메뉴 건너뛰기




Volumn 9, Issue 6, 2013, Pages

A Six Months Exercise Intervention Influences the Genome-wide DNA Methylation Pattern in Human Adipose Tissue

Author keywords

[No Author keywords available]

Indexed keywords

GENOMIC DNA; INSULIN; MESSENGER RNA;

EID: 84879678934     PISSN: 15537390     EISSN: 15537404     Source Type: Journal    
DOI: 10.1371/journal.pgen.1003572     Document Type: Article
Times cited : (491)

References (60)
  • 1
    • 84864011135 scopus 로고    scopus 로고
    • Time use and physical activity: a shift away from movement across the globe
    • Ng SW, Popkin BM, (2012) Time use and physical activity: a shift away from movement across the globe. Obes Rev 13: 659-80.
    • (2012) Obes Rev , vol.13 , pp. 659-680
    • Ng, S.W.1    Popkin, B.M.2
  • 3
    • 78649842241 scopus 로고    scopus 로고
    • Genomics, type 2 diabetes, and obesity
    • McCarthy MI, (2010) Genomics, type 2 diabetes, and obesity. N Engl J Med 363: 2339-2350.
    • (2010) N Engl J Med , vol.363 , pp. 2339-2350
    • McCarthy, M.I.1
  • 4
    • 80054707972 scopus 로고    scopus 로고
    • Heritability and familiality of type 2 diabetes and related quantitative traits in the Botnia Study
    • Almgren P, Lehtovirta M, Isomaa B, Sarelin L, Taskinen MR, et al. (2011) Heritability and familiality of type 2 diabetes and related quantitative traits in the Botnia Study. Diabetologia 54: 2811-2819.
    • (2011) Diabetologia , vol.54 , pp. 2811-2819
    • Almgren, P.1    Lehtovirta, M.2    Isomaa, B.3    Sarelin, L.4    Taskinen, M.R.5
  • 5
    • 0003014882 scopus 로고    scopus 로고
    • Metabolic consequences of a family history of NIDDM (the Botnia study): evidence for sex-specific parental effects
    • Groop L, Forsblom C, Lehtovirta M, Tuomi T, Karanko S, et al. (1996) Metabolic consequences of a family history of NIDDM (the Botnia study): evidence for sex-specific parental effects. Diabetes 45: 1585-1593.
    • (1996) Diabetes , vol.45 , pp. 1585-1593
    • Groop, L.1    Forsblom, C.2    Lehtovirta, M.3    Tuomi, T.4    Karanko, S.5
  • 6
    • 77955515264 scopus 로고    scopus 로고
    • A family history of diabetes is associated with reduced physical fitness in the Prevalence, Prediction and Prevention of Diabetes (PPP)-Botnia study
    • Isomaa B, Forsen B, Lahti K, Holmstrom N, Waden J, et al. (2010) A family history of diabetes is associated with reduced physical fitness in the Prevalence, Prediction and Prevention of Diabetes (PPP)-Botnia study. Diabetologia 53: 1709-1713.
    • (2010) Diabetologia , vol.53 , pp. 1709-1713
    • Isomaa, B.1    Forsen, B.2    Lahti, K.3    Holmstrom, N.4    Waden, J.5
  • 7
    • 0037034257 scopus 로고    scopus 로고
    • Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin
    • Knowler WC, Barrett-Connor E, Fowler SE, Hamman RF, Lachin JM, et al. (2002) Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin. N Engl J Med 346: 393-403.
    • (2002) N Engl J Med , vol.346 , pp. 393-403
    • Knowler, W.C.1    Barrett-Connor, E.2    Fowler, S.E.3    Hamman, R.F.4    Lachin, J.M.5
  • 8
    • 0035799806 scopus 로고    scopus 로고
    • Prevention of type 2 diabetes mellitus by changes in lifestyle among subjects with impaired glucose tolerance
    • Tuomilehto J, Lindstrom J, Eriksson JG, Valle TT, Hamalainen H, et al. (2001) Prevention of type 2 diabetes mellitus by changes in lifestyle among subjects with impaired glucose tolerance. N Engl J Med 344: 1343-1350.
    • (2001) N Engl J Med , vol.344 , pp. 1343-1350
    • Tuomilehto, J.1    Lindstrom, J.2    Eriksson, J.G.3    Valle, T.T.4    Hamalainen, H.5
  • 11
    • 36049002392 scopus 로고    scopus 로고
    • Genetic and epigenetic factors are associated with expression of respiratory chain component NDUFB6 in human skeletal muscle
    • Ling C, Poulsen P, Simonsson S, Ronn T, Holmkvist J, et al. (2007) Genetic and epigenetic factors are associated with expression of respiratory chain component NDUFB6 in human skeletal muscle. J Clin Invest 117: 3427-3435.
    • (2007) J Clin Invest , vol.117 , pp. 3427-3435
    • Ling, C.1    Poulsen, P.2    Simonsson, S.3    Ronn, T.4    Holmkvist, J.5
  • 12
    • 44749089106 scopus 로고    scopus 로고
    • Age influences DNA methylation and gene expression of COX7A1 in human skeletal muscle
    • Ronn T, Poulsen P, Hansson O, Holmkvist J, Almgren P, et al. (2008) Age influences DNA methylation and gene expression of COX7A1 in human skeletal muscle. Diabetologia 51: 1159-1168.
    • (2008) Diabetologia , vol.51 , pp. 1159-1168
    • Ronn, T.1    Poulsen, P.2    Hansson, O.3    Holmkvist, J.4    Almgren, P.5
  • 13
    • 79955096234 scopus 로고    scopus 로고
    • Maternal diet and aging alter the epigenetic control of a promoter-enhancer interaction at the Hnf4a gene in rat pancreatic islets
    • Sandovici I, Smith NH, Nitert MD, Ackers-Johnson M, Uribe-Lewis S, et al. (2011) Maternal diet and aging alter the epigenetic control of a promoter-enhancer interaction at the Hnf4a gene in rat pancreatic islets. Proc Natl Acad Sci U S A 108: 5449-5454.
    • (2011) Proc Natl Acad Sci U S A , vol.108 , pp. 5449-5454
    • Sandovici, I.1    Smith, N.H.2    Nitert, M.D.3    Ackers-Johnson, M.4    Uribe-Lewis, S.5
  • 14
    • 0036144048 scopus 로고    scopus 로고
    • DNA methylation patterns and epigenetic memory
    • Bird A, (2002) DNA methylation patterns and epigenetic memory. Genes Dev 16: 6-21.
    • (2002) Genes Dev , vol.16 , pp. 6-21
    • Bird, A.1
  • 15
    • 76549135113 scopus 로고    scopus 로고
    • Evolution in health and medicine Sackler colloquium: Stochastic epigenetic variation as a driving force of development, evolutionary adaptation, and disease
    • Feinberg AP, Irizarry RA, (2010) Evolution in health and medicine Sackler colloquium: Stochastic epigenetic variation as a driving force of development, evolutionary adaptation, and disease. Proc Natl Acad Sci U S A 107 Suppl 1: 1757-1764.
    • (2010) Proc Natl Acad Sci U S A , vol.107 , Issue.SUPPL. , pp. 1757-1764
    • Feinberg, A.P.1    Irizarry, R.A.2
  • 16
    • 69149087790 scopus 로고    scopus 로고
    • Non-CpG methylation of the PGC-1alpha promoter through DNMT3B controls mitochondrial density
    • Barres R, Osler ME, Yan J, Rune A, Fritz T, et al. (2009) Non-CpG methylation of the PGC-1alpha promoter through DNMT3B controls mitochondrial density. Cell Metab 10: 189-198.
    • (2009) Cell Metab , vol.10 , pp. 189-198
    • Barres, R.1    Osler, M.E.2    Yan, J.3    Rune, A.4    Fritz, T.5
  • 17
    • 41149172495 scopus 로고    scopus 로고
    • Epigenetic regulation of PPARGC1A in human type 2 diabetic islets and effect on insulin secretion
    • Ling C, Del Guerra S, Lupi R, Ronn T, Granhall C, et al. (2008) Epigenetic regulation of PPARGC1A in human type 2 diabetic islets and effect on insulin secretion. Diabetologia 51: 615-622.
    • (2008) Diabetologia , vol.51 , pp. 615-622
    • Ling, C.1    Del Guerra, S.2    Lupi, R.3    Ronn, T.4    Granhall, C.5
  • 18
    • 73249133400 scopus 로고    scopus 로고
    • Epigenetics: a molecular link between environmental factors and type 2 diabetes
    • Ling C, Groop L, (2009) Epigenetics: a molecular link between environmental factors and type 2 diabetes. Diabetes 58: 2718-2725.
    • (2009) Diabetes , vol.58 , pp. 2718-2725
    • Ling, C.1    Groop, L.2
  • 19
    • 84858800629 scopus 로고    scopus 로고
    • DNA methylation profiling identifies epigenetic dysregulation in pancreatic islets from type 2 diabetic patients
    • Volkmar M, Dedeurwaerder S, Cunha DA, Ndlovu MN, Defrance M, et al. (2012) DNA methylation profiling identifies epigenetic dysregulation in pancreatic islets from type 2 diabetic patients. EMBO J 31: 1405-1426.
    • (2012) EMBO J , vol.31 , pp. 1405-1426
    • Volkmar, M.1    Dedeurwaerder, S.2    Cunha, D.A.3    Ndlovu, M.N.4    Defrance, M.5
  • 20
    • 78951472134 scopus 로고    scopus 로고
    • Insulin promoter DNA methylation correlates negatively with insulin gene expression and positively with HbA(1c) levels in human pancreatic islets
    • Yang BT, Dayeh TA, Kirkpatrick CL, Taneera J, Kumar R, et al. (2011) Insulin promoter DNA methylation correlates negatively with insulin gene expression and positively with HbA(1c) levels in human pancreatic islets. Diabetologia 54: 360-367.
    • (2011) Diabetologia , vol.54 , pp. 360-367
    • Yang, B.T.1    Dayeh, T.A.2    Kirkpatrick, C.L.3    Taneera, J.4    Kumar, R.5
  • 21
    • 84863334811 scopus 로고    scopus 로고
    • Increased DNA Methylation and Decreased Expression of PDX-1 in Pancreatic Islets from Patients with Type 2 Diabetes
    • Yang BT, Dayeh TA, Volkov PA, Kirkpatrick CL, Malmgren S, et al. (2012) Increased DNA Methylation and Decreased Expression of PDX-1 in Pancreatic Islets from Patients with Type 2 Diabetes. Mol Endocrinol 26: 1203-12.
    • (2012) Mol Endocrinol , vol.26 , pp. 1203-1212
    • Yang, B.T.1    Dayeh, T.A.2    Volkov, P.A.3    Kirkpatrick, C.L.4    Malmgren, S.5
  • 22
    • 75649087405 scopus 로고    scopus 로고
    • Differential epigenomic and transcriptomic responses in subcutaneous adipose tissue between low and high responders to caloric restriction
    • Bouchard L, Rabasa-Lhoret R, Faraj M, Lavoie ME, Mill J, et al. (2010) Differential epigenomic and transcriptomic responses in subcutaneous adipose tissue between low and high responders to caloric restriction. Am J Clin Nutr 91: 309-320.
    • (2010) Am J Clin Nutr , vol.91 , pp. 309-320
    • Bouchard, L.1    Rabasa-Lhoret, R.2    Faraj, M.3    Lavoie, M.E.4    Mill, J.5
  • 23
    • 84870319843 scopus 로고    scopus 로고
    • Impact of an Exercise Intervention on DNA Methylation in Skeletal Muscle From First-Degree Relatives of Patients With Type 2 Diabetes
    • Nitert MD, Dayeh T, Volkov P, Elgzyri T, Hall E, et al. (2012) Impact of an Exercise Intervention on DNA Methylation in Skeletal Muscle From First-Degree Relatives of Patients With Type 2 Diabetes. Diabetes 61: 3322-32.
    • (2012) Diabetes , vol.61 , pp. 3322-3332
    • Nitert, M.D.1    Dayeh, T.2    Volkov, P.3    Elgzyri, T.4    Hall, E.5
  • 24
    • 0042424602 scopus 로고    scopus 로고
    • Statistical significance for genomewide studies
    • Storey JD, Tibshirani R, (2003) Statistical significance for genomewide studies. Proc Natl Acad Sci U S A 100: 9440-9445.
    • (2003) Proc Natl Acad Sci U S A , vol.100 , pp. 9440-9445
    • Storey, J.D.1    Tibshirani, R.2
  • 25
    • 80053304450 scopus 로고    scopus 로고
    • High density DNA methylation array with single CpG site resolution
    • Bibikova M, Barnes B, Tsan C, Ho V, Klotzle B, et al. (2011) High density DNA methylation array with single CpG site resolution. Genomics 98: 288-295.
    • (2011) Genomics , vol.98 , pp. 288-295
    • Bibikova, M.1    Barnes, B.2    Tsan, C.3    Ho, V.4    Klotzle, B.5
  • 26
    • 84862173149 scopus 로고    scopus 로고
    • SWAN: Subset-quantile within array normalization for illumina infinium HumanMethylation450 BeadChips
    • Maksimovic J, Gordon L, Oshlack A, (2012) SWAN: Subset-quantile within array normalization for illumina infinium HumanMethylation450 BeadChips. Genome Biol 13: R44.
    • (2012) Genome Biol , vol.13
    • Maksimovic, J.1    Gordon, L.2    Oshlack, A.3
  • 27
    • 84874353239 scopus 로고    scopus 로고
    • Discovery of cross-reactive probes and polymorphic CpGs in the Illumina Infinium HumanMethylation450 microarray
    • Chen YA, Lemire M, Choufani S, Butcher DT, Grafodatskaya D, et al. (2013) Discovery of cross-reactive probes and polymorphic CpGs in the Illumina Infinium HumanMethylation450 microarray. Epigenetics 8: 203-9.
    • (2013) Epigenetics , vol.8 , pp. 203-209
    • Chen, Y.A.1    Lemire, M.2    Choufani, S.3    Butcher, D.T.4    Grafodatskaya, D.5
  • 28
    • 84860572791 scopus 로고    scopus 로고
    • Epigenome-wide scans identify differentially methylated regions for age and age-related phenotypes in a healthy ageing population
    • Bell JT, Tsai PC, Yang TP, Pidsley R, Nisbet J, et al. (2012) Epigenome-wide scans identify differentially methylated regions for age and age-related phenotypes in a healthy ageing population. PLoS Genet 8: e1002629.
    • (2012) PLoS Genet , vol.8
    • Bell, J.T.1    Tsai, P.C.2    Yang, T.P.3    Pidsley, R.4    Nisbet, J.5
  • 30
    • 77950657253 scopus 로고    scopus 로고
    • Human aging-associated DNA hypermethylation occurs preferentially at bivalent chromatin domains
    • Rakyan VK, Down TA, Maslau S, Andrew T, Yang TP, et al. (2010) Human aging-associated DNA hypermethylation occurs preferentially at bivalent chromatin domains. Genome Res 20: 434-439.
    • (2010) Genome Res , vol.20 , pp. 434-439
    • Rakyan, V.K.1    Down, T.A.2    Maslau, S.3    Andrew, T.4    Yang, T.P.5
  • 31
    • 80052725500 scopus 로고    scopus 로고
    • RLIP76, a glutathione-conjugate transporter, plays a major role in the pathogenesis of metabolic syndrome
    • Singhal J, Nagaprashantha L, Vatsyayan R, Awasthi S, Singhal SS, (2011) RLIP76, a glutathione-conjugate transporter, plays a major role in the pathogenesis of metabolic syndrome. PLoS One 6: e24688.
    • (2011) PLoS One , vol.6
    • Singhal, J.1    Nagaprashantha, L.2    Vatsyayan, R.3    Awasthi, S.4    Singhal, S.S.5
  • 32
    • 34548188298 scopus 로고    scopus 로고
    • Activation of RalA is required for insulin-stimulated Glut4 trafficking to the plasma membrane via the exocyst and the motor protein Myo1c
    • Chen XW, Leto D, Chiang SH, Wang Q, Saltiel AR, (2007) Activation of RalA is required for insulin-stimulated Glut4 trafficking to the plasma membrane via the exocyst and the motor protein Myo1c. Dev Cell 13: 391-404.
    • (2007) Dev Cell , vol.13 , pp. 391-404
    • Chen, X.W.1    Leto, D.2    Chiang, S.H.3    Wang, Q.4    Saltiel, A.R.5
  • 33
    • 79952775519 scopus 로고    scopus 로고
    • Corepressor SMRT promotes oxidative phosphorylation in adipose tissue and protects against diet-induced obesity and insulin resistance
    • Fang S, Suh JM, Atkins AR, Hong SH, Leblanc M, et al. (2011) Corepressor SMRT promotes oxidative phosphorylation in adipose tissue and protects against diet-induced obesity and insulin resistance. Proc Natl Acad Sci U S A 108: 3412-3417.
    • (2011) Proc Natl Acad Sci U S A , vol.108 , pp. 3412-3417
    • Fang, S.1    Suh, J.M.2    Atkins, A.R.3    Hong, S.H.4    Leblanc, M.5
  • 34
    • 77953297721 scopus 로고    scopus 로고
    • The silencing mediator of retinoid and thyroid hormone receptors (SMRT) regulates adipose tissue accumulation and adipocyte insulin sensitivity in vivo
    • Sutanto MM, Ferguson KK, Sakuma H, Ye H, Brady MJ, et al. (2010) The silencing mediator of retinoid and thyroid hormone receptors (SMRT) regulates adipose tissue accumulation and adipocyte insulin sensitivity in vivo. J Biol Chem 285: 18485-18495.
    • (2010) J Biol Chem , vol.285 , pp. 18485-18495
    • Sutanto, M.M.1    Ferguson, K.K.2    Sakuma, H.3    Ye, H.4    Brady, M.J.5
  • 35
    • 84861917539 scopus 로고    scopus 로고
    • Class II histone deacetylases downregulate GLUT4 transcription in response to increased cAMP signaling in cultured adipocytes and fasting mice
    • Weems JC, Griesel BA, Olson AL, (2012) Class II histone deacetylases downregulate GLUT4 transcription in response to increased cAMP signaling in cultured adipocytes and fasting mice. Diabetes 61: 1404-1414.
    • (2012) Diabetes , vol.61 , pp. 1404-1414
    • Weems, J.C.1    Griesel, B.A.2    Olson, A.L.3
  • 36
    • 84858055958 scopus 로고    scopus 로고
    • Acute exercise remodels promoter methylation in human skeletal muscle
    • Barres R, Yan J, Egan B, Treebak JT, Rasmussen M, et al. (2012) Acute exercise remodels promoter methylation in human skeletal muscle. Cell Metab 15: 405-411.
    • (2012) Cell Metab , vol.15 , pp. 405-411
    • Barres, R.1    Yan, J.2    Egan, B.3    Treebak, J.T.4    Rasmussen, M.5
  • 37
    • 79952429678 scopus 로고    scopus 로고
    • Physical activity and global genomic DNA methylation in a cancer-free population
    • Zhang FF, Cardarelli R, Carroll J, Zhang S, Fulda KG, et al. (2011) Physical activity and global genomic DNA methylation in a cancer-free population. Epigenetics 6: 293-299.
    • (2011) Epigenetics , vol.6 , pp. 293-299
    • Zhang, F.F.1    Cardarelli, R.2    Carroll, J.3    Zhang, S.4    Fulda, K.G.5
  • 38
    • 33751505540 scopus 로고    scopus 로고
    • DNA methylation profiling of human chromosomes 6, 20 and 22
    • Eckhardt F, Lewin J, Cortese R, Rakyan VK, Attwood J, et al. (2006) DNA methylation profiling of human chromosomes 6, 20 and 22. Nat Genet 38: 1378-1385.
    • (2006) Nat Genet , vol.38 , pp. 1378-1385
    • Eckhardt, F.1    Lewin, J.2    Cortese, R.3    Rakyan, V.K.4    Attwood, J.5
  • 39
    • 59149084538 scopus 로고    scopus 로고
    • The human colon cancer methylome shows similar hypo- and hypermethylation at conserved tissue-specific CpG island shores
    • Irizarry RA, Ladd-Acosta C, Wen B, Wu Z, Montano C, et al. (2009) The human colon cancer methylome shows similar hypo- and hypermethylation at conserved tissue-specific CpG island shores. Nat Genet 41: 178-186.
    • (2009) Nat Genet , vol.41 , pp. 178-186
    • Irizarry, R.A.1    Ladd-Acosta, C.2    Wen, B.3    Wu, Z.4    Montano, C.5
  • 40
    • 84863986133 scopus 로고    scopus 로고
    • Functions of DNA methylation: islands, start sites, gene bodies and beyond
    • Jones PA, (2012) Functions of DNA methylation: islands, start sites, gene bodies and beyond. Nat Rev Genet 13: 484-492.
    • (2012) Nat Rev Genet , vol.13 , pp. 484-492
    • Jones, P.A.1
  • 41
    • 84876458561 scopus 로고    scopus 로고
    • Identification of CpG-SNPs associated with type 2 diabetes and differential DNA methylation in human pancreatic islets
    • Dayeh TA, Olsson AH, Volkov P, Almgren P, Ronn T, et al. (2013) Identification of CpG-SNPs associated with type 2 diabetes and differential DNA methylation in human pancreatic islets. Diabetologia 56: 1036-46.
    • (2013) Diabetologia , vol.56 , pp. 1036-1046
    • Dayeh, T.A.1    Olsson, A.H.2    Volkov, P.3    Almgren, P.4    Ronn, T.5
  • 42
    • 77649267695 scopus 로고    scopus 로고
    • Dynamic changes in the human methylome during differentiation
    • Laurent L, Wong E, Li G, Huynh T, Tsirigos A, et al. (2010) Dynamic changes in the human methylome during differentiation. Genome Res 20: 320-331.
    • (2010) Genome Res , vol.20 , pp. 320-331
    • Laurent, L.1    Wong, E.2    Li, G.3    Huynh, T.4    Tsirigos, A.5
  • 43
    • 72449176438 scopus 로고    scopus 로고
    • Exercise, abdominal obesity, skeletal muscle, and metabolic risk: evidence for a dose response
    • Slentz CA, Houmard JA, Kraus WE, (2009) Exercise, abdominal obesity, skeletal muscle, and metabolic risk: evidence for a dose response. Obesity (Silver Spring) 17 Suppl 3: S27-33.
    • (2009) Obesity (Silver Spring) , vol.17 , Issue.SUPPL.
    • Slentz, C.A.1    Houmard, J.A.2    Kraus, W.E.3
  • 44
    • 78049349396 scopus 로고    scopus 로고
    • Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution
    • Heid IM, Jackson AU, Randall JC, Winkler TW, Qi L, et al. (2010) Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution. Nat Genet 42: 949-960.
    • (2010) Nat Genet , vol.42 , pp. 949-960
    • Heid, I.M.1    Jackson, A.U.2    Randall, J.C.3    Winkler, T.W.4    Qi, L.5
  • 45
    • 84874427659 scopus 로고    scopus 로고
    • Insights Into the Molecular Mechanism for Type 2 Diabetes Susceptibility at the KCNQ1 Locus From Temporal Changes in Imprinting Status in Human Islets
    • Travers ME, Mackay DJ, Nitert MD, Morris AP, Lindgren CM, et al. (2012) Insights Into the Molecular Mechanism for Type 2 Diabetes Susceptibility at the KCNQ1 Locus From Temporal Changes in Imprinting Status in Human Islets. Diabetes 62: 987-92.
    • (2012) Diabetes , vol.62 , pp. 987-992
    • Travers, M.E.1    Mackay, D.J.2    Nitert, M.D.3    Morris, A.P.4    Lindgren, C.M.5
  • 46
    • 84868035640 scopus 로고    scopus 로고
    • Adipose Tissue TCF7L2 Splicing Is Regulated by Weight Loss and Associates With Glucose and Fatty Acid Metabolism
    • Kaminska D, Kuulasmaa T, Venesmaa S, Kakela P, Vaittinen M, et al. (2012) Adipose Tissue TCF7L2 Splicing Is Regulated by Weight Loss and Associates With Glucose and Fatty Acid Metabolism. Diabetes 61: 2807-2813.
    • (2012) Diabetes , vol.61 , pp. 2807-2813
    • Kaminska, D.1    Kuulasmaa, T.2    Venesmaa, S.3    Kakela, P.4    Vaittinen, M.5
  • 47
    • 64149124055 scopus 로고    scopus 로고
    • Unique splicing pattern of the TCF7L2 gene in human pancreatic islets
    • Osmark P, Hansson O, Jonsson A, Ronn T, Groop L, et al. (2009) Unique splicing pattern of the TCF7L2 gene in human pancreatic islets. Diabetologia 52: 850-854.
    • (2009) Diabetologia , vol.52 , pp. 850-854
    • Osmark, P.1    Hansson, O.2    Jonsson, A.3    Ronn, T.4    Groop, L.5
  • 48
    • 84863520388 scopus 로고    scopus 로고
    • Make way for the 'next generation': application and prospects for genome-wide, epigenome-specific technologies in endocrine research
    • Emes RD, Farrell WE, (2012) Make way for the 'next generation': application and prospects for genome-wide, epigenome-specific technologies in endocrine research. J Mol Endocrinol 49: R19-27.
    • (2012) J Mol Endocrinol , vol.49
    • Emes, R.D.1    Farrell, W.E.2
  • 49
    • 77953812571 scopus 로고    scopus 로고
    • Epigenetics and gene expression
    • Gibney ER, Nolan CM, (2010) Epigenetics and gene expression. Heredity (Edinb) 105: 4-13.
    • (2010) Heredity (Edinb) , vol.105 , pp. 4-13
    • Gibney, E.R.1    Nolan, C.M.2
  • 50
    • 72549083582 scopus 로고    scopus 로고
    • Exercise-induced histone modifications in human skeletal muscle
    • McGee SL, Fairlie E, Garnham AP, Hargreaves M, (2009) Exercise-induced histone modifications in human skeletal muscle. J Physiol 587: 5951-5958.
    • (2009) J Physiol , vol.587 , pp. 5951-5958
    • McGee, S.L.1    Fairlie, E.2    Garnham, A.P.3    Hargreaves, M.4
  • 51
    • 82655181792 scopus 로고    scopus 로고
    • Nuclear hormone receptor co-repressors: structure and function
    • Watson PJ, Fairall L, Schwabe JW, (2012) Nuclear hormone receptor co-repressors: structure and function. Mol Cell Endocrinol 348: 440-449.
    • (2012) Mol Cell Endocrinol , vol.348 , pp. 440-449
    • Watson, P.J.1    Fairall, L.2    Schwabe, J.W.3
  • 52
    • 84869106554 scopus 로고    scopus 로고
    • Inhibition of Class I Histone Deacetylases Unveils a Mitochondrial Signature and Enhances Oxidative Metabolism in Skeletal Muscle and Adipose Tissue
    • Galmozzi A, Mitro N, Ferrari A, Gers E, Gilardi F, et al. (2012) Inhibition of Class I Histone Deacetylases Unveils a Mitochondrial Signature and Enhances Oxidative Metabolism in Skeletal Muscle and Adipose Tissue. Diabetes 62: 732-42.
    • (2012) Diabetes , vol.62 , pp. 732-742
    • Galmozzi, A.1    Mitro, N.2    Ferrari, A.3    Gers, E.4    Gilardi, F.5
  • 53
    • 84863560008 scopus 로고    scopus 로고
    • First-Degree Relatives of Type 2 Diabetic Patients Have Reduced Expression of Genes Involved in Fatty Acid Metabolism in Skeletal Muscle
    • Elgzyri T, Parikh H, Zhou Y, Nitert MD, Ronn T, et al. (2012) First-Degree Relatives of Type 2 Diabetic Patients Have Reduced Expression of Genes Involved in Fatty Acid Metabolism in Skeletal Muscle. J Clin Endocrinol Metab 97: E1332-7.
    • (2012) J Clin Endocrinol Metab , vol.97
    • Elgzyri, T.1    Parikh, H.2    Zhou, Y.3    Nitert, M.D.4    Ronn, T.5
  • 56
    • 28744458859 scopus 로고    scopus 로고
    • Bioconductor: open software development for computational biology and bioinformatics
    • Gentleman RC, Carey VJ, Bates DM, Bolstad B, Dettling M, et al. (2004) Bioconductor: open software development for computational biology and bioinformatics. Genome Biol 5: R80.
    • (2004) Genome Biol , vol.5
    • Gentleman, R.C.1    Carey, V.J.2    Bates, D.M.3    Bolstad, B.4    Dettling, M.5
  • 57
    • 46249088370 scopus 로고    scopus 로고
    • lumi: a pipeline for processing Illumina microarray
    • Du P, Kibbe WA, Lin SM, (2008) lumi: a pipeline for processing Illumina microarray. Bioinformatics 24: 1547-1548.
    • (2008) Bioinformatics , vol.24 , pp. 1547-1548
    • Du, P.1    Kibbe, W.A.2    Lin, S.M.3
  • 58
    • 78649475003 scopus 로고    scopus 로고
    • Comparison of Beta-value and M-value methods for quantifying methylation levels by microarray analysis
    • Du P, Zhang X, Huang CC, Jafari N, Kibbe WA, et al. (2010) Comparison of Beta-value and M-value methods for quantifying methylation levels by microarray analysis. BMC Bioinformatics 11: 587.
    • (2010) BMC Bioinformatics , vol.11 , pp. 587
    • Du, P.1    Zhang, X.2    Huang, C.C.3    Jafari, N.4    Kibbe, W.A.5
  • 59
    • 33845432928 scopus 로고    scopus 로고
    • Adjusting batch effects in microarray expression data using empirical Bayes methods
    • Johnson WE, Li C, Rabinovic A, (2007) Adjusting batch effects in microarray expression data using empirical Bayes methods. Biostatistics 8: 118-127.
    • (2007) Biostatistics , vol.8 , pp. 118-127
    • Johnson, W.E.1    Li, C.2    Rabinovic, A.3
  • 60
    • 0142121516 scopus 로고    scopus 로고
    • Exploration, normalization, and summaries of high density oligonucleotide array probe level data
    • Irizarry RA, Hobbs B, Collin F, Beazer-Barclay YD, Antonellis KJ, et al. (2003) Exploration, normalization, and summaries of high density oligonucleotide array probe level data. Biostatistics 4: 249-264.
    • (2003) Biostatistics , vol.4 , pp. 249-264
    • Irizarry, R.A.1    Hobbs, B.2    Collin, F.3    Beazer-Barclay, Y.D.4    Antonellis, K.J.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.