen, L.2    Kuusisto, J.3
  • 34
    • 0038802829 scopus 로고    scopus 로고
    • Influence of common variants in the CETP, LPL, HL and Apo E genes on LDL heterogeneity in healtry, middle-aged men
    • Skoglund-Andersson C, Ehrenborg E, Fischer RM, et al. Influence of common variants in the CETP, LPL, HL and Apo E genes on LDL heterogeneity in healtry, middle-aged men. Atherosclerosis 2003; 167:311-317. LDL particle size is a genetically influenced trait. This original article gives important information about the role of several gene variants in the regulation of LDL heterogeneity.
    • (2003) Atherosclerosis , vol.167 , pp. 311-317
    • Skoglund-Andersson, C.1    Ehrenborg, E.2    Fischer, R.M.3
  • 35
    • 0034925267 scopus 로고    scopus 로고
    • Plasma cholesteryl ester transfer protein activity is not linked to insulin sensitivity
    • Maclean PS, Tanner CJ, Houmard JA, Barakat HA. Plasma cholesteryl ester transfer protein activity is not linked to insulin sensitivity. Metabolism 2001; 50:783-788.
    • (2001) Metabolism , vol.50 , pp. 783-788
    • Maclean, P.S.1    Tanner, C.J.2    Houmard, J.A.3    Barakat, H.A.4
  • 36
    • 0036242302 scopus 로고    scopus 로고
    • Association between HDL-cholesterol and the Taq1B polymorphism in the cholesterol ester transfer protein gene in obese women
    • Heilbronn LK, Noakes M, Clifton PM. Association between HDL-cholesterol and the Taq1B polymorphism in the cholesterol ester transfer protein gene in obese women. Atherosclerosis 2002; 162:419-424.
    • (2002) Atherosclerosis , vol.162 , pp. 419-424
    • Heilbronn, L.K.1    Noakes, M.2    Clifton, P.M.3
  • 37
    • 0033913206 scopus 로고    scopus 로고
    • G-250A substitution in promoter of hepatic lipase gene is associated with dyslipidemia and insulin resistance in healthy control subjects and in members of families with familial combined hyperlipidemia
    • Pihlajamäki J, Karjalainen L, Karhapää P, et al. G-250A substitution in promoter of hepatic lipase gene is associated with dyslipidemia and insulin resistance in healthy control subjects and in members of families with familial combined hyperlipidemia. Arterioscler Thromb Vasc Biol 2000; 20:1789-1795.
    • (2000) Arterioscler Thromb Vasc Biol , vol.20 , pp. 1789-1795
    • Pihlajamäki, J.1    Karjalainen, L.2    Karhapää, P.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.