Backbone cyclic peptidomimetic melanocortin-4 receptor agonist as a novel orally administrated drug lead for treating obesity

Journal of Medicinal Chemistry

Volumn 51, Issue 4, 2008, Pages 1026-1034

  Hess, Shmuel ^a   Linde, Yaniv ^b   Ovadia, Oded ^a   Safrai, Eli ^b   Shalev, Deborah E ^b   Swed, Avi ^a   Halbfinger, Efrat ^c   Lapidot, Tair ^c   Winkler, Ilan ^c   Gabinet, Yael ^c   Faier, Avi ^c   Yarden, Dana ^c   Xiang, Zhimin ^d   Portillo, Federico P ^d   Haskell Luevano, Carrie ^d   Gilon, Chaim ^b   Hoffman, Amnon ^a  

^a HEBREW UNIVERSITY OF JERUSALEM   (Israel)

^b HEBREW UNIVERSITY OF JERUSALEM   (Israel)

^c BIOLINERX LTD   (Israel)

^d UNIVERSITY OF FLORIDA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA INTERMEDIN; ALPHA INTERMEDIN DERIVATIVE; AMINO ACID DERIVATIVE; ATENOLOL; BL 3020 1; BL 3020 15; BL 3020 16; BL 3020 8; HISTIDYLPHENYLALANYLARGINYLTRYPTOPHAN; HORMONE RECEPTOR STIMULATING AGENT; MANNITOL; MELANOCORTIN 4 RECEPTOR; PROPRANOLOL; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CYCLIZATION; DRUG POTENCY; FOOD INTAKE; INTESTINE CELL; INTESTINE MUCOSA PERMEABILITY; MALE; MOUSE; NONHUMAN; OBESITY; PROTEIN ANALYSIS; PROTEIN STABILITY; PROTEIN SYNTHESIS; RAT; RECEPTOR BINDING; SINGLE DRUG DOSE; TREATMENT DURATION; WEIGHT GAIN;

ADMINISTRATION, ORAL; ANIMALS; ANTI-OBESITY AGENTS; BIOLOGICAL AVAILABILITY; BRAIN; CELL LINE; HUMANS; INJECTIONS, INTRAVENOUS; INTESTINAL ABSORPTION; LIGANDS; MAGNETIC RESONANCE SPECTROSCOPY; MALE; MICE; MOLECULAR MIMICRY; PEPTIDES, CYCLIC; RATS; RATS, WISTAR; RECEPTOR, MELANOCORTIN, TYPE 4; STRUCTURE-ACTIVITY RELATIONSHIP; TISSUE DISTRIBUTION;

EID: 39749193898     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm701093y     Document Type: Article

References (40)