메뉴 건너뛰기




Volumn 7, Issue 10, 2008, Pages 1685-1698

PKC1 is essential for protection against both oxidative and nitrosative stresses, cell integrity, and normal manifestation of virulence factors in the pathogenic fungus Cryptococcus neoformans

Author keywords

[No Author keywords available]

Indexed keywords

CHITIN; FUNGAL PROTEIN; MELANIN; MITOGEN ACTIVATED PROTEIN KINASE; NITROSO DERIVATIVE; PROTEIN KINASE C; VIRULENCE FACTOR;

EID: 54249109568     PISSN: 15359778     EISSN: None     Source Type: Journal    
DOI: 10.1128/EC.00146-08     Document Type: Article
Times cited : (91)

References (47)
  • 2
    • 34249736906 scopus 로고    scopus 로고
    • Chitosan, the deacetylated form of chitin, is necessary for cell wall integrity in Cryptococcus neoformans
    • Baker, L. G., C. A. Specht, M. J. Donlin, and J. Lodge. 2007. Chitosan, the deacetylated form of chitin, is necessary for cell wall integrity in Cryptococcus neoformans. Eukaryot. Cell 6:855-867.
    • (2007) Eukaryot. Cell , vol.6 , pp. 855-867
    • Baker, L.G.1    Specht, C.A.2    Donlin, M.J.3    Lodge, J.4
  • 3
    • 27744569817 scopus 로고    scopus 로고
    • A chitin synthase and its regulator protein are critical for chitosan production and growth of the fungal pathogen Cryptococcus neoformans
    • Banks, I. R., C. A. Specht, M. J. Donlin, K. J. Gerik, S. M. Levitz, and J. K. Lodge. 2005. A chitin synthase and its regulator protein are critical for chitosan production and growth of the fungal pathogen Cryptococcus neoformans. Eukaryot. Cell 4:1902-1912.
    • (2005) Eukaryot. Cell , vol.4 , pp. 1902-1912
    • Banks, I.R.1    Specht, C.A.2    Donlin, M.J.3    Gerik, K.J.4    Levitz, S.M.5    Lodge, J.K.6
  • 4
    • 33750034228 scopus 로고    scopus 로고
    • Chitosomes: Past, present and future
    • Bartnicki-Garcia, S. 2006. Chitosomes: past, present and future. FEMS Yeast Res. 6:957-965.
    • (2006) FEMS Yeast Res , vol.6 , pp. 957-965
    • Bartnicki-Garcia, S.1
  • 6
    • 0142184966 scopus 로고    scopus 로고
    • Chitin synthesis in Saccharomyces cerevisiae in response to supplementation of growth medium with glucosamine and cell wall stress
    • Bulik, D. A., M. Olczak, H. A. Lucero, B. C. Osmond, P. W. Robbins, and C. A. Specht. 2003. Chitin synthesis in Saccharomyces cerevisiae in response to supplementation of growth medium with glucosamine and cell wall stress. Eukaryot. Cell 2:886-900.
    • (2003) Eukaryot. Cell , vol.2 , pp. 886-900
    • Bulik, D.A.1    Olczak, M.2    Lucero, H.A.3    Osmond, B.C.4    Robbins, P.W.5    Specht, C.A.6
  • 8
    • 0016835476 scopus 로고
    • Pigment production by Cryptococcus neoformans from para- and ortho-diphenols: Effect of the nitrogen source
    • Chaskes, S., and R. L. Tyndall. 1975. Pigment production by Cryptococcus neoformans from para- and ortho-diphenols: effect of the nitrogen source. J. Clin. Microbiol. 6:509-514.
    • (1975) J. Clin. Microbiol , vol.6 , pp. 509-514
    • Chaskes, S.1    Tyndall, R.L.2
  • 10
    • 0037218164 scopus 로고    scopus 로고
    • Superoxide dismutase influences the virulence of Cryptococcus neoformans by affecting growth within macrophages
    • Cox, G. M., T. S. Harrison, H. C. McDade, C. P. Taborda, G. Heinrich, A. Casadevall, and J. R. Perfect. 2003. Superoxide dismutase influences the virulence of Cryptococcus neoformans by affecting growth within macrophages. Infect. Immun. 71:173-180.
    • (2003) Infect. Immun , vol.71 , pp. 173-180
    • Cox, G.M.1    Harrison, T.S.2    McDade, H.C.3    Taborda, C.P.4    Heinrich, G.5    Casadevall, A.6    Perfect, J.R.7
  • 13
    • 0035047590 scopus 로고    scopus 로고
    • Cyclic AMP-dependent protein kinase controls virulence of the fungal pathogen Cryptococcus neoformans
    • D'Souza, C. A., J. A. Alspaugh, C. Yue, T. Harashima, G. M. Cox, J. R. Perfect, and J. Heitman. 2001. Cyclic AMP-dependent protein kinase controls virulence of the fungal pathogen Cryptococcus neoformans. Mol. Cell. Biol. 21:3179-3191.
    • (2001) Mol. Cell. Biol , vol.21 , pp. 3179-3191
    • D'Souza, C.A.1    Alspaugh, J.A.2    Yue, C.3    Harashima, T.4    Cox, G.M.5    Perfect, J.R.6    Heitman, J.7
  • 14
    • 0025079475 scopus 로고
    • Isolation of the URA5 gene from Cryptococcus neoformans var. neoformans and its use as a selective marker for transformation
    • Edman, J. C., and K. J. Kwon-Chung. 1990. Isolation of the URA5 gene from Cryptococcus neoformans var. neoformans and its use as a selective marker for transformation. Mol. Cell. Biol. 10:4538-4544.
    • (1990) Mol. Cell. Biol , vol.10 , pp. 4538-4544
    • Edman, J.C.1    Kwon-Chung, K.J.2
  • 15
    • 34249034938 scopus 로고    scopus 로고
    • Extracellular glycosylphosphatidylinositol-anchored mannoproteins and proteases of Cryptococcus neoformans
    • Eigenheer, R. A., Y. Jin Lee, E. Blumwald, B. S. Phinney, and A. Gelli. 2007. Extracellular glycosylphosphatidylinositol-anchored mannoproteins and proteases of Cryptococcus neoformans. FEMS Yeast Res. 7:499-510.
    • (2007) FEMS Yeast Res , vol.7 , pp. 499-510
    • Eigenheer, R.A.1    Jin Lee, Y.2    Blumwald, E.3    Phinney, B.S.4    Gelli, A.5
  • 17
    • 33745727752 scopus 로고    scopus 로고
    • Improvements to gene deletion in the fungal pathogen Cryptococcus neoformans: Absence of Ku proteins increases homologous recombination, and co-transformation of independent DNA molecules allows rapid complementation of deletion phenotypes
    • Goins, C. L., K. J. Gerik, and J. K. Lodge. 2006. Improvements to gene deletion in the fungal pathogen Cryptococcus neoformans: absence of Ku proteins increases homologous recombination, and co-transformation of independent DNA molecules allows rapid complementation of deletion phenotypes. Fungal Genet. Biol. 43:531-544.
    • (2006) Fungal Genet. Biol , vol.43 , pp. 531-544
    • Goins, C.L.1    Gerik, K.J.2    Lodge, J.K.3
  • 18
    • 0021997066 scopus 로고
    • Virulence of Cryptococcus neoformans. Regulation of capsule synthesis by carbon dioxide
    • Granger, D. L., J. R. Perfect, and D. T. Durack. 1985. Virulence of Cryptococcus neoformans. Regulation of capsule synthesis by carbon dioxide. J. Clin. Investig. 76:508-516.
    • (1985) J. Clin. Investig , vol.76 , pp. 508-516
    • Granger, D.L.1    Perfect, J.R.2    Durack, D.T.3
  • 19
    • 0035066932 scopus 로고    scopus 로고
    • A role for the Pkc1p/Mpk1p kinase cascade in the morphogenesis checkpoint
    • Harrison, J. C., E. S. Bardes, Y. Ohya, and D. J. Lew. 2001. A role for the Pkc1p/Mpk1p kinase cascade in the morphogenesis checkpoint. Nat. Cell Biol. 3:417-420.
    • (2001) Nat. Cell Biol , vol.3 , pp. 417-420
    • Harrison, J.C.1    Bardes, E.S.2    Ohya, Y.3    Lew, D.J.4
  • 20
    • 1642576083 scopus 로고    scopus 로고
    • Stress-specific activation mechanisms for the "cell integrity" MAPK pathway
    • Harrison, J. C., T. R. Zyla, E. S. Bardes, and D. J. Lew. 2004. Stress-specific activation mechanisms for the "cell integrity" MAPK pathway. J. Biol. Chem. 279:2616-2622.
    • (2004) J. Biol. Chem , vol.279 , pp. 2616-2622
    • Harrison, J.C.1    Zyla, T.R.2    Bardes, E.S.3    Lew, D.J.4
  • 21
    • 0033009538 scopus 로고    scopus 로고
    • The protein kinase C-mediated MAP kinase pathway is involved in the maintenance of cellular integrity in Saccharomyces cerevisiae
    • Heinisch, J. J., A. Lorberg, H. P. Schmitz, and J. J. Jacoby. 1999. The protein kinase C-mediated MAP kinase pathway is involved in the maintenance of cellular integrity in Saccharomyces cerevisiae. Mol. Microbiol. 32:671-680.
    • (1999) Mol. Microbiol , vol.32 , pp. 671-680
    • Heinisch, J.J.1    Lorberg, A.2    Schmitz, H.P.3    Jacoby, J.J.4
  • 22
    • 23344448602 scopus 로고    scopus 로고
    • The role and mechanism of diacylglycerol-protein kinase C1 signaling in melanogenesis by Cryptococcus neoformans
    • Heung, L. J., A. E. Kaiser, C. Luberto, and M. Del Poeta. 2005. The role and mechanism of diacylglycerol-protein kinase C1 signaling in melanogenesis by Cryptococcus neoformans. J. Biol. Chem. 280:28547-28555.
    • (2005) J. Biol. Chem , vol.280 , pp. 28547-28555
    • Heung, L.J.1    Kaiser, A.E.2    Luberto, C.3    Del Poeta, M.4
  • 23
    • 2442701773 scopus 로고    scopus 로고
    • The sphingolipid pathway regulates Pkc1 through the formation of diacylglycerol in Cryptococcus neoformans
    • Heung, L. J., C. Luberto, A. Plowden, Y. A. Hannun, and M. Del Poeta. 2004. The sphingolipid pathway regulates Pkc1 through the formation of diacylglycerol in Cryptococcus neoformans. J. Biol. Chem. 279:21144-21153.
    • (2004) J. Biol. Chem , vol.279 , pp. 21144-21153
    • Heung, L.J.1    Luberto, C.2    Plowden, A.3    Hannun, Y.A.4    Del Poeta, M.5
  • 24
    • 25444448242 scopus 로고    scopus 로고
    • Two new fluorescent dyes applicable for visualization of fungal cell walls
    • Hoch, H. C., C. D. Galvani, D. H. Szarowski, and J. N. Turner. 2005. Two new fluorescent dyes applicable for visualization of fungal cell walls. Mycologia 97:580-588.
    • (2005) Mycologia , vol.97 , pp. 580-588
    • Hoch, H.C.1    Galvani, C.D.2    Szarowski, D.H.3    Turner, J.N.4
  • 25
    • 0033970530 scopus 로고    scopus 로고
    • Development of positive selectable markers for the fungal pathogen Cryptococcus neoformans
    • Hua, J., J. D. Meyer, and J. K. Lodge. 2000. Development of positive selectable markers for the fungal pathogen Cryptococcus neoformans. Clin. Diagn. Lab Immunol. 7:125-128.
    • (2000) Clin. Diagn. Lab Immunol , vol.7 , pp. 125-128
    • Hua, J.1    Meyer, J.D.2    Lodge, J.K.3
  • 26
    • 0033452784 scopus 로고    scopus 로고
    • Genome-wide analysis of gene expression regulated by the yeast cell wall integrity signalling pathway
    • Jung, U. S., and D. E. Levin. 1999. Genome-wide analysis of gene expression regulated by the yeast cell wall integrity signalling pathway. Mol. Microbiol. 34:1049-1057.
    • (1999) Mol. Microbiol , vol.34 , pp. 1049-1057
    • Jung, U.S.1    Levin, D.E.2
  • 27
    • 11944273348 scopus 로고
    • The protein kinase C-activated MAP kinase pathway of Saccharomyces cerevisiae mediates a novel aspect of the heat shock response
    • Kamada, Y., U. S. Jung, J. Piotrowski, and D. E. Levin. 1995. The protein kinase C-activated MAP kinase pathway of Saccharomyces cerevisiae mediates a novel aspect of the heat shock response. Genes Dev. 9:1559-1571.
    • (1995) Genes Dev , vol.9 , pp. 1559-1571
    • Kamada, Y.1    Jung, U.S.2    Piotrowski, J.3    Levin, D.E.4
  • 28
    • 33645106541 scopus 로고    scopus 로고
    • Calcineurin, Mpk1 and Hog1 MAPK pathways independently control fludioxonil antifungal sensitivity in Cryptococcus neoformans
    • Kojima, K., Y. S. Bahn, and J. Heitman. 2006. Calcineurin, Mpk1 and Hog1 MAPK pathways independently control fludioxonil antifungal sensitivity in Cryptococcus neoformans. Microbiology 152:591-604.
    • (2006) Microbiology , vol.152 , pp. 591-604
    • Kojima, K.1    Bahn, Y.S.2    Heitman, J.3
  • 29
    • 0038460048 scopus 로고    scopus 로고
    • The Cryptococcus neoformans MAP kinase Mpk1 regulates cell integrity in response to antifungal drugs and loss of calcineurin function
    • Kraus, P. R., D. S. Fox, G. M. Cox, and J. Heitman. 2003. The Cryptococcus neoformans MAP kinase Mpk1 regulates cell integrity in response to antifungal drugs and loss of calcineurin function. Mol. Microbiol. 48:1377-1387.
    • (2003) Mol. Microbiol , vol.48 , pp. 1377-1387
    • Kraus, P.R.1    Fox, D.S.2    Cox, G.M.3    Heitman, J.4
  • 30
    • 0026584373 scopus 로고
    • Dominant mutations in a gene encoding a putative protein kinase (BCK1) bypass the requirement for a Saccharomyces cerevisiae protein kinase C homolog
    • Lee, K. S., and D. E. Levin. 1992. Dominant mutations in a gene encoding a putative protein kinase (BCK1) bypass the requirement for a Saccharomyces cerevisiae protein kinase C homolog. Mol. Cell. Biol. 12:172-182.
    • (1992) Mol. Cell. Biol , vol.12 , pp. 172-182
    • Lee, K.S.1    Levin, D.E.2
  • 31
    • 20544432791 scopus 로고    scopus 로고
    • Cell wall integrity signaling in Saccharomyces cerevisiae
    • Levin, D. E. 2005. Cell wall integrity signaling in Saccharomyces cerevisiae. Microbiol. Mol. Biol. Rev. 69:262-291.
    • (2005) Microbiol. Mol. Biol. Rev , vol.69 , pp. 262-291
    • Levin, D.E.1
  • 32
    • 0025300349 scopus 로고
    • A candidate protein kinase C gene, PKC1, is required for the S. cerevisiae cell cycle
    • Levin, D. E., F. O. Fields, R. Kunisawa, J. M. Bishop, and J. Thorner. 1990. A candidate protein kinase C gene, PKC1, is required for the S. cerevisiae cell cycle. Cell 62:213-224.
    • (1990) Cell , vol.62 , pp. 213-224
    • Levin, D.E.1    Fields, F.O.2    Kunisawa, R.3    Bishop, J.M.4    Thorner, J.5
  • 33
    • 0035119757 scopus 로고    scopus 로고
    • A new dominant selectable marker for use in Cryptococcus neoformans
    • McDade, H. C., and G. M. Cox. 2001. A new dominant selectable marker for use in Cryptococcus neoformans. Med. Mycol. 39:151-154.
    • (2001) Med. Mycol , vol.39 , pp. 151-154
    • McDade, H.C.1    Cox, G.M.2
  • 34
    • 0001369336 scopus 로고
    • A buffer solution for colorimetric comparison
    • McIlvaine, T. C. 1921. A buffer solution for colorimetric comparison. J. Biol. Chem. 49:183-186.
    • (1921) J. Biol. Chem , vol.49 , pp. 183-186
    • McIlvaine, T.C.1
  • 35
    • 33645054564 scopus 로고    scopus 로고
    • Posttranslational, translational, and transcriptional responses to nitric oxide stress in Cryptococcus neoformans: Implications for virulence
    • Missall, T. A., M. E. Pusateri, M. J. Donlin, K. T. Chambers, J. A. Corbett, and J. K. Lodge. 2006. Posttranslational, translational, and transcriptional responses to nitric oxide stress in Cryptococcus neoformans: implications for virulence. Eukaryot. Cell 5:518-529.
    • (2006) Eukaryot. Cell , vol.5 , pp. 518-529
    • Missall, T.A.1    Pusateri, M.E.2    Donlin, M.J.3    Chambers, K.T.4    Corbett, J.A.5    Lodge, J.K.6
  • 36
    • 1542511805 scopus 로고    scopus 로고
    • Thiol peroxidase is critical for virulence and resistance to nitric oxide and peroxide in the fungal pathogen, Cryptococcus neoformans
    • Missall, T. A., M. E. Pusateri, and J. K. Lodge. 2004. Thiol peroxidase is critical for virulence and resistance to nitric oxide and peroxide in the fungal pathogen, Cryptococcus neoformans. Mol. Microbiol. 51:1447-1458.
    • (2004) Mol. Microbiol , vol.51 , pp. 1447-1458
    • Missall, T.A.1    Pusateri, M.E.2    Lodge, J.K.3
  • 37
    • 0037331111 scopus 로고    scopus 로고
    • Sequence length required for homologous recombination in Cryptococcus neoformans
    • Nelson, R. T., B. A. Pryor, and J. K. Lodge. 2003. Sequence length required for homologous recombination in Cryptococcus neoformans. Fungal Genet. Biol. 38:1-9.
    • (2003) Fungal Genet. Biol , vol.38 , pp. 1-9
    • Nelson, R.T.1    Pryor, B.A.2    Lodge, J.K.3
  • 38
    • 0035102985 scopus 로고    scopus 로고
    • Identification of virulence mutants of the fungal pathogen Cryptococcus neoformans using signature-tagged mutagenesis
    • Nelson, R. T., J. Hua, B. Pryor, and J. K. Lodge. 2001. Identification of virulence mutants of the fungal pathogen Cryptococcus neoformans using signature-tagged mutagenesis. Genetics. 157:935-947.
    • (2001) Genetics , vol.157 , pp. 935-947
    • Nelson, R.T.1    Hua, J.2    Pryor, B.3    Lodge, J.K.4
  • 39
    • 0041971075 scopus 로고    scopus 로고
    • Sexual cycle of Cryptococcus neoformans var. grubii and virulence of congenic a and α isolates
    • Nielsen, K., G. M. Cox, P. Wang, D. L. Toffaletti, J. R. Perfect, and J. Heitman. 2003. Sexual cycle of Cryptococcus neoformans var. grubii and virulence of congenic a and α isolates. Infect. Immun. 2003 71:4831-4841.
    • (2003) Infect. Immun. 2003 , vol.71 , pp. 4831-4841
    • Nielsen, K.1    Cox, G.M.2    Wang, P.3    Toffaletti, D.L.4    Perfect, J.R.5    Heitman, J.6
  • 40
    • 0344826555 scopus 로고    scopus 로고
    • Cell wall alpha-1,3-glucan is required to anchor the Cryptococcus neoformans capsule
    • Reese, A. J., and T. L. Doering. 2003. Cell wall alpha-1,3-glucan is required to anchor the Cryptococcus neoformans capsule. Mol. Microbiol. 50:1401-1409.
    • (2003) Mol. Microbiol , vol.50 , pp. 1401-1409
    • Reese, A.J.1    Doering, T.L.2
  • 41
    • 0016257684 scopus 로고
    • Synthesis of cell wall microfibrils in vitro by a "soluble" chitin synthetase from Mucor rouxii
    • Ruiz-Herrera, J., and S. Bartnicki-Garcia. 1974. Synthesis of cell wall microfibrils in vitro by a "soluble" chitin synthetase from Mucor rouxii. Science 186:357-359.
    • (1974) Science , vol.186 , pp. 357-359
    • Ruiz-Herrera, J.1    Bartnicki-Garcia, S.2
  • 42
    • 0027467293 scopus 로고
    • Gene transfer in Cryptococcus neoformans by use of biolistic delivery of DNA
    • Toffaletti, D. L., T. H. Rude, S. A. Johnston, D. T. Durack, and J. R. Perfect. 1993. Gene transfer in Cryptococcus neoformans by use of biolistic delivery of DNA. J. Bacteriol. 175:1405-1411.
    • (1993) J. Bacteriol , vol.175 , pp. 1405-1411
    • Toffaletti, D.L.1    Rude, T.H.2    Johnston, S.A.3    Durack, D.T.4    Perfect, J.R.5
  • 43
    • 0037044801 scopus 로고    scopus 로고
    • Regulation of the cell integrity pathway by rapamycin-sensitive TOR function in budding yeast
    • Torres, J., C. J. Di Como, E. Herrero, and M. A. De La Torre-Ruiz. 2002. Regulation of the cell integrity pathway by rapamycin-sensitive TOR function in budding yeast. J. Biol. Chem. 277:43495-43504.
    • (2002) J. Biol. Chem , vol.277 , pp. 43495-43504
    • Torres, J.1    Di Como, C.J.2    Herrero, E.3    De La Torre-Ruiz, M.A.4
  • 44
    • 0042838332 scopus 로고    scopus 로고
    • The yeasts Rho1p and Pkc1p regulate the transport of chitin synthase III (Chs3p) from internal stores to the plasma membrane
    • Valdivia, R. H., and R. Schekman. 2003. The yeasts Rho1p and Pkc1p regulate the transport of chitin synthase III (Chs3p) from internal stores to the plasma membrane. Proc. Natl. Acad. Sci. USA 100:10287-10292.
    • (2003) Proc. Natl. Acad. Sci. USA , vol.100 , pp. 10287-10292
    • Valdivia, R.H.1    Schekman, R.2
  • 45
    • 16844368767 scopus 로고    scopus 로고
    • Pkc1 and the upstream elements of the cell integrity pathway in Saccharomyces cerevisiae, Rom2 and Mtl1, are required for cellular responses to oxidative stress
    • Vilella, F., E. Herrero, J. Torres, and M. A. de la Torre-Ruiz. 2005. Pkc1 and the upstream elements of the cell integrity pathway in Saccharomyces cerevisiae, Rom2 and Mtl1, are required for cellular responses to oxidative stress. J. Biol. Chem. 280:9149-9159.
    • (2005) J. Biol. Chem , vol.280 , pp. 9149-9159
    • Vilella, F.1    Herrero, E.2    Torres, J.3    de la Torre-Ruiz, M.A.4
  • 46
    • 2642616985 scopus 로고    scopus 로고
    • Temperature-induced expression of yeast FKS2 is under the dual control of protein kinase C and calcineurin
    • Zhao, C., U. S. Jung, P. Garrett-Engele, T. Roe, M. S. Cyert, and D. E. Levin. 1998. Temperature-induced expression of yeast FKS2 is under the dual control of protein kinase C and calcineurin. Mol. Cell. Biol. 18:1013-1022.
    • (1998) Mol. Cell. Biol , vol.18 , pp. 1013-1022
    • Zhao, C.1    Jung, U.S.2    Garrett-Engele, P.3    Roe, T.4    Cyert, M.S.5    Levin, D.E.6
  • 47
    • 0034867481 scopus 로고    scopus 로고
    • Laccase of Cryptococcus neoformans is a cell wall-associated virulence factor
    • Zhu, X., J. Gibbons, J. Garcia-Rivera, A. Casadevall, and P. R. Williamson. 2001. Laccase of Cryptococcus neoformans is a cell wall-associated virulence factor. Infect. Immun. 69:5589-5596.
    • (2001) Infect. Immun , vol.69 , pp. 5589-5596
    • Zhu, X.1    Gibbons, J.2    Garcia-Rivera, J.3    Casadevall, A.4    Williamson, P.R.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.