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Volumn 12, Issue 12, 2013, Pages 1564-1577

Stress signaling pathways for the pathogenicity of Cryptococcus

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL; CRYPTOCOCCOSIS; CRYPTOCOCCUS; HUMAN; METABOLISM; MICROBIOLOGY; PATHOGENICITY; REVIEW; SIGNAL TRANSDUCTION; VIRULENCE;

EID: 84888214854     PISSN: 15359778     EISSN: None     Source Type: Journal    
DOI: 10.1128/EC.00218-13     Document Type: Review
Times cited : (54)

References (133)
  • 1
    • 80053994065 scopus 로고    scopus 로고
    • Host defenses against cryptococcosis
    • Price MS, Perfect JR. 2011. Host defenses against cryptococcosis. Immunol. Invest. 40:786-808.
    • (2011) Immunol. Invest , vol.40 , pp. 786-808
    • Price, M.S.1    Perfect, J.R.2
  • 2
    • 84055199825 scopus 로고    scopus 로고
    • The impact of the host on fungal infections
    • Perfect JR. 2012. The impact of the host on fungal infections. Am. J. Med. 125:S39-S51.
    • (2012) Am. J. Med , vol.125
    • Perfect, J.R.1
  • 4
    • 33750289222 scopus 로고    scopus 로고
    • The biology of the Cryptococcus neoformans species complex
    • Lin X, Heitman J. 2006. The biology of the Cryptococcus neoformans species complex. Annu. Rev. Microbiol. 60:69-105.
    • (2006) Annu. Rev. Microbiol , vol.60 , pp. 69-105
    • Lin, X.1    Heitman, J.2
  • 6
    • 80755163487 scopus 로고    scopus 로고
    • Cryptococcus gattii: A resurgent fungal pathogen
    • Chaturvedi V, Chaturvedi S. 2011. Cryptococcus gattii: a resurgent fungal pathogen. Trends Microbiol. 19:564-571.
    • (2011) Trends Microbiol , vol.19 , pp. 564-571
    • Chaturvedi, V.1    Chaturvedi, S.2
  • 13
  • 14
    • 0035663078 scopus 로고    scopus 로고
    • Capsule and melanin synthesis in Cryptococcus neoformans
    • McFadden DC, Casadevall A. 2001. Capsule and melanin synthesis in Cryptococcus neoformans. Med. Mycol. 39(Suppl 1):19-30.
    • (2001) Med. Mycol , vol.39 , Issue.SUPPL. 1 , pp. 19-30
    • McFadden, D.C.1    Casadevall, A.2
  • 15
    • 0033783106 scopus 로고    scopus 로고
    • Pathogenic roles for fungal melanins
    • Jacobson ES. 2000. Pathogenic roles for fungal melanins. Clin. Microbiol. Rev. 13:708-717.
    • (2000) Clin. Microbiol. Rev , vol.13 , pp. 708-717
    • Jacobson, E.S.1
  • 17
    • 84856956876 scopus 로고    scopus 로고
    • Catch me if you can: Phagocytosis and killing avoidance by Cryptococcus neoformans
    • Garcia-Rodas R, Zaragoza O. 2012. Catch me if you can: phagocytosis and killing avoidance by Cryptococcus neoformans. FEMS Immunol. Med. Microbiol. 64:147-161.
    • (2012) FEMS Immunol. Med. Microbiol , vol.64 , pp. 147-161
    • Garcia-Rodas, R.1    Zaragoza, O.2
  • 18
    • 84863077448 scopus 로고    scopus 로고
    • The cAMP/protein kinase A pathway and virulence in Cryptococcus neoformans
    • Kronstad JW, Hu G, Choi J. 2011. The cAMP/protein kinase A pathway and virulence in Cryptococcus neoformans. Mycobiology 39:143-150.
    • (2011) Mycobiology , vol.39 , pp. 143-150
    • Kronstad, J.W.1    Hu, G.2    Choi, J.3
  • 20
    • 38049146021 scopus 로고    scopus 로고
    • Iron and fungal pathogenesis: A case study with Cryptococcus neoformans
    • Jung WH, Kronstad JW. 2008. Iron and fungal pathogenesis: a case study with Cryptococcus neoformans. Cell. Microbiol. 10:277-284.
    • (2008) Cell. Microbiol , vol.10 , pp. 277-284
    • Jung, W.H.1    Kronstad, J.W.2
  • 21
    • 56949096743 scopus 로고    scopus 로고
    • Ionizing radiation: How fungi cope, adapt, and exploit with the help of melanin
    • Dadachova E, Casadevall A. 2008. Ionizing radiation: how fungi cope, adapt, and exploit with the help of melanin. Curr. Opin. Microbiol. 11: 525-531.
    • (2008) Curr. Opin. Microbiol , vol.11 , pp. 525-531
    • Dadachova, E.1    Casadevall, A.2
  • 22
    • 80053071743 scopus 로고    scopus 로고
    • Protection of melanized Cryptococcus neoformans from lethal dose gamma irradiation involves changes in melanin's chemical structure and paramagnetism
    • doi:10.1371/journal.pone.0025092
    • Khajo A, Bryan RA, Friedman M, Burger RM, Levitsky Y, Casadevall A, Magliozzo RS, Dadachova E. 2011. Protection of melanized Cryptococcus neoformans from lethal dose gamma irradiation involves changes in melanin's chemical structure and paramagnetism. PLoS One 6:e25092. doi:10.1371/journal.pone.0025092.
    • (2011) PLoS One , vol.6
    • Khajo, A.1    Bryan, R.A.2    Friedman, M.3    Burger, R.M.4    Levitsky, Y.5    Casadevall, A.6    Magliozzo, R.S.7    Dadachova, E.8
  • 24
    • 9144254513 scopus 로고    scopus 로고
    • Regulation of the osmoregulatory HOG MAPK cascade in yeast
    • Saito H, Tatebayashi K. 2004. Regulation of the osmoregulatory HOG MAPK cascade in yeast. J. Biochem. 136:267-272.
    • (2004) J. Biochem , vol.136 , pp. 267-272
    • Saito, H.1    Tatebayashi, K.2
  • 25
    • 0036683337 scopus 로고    scopus 로고
    • Yeast go the whole HOG for the hyperosmotic response
    • O'Rourke SM, Herskowitz I, O'Shea EK. 2002. Yeast go the whole HOG for the hyperosmotic response. Trends Genet. 18:405-412.
    • (2002) Trends Genet , vol.18 , pp. 405-412
    • O'Rourke, S.M.1    Herskowitz, I.2    O'Shea, E.K.3
  • 26
    • 0037032817 scopus 로고    scopus 로고
    • Mitogen-activated protein kinase pathways mediated by ERK, JNK, and p38 protein kinases
    • Johnson GL, Lapadat R. 2002. Mitogen-activated protein kinase pathways mediated by ERK, JNK, and p38 protein kinases. Science 298:1911-1912.
    • (2002) Science , vol.298 , pp. 1911-1912
    • Johnson, G.L.1    Lapadat, R.2
  • 29
    • 0028823892 scopus 로고
    • Mitogen and stress response pathways: MAP kinase cascades and phosphatase regulation in mammals and yeast
    • Waskiewicz AJ, Cooper JA. 1995. Mitogen and stress response pathways: MAP kinase cascades and phosphatase regulation in mammals and yeast. Curr. Opin. Cell Biol. 7:798-805.
    • (1995) Curr. Opin. Cell Biol , vol.7 , pp. 798-805
    • Waskiewicz, A.J.1    Cooper, J.A.2
  • 30
    • 44449112421 scopus 로고    scopus 로고
    • Specificity in two-component signal transduction pathways
    • Laub MT, Goulian M. 2007. Specificity in two-component signal transduction pathways. Annu. Rev. Genet. 41:121-145.
    • (2007) Annu. Rev. Genet , vol.41 , pp. 121-145
    • Laub, M.T.1    Goulian, M.2
  • 31
    • 0036166981 scopus 로고    scopus 로고
    • Histidine kinases as targets for new antimicrobial agents
    • Matsushita M, Janda KD. 2002. Histidine kinases as targets for new antimicrobial agents. Bioorg. Med. Chem. 10:855-867.
    • (2002) Bioorg. Med. Chem , vol.10 , pp. 855-867
    • Matsushita, M.1    Janda, K.D.2
  • 32
    • 0035807112 scopus 로고    scopus 로고
    • Fungal histidine kinases
    • doi:10.1126/scisignal.982001re1
    • Santos JL, Shiozaki K. 2001. Fungal histidine kinases. Sci. STKE 2001: re1. doi:10.1126/scisignal.982001re1.
    • (2001) Sci. STKE 2001: Re1
    • Santos, J.L.1    Shiozaki, K.2
  • 33
    • 57349172858 scopus 로고    scopus 로고
    • Master and Commander in fungal pathogens: The two-component system and the HOG signaling pathway
    • Bahn YS. 2008. Master and Commander in fungal pathogens: the two-component system and the HOG signaling pathway. Eukaryot. Cell 7:2017-2036.
    • (2008) Eukaryot. Cell , vol.7 , pp. 2017-2036
    • Bahn, Y.S.1
  • 34
    • 18244375808 scopus 로고    scopus 로고
    • Specialization of the HOG pathway and its impact on differentiation and virulence of Cryptococcus neoformans
    • Bahn YS, Kojima K, Cox GM, Heitman J. 2005. Specialization of the HOG pathway and its impact on differentiation and virulence of Cryptococcus neoformans. Mol. Biol. Cell 16:2285-2300.
    • (2005) Mol. Biol. Cell , vol.16 , pp. 2285-2300
    • Bahn, Y.S.1    Kojima, K.2    Cox, G.M.3    Heitman, J.4
  • 35
    • 37549040996 scopus 로고    scopus 로고
    • Ssk2 mitogen-activated protein kinase kinase kinase governs divergent patterns of the stress activated Hog1 signaling pathway in Cryptococcus neoformans
    • Bahn YS, Geunes-Boyer S, Heitman J. 2007. Ssk2 mitogen-activated protein kinase kinase kinase governs divergent patterns of the stress activated Hog1 signaling pathway in Cryptococcus neoformans. Eukaryot. Cell 6:2278-2289.
    • (2007) Eukaryot. Cell , vol.6 , pp. 2278-2289
    • Bahn, Y.S.1    Geunes-Boyer, S.2    Heitman, J.3
  • 36
    • 33745635366 scopus 로고    scopus 로고
    • A unique fungal two-component system regulates stress responses, drug sensitivity, sexual development, and virulence of Cryptococcus neoformans
    • Bahn YS, Kojima K, Cox GM, Heitman J. 2006. A unique fungal two-component system regulates stress responses, drug sensitivity, sexual development, and virulence of Cryptococcus neoformans. Mol. Biol. Cell 17:3122-3135.
    • (2006) Mol. Biol. Cell , vol.17 , pp. 3122-3135
    • Bahn, Y.S.1    Kojima, K.2    Cox, G.M.3    Heitman, J.4
  • 37
    • 79960130013 scopus 로고    scopus 로고
    • Multiple roles of Ypd1 phosphotransfer protein in viability, stress response, and virulence factor regulation in Cryptococcus neoformans
    • Lee JW, Ko YJ, Kim SY, Bahn YS. 2011. Multiple roles of Ypd1 phosphotransfer protein in viability, stress response, and virulence factor regulation in Cryptococcus neoformans. Eukaryot. Cell 10:998-1002.
    • (2011) Eukaryot. Cell , vol.10 , pp. 998-1002
    • Lee, J.W.1    Ko, Y.J.2    Kim, S.Y.3    Bahn, Y.S.4
  • 38
    • 84880795175 scopus 로고    scopus 로고
    • Histidine phosphotransfer proteins in fungal two-component signal transduction pathways
    • Fassler JS, West AH. 2013. Histidine phosphotransfer proteins in fungal two-component signal transduction pathways. Eukaryot. Cell 12:1052-1060.
    • (2013) Eukaryot. Cell , vol.12 , pp. 1052-1060
    • Fassler, J.S.1    West, A.H.2
  • 39
    • 70449703215 scopus 로고    scopus 로고
    • An efficient gene-disruption method in Cryptococcus neoformans by double-joint PCR with NAT-split markers
    • Kim MS, Kim SY, Yoon JK, Lee YW, Bahn YS. 2009. An efficient gene-disruption method in Cryptococcus neoformans by double-joint PCR with NAT-split markers. Biochem. Biophys. Res. Commun. 390: 983-988.
    • (2009) Biochem. Biophys. Res. Commun , vol.390 , pp. 983-988
    • Kim, M.S.1    Kim, S.Y.2    Yoon, J.K.3    Lee, Y.W.4    Bahn, Y.S.5
  • 40
    • 68549130732 scopus 로고    scopus 로고
    • Remodeling of global transcription patterns of Cryptococcus neoformans genes mediated by the stress-activated HOG signaling pathways
    • Ko YJ, Yu YM, Kim GB, Lee GW, Maeng PJ, Kim S, Floyd A, Heitman J, Bahn YS. 2009. Remodeling of global transcription patterns of Cryptococcus neoformans genes mediated by the stress-activated HOG signaling pathways. Eukaryot. Cell 8:1197-1217.
    • (2009) Eukaryot. Cell , vol.8 , pp. 1197-1217
    • Ko, Y.J.1    Yu, Y.M.2    Kim, G.B.3    Lee, G.W.4    Maeng, P.J.5    Kim, S.6    Floyd, A.7    Heitman, J.8    Bahn, Y.S.9
  • 41
    • 84859005247 scopus 로고    scopus 로고
    • Two cation transporters Ena1 and Nha1 cooperatively modulate ion homeostasis, antifungal drug resistance, and virulence of Cryptococcus neoformans via the HOG pathway
    • Jung KW, Strain AK, Nielsen K, Jung KH, Bahn YS. 2012. Two cation transporters Ena1 and Nha1 cooperatively modulate ion homeostasis, antifungal drug resistance, and virulence of Cryptococcus neoformans via the HOG pathway. Fungal Genet. Biol. 49:332-345.
    • (2012) Fungal Genet. Biol , vol.49 , pp. 332-345
    • Jung, K.W.1    Strain, A.K.2    Nielsen, K.3    Jung, K.H.4    Bahn, Y.S.5
  • 42
    • 61949322731 scopus 로고    scopus 로고
    • Identification of ENA1 as a virulence gene of the human pathogenic fungus Cryptococcus neoformans through signature-tagged insertional mutagenesis
    • Idnurm A, Walton FJ, Floyd A, Reedy JL, Heitman J. 2009. Identification of ENA1 as a virulence gene of the human pathogenic fungus Cryptococcus neoformans through signature-tagged insertional mutagenesis. Eukaryot. Cell 8:315-326.
    • (2009) Eukaryot. Cell , vol.8 , pp. 315-326
    • Idnurm, A.1    Walton, F.J.2    Floyd, A.3    Reedy, J.L.4    Heitman, J.5
  • 43
    • 84873874951 scopus 로고    scopus 로고
    • Global transcriptome profile of Cryptococcus neoformans during exposure to hydrogen peroxide induced oxidative stress
    • doi:10.1371/journal.pone.0055110
    • Upadhya R, Campbell LT, Donlin MJ, Aurora R, Lodge JK. 2013. Global transcriptome profile of Cryptococcus neoformans during exposure to hydrogen peroxide induced oxidative stress. PLoS One 8:e55110. doi:10.1371/journal.pone.0055110.
    • (2013) PLoS One , vol.8
    • Upadhya, R.1    Campbell, L.T.2    Donlin, M.J.3    Aurora, R.4    Lodge, J.K.5
  • 44
    • 84887030332 scopus 로고    scopus 로고
    • Sulphiredoxin plays peroxiredoxin-dependent and-independent roles via the HOG signaling pathway in Cryptococcus neoformans and contributes to fungal virulence
    • 3 October, doi:10.1111/mmi.12388. [Epub ahead of print.]
    • Upadhya R, Kim H, Jung KW, Park G, Lam W, Lodge JK, Bahn YS. 3 October 2013. Sulphiredoxin plays peroxiredoxin-dependent and-independent roles via the HOG signaling pathway in Cryptococcus neoformans and contributes to fungal virulence. Mol. Microbiol. doi:10.1111/mmi.12388. [Epub ahead of print.]
    • (2013) Mol. Microbiol
    • Upadhya, R.1    Kim, H.2    Jung, K.W.3    Park, G.4    Lam, W.5    Lodge, J.K.6    Bahn, Y.S.7
  • 45
    • 79954576036 scopus 로고    scopus 로고
    • Hrk1 plays both Hog1-dependent and-independent roles in controlling stress response and antifungal drug resistance in Cryptococcus neoformans
    • doi:10.1371/journal.pone.0018769
    • Kim SY, Ko YJ, Jung KW, Strain A, Nielsen K, Bahn YS. 2011. Hrk1 plays both Hog1-dependent and-independent roles in controlling stress response and antifungal drug resistance in Cryptococcus neoformans. PLoS One 6:e18769. doi:10.1371/journal.pone.0018769.
    • (2011) PLoS One , vol.6
    • Kim, S.Y.1    Ko, Y.J.2    Jung, K.W.3    Strain, A.4    Nielsen, K.5    Bahn, Y.S.6
  • 46
  • 47
    • 0029785855 scopus 로고    scopus 로고
    • Conjugation, meiosis, and the osmotic stress response are regulated by Spc1 kinase through Atf1 transcription factor in fission yeast
    • Shiozaki K, Russell P. 1996. Conjugation, meiosis, and the osmotic stress response are regulated by Spc1 kinase through Atf1 transcription factor in fission yeast. Genes Dev. 10:2276-2288.
    • (1996) Genes Dev , vol.10 , pp. 2276-2288
    • Shiozaki, K.1    Russell, P.2
  • 48
    • 22644440257 scopus 로고    scopus 로고
    • Function of the thioredoxin proteins in Cryptococcus neoformans during stress or virulence and regulation by putative transcriptional modulators
    • Missall TA, Lodge JK. 2005. Function of the thioredoxin proteins in Cryptococcus neoformans during stress or virulence and regulation by putative transcriptional modulators. Mol. Microbiol. 57:847-858.
    • (2005) Mol. Microbiol , vol.57 , pp. 847-858
    • Missall, T.A.1    Lodge, J.K.2
  • 49
    • 78349308578 scopus 로고    scopus 로고
    • 2 sensing pathway via differential expression of carbonic anhydrase in Cryptococcus neoformans
    • Kim MS, Ko YJ, Maeng S, Floyd A, Heitman J, Bahn YS. 2010. Comparative transcriptome analysis of the CO2 sensing pathway via differential expression of carbonic anhydrase in Cryptococcus neoformans. Genetics 185:1207-1219.
    • (2010) Genetics , vol.185 , pp. 1207-1219
    • Kim, M.S.1    Ko, Y.J.2    Maeng, S.3    Floyd, A.4    Heitman, J.5    Bahn, Y.S.6
  • 50
    • 84855215088 scopus 로고    scopus 로고
    • A flucytosineresponsive Mbp1/Swi4-like protein, Mbs1, plays pleiotropic roles in antifungal drug resistance, stress response, and virulence of Cryptococcus neoformans
    • Song MH, Lee JW, Kim MS, Yoon JK, White TC, Floyd A, Heitman J, Strain AK, Nielsen JN, Nielsen K, Bahn YS. 2012. A flucytosineresponsive Mbp1/Swi4-like protein, Mbs1, plays pleiotropic roles in antifungal drug resistance, stress response, and virulence of Cryptococcus neoformans. Eukaryot. Cell 11:53-67.
    • (2012) Eukaryot. Cell , vol.11 , pp. 53-67
    • Song, M.H.1    Lee, J.W.2    Kim, M.S.3    Yoon, J.K.4    White, T.C.5    Floyd, A.6    Heitman, J.7    Strain, A.K.8    Nielsen, J.N.9    Nielsen, K.10    Bahn, Y.S.11
  • 53
    • 33645106541 scopus 로고    scopus 로고
    • Calcineurin, Mpk1 and Hog1 MAPK pathways independently control fludioxonil antifungal sensitivity in Cryptococcus neoformans
    • Kojima K, Bahn YS, Heitman J. 2006. Calcineurin, Mpk1 and Hog1 MAPK pathways independently control fludioxonil antifungal sensitivity in Cryptococcus neoformans. Microbiology 152:591-604.
    • (2006) Microbiology , vol.152 , pp. 591-604
    • Kojima, K.1    Bahn, Y.S.2    Heitman, J.3
  • 55
    • 14644435106 scopus 로고    scopus 로고
    • Glucose sensing via the protein kinase A pathway in Schizosaccharomyces pombe
    • Hoffman CS. 2005. Glucose sensing via the protein kinase A pathway in Schizosaccharomyces pombe. Biochem. Soc. Trans. 33:257-260.
    • (2005) Biochem. Soc. Trans , vol.33 , pp. 257-260
    • Hoffman, C.S.1
  • 56
  • 57
    • 0032835137 scopus 로고    scopus 로고
    • Novel sensing mechanisms and targets for the cAMP-protein kinase A pathway in the yeast Saccharomyces cerevisiae
    • Thevelein JM, de Winde JH. 1999. Novel sensing mechanisms and targets for the cAMP-protein kinase A pathway in the yeast Saccharomyces cerevisiae. Mol. Microbiol. 33:904-918.
    • (1999) Mol. Microbiol , vol.33 , pp. 904-918
    • Thevelein, J.M.1    de Winde, J.H.2
  • 59
    • 59849124593 scopus 로고    scopus 로고
    • Signalling pathways in the pathogenesis of Cryptococcus
    • Kozubowski L, Lee SC, Heitman J. 2009. Signalling pathways in the pathogenesis of Cryptococcus. Cell. Microbiol. 11:370-380.
    • (2009) Cell. Microbiol , vol.11 , pp. 370-380
    • Kozubowski, L.1    Lee, S.C.2    Heitman, J.3
  • 60
    • 0742269682 scopus 로고    scopus 로고
    • Cyclic AMP signaling in Cryptococcus neoformans
    • Pukkila-Worley R, Alspaugh JA. 2004. Cyclic AMP signaling in Cryptococcus neoformans. FEMS Yeast Res. 4:361-367.
    • (2004) FEMS Yeast Res , vol.4 , pp. 361-367
    • Pukkila-Worley, R.1    Alspaugh, J.A.2
  • 61
    • 0031797155 scopus 로고    scopus 로고
    • Signal transduction pathways regulating differentiation and pathogenicity of Cryptococcus neoformans
    • Alspaugh JA, Perfect JR, Heitman J. 1998. Signal transduction pathways regulating differentiation and pathogenicity of Cryptococcus neoformans. Fungal Genet. Biol. 25:1-14.
    • (1998) Fungal Genet. Biol , vol.25 , pp. 1-14
    • Alspaugh, J.A.1    Perfect, J.R.2    Heitman, J.3
  • 63
    • 77649317375 scopus 로고    scopus 로고
    • Comparative transcriptome analysis reveals novel roles of the Ras and cyclic AMP signaling pathways in environmental stress response and antifungal drug sensitivity in Cryptococcus neoformans
    • Maeng S, Ko YJ, Kim GB, Jung KW, Floyd A, Heitman J, Bahn YS. 2010. Comparative transcriptome analysis reveals novel roles of the Ras and cyclic AMP signaling pathways in environmental stress response and antifungal drug sensitivity in Cryptococcus neoformans. Eukaryot. Cell 9:360-378.
    • (2010) Eukaryot. Cell , vol.9 , pp. 360-378
    • Maeng, S.1    Ko, Y.J.2    Kim, G.B.3    Jung, K.W.4    Floyd, A.5    Heitman, J.6    Bahn, Y.S.7
  • 64
    • 33645130011 scopus 로고    scopus 로고
    • Glucose signaling in Saccharomyces cerevisiae
    • Santangelo GM. 2006. Glucose signaling in Saccharomyces cerevisiae. Microbiol. Mol. Biol. Rev. 70:253-282.
    • (2006) Microbiol. Mol. Biol. Rev , vol.70 , pp. 253-282
    • Santangelo, G.M.1
  • 65
    • 82555169608 scopus 로고    scopus 로고
    • Candida albicans developmental regulation: Adenylyl cyclase as a coincidence detector of parallel signals
    • Hogan DA, Muhlschlegel FA. 2011. Candida albicans developmental regulation: adenylyl cyclase as a coincidence detector of parallel signals. Curr. Opin. Microbiol. 14:682-686.
    • (2011) Curr. Opin. Microbiol , vol.14 , pp. 682-686
    • Hogan, D.A.1    Muhlschlegel, F.A.2
  • 66
    • 74749098838 scopus 로고    scopus 로고
    • The Ras/cAMP/PKA signaling pathway and virulence in Candida albicans
    • Hogan DA, Sundstrom P. 2009. The Ras/cAMP/PKA signaling pathway and virulence in Candida albicans. Future Microbiol. 4:1263-1270.
    • (2009) Future Microbiol , vol.4 , pp. 1263-1270
    • Hogan, D.A.1    Sundstrom, P.2
  • 67
    • 0034052527 scopus 로고    scopus 로고
    • RAS1 regulates filamentation, mating and growth at high temperature of Cryptococcus neoformans
    • Alspaugh JA, Cavallo LM, Perfect JR, Heitman J. 2000. RAS1 regulates filamentation, mating and growth at high temperature of Cryptococcus neoformans. Mol. Microbiol. 36:352-365.
    • (2000) Mol. Microbiol , vol.36 , pp. 352-365
    • Alspaugh, J.A.1    Cavallo, L.M.2    Perfect, J.R.3    Heitman, J.4
  • 68
    • 20444488798 scopus 로고    scopus 로고
    • A Rac homolog functions downstream of Ras1 to control hyphal differentiation and high-temperature growth in the pathogenic fungus Cryptococcus neoformans
    • Vallim MA, Nichols CB, Fernandes L, Cramer KL, Alspaugh JA. 2005. A Rac homolog functions downstream of Ras1 to control hyphal differentiation and high-temperature growth in the pathogenic fungus Cryptococcus neoformans. Eukaryot. Cell 4:1066-1078.
    • (2005) Eukaryot. Cell , vol.4 , pp. 1066-1078
    • Vallim, M.A.1    Nichols, C.B.2    Fernandes, L.3    Cramer, K.L.4    Alspaugh, J.A.5
  • 69
    • 33846622349 scopus 로고    scopus 로고
    • A Ras1-Cdc24 signal transduction pathway mediates thermotolerance in the fungal pathogen Cryptococcus neoformans
    • Nichols CB, Perfect ZH, Alspaugh JA. 2007. A Ras1-Cdc24 signal transduction pathway mediates thermotolerance in the fungal pathogen Cryptococcus neoformans. Mol. Microbiol. 63:1118-1130.
    • (2007) Mol. Microbiol , vol.63 , pp. 1118-1130
    • Nichols, C.B.1    Perfect, Z.H.2    Alspaugh, J.A.3
  • 70
    • 0036205611 scopus 로고    scopus 로고
    • Cyclase-associated proteins: CA-Pacity for linking signal transduction and actin polymerization
    • Hubberstey AV, Mottillo EP. 2002. Cyclase-associated proteins: CA-Pacity for linking signal transduction and actin polymerization. FASEB J. 16:487-499.
    • (2002) FASEB J , vol.16 , pp. 487-499
    • Hubberstey, A.V.1    Mottillo, E.P.2
  • 71
    • 11144276482 scopus 로고    scopus 로고
    • Adenylyl cyclase-associated protein Aca1 regulates virulence and differentiation of Cryptococcus neoformans via the cyclic AMP-protein kinase A cascade
    • Bahn YS, Hicks JK, Giles SS, Cox GM, Heitman J. 2004. Adenylyl cyclase-associated protein Aca1 regulates virulence and differentiation of Cryptococcus neoformans via the cyclic AMP-protein kinase A cascade. Eukaryot. Cell 3:1476-1491.
    • (2004) Eukaryot. Cell , vol.3 , pp. 1476-1491
    • Bahn, Y.S.1    Hicks, J.K.2    Giles, S.S.3    Cox, G.M.4    Heitman, J.5
  • 72
    • 0030048768 scopus 로고    scopus 로고
    • A conserved proline-rich region of the Saccharomyces cerevisiae cyclase-associated protein binds SH3 domains and modulates cytoskeletal localization
    • Freeman NL, Lila T, Mintzer KA, Chen Z, Pahk AJ, Ren R, Drubin DG, Field J. 1996. A conserved proline-rich region of the Saccharomyces cerevisiae cyclase-associated protein binds SH3 domains and modulates cytoskeletal localization. Mol. Cell. Biol. 16:548-556.
    • (1996) Mol. Cell. Biol , vol.16 , pp. 548-556
    • Freeman, N.L.1    Lila, T.2    Mintzer, K.A.3    Chen, Z.4    Pahk, A.J.5    Ren, R.6    Drubin, D.G.7    Field, J.8
  • 74
    • 34047229668 scopus 로고    scopus 로고
    • Transcriptional regulation by protein kinase A in Cryptococcus neoformans
    • doi:10.1371/journal.ppat.0030042
    • Hu G, Steen BR, Lian T, Sham AP, Tam N, Tangen KL, Kronstad JW. 2007. Transcriptional regulation by protein kinase A in Cryptococcus neoformans. PLoS Pathog. 3:e42. doi:10.1371/journal.ppat.0030042.
    • (2007) PLoS Pathog , vol.3
    • Hu, G.1    Steen, B.R.2    Lian, T.3    Sham, A.P.4    Tam, N.5    Tangen, K.L.6    Kronstad, J.W.7
  • 75
    • 33746267436 scopus 로고    scopus 로고
    • Transcription factor Nrg1 mediates capsule formation, stress response, and pathogenesis in Cryptococcus neoformans
    • Cramer KL, Gerrald QD, Nichols CB, Price MS, Alspaugh JA. 2006. Transcription factor Nrg1 mediates capsule formation, stress response, and pathogenesis in Cryptococcus neoformans. Eukaryot. Cell 5:1147-1156.
    • (2006) Eukaryot. Cell , vol.5 , pp. 1147-1156
    • Cramer, K.L.1    Gerrald, Q.D.2    Nichols, C.B.3    Price, M.S.4    Alspaugh, J.A.5
  • 76
    • 84880049738 scopus 로고    scopus 로고
    • Msi1-like (MSIL) proteins in fungi
    • Yang DH, Maeng S, Bahn YS. 2013. Msi1-like (MSIL) proteins in fungi. Mycobiology 41:1-12.
    • (2013) Mycobiology , vol.41 , pp. 1-12
    • Yang, D.H.1    Maeng, S.2    Bahn, Y.S.3
  • 77
    • 0030272047 scopus 로고    scopus 로고
    • Nucleosome assembly by a complex of CAF-1 and acetylated histones H3/H4
    • Verreault A, Kaufman PD, Kobayashi R, Stillman B. 1996. Nucleosome assembly by a complex of CAF-1 and acetylated histones H3/H4. Cell 87:95-104.
    • (1996) Cell , vol.87 , pp. 95-104
    • Verreault, A.1    Kaufman, P.D.2    Kobayashi, R.3    Stillman, B.4
  • 78
    • 0032912468 scopus 로고    scopus 로고
    • Role of Saccharomyces cerevisiae chromatin assembly factor-I in repair of ultraviolet radiation damage in vivo
    • Game JC, Kaufman PD. 1999. Role of Saccharomyces cerevisiae chromatin assembly factor-I in repair of ultraviolet radiation damage in vivo. Genetics 151:485-497.
    • (1999) Genetics , vol.151 , pp. 485-497
    • Game, J.C.1    Kaufman, P.D.2
  • 81
    • 34347256711 scopus 로고    scopus 로고
    • TOR signaling and S6 kinase 1: Yeast catches up
    • Powers T. 2007. TOR signaling and S6 kinase 1: yeast catches up. Cell Metab. 6:1-2.
    • (2007) Cell Metab , vol.6 , pp. 1-2
    • Powers, T.1
  • 85
    • 38949137849 scopus 로고    scopus 로고
    • Life span extension by calorie restriction depends on Rim15 and transcription factors downstream of Ras/PKA, Tor, and Sch9
    • doi:10.1371/journal.pgen.0040013
    • Wei M, Fabrizio P, Hu J, Ge H, Cheng C, Li L, Longo VD. 2008. Life span extension by calorie restriction depends on Rim15 and transcription factors downstream of Ras/PKA, Tor, and Sch9. PLoS Genet. 4:e13. doi:10.1371/journal.pgen.0040013.
    • (2008) PLoS Genet , vol.4
    • Wei, M.1    Fabrizio, P.2    Hu, J.3    Ge, H.4    Cheng, C.5    Li, L.6    Longo, V.D.7
  • 87
    • 80053284180 scopus 로고    scopus 로고
    • Role of Sch9 in regulating Ras-cAMP signal pathway in Saccharomyces cerevisiae
    • Zhang A, Shen Y, Gao W, Dong J. 2011. Role of Sch9 in regulating Ras-cAMP signal pathway in Saccharomyces cerevisiae. FEBS Lett. 585: 3026-3032.
    • (2011) FEBS Lett , vol.585 , pp. 3026-3032
    • Zhang, A.1    Shen, Y.2    Gao, W.3    Dong, J.4
  • 88
    • 0030850943 scopus 로고    scopus 로고
    • The Sch9 protein kinase in the yeast Saccharomyces cerevisiae controls cAPK activity and is required for nitrogen activation of the fermentable-growth-medium-induced (FGM) pathway
    • Crauwels M, Donaton MC, Pernambuco MB, Winderickx J, de Winde JH, Thevelein JM. 1997. The Sch9 protein kinase in the yeast Saccharomyces cerevisiae controls cAPK activity and is required for nitrogen activation of the fermentable-growth-medium-induced (FGM) pathway. Microbiology 143:2627-2637.
    • (1997) Microbiology , vol.143 , pp. 2627-2637
    • Crauwels, M.1    Donaton, M.C.2    Pernambuco, M.B.3    Winderickx, J.4    de Winde, J.H.5    Thevelein, J.M.6
  • 89
    • 8844275869 scopus 로고    scopus 로고
    • A Sch9 protein kinase homologue controlling virulence independently of the cAMP pathway in Cryptococcus neoformans
    • Wang P, Cox GM, Heitman J. 2004. A Sch9 protein kinase homologue controlling virulence independently of the cAMP pathway in Cryptococcus neoformans. Curr. Genet. 46:247-255.
    • (2004) Curr. Genet , vol.46 , pp. 247-255
    • Wang, P.1    Cox, G.M.2    Heitman, J.3
  • 90
    • 68249103865 scopus 로고    scopus 로고
    • How human pathogenic fungi sense and adapt to pH: The link to virulence
    • Davis DA. 2009. How human pathogenic fungi sense and adapt to pH: the link to virulence. Curr. Opin. Microbiol. 12:365-370.
    • (2009) Curr. Opin. Microbiol , vol.12 , pp. 365-370
    • Davis, D.A.1
  • 91
    • 0142092728 scopus 로고    scopus 로고
    • Adaptation to environmental pH in Candida albicans and its relation to pathogenesis
    • Davis D. 2003. Adaptation to environmental pH in Candida albicans and its relation to pathogenesis. Curr. Genet. 44:1-7.
    • (2003) Curr. Genet , vol.44 , pp. 1-7
    • Davis, D.1
  • 92
    • 77958174279 scopus 로고    scopus 로고
    • Integrative responses to high pH stress in S. cerevisiae
    • Arino J. 2010. Integrative responses to high pH stress in S. cerevisiae. OMICS 14:517-523.
    • (2010) OMICS , vol.14 , pp. 517-523
    • Arino, J.1
  • 94
    • 84856337339 scopus 로고    scopus 로고
    • pH response pathways in fungi: Adapting to host-derived and environmental signals
    • Selvig K, Alspaugh JA. 2011. pH response pathways in fungi: adapting to host-derived and environmental signals. Mycobiology 39:249-256.
    • (2011) Mycobiology , vol.39 , pp. 249-256
    • Selvig, K.1    Alspaugh, J.A.2
  • 95
    • 0024370139 scopus 로고
    • Estimation of pH in individual alveolar macrophage phagolysosomes
    • Nyberg K, Johansson U, Rundquist I, Camner P. 1989. Estimation of pH in individual alveolar macrophage phagolysosomes. Exp. Lung Res. 15:499-510.
    • (1989) Exp. Lung Res , vol.15 , pp. 499-510
    • Nyberg, K.1    Johansson, U.2    Rundquist, I.3    Camner, P.4
  • 96
    • 77649265932 scopus 로고    scopus 로고
    • Interaction of Cryptococcus neoformans Rim101 and protein kinase A regulates capsule
    • doi:10.1371/journal.ppat.1000776
    • O'Meara TR, Norton D, Price MS, Hay C, Clements MF, Nichols CB, Alspaugh JA. 2010. Interaction of Cryptococcus neoformans Rim101 and protein kinase A regulates capsule. PLoS Pathog. 6:e1000776. doi:10.1371/journal.ppat.1000776.
    • (2010) PLoS Pathog , vol.6
    • O'Meara, T.R.1    Norton, D.2    Price, M.S.3    Hay, C.4    Clements, M.F.5    Nichols, C.B.6    Alspaugh, J.A.7
  • 97
    • 52949114243 scopus 로고    scopus 로고
    • Systematic genetic analysis of virulence in the human fungal pathogen Cryptococcus neoformans
    • Liu OW, Chun CD, Chow ED, Chen C, Madhani HD, Noble SM. 2008. Systematic genetic analysis of virulence in the human fungal pathogen Cryptococcus neoformans. Cell 135:174-188.
    • (2008) Cell , vol.135 , pp. 174-188
    • Liu, O.W.1    Chun, C.D.2    Chow, E.D.3    Chen, C.4    Madhani, H.D.5    Noble, S.M.6
  • 100
    • 84874614624 scopus 로고    scopus 로고
    • Cryptococcus Neoformans Rim101 is Associated With Cell Wall Remodeling and Evasion of the Host Immune Responses
    • doi: 10.1128/mBio.00522-12 e00522-12
    • O'Meara TR, Holmer SM, Selvig K, Dietrich F, Alspaugh JA. 2013. Cryptococcus neoformans Rim101 is associated with cell wall remodeling and evasion of the host immune responses. mBio 4(1):e00522-12. doi: 10.1128/mBio.00522-12.
    • (2013) mBio , vol.4 , Issue.1
    • O'Meara, T.R.1    Holmer, S.M.2    Selvig, K.3    Dietrich, F.4    Alspaugh, J.A.5
  • 103
    • 0033779701 scopus 로고    scopus 로고
    • Calcineurin: Form and function
    • Rusnak F, Mertz P. 2000. Calcineurin: form and function. Physiol. Rev. 80:1483-1521.
    • (2000) Physiol. Rev , vol.80 , pp. 1483-1521
    • Rusnak, F.1    Mertz, P.2
  • 104
    • 0036797844 scopus 로고    scopus 로고
    • Good fungi gone bad: The corruption of calcineurin
    • Fox DS, Heitman J. 2002. Good fungi gone bad: the corruption of calcineurin. Bioessays 24:894-903.
    • (2002) Bioessays , vol.24 , pp. 894-903
    • Fox, D.S.1    Heitman, J.2
  • 105
    • 0242690174 scopus 로고    scopus 로고
    • Coping with stress: Calmodulin and calcineurin in model and pathogenic fungi
    • Kraus PR, Heitman J. 2003. Coping with stress: calmodulin and calcineurin in model and pathogenic fungi. Biochem. Biophys. Res. Commun. 311:1151-1157.
    • (2003) Biochem. Biophys. Res. Commun , vol.311 , pp. 1151-1157
    • Kraus, P.R.1    Heitman, J.2
  • 108
    • 20444462002 scopus 로고    scopus 로고
    • Calcium-and calcineurinindependent roles for calmodulin in Cryptococcus neoformans morphogenesis and high-temperature growth
    • Kraus PR, Nichols CB, Heitman J. 2005. Calcium-and calcineurinindependent roles for calmodulin in Cryptococcus neoformans morphogenesis and high-temperature growth. Eukaryot. Cell 4:1079-1087.
    • (2005) Eukaryot. Cell , vol.4 , pp. 1079-1087
    • Kraus, P.R.1    Nichols, C.B.2    Heitman, J.3
  • 109
  • 110
    • 0035114113 scopus 로고    scopus 로고
    • Calcineurin regulatory subunit is essential for virulence and mediates interactions with FKBP12-FK506 in Cryptococcus neoformans
    • Fox DS, Cruz MC, Sia RA, Ke H, Cox GM, Cardenas ME, Heitman J. 2001. Calcineurin regulatory subunit is essential for virulence and mediates interactions with FKBP12-FK506 in Cryptococcus neoformans. Mol. Microbiol. 39:835-849.
    • (2001) Mol. Microbiol , vol.39 , pp. 835-849
    • Fox, D.S.1    Cruz, M.C.2    Sia, R.A.3    Ke, H.4    Cox, G.M.5    Cardenas, M.E.6    Heitman, J.7
  • 111
    • 0343192437 scopus 로고    scopus 로고
    • Identification and characterization of a highly conserved calcineurin binding protein, CBP1/calcipressin, in Cryptococcus neoformans
    • Gorlach J, Fox DS, Cutler NS, Cox GM, Perfect JR, Heitman J. 2000. Identification and characterization of a highly conserved calcineurin binding protein, CBP1/calcipressin, in Cryptococcus neoformans. EMBO J. 19:3618-3629.
    • (2000) EMBO J , vol.19 , pp. 3618-3629
    • Gorlach, J.1    Fox, D.S.2    Cutler, N.S.3    Cox, G.M.4    Perfect, J.R.5    Heitman, J.6
  • 112
    • 0034959767 scopus 로고    scopus 로고
    • Two cyclophilin A homologs with shared and distinct functions important for growth and virulence of Cryptococcus neoformans
    • Wang P, Cardenas ME, Cox GM, Perfect JR, Heitman J. 2001. Two cyclophilin A homologs with shared and distinct functions important for growth and virulence of Cryptococcus neoformans. EMBO Rep. 2:511-518.
    • (2001) EMBO Rep , vol.2 , pp. 511-518
    • Wang, P.1    Cardenas, M.E.2    Cox, G.M.3    Perfect, J.R.4    Heitman, J.5
  • 113
    • 79957992936 scopus 로고    scopus 로고
    • A novel specificity protein 1 (SP1)-like gene regulating protein kinase C-1 (Pkc1)-dependent cell wall integrity and virulence factors in Cryptococcus neoformans
    • Adler A, Park YD, Larsen P, Nagarajan V, Wollenberg K, Qiu J, Myers TG, Williamson PR. 2011. A novel specificity protein 1 (SP1)-like gene regulating protein kinase C-1 (Pkc1)-dependent cell wall integrity and virulence factors in Cryptococcus neoformans. J. Biol. Chem. 286:20977-20990.
    • (2011) J. Biol. Chem , vol.286 , pp. 20977-20990
    • Adler, A.1    Park, Y.D.2    Larsen, P.3    Nagarajan, V.4    Wollenberg, K.5    Qiu, J.6    Myers, T.G.7    Williamson, P.R.8
  • 114
    • 84871240855 scopus 로고    scopus 로고
    • The Crz1/Sp1 transcription factor of Cryptococcus neoformans is activated by calcineurin and regulates cell wall integrity
    • doi:10.1371/journal.pone.0051403
    • Lev S, Desmarini D, Chayakulkeeree M, Sorrell TC, Djordjevic JT. 2012. The Crz1/Sp1 transcription factor of Cryptococcus neoformans is activated by calcineurin and regulates cell wall integrity. PLoS One 7:e51403. doi:10.1371/journal.pone.0051403.
    • (2012) PLoS One , vol.7
    • Lev, S.1    Desmarini, D.2    Chayakulkeeree, M.3    Sorrell, T.C.4    Djordjevic, J.T.5
  • 115
    • 84903647452 scopus 로고    scopus 로고
    • The CRZ1/SP1-like gene links survival under limited aeration, cell integrity and biofilm formation in the pathogenic yeast Cryptococcus neoformans
    • 22 April, doi:10.5507/bp.2013.024. Epub ahead of print
    • Moranova Z, Virtudazo E, Hricova K, Ohkusu M, Kawamoto S, Husickova V, Raclavsky V. 22 April 2013. The CRZ1/SP1-like gene links survival under limited aeration, cell integrity and biofilm formation in the pathogenic yeast Cryptococcus neoformans. Biomed. Pap. Med. Fac. Univ. Palacky Olomouc Czech Repub. doi:10.5507/bp.2013.024. Epub ahead of print.
    • (2013) Biomed. Pap. Med. Fac. Univ. Palacky Olomouc Czech Repub
    • Moranova, Z.1    Virtudazo, E.2    Hricova, K.3    Ohkusu, M.4    Kawamoto, S.5    Husickova, V.6    Raclavsky, V.7
  • 116
    • 2442701773 scopus 로고    scopus 로고
    • The sphingolipid pathway regulates Pkc1 through the formation of diacylglycerol in Cryptococcus neoformans
    • Heung LJ, Luberto C, Plowden A, Hannun YA, Del Poeta M. 2004. The sphingolipid pathway regulates Pkc1 through the formation of diacylglycerol in Cryptococcus neoformans. J. Biol. Chem. 279:21144-21153.
    • (2004) J. Biol. Chem , vol.279 , pp. 21144-21153
    • Heung, L.J.1    Luberto, C.2    Plowden, A.3    Hannun, Y.A.4    Del Poeta, M.5
  • 118
  • 119
    • 84862805988 scopus 로고    scopus 로고
    • Involvement of PDK1, PKC and TOR signalling pathways in basal fluconazole tolerance in Cryptococcus neoformans
    • Lee H, Khanal Lamichhane A, Garraffo HM, Kwon-Chung KJ, Chang YC. 2012. Involvement of PDK1, PKC and TOR signalling pathways in basal fluconazole tolerance in Cryptococcus neoformans. Mol. Microbiol. 84:130-146.
    • (2012) Mol. Microbiol , vol.84 , pp. 130-146
    • Lee, H.1    Khanal, L.A.2    Garraffo, H.M.3    Kwon-Chung, K.J.4    Chang, Y.C.5
  • 120
    • 84871995941 scopus 로고    scopus 로고
    • Cryptococcus neoformans phosphoinositide-dependent kinase 1 (PDK1) ortholog is required for stress tolerance and survival in murine phagocytes
    • Chabrier-Rosello Y, Gerik KJ, Koselny K, DiDone L, Lodge JK, Krysan DJ. 2013. Cryptococcus neoformans phosphoinositide-dependent kinase 1 (PDK1) ortholog is required for stress tolerance and survival in murine phagocytes. Eukaryot. Cell 12:12-22.
    • (2013) Eukaryot. Cell , vol.12 , pp. 12-22
    • Chabrier-Rosello, Y.1    Gerik, K.J.2    Koselny, K.3    Didone, L.4    Lodge, J.K.5    Krysan, D.J.6
  • 121
    • 79957449178 scopus 로고    scopus 로고
    • Identification, in vitro activity and mode of action of phosphoinositide-dependent-1 kinase inhibitors as antifungal molecules
    • Baxter BK, DiDone L, Ogu D, Schor S, Krysan DJ. 2011. Identification, in vitro activity and mode of action of phosphoinositide-dependent-1 kinase inhibitors as antifungal molecules. ACS Chem. Biol. 6:502-510.
    • (2011) ACS Chem. Biol , vol.6 , pp. 502-510
    • Baxter, B.K.1    Didone, L.2    Ogu, D.3    Schor, S.4    Krysan, D.J.5
  • 122
    • 84871963156 scopus 로고    scopus 로고
    • Role of Cryptococcus neoformans Rho1 GTPases in the PKC1 signaling pathway in response to thermal stress
    • Lam WC, Gerik KJ, Lodge JK. 2013. Role of Cryptococcus neoformans Rho1 GTPases in the PKC1 signaling pathway in response to thermal stress. Eukaryot. Cell 12:118-131.
    • (2013) Eukaryot. Cell , vol.12 , pp. 118-131
    • Lam, W.C.1    Gerik, K.J.2    Lodge, J.K.3
  • 123
    • 54249109568 scopus 로고    scopus 로고
    • PKC1 is essential for protection against both oxidative and nitrosative stresses, cell integrity, and normal manifestation of virulence factors in the pathogenic fungus Cryptococcus neoformans
    • Gerik KJ, Bhimireddy SR, Ryerse JS, Specht CA, Lodge JK. 2008. PKC1 is essential for protection against both oxidative and nitrosative stresses, cell integrity, and normal manifestation of virulence factors in the pathogenic fungus Cryptococcus neoformans. Eukaryot. Cell 7:1685-1698.
    • (2008) Eukaryot. Cell , vol.7 , pp. 1685-1698
    • Gerik, K.J.1    Bhimireddy, S.R.2    Ryerse, J.S.3    Specht, C.A.4    Lodge, J.K.5
  • 124
    • 34250899722 scopus 로고    scopus 로고
    • Signal integration in the endoplasmic reticulum unfolded protein response
    • Ron D, Walter P. 2007. Signal integration in the endoplasmic reticulum unfolded protein response. Nat. Rev. Mol. Cell Biol. 8:519-529
    • (2007) Nat. Rev. Mol. Cell Biol , vol.8 , pp. 519-529
    • Ron, D.1    Walter, P.2
  • 125
    • 0030297537 scopus 로고    scopus 로고
    • A novel mechanism for regulating activity of a transcription factor that controls the unfolded protein response
    • Cox JS, Walter P. 1996. A novel mechanism for regulating activity of a transcription factor that controls the unfolded protein response. Cell 87:391-404.
    • (1996) Cell , vol.87 , pp. 391-404
    • Cox, J.S.1    Walter, P.2
  • 126
    • 0030954870 scopus 로고    scopus 로고
    • The transmembrane kinase Ire1p is a site-specific endonuclease that initiates mRNA splicing in the unfolded protein response
    • Sidrauski C, Walter P. 1997. The transmembrane kinase Ire1p is a site-specific endonuclease that initiates mRNA splicing in the unfolded protein response. Cell 90:1031-1039.
    • (1997) Cell , vol.90 , pp. 1031-1039
    • Sidrauski, C.1    Walter, P.2
  • 127
    • 0030297538 scopus 로고    scopus 로고
    • tRNA ligase is required for regulated mRNA splicing in the unfolded protein response
    • Sidrauski C, Cox JS, Walter P. 1996. tRNA ligase is required for regulated mRNA splicing in the unfolded protein response. Cell 87:405-413.
    • (1996) Cell , vol.87 , pp. 405-413
    • Sidrauski, C.1    Cox, J.S.2    Walter, P.3
  • 128
    • 80052309751 scopus 로고    scopus 로고
    • Unique evolution of the UPR pathway with a novel bZIP transcription factor, Hxl1, for controlling pathogenicity of Cryptococcus neoformans
    • doi:10.1371/journal.ppat.1002177
    • Cheon SA, Jung KW, Chen YL, Heitman J, Bahn YS, Kang HA. 2011. Unique evolution of the UPR pathway with a novel bZIP transcription factor, Hxl1, for controlling pathogenicity of Cryptococcus neoformans. PLoS Pathog. 7:e1002177. doi:10.1371/journal.ppat.1002177.
    • (2011) PLoS Pathog , vol.7
    • Cheon, S.A.1    Jung, K.W.2    Chen, Y.L.3    Heitman, J.4    Bahn, Y.S.5    Kang, H.A.6
  • 129
    • 84874589634 scopus 로고    scopus 로고
    • Essential roles of the Kar2/BiP molecular chaperone downstream of the UPR pathway in Cryptococcus neoformans
    • doi:10.1371/journal.pone.0058956
    • Jung KW, Kang HA, Bahn YS. 2013. Essential roles of the Kar2/BiP molecular chaperone downstream of the UPR pathway in Cryptococcus neoformans. PLoS One 8:e58956. doi:10.1371/journal.pone.0058956.
    • (2013) PLoS One , vol.8
    • Jung, K.W.1    Kang, H.A.2    Bahn, Y.S.3
  • 130
    • 84875058619 scopus 로고    scopus 로고
    • Dissection of Ire1 functions reveals stress response mechanisms uniquely evolved in Candida glabrata
    • doi:10.1371 /journal.ppat.1003160
    • Miyazaki T, Nakayama H, Nagayoshi Y, Kakeya H, Kohno S. 2013. Dissection of Ire1 functions reveals stress response mechanisms uniquely evolved in Candida glabrata. PLoS Pathog. 9:e1003160. doi:10.1371 /journal.ppat.1003160.
    • (2013) PLoS Pathog , vol.9
    • Miyazaki, T.1    Nakayama, H.2    Nagayoshi, Y.3    Kakeya, H.4    Kohno, S.5
  • 131
    • 84879506957 scopus 로고    scopus 로고
    • Uncoupling of mRNA synthesis and degradation impairs adaptation to host temperature in Cryptococcus neoformans
    • Bloom AL, Solomons JT, Havel VE, Panepinto JC. 2013. Uncoupling of mRNA synthesis and degradation impairs adaptation to host temperature in Cryptococcus neoformans. Mol. Microbiol. 89:65-83.
    • (2013) Mol. Microbiol , vol.89 , pp. 65-83
    • Bloom, A.L.1    Solomons, J.T.2    Havel, V.E.3    Panepinto, J.C.4
  • 132
    • 79960136702 scopus 로고    scopus 로고
    • Ccr4 promotes resolution of the endoplasmic reticulum stress response during host temperature adaptation in Cryptococcus neoformans
    • Havel VE, Wool NK, Ayad D, Downey KM, Wilson CF, Larsen P, Djordjevic JT, Panepinto JC. 2011. Ccr4 promotes resolution of the endoplasmic reticulum stress response during host temperature adaptation in Cryptococcus neoformans. Eukaryot. Cell 10:895-901.
    • (2011) Eukaryot. Cell , vol.10 , pp. 895-901
    • Havel, V.E.1    Wool, N.K.2    Ayad, D.3    Downey, K.M.4    Wilson, C.F.5    Larsen, P.6    Djordjevic, J.T.7    Panepinto, J.C.8


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