Positional cloning of a type 2 diabetes quantitative trait locus; Tomosyn-2, a negative regulator of insulin secretion

PLoS Genetics

Volumn 7, Issue 10, 2011, Pages

  Bhatnagar, Sushant ^a   Oler, Angie T ^a   Rabaglia, Mary E ^a   Stapleton, Donald S ^a   Schueler, Kathryn L ^a   Truchan, Nathan A ^a   Worzella, Sara L ^a   Stoehr, Jonathan P ^a   Clee, Susanne M ^b   Yandell, Brian S ^c   Keller, Mark P ^a   Thurmond, Debbie C ^d   Attie, Alan D ^a  

^a UNIVERSITY OF WISCONSIN MADISON   (United States)

^b UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^c University of Wisconsin Madison   (United States)

^d INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GLUCOSE; INSULIN; SNARE PROTEIN; 8 BROMO CYCLIC AMP; LEPTIN; STXBP5L PROTEIN, MOUSE; SYNAPTOBREVIN; SYNTAXIN; SYNTAXIN 1;

ALLELE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BINDING AFFINITY; CONGENIC STRAIN; CONTROLLED STUDY; EMBRYO; GENE EXPRESSION; GENE FUNCTION; GLUCOSE BLOOD LEVEL; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; INSULIN BLOOD LEVEL; INSULIN RELEASE; INTROGRESSION; MOUSE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; PANCREAS ISLET CELL; PHENOTYPE; PROTEIN DEGRADATION; QUANTITATIVE TRAIT LOCUS MAPPING; REGULATOR GENE; SINGLE NUCLEOTIDE POLYMORPHISM; TOMOSYN 2 GENE; ANIMAL; C57BL MOUSE; CELL STRAIN HEK293; CHROMOSOME MAP; DISEASE MODEL; GENETIC PREDISPOSITION; GENETICS; HYPOGLYCEMIA; METABOLISM; MOLECULAR CLONING; PANCREAS ISLET; PATHOLOGY; QUANTITATIVE TRAIT LOCUS; RAT; SECRETION;

MUS;

8-BROMO CYCLIC ADENOSINE MONOPHOSPHATE; ANIMALS; CHROMOSOME MAPPING; CLONING, MOLECULAR; DIABETES MELLITUS, TYPE 2; DISEASE MODELS, ANIMAL; GENETIC PREDISPOSITION TO DISEASE; GLUCOSE; HEK293 CELLS; HUMANS; HYPOGLYCEMIA; INSULIN; ISLETS OF LANGERHANS; LEPTIN; MICE; MICE, INBRED C57BL; POLYMORPHISM, SINGLE NUCLEOTIDE; QA-SNARE PROTEINS; QUANTITATIVE TRAIT LOCI; R-SNARE PROTEINS; RATS; SNARE PROTEINS; SYNTAXIN 1;

EID: 80055076208     PISSN: 15537390     EISSN: 15537404     Source Type: Journal    
DOI: 10.1371/journal.pgen.1002323     Document Type: Article

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