Role for the obesity-related FTO gene in the cellular sensing of amino acids

Proceedings of the National Academy of Sciences of the United States of America

Volumn 110, Issue 7, 2013, Pages 2557-2562

  Gulati, Pawan ^a,b   Cheung, Man Ka ^a,b   Antrobus, Robin ^c   Church, Chris D ^d   Harding, Heather P ^a,b   Tung, Yi Chun Loraine ^a,b   Rimmington, Debra ^a,b   Ma, Marcella ^a,b   Ron, David ^a,b   Lehner, Paul J ^c   Ashcroft, Frances M ^e   Cox, Roger D ^d   Coll, Anthony P ^a,b   O'Rahilly, Stephen ^a,b   Yeo, Giles S H ^a,b  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^b ADDENBROOKE S HOSPITAL   (United Kingdom)

^c UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^d MEDICAL RESEARCH COUNCIL   (United Kingdom)

^e UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

Demethylase; Genetics; Translation; tRNA synthetase

Indexed keywords

AMINO ACID; MAMMALIAN TARGET OF RAPAMYCIN COMPLEX 1; TRANSFER RNA;

ANIMAL CELL; ARTICLE; AUTOPHAGOSOME; BODY COMPOSITION; CELL FRACTIONATION; CELLULAR DISTRIBUTION; DISEASE SEVERITY; FTO GENE; GENE; GROWTH RATE; GROWTH RETARDATION; HUMAN; HUMAN CELL; LOSS OF FUNCTION MUTATION; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; PROTEIN SYNTHESIS; RNA TRANSLATION; SIGNAL TRANSDUCTION; SINGLE NUCLEOTIDE POLYMORPHISM; SURVIVAL RATE;

AMINO ACIDS; ANIMALS; BODY COMPOSITION; CELL FRACTIONATION; CHROMATOGRAPHY, LIQUID; ELECTROPHORESIS, POLYACRYLAMIDE GEL; FIBROBLASTS; HEK293 CELLS; HUMANS; IMMUNOPRECIPITATION; MICE; OBESITY; POLYMORPHISM, SINGLE NUCLEOTIDE; PROTEINS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; TANDEM MASS SPECTROMETRY; TOR SERINE-THREONINE KINASES;

EID: 84873735640     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1222796110     Document Type: Article

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