-
1
-
-
0032541986
-
Pyrimidinylimidazole inhibitors of CSBP/p38 kinase demonstrating decreased inhibition of hepatic cytochrome P450 enzymes
-
Adams J.L., Boehm J.C., Kassis S., Gorycki P.D., Webb E.F., Hall R., Sorenson M., Lee J.C., Ayrton A., Griswold D.E., Gallagher T.F. Pyrimidinylimidazole inhibitors of CSBP/p38 kinase demonstrating decreased inhibition of hepatic cytochrome P450 enzymes. Bioorg. Med. Chem. Lett. 8:1998;3111-3116.
-
(1998)
Bioorg. Med. Chem. Lett.
, vol.8
, pp. 3111-3116
-
-
Adams, J.L.1
Boehm, J.C.2
Kassis, S.3
Gorycki, P.D.4
Webb, E.F.5
Hall, R.6
Sorenson, M.7
Lee, J.C.8
Ayrton, A.9
Griswold, D.E.10
Gallagher, T.F.11
-
2
-
-
0030426902
-
Pharmacological profile of SB 203580, a selective inhibitor of CSBP/p38 kinase, in animal models of arthritis, bone resorption, endotoxin shock and immune function
-
Badger A.M., Bradbeer J.N., Votta B., Lee J.C., Adams J.L., Griswold D.E. Pharmacological profile of SB 203580, a selective inhibitor of CSBP/p38 kinase, in animal models of arthritis, bone resorption, endotoxin shock and immune function. J. Pharmacol. Exp. Ther. 279:1996;1453-1461.
-
(1996)
J. Pharmacol. Exp. Ther.
, vol.279
, pp. 1453-1461
-
-
Badger, A.M.1
Bradbeer, J.N.2
Votta, B.3
Lee, J.C.4
Adams, J.L.5
Griswold, D.E.6
-
3
-
-
0031803059
-
SB 203580 inhibits p38 mitogen-activated protein kinase, nitric oxide production, and inducible nitric oxide synthase in bovine cartilage-derived chondrocytes
-
Badger A.M., Cook M.N., Lark M.W., Newman-Tarr T.M., Swift B.A., Nelson A.H., Barone F.C., Kumar S. SB 203580 inhibits p38 mitogen-activated protein kinase, nitric oxide production, and inducible nitric oxide synthase in bovine cartilage-derived chondrocytes. J. Immunol. 161:1998;467-473.
-
(1998)
J. Immunol.
, vol.161
, pp. 467-473
-
-
Badger, A.M.1
Cook, M.N.2
Lark, M.W.3
Newman-Tarr, T.M.4
Swift, B.A.5
Nelson, A.H.6
Barone, F.C.7
Kumar, S.8
-
4
-
-
0028875683
-
Cdc42 and PAK-mediated signaling leads to Jun kinase and p38 mitogen-activated protein kinase activation
-
Bagrodia S., Derijard B., Davis R.J., Cerione R.A. Cdc42 and PAK-mediated signaling leads to Jun kinase and p38 mitogen-activated protein kinase activation. J. Biol. Chem. 270:1995;27995-27998.
-
(1995)
J. Biol. Chem.
, vol.270
, pp. 27995-27998
-
-
Bagrodia, S.1
Derijard, B.2
Davis, R.J.3
Cerione, R.A.4
-
6
-
-
0032563807
-
Nuclear export of the stress-activated protein kinase p38 mediated by its substrate MAPKAP kinase-2
-
Ben-Levy R., Hooper S., Wilson R., Paterson H.F., Marshall C.J. Nuclear export of the stress-activated protein kinase p38 mediated by its substrate MAPKAP kinase-2. Curr. Biol. 8:1998;1049-1057.
-
(1998)
Curr. Biol.
, vol.8
, pp. 1049-1057
-
-
Ben-Levy, R.1
Hooper, S.2
Wilson, R.3
Paterson, H.F.4
Marshall, C.J.5
-
7
-
-
0030764621
-
Phosphorylation of the respiratory burst oxidase subunit p67(phox) during human neutrophil activation. Regulation by protein kinase C-dependent and independent pathways
-
Benna J.E., Dang P.M., Gaudry M., Fay M., Morel F., Hakim J., Gougerot-Pocidalo M.A. Phosphorylation of the respiratory burst oxidase subunit p67(phox) during human neutrophil activation. Regulation by protein kinase C-dependent and independent pathways. J. Biol. Chem. 272:1997;17204-17208.
-
(1997)
J. Biol. Chem.
, vol.272
, pp. 17204-17208
-
-
Benna, J.E.1
Dang, P.M.2
Gaudry, M.3
Fay, M.4
Morel, F.5
Hakim, J.6
Gougerot-Pocidalo, M.A.7
-
8
-
-
0029983730
-
The p38/RK mitogen-activated protein kinase pathway regulates interleukin-6 synthesis response to tumor necrosis factor
-
Beyaert R., Cuenda A., Vanden Berghe W., Plaisance S., Lee J.C., Haegeman G., Cohen P., Fiers W. The p38/RK mitogen-activated protein kinase pathway regulates interleukin-6 synthesis response to tumor necrosis factor. EMBO Journal. 15:1996;1914-1923.
-
(1996)
EMBO Journal
, vol.15
, pp. 1914-1923
-
-
Beyaert, R.1
Cuenda, A.2
Vanden Berghe, W.3
Plaisance, S.4
Lee, J.C.5
Haegeman, G.6
Cohen, P.7
Fiers, W.8
-
9
-
-
0032032424
-
Extracellular signal-regulated kinase and p38 subgroups of mitogen-activated protein kinases regulate inducible nitric oxide synthase and tumor necrosis factor-alpha gene expression in endotoxin-stimulated primary glial cultures
-
Bhat N.R., Zhang P., Lee J.C., Hogan E.L. Extracellular signal-regulated kinase and p38 subgroups of mitogen-activated protein kinases regulate inducible nitric oxide synthase and tumor necrosis factor-alpha gene expression in endotoxin-stimulated primary glial cultures. J. Neurosci. 18:1998;1633-1641.
-
(1998)
J. Neurosci.
, vol.18
, pp. 1633-1641
-
-
Bhat, N.R.1
Zhang, P.2
Lee, J.C.3
Hogan, E.L.4
-
11
-
-
0029559182
-
Kinetic mechanisms of the forward and reverse pp60c-src tyrosine kinase reactions
-
Boemer R.J., Barker S.C., Knight W.B. Kinetic mechanisms of the forward and reverse pp60c-src tyrosine kinase reactions. Biochemistry. 34:1995;16419-16423.
-
(1995)
Biochemistry
, vol.34
, pp. 16419-16423
-
-
Boemer, R.J.1
Barker, S.C.2
Knight, W.B.3
-
12
-
-
0030919654
-
Phosphorylation and activation of cytosolic phospholipase A2 by 38-kDa mitogen-activated protein kinase in collagen-stimulated human platelets
-
Borsch-Haubold A.G., Kramer R.M., Watson S.P. Phosphorylation and activation of cytosolic phospholipase A2 by 38-kDa mitogen-activated protein kinase in collagen-stimulated human platelets. Eur. J. Biochem. 245:1997;751-759.
-
(1997)
Eur. J. Biochem.
, vol.245
, pp. 751-759
-
-
Borsch-Haubold, A.G.1
Kramer, R.M.2
Watson, S.P.3
-
13
-
-
0032534749
-
Analysis of signal transduction pathways regulating cytokine-mediated Fc receptor activation on human eosinophils
-
Bracke M., Coffer P.J., Lammers J.W.J., Koenderman L. Analysis of signal transduction pathways regulating cytokine-mediated Fc receptor activation on human eosinophils. J. Immunol. 161:1998;6768-6774.
-
(1998)
J. Immunol.
, vol.161
, pp. 6768-6774
-
-
Bracke, M.1
Coffer, P.J.2
Lammers, J.W.J.3
Koenderman, L.4
-
14
-
-
0000370303
-
Identification of a common nucleotide sequence in the 3′-untranslated region of mRNA molecules specifying inflammatory mediators
-
Caput D., Beutler B., Hartog K., Thayer R., Brown-Shimer S., Cermai A. Identification of a common nucleotide sequence in the 3′-untranslated region of mRNA molecules specifying inflammatory mediators. Proc. Natl. Acad. Sci. U. S. A. 83:1986;1670-1674.
-
(1986)
Proc. Natl. Acad. Sci. U. S. A.
, vol.83
, pp. 1670-1674
-
-
Caput, D.1
Beutler, B.2
Hartog, K.3
Thayer, R.4
Brown-Shimer, S.5
Cermai, A.6
-
15
-
-
0030565457
-
Comparison of the substrate specificity of MAPKAP kinase-2 and MAPKAP kinase-3 and their activation by cytokines and cellular stress
-
Clifton A.D., Young P.R., Cohen P.A. Comparison of the substrate specificity of MAPKAP kinase-2 and MAPKAP kinase-3 and their activation by cytokines and cellular stress. FEBS Lett. 392:1996;124-209.
-
(1996)
FEBS Lett.
, vol.392
, pp. 124-209
-
-
Clifton, A.D.1
Young, P.R.2
Cohen, P.A.3
-
16
-
-
0029043582
-
How MAP kinases are regulated
-
Cobb M.H., Goldsmith E.J. How MAP kinases are regulated. J. Biol. Chem. 270:1995;14843-14846.
-
(1995)
J. Biol. Chem.
, vol.270
, pp. 14843-14846
-
-
Cobb, M.H.1
Goldsmith, E.J.2
-
17
-
-
0030783156
-
The search for physiological substrates of MAP and SAP kinases in mammalian cells
-
Cohen P. The search for physiological substrates of MAP and SAP kinases in mammalian cells. Trends Cell Biol. 7:1997;353-361.
-
(1997)
Trends Cell Biol.
, vol.7
, pp. 353-361
-
-
Cohen, P.1
-
18
-
-
0020478357
-
Adenosine cyclic 3′-5′-monophosphate dependent protein kinase: Kinetic mechanism of the bovine skeletal muscle catalytic subunit
-
Cook P.F., Neville M.E. Jr., Vrana K.E., Hartl F.T., Roskoski R. Jr. Adenosine cyclic 3′-5′-monophosphate dependent protein kinase: kinetic mechanism of the bovine skeletal muscle catalytic subunit. Biochemistry. 21:1982;5794-5799.
-
(1982)
Biochemistry
, vol.21
, pp. 5794-5799
-
-
Cook, P.F.1
Neville, M.E.2
Vrana, K.E.3
Hartl, F.T.4
Roskoski, R.5
-
19
-
-
0032193226
-
P38 MAPK is required for CD40-induced gene expression and proliferation in B lymphocytes
-
Craxton A., Shu G., Graves J.D., Saklatvala J., Krebs E.G., Clark E.A. p38 MAPK is required for CD40-induced gene expression and proliferation in B lymphocytes. J. Immunol. 161:1998;3225-3236.
-
(1998)
J. Immunol.
, vol.161
, pp. 3225-3236
-
-
Craxton, A.1
Shu, G.2
Graves, J.D.3
Saklatvala, J.4
Krebs, E.G.5
Clark, E.A.6
-
20
-
-
0028988138
-
SB 203580 is a specific inhibitor of a MAP kinase homologue which is stimulated by cellular stresses and interleukin-1
-
Cuenda A., Rouse J., Doza Y.N., Meier R., Cohen P., Gallagher T.F., Young P.R., Lee J.C. SB 203580 is a specific inhibitor of a MAP kinase homologue which is stimulated by cellular stresses and interleukin-1. FEBS Lett. 364:1995;229-233.
-
(1995)
FEBS Lett.
, vol.364
, pp. 229-233
-
-
Cuenda, A.1
Rouse, J.2
Doza, Y.N.3
Meier, R.4
Cohen, P.5
Gallagher, T.F.6
Young, P.R.7
Lee, J.C.8
-
21
-
-
0031024646
-
Activation of stress-activated protein kinase-3 (SAPK3) by cytokines and cellular stresses is mediated via SAPKK3 (MKK6); Comparison of the specificities of SAPK3 and SAPK2 (RK/p38)
-
Cuenda A., Cohen P., Buee-Scherrer V., Goedert M. Activation of stress-activated protein kinase-3 (SAPK3) by cytokines and cellular stresses is mediated via SAPKK3 (MKK6); comparison of the specificities of SAPK3 and SAPK2 (RK/p38). EMBO J. 16:1997;295-305.
-
(1997)
EMBO J.
, vol.16
, pp. 295-305
-
-
Cuenda, A.1
Cohen, P.2
Buee-Scherrer, V.3
Goedert, M.4
-
22
-
-
0030725612
-
Activation of the novel MAP kinase homologue SAPK4 by cytokines and cellular stresses is mediated by SKK3 (MKK6)
-
Cuenda A., Goedert M., Craxton M., Jakes R., Cohen P. Activation of the novel MAP kinase homologue SAPK4 by cytokines and cellular stresses is mediated by SKK3 (MKK6). Biochem. Soc. Trans. 25:1997;S569.
-
(1997)
Biochem. Soc. Trans.
, vol.25
, pp. 569
-
-
Cuenda, A.1
Goedert, M.2
Craxton, M.3
Jakes, R.4
Cohen, P.5
-
23
-
-
0032479983
-
Mitogen- And stress-activated protein kinase-1 (MSK1) is directly activated by MAPK and SAPK2/p38, and may mediate activation of CREB
-
Deak M., Clifton A.D., Lucocq J.M., Alessi D.R. Mitogen- and stress-activated protein kinase-1 (MSK1) is directly activated by MAPK and SAPK2/p38, and may mediate activation of CREB. EMBO J. 17:1998;4426-4441.
-
(1998)
EMBO J.
, vol.17
, pp. 4426-4441
-
-
Deak, M.1
Clifton, A.D.2
Lucocq, J.M.3
Alessi, D.R.4
-
24
-
-
0032491233
-
Pyrroles and other heterocycles as inhibitors of p38 kinase
-
de Laszlo S.E., Visco D., Agarwal L., Chang L., Chin J., Croft G., Forsyth A., Fletcher D., Frantz B., Hacker C., Hanlon W., Harper C., Kostura M., Li B., Luell S., MacCoss M., Mantlo N., O'Neill E.A., Orevillo C., Pang M., Parsons J., Rolando A., Sahly Y., Sidler K., Widmer W.R., O'Keefe S.J. Pyrroles and other heterocycles as inhibitors of p38 kinase. Bioorg. Med. Chem. Lett. 8:1998;2689-2694.
-
(1998)
Bioorg. Med. Chem. Lett.
, vol.8
, pp. 2689-2694
-
-
De Laszlo, S.E.1
Visco, D.2
Agarwal, L.3
Chang, L.4
Chin, J.5
Croft, G.6
Forsyth, A.7
Fletcher, D.8
Frantz, B.9
Hacker, C.10
Hanlon, W.11
Harper, C.12
Kostura, M.13
Li, B.14
Luell, S.15
MacCoss, M.16
Mantlo, N.17
O'Neill, E.A.18
Orevillo, C.19
Pang, M.20
Parsons, J.21
Rolando, A.22
Sahly, Y.23
Sidler, K.24
Widmer, W.R.25
O'Keefe, S.J.26
more..
-
25
-
-
0028329953
-
JNK1: A protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domain
-
Derijard B., Hibi M., Wu I.H., Barrett T., Su B., Deng T., Karin M., Davis R.J. JNK1: a protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domain. Cell. 76:1994;1025-1037.
-
(1994)
Cell
, vol.76
, pp. 1025-1037
-
-
Derijard, B.1
Hibi, M.2
Wu, I.H.3
Barrett, T.4
Su, B.5
Deng, T.6
Karin, M.7
Davis, R.J.8
-
26
-
-
0028935974
-
Independent human MAP-kinase signal transduction pathways defined by MEK and MKK isoforms
-
Derijard B., Raingeaud J., Barrett T., Wu I.H., Han J., Ulevitch R.J., Davis R.J. Independent human MAP-kinase signal transduction pathways defined by MEK and MKK isoforms. Science. 267:1995;682-685.
-
(1995)
Science
, vol.267
, pp. 682-685
-
-
Derijard, B.1
Raingeaud, J.2
Barrett, T.3
Wu, I.H.4
Han, J.5
Ulevitch, R.J.6
Davis, R.J.7
-
27
-
-
0028969480
-
Activation of the MAP kinase homologue RK requires the phosphorylation of Thr-180 and Tyr-182 and both residues are phosphorylated in chemically stressed KB cells
-
Doza Y.N., Cuenda A., Thomas G.M., Cohen P., Nebreda A.R. Activation of the MAP kinase homologue RK requires the phosphorylation of Thr-180 and Tyr-182 and both residues are phosphorylated in chemically stressed KB cells. FEBS Lett. 364:1995;223-228.
-
(1995)
FEBS Lett.
, vol.364
, pp. 223-228
-
-
Doza, Y.N.1
Cuenda, A.2
Thomas, G.M.3
Cohen, P.4
Nebreda, A.R.5
-
28
-
-
0031916832
-
Selective activation of p38 mitogen-activated protein (MAP) kinase: Isoforms by the kinase kinases MKK3 and MKK6
-
Enslen H., Raingeaud J., Davis R.J. Selective activation of p38 mitogen-activated protein (MAP) kinase: isoforms by the kinase kinases MKK3 and MKK6. J. Biol. Chem. 273:1998;1741-1748.
-
(1998)
J. Biol. Chem.
, vol.273
, pp. 1741-1748
-
-
Enslen, H.1
Raingeaud, J.2
Davis, R.J.3
-
29
-
-
0032102902
-
Conversion of SB 203580-insensitive MAP kinase family members to drug-sensitive forms by a single amino-acid substitution
-
Eyers P.A., Craxton M., Morrice N., Cohen P., Goedert M. Conversion of SB 203580-insensitive MAP kinase family members to drug-sensitive forms by a single amino-acid substitution. Chem. Biol. 5:1998;321-328.
-
(1998)
Chem. Biol.
, vol.5
, pp. 321-328
-
-
Eyers, P.A.1
Craxton, M.2
Morrice, N.3
Cohen, P.4
Goedert, M.5
-
30
-
-
0032502772
-
Human mitogen-activated protein kinase kinase 7 (MKK7) is a highly conserved c-Jun N-terminal kinase/stress-activated protein kinase (JNK/SAPK) activated by environmental stresses and physiological stimuli
-
Foltz I.N., Gerl R.E., Wieler J.S., Luckach M., Salmon R.A., Schrader J.W. Human mitogen-activated protein kinase kinase 7 (MKK7) is a highly conserved c-Jun N-terminal kinase/stress-activated protein kinase (JNK/SAPK) activated by environmental stresses and physiological stimuli. J. Biol. Chem. 273:1998;9344-9351.
-
(1998)
J. Biol. Chem.
, vol.273
, pp. 9344-9351
-
-
Foltz, I.N.1
Gerl, R.E.2
Wieler, J.S.3
Luckach, M.4
Salmon, R.A.5
Schrader, J.W.6
-
31
-
-
0031793432
-
A single amino acid makes ERK2 susceptible to pyridinyl imidazole inhibitors of p38 MAP kinase
-
Fox T., Coll J.T., Xie X., Ford P.J., Germann U.A., Porter M.D., Parhanisamy S., Fleming M.A., Galullo V., Su M.S.S., Wilson K. A single amino acid makes ERK2 susceptible to pyridinyl imidazole inhibitors of p38 MAP kinase. Protein Sci. 7:1998;2249-2255.
-
(1998)
Protein Sci.
, vol.7
, pp. 2249-2255
-
-
Fox, T.1
Coll, J.T.2
Xie, X.3
Ford, P.J.4
Germann, U.A.5
Porter, M.D.6
Parhanisamy, S.7
Fleming, M.A.8
Galullo, V.9
Su, M.S.S.10
Wilson, K.11
-
32
-
-
0032578559
-
The activation state of p38 mitogen-activated protein kinase determines the efficiency of ATP competition of pyridinylimidazole inhibitor binding
-
Frantz B., Klatt T., Pang M., Parsons J., Rolando A., Williams H., Tocci M.J., O'Keefe S.J., O'Neill E.A. The activation state of p38 mitogen-activated protein kinase determines the efficiency of ATP competition of pyridinylimidazole inhibitor binding. Biochemistry. 37:1998;13846-13853.
-
(1998)
Biochemistry
, vol.37
, pp. 13846-13853
-
-
Frantz, B.1
Klatt, T.2
Pang, M.3
Parsons, J.4
Rolando, A.5
Williams, H.6
Tocci, M.J.7
O'Keefe, S.J.8
O'Neill, E.A.9
-
33
-
-
0028848575
-
Models and mechanism of exercise-induced asthma
-
Freed A.N. Models and mechanism of exercise-induced asthma. J. Eur. Respir. 8:1995;1765-1770.
-
(1995)
J. Eur. Respir.
, vol.8
, pp. 1765-1770
-
-
Freed, A.N.1
-
34
-
-
0030977270
-
MNK1, a new MAP kinase-activated protein kinase, isolated by a novel expression screening method for identifying protein kinase substrates
-
Fukunaga R., Hunter T. MNK1, a new MAP kinase-activated protein kinase, isolated by a novel expression screening method for identifying protein kinase substrates. EMBO J. 16:1997;1921-1933.
-
(1997)
EMBO J.
, vol.16
, pp. 1921-1933
-
-
Fukunaga, R.1
Hunter, T.2
-
35
-
-
0029042823
-
2,4,5-Triarylimidazole inhibitors of IL-1 biosynthesis
-
Gallagher T.F., Fier-Thompson S.M., Garigipati R.S., Sorenson M.E., Smietana J.M., Lee D., Lee J.C., Laydon J.T., Griswold D.E., Chabot-Fletcher M.C., Breton J.J., Adams J.L. 2,4,5-Triarylimidazole inhibitors of IL-1 biosynthesis. Bioorg. Med. Chem. Lett. 5:1995;1171-1176.
-
(1995)
Bioorg. Med. Chem. Lett.
, vol.5
, pp. 1171-1176
-
-
Gallagher, T.F.1
Fier-Thompson, S.M.2
Garigipati, R.S.3
Sorenson, M.E.4
Smietana, J.M.5
Lee, D.6
Lee, J.C.7
Laydon, J.T.8
Griswold, D.E.9
Chabot-Fletcher, M.C.10
Breton, J.J.11
Adams, J.L.12
-
36
-
-
17644437502
-
Regulation of stress-induced cytokine production by pyridinylimidazoles: Inhibition of CSBP kinase
-
Gallagher T.F., Seibel G.L., Kassis S., Laydon J.T., Lee J.C., Lee D., Boehm J.C., Bender P.E., Erhard K.F., Krog A.J., Hofmann G.A., Adams J.L. Regulation of stress-induced cytokine production by pyridinylimidazoles: inhibition of CSBP kinase. Bioorg. Med. Chem. 5:1997;49-64.
-
(1997)
Bioorg. Med. Chem.
, vol.5
, pp. 49-64
-
-
Gallagher, T.F.1
Seibel, G.L.2
Kassis, S.3
Laydon, J.T.4
Lee, J.C.5
Lee, D.6
Boehm, J.C.7
Bender, P.E.8
Erhard, K.F.9
Krog, A.J.10
Hofmann, G.A.11
Adams, J.L.12
-
37
-
-
0030927106
-
Activation of the novel stress-activated protein kinase SAPK4 by cytokines and cellular stresses is mediated by SKK3 (MKK6) - comparison of its substrate specificity with that of other SAP kinases
-
Goedert M., Cuenda A., Craxton M., Jakes R., Cohen P. Activation of the novel stress-activated protein kinase SAPK4 by cytokines and cellular stresses is mediated by SKK3 (MKK6) - comparison of its substrate specificity with that of other SAP kinases. EMBO J. 16:1997;3563-3571.
-
(1997)
EMBO J.
, vol.16
, pp. 3563-3571
-
-
Goedert, M.1
Cuenda, A.2
Craxton, M.3
Jakes, R.4
Cohen, P.5
-
38
-
-
0030963035
-
Phosphorylation of microtubule-associated protein tau by stress-activated protein kinases
-
Goedert M., Hasegawa M., Jakes R., Lawler S., Cuenda A., Cohen P. Phosphorylation of microtubule-associated protein tau by stress-activated protein kinases. FEBS Lett. 409:1997;57-62.
-
(1997)
FEBS Lett.
, vol.409
, pp. 57-62
-
-
Goedert, M.1
Hasegawa, M.2
Jakes, R.3
Lawler, S.4
Cuenda, A.5
Cohen, P.6
-
39
-
-
0031056783
-
Regulation of actin filament dynamics by p38 map kinase-mediated phosphorylation of heat shock protein 27
-
Guay J., Lambert H., Gingras-Breton G., Lavoie N.J., Huot J., Landry J. Regulation of actin filament dynamics by p38 map kinase-mediated phosphorylation of heat shock protein 27. J. Cell Sci. 110:1997;357-368.
-
(1997)
J. Cell Sci.
, vol.110
, pp. 357-368
-
-
Guay, J.1
Lambert, H.2
Gingras-Breton, G.3
Lavoie, N.J.4
Huot, J.5
Landry, J.6
-
40
-
-
10744227768
-
Acquisition of sensitivity of stress-activated protein kinases to the p38 inhibitor, SB 203580, by alteration of one or more amino acids within the ATP binding pocket
-
Gum R., McLaughlin M.M., Kumar S., Wang Z.L., Bower M.J., Lee J.C., Adams J.L., Livi G.P., Goldsmith E.J., Young P.R. Acquisition of sensitivity of stress-activated protein kinases to the p38 inhibitor, SB 203580, by alteration of one or more amino acids within the ATP binding pocket. J. Biol. Chem. 273:1998;15605-15610.
-
(1998)
J. Biol. Chem.
, vol.273
, pp. 15605-15610
-
-
Gum, R.1
McLaughlin, M.M.2
Kumar, S.3
Wang, Z.L.4
Bower, M.J.5
Lee, J.C.6
Adams, J.L.7
Livi, G.P.8
Goldsmith, E.J.9
Young, P.R.10
-
41
-
-
0027209916
-
Adenovirus E1A negatively and positively modulates transcription of AP-1 dependent genes by dimer-specific regulation of the DNA binding and transactivation activities of Jun
-
Hagmeyer B.M., Konig H., Herr I., Offringa R., Zantema A., van der Eb A., Herrlich P., Angel P. Adenovirus E1A negatively and positively modulates transcription of AP-1 dependent genes by dimer-specific regulation of the DNA binding and transactivation activities of Jun. EMBO J. 12:1993;3559-3572.
-
(1993)
EMBO J.
, vol.12
, pp. 3559-3572
-
-
Hagmeyer, B.M.1
Konig, H.2
Herr, I.3
Offringa, R.4
Zantema, A.5
Van Der Eb, A.6
Herrlich, P.7
Angel, P.8
-
42
-
-
0033120590
-
Differential expression and activation of p38 mitogen-activated protein kinase alpha, beta, gamma, and delta in inflammatory cell lineages
-
Hale K.K., Trollinger D., Rihanek M., Manthey C.L. Differential expression and activation of p38 mitogen-activated protein kinase alpha, beta, gamma, and delta in inflammatory cell lineages. J. Immunol. 162:1999;4246-4352.
-
(1999)
J. Immunol.
, vol.162
, pp. 4246-4352
-
-
Hale, K.K.1
Trollinger, D.2
Rihanek, M.3
Manthey, C.L.4
-
43
-
-
0025828480
-
Interactive effects of the tumor necrosis factor promoter and 3′-untranslated regions
-
Han J., Huenz G., Beutler B. Interactive effects of the tumor necrosis factor promoter and 3′-untranslated regions. J. Immunol. 146:1991;1843-1848.
-
(1991)
J. Immunol.
, vol.146
, pp. 1843-1848
-
-
Han, J.1
Huenz, G.2
Beutler, B.3
-
44
-
-
0027936755
-
A MAP kinase targeted by endotoxin in mammalian cells
-
Han J., Lee J.D., Jiang Y., Li Z., Feng L., Ulevitch R.J. A MAP kinase targeted by endotoxin in mammalian cells. Science. 265:1994;808-811.
-
(1994)
Science
, vol.265
, pp. 808-811
-
-
Han, J.1
Lee, J.D.2
Jiang, Y.3
Li, Z.4
Feng, L.5
Ulevitch, R.J.6
-
45
-
-
0030044182
-
Characterization of the structure and function of a novel MAP kinase kinase (MKK6)
-
Han J., Lee J.D., Jiang Y., Li Z., Feng L., Ulevitch R.J. Characterization of the structure and function of a novel MAP kinase kinase (MKK6). J. Biol. Chem. 271:1996;2886-2891.
-
(1996)
J. Biol. Chem.
, vol.271
, pp. 2886-2891
-
-
Han, J.1
Lee, J.D.2
Jiang, Y.3
Li, Z.4
Feng, L.5
Ulevitch, R.J.6
-
46
-
-
0030894683
-
Activation of the transcription factor MEF2C by the MAP kinase p38 in inflammation
-
Han J., Jiang Y., Li Z., Kravchenko V.V., Ulevitch R.J. Activation of the transcription factor MEF2C by the MAP kinase p38 in inflammation. Nature. 386:1997;296-299.
-
(1997)
Nature
, vol.386
, pp. 296-299
-
-
Han, J.1
Jiang, Y.2
Li, Z.3
Kravchenko, V.V.4
Ulevitch, R.J.5
-
47
-
-
0032495987
-
The role of p38 MAP kinase in TGF-beta-induced signal transduction in human neutrophils
-
Hannigan M., Zhan L., Ai Y., Huang C.K. The role of p38 MAP kinase in TGF-beta-induced signal transduction in human neutrophils. Biochem. Biophys. Res. Commun. 246:1998;55-58.
-
(1998)
Biochem. Biophys. Res. Commun.
, vol.246
, pp. 55-58
-
-
Hannigan, M.1
Zhan, L.2
Ai, Y.3
Huang, C.K.4
-
48
-
-
0033617341
-
Stress-activated protein kinase-3 interacts with the PDZ domain of alpha1-syntrophin. A mechanism for specific substrate recognition
-
Hasegawa M., Cuenda A., Spillantini M.G., Thomas G.M., Buee-Scherrer V., Cohen P., Goedert M. Stress-activated protein kinase-3 interacts with the PDZ domain of alpha1-syntrophin. A mechanism for specific substrate recognition. J. Biol. Chem. 274:1999;12626-12631.
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 12626-12631
-
-
Hasegawa, M.1
Cuenda, A.2
Spillantini, M.G.3
Thomas, G.M.4
Buee-Scherrer, V.5
Cohen, P.6
Goedert, M.7
-
49
-
-
0032973284
-
Hyperosmolarity-induced interleukin-8 expression in human bronchial epithelial cells through p38 mitogen-activated protein kinase
-
Hashimoto S., Matsumoto K., Gon Y., Nakayama T., Takeshita I., Horie T. Hyperosmolarity-induced interleukin-8 expression in human bronchial epithelial cells through p38 mitogen-activated protein kinase. Am. J. Respir. Crit. Care Med. 159:1999;634-640.
-
(1999)
Am. J. Respir. Crit. Care Med.
, vol.159
, pp. 634-640
-
-
Hashimoto, S.1
Matsumoto, K.2
Gon, Y.3
Nakayama, T.4
Takeshita, I.5
Horie, T.6
-
50
-
-
0033529034
-
Protein modification: Docking sites for kinases
-
Holland P.M., Cooper J.A. Protein modification: docking sites for kinases. Curr. Biol. 9:1999;329-331.
-
(1999)
Curr. Biol.
, vol.9
, pp. 329-331
-
-
Holland, P.M.1
Cooper, J.A.2
-
51
-
-
0031015362
-
LSP1 is the major substrate for mitogen-activated protein kinase-activated protein kinase 2 in human neutrophils
-
Huang C.K., Zhan L., Ai Y., Jongstra J. LSP1 is the major substrate for mitogen-activated protein kinase-activated protein kinase 2 in human neutrophils. J. Biol. Chem. 272:1997;17-19.
-
(1997)
J. Biol. Chem.
, vol.272
, pp. 17-19
-
-
Huang, C.K.1
Zhan, L.2
Ai, Y.3
Jongstra, J.4
-
52
-
-
0030812347
-
Apoptosis signaling pathway in T cells is composed of ICE/Ced-3 family proteases and MAP kinase kinase 6b
-
Huang S., Jiang Y., Li Z., Nishida E., Mathias P., Lin S., Ulevitch R.J., Nenerow G.R., Han J. Apoptosis signaling pathway in T cells is composed of ICE/Ced-3 family proteases and MAP kinase kinase 6b. Immunity. 6:1997;739-749.
-
(1997)
Immunity
, vol.6
, pp. 739-749
-
-
Huang, S.1
Jiang, Y.2
Li, Z.3
Nishida, E.4
Mathias, P.5
Lin, S.6
Ulevitch, R.J.7
Nenerow, G.R.8
Han, J.9
-
53
-
-
14444281569
-
Induction of apoptosis by ASK1, a mammalian MAPKKK that activates SAPK/JNK and p38 signaling pathways
-
Ichijo H., Nishida E., Irie K., Ten Dijke P., Saitoh M., Moriguchi T., Takagi M., Matsumoto K., Miyazono K., Gotoh Y. Induction of apoptosis by ASK1, a mammalian MAPKKK that activates SAPK/JNK and p38 signaling pathways. Science. 275:1997;90-94.
-
(1997)
Science
, vol.275
, pp. 90-94
-
-
Ichijo, H.1
Nishida, E.2
Irie, K.3
Ten Dijke, P.4
Saitoh, M.5
Moriguchi, T.6
Takagi, M.7
Matsumoto, K.8
Miyazono, K.9
Gotoh, Y.10
-
54
-
-
0031934170
-
Pharmacological effects of SB 220025, a selective inhibitor of p38 mitogen-activated protein kinase, in angiogenesis and chronic inflammatory disease models
-
Jackson J.R., Bolognese B., Hillegass L., Kassis S., Adams J., Griswold D.E., Winkler J.D. Pharmacological effects of SB 220025, a selective inhibitor of p38 mitogen-activated protein kinase, in angiogenesis and chronic inflammatory disease models. J. Pharmacol. Exp. Ther. 284:1998;687-692.
-
(1998)
J. Pharmacol. Exp. Ther.
, vol.284
, pp. 687-692
-
-
Jackson, J.R.1
Bolognese, B.2
Hillegass, L.3
Kassis, S.4
Adams, J.5
Griswold, D.E.6
Winkler, J.D.7
-
55
-
-
0029991520
-
Regulation of the c-fos promoter by the ternary complex factor Sap-1a and its coactivator CBP
-
Janknecht R., Nordheim A. Regulation of the c-fos promoter by the ternary complex factor Sap-1a and its coactivator CBP. Oncogene. 12:1996;1961-1969.
-
(1996)
Oncogene
, vol.12
, pp. 1961-1969
-
-
Janknecht, R.1
Nordheim, A.2
-
56
-
-
0030597282
-
MAP kinase-dependent transcriptional coactivation by Elk-1 and its cofactor CBP
-
Janknecht R., Nordheim A. MAP kinase-dependent transcriptional coactivation by Elk-1 and its cofactor CBP. Biochem. Biophys. Res. Commun. 228:1996;831-837.
-
(1996)
Biochem. Biophys. Res. Commun.
, vol.228
, pp. 831-837
-
-
Janknecht, R.1
Nordheim, A.2
-
57
-
-
0030901584
-
Convergence of MAP kinase pathways on the ternary complex factor Sap-1a
-
Janknecht R., Hunter T. Convergence of MAP kinase pathways on the ternary complex factor Sap-1a. EMBO J. 16:1997;1620-1627.
-
(1997)
EMBO J.
, vol.16
, pp. 1620-1627
-
-
Janknecht, R.1
Hunter, T.2
-
58
-
-
0029982565
-
Characterization of the structure and function of a new mitogen-activated protein kinase (p38beta)
-
Jiang Y., Chen C., Li Z., Guo W., Gegner J.A., Lin S., Han J. Characterization of the structure and function of a new mitogen-activated protein kinase (p38beta). J. Biol. Chem. 271:1996;17920-17926.
-
(1996)
J. Biol. Chem.
, vol.271
, pp. 17920-17926
-
-
Jiang, Y.1
Chen, C.2
Li, Z.3
Guo, W.4
Gegner, J.A.5
Lin, S.6
Han, J.7
-
59
-
-
0030828701
-
Characterization of the structure and function of the fourth member of p38 group mitogen-activated protein kinases, p38delta
-
Jiang Y., Gram H., Zhao M., New L., Gu J., Feng L., Di Padova F., Ulevitch R.J., Han J. Characterization of the structure and function of the fourth member of p38 group mitogen-activated protein kinases, p38delta. J. Biol. Chem. 272:1997;30122-30128.
-
(1997)
J. Biol. Chem.
, vol.272
, pp. 30122-30128
-
-
Jiang, Y.1
Gram, H.2
Zhao, M.3
New, L.4
Gu, J.5
Feng, L.6
Di Padova, F.7
Ulevitch, R.J.8
Han, J.9
-
60
-
-
0030694387
-
BMK1/ERK5 regulates serum-induced early gene expression through transcription factor MEF2C
-
Kato Y., Kravchenko V.V., Tapping R.I., Han J., Ulevitch R.J., Lee J.D. BMK1/ERK5 regulates serum-induced early gene expression through transcription factor MEF2C. EMBO J. 16:1997;7054-7066.
-
(1997)
EMBO J.
, vol.16
, pp. 7054-7066
-
-
Kato, Y.1
Kravchenko, V.V.2
Tapping, R.I.3
Han, J.4
Ulevitch, R.J.5
Lee, J.D.6
-
61
-
-
0033103805
-
Impaired on/off regulation of TNF biosynthesis in mice lacking TNF AU-rich elements: Implications for joint and gut-associated immunopathologies
-
Kontoyiannis D., Pasparakis M., Pizarro T.T., Cominelli F., Kollias G. Impaired on/off regulation of TNF biosynthesis in mice lacking TNF AU-rich elements: implications for joint and gut-associated immunopathologies. Immunity. 10:1999;387-398.
-
(1999)
Immunity
, vol.10
, pp. 387-398
-
-
Kontoyiannis, D.1
Pasparakis, M.2
Pizarro, T.T.3
Cominelli, F.4
Kollias, G.5
-
62
-
-
0033145354
-
MAPKAP kinase 2 is essential for LPS-induced TNF-α biosynthesis
-
Kotyarov A., Neininger A., Schubert C., Eckert R., Birchmeler C., Volk H.-D., Gaestel M. MAPKAP kinase 2 is essential for LPS-induced TNF-α biosynthesis. Nat. Cell Biol. 1:1999;94-99.
-
(1999)
Nat. Cell Biol.
, vol.1
, pp. 94-99
-
-
Kotyarov, A.1
Neininger, A.2
Schubert, C.3
Eckert, R.4
Birchmeler, C.5
Volk, H.-D.6
Gaestel, M.7
-
64
-
-
0032577491
-
Hyperosmolality causes growth arrest of murine kidney cells. Induction of GADD45 and GADD153 by osmosensing via stress-activated protein kinase 2
-
Kultz D., Madhany S., Burg M.B. Hyperosmolality causes growth arrest of murine kidney cells. Induction of GADD45 and GADD153 by osmosensing via stress-activated protein kinase 2. J. Biol. Chem. 273:1998;13645-13651.
-
(1998)
J. Biol. Chem.
, vol.273
, pp. 13645-13651
-
-
Kultz, D.1
Madhany, S.2
Burg, M.B.3
-
65
-
-
0031587929
-
Novel homologues of CSBP/p38 MAP kinase: Activation, substrate specificity and sensitivity to inhibition by pyridinyl imidazoles
-
Kumar S., McDonnell P.C., Gum R.J., Hand A.T., Lee J.C., Young P.R. Novel homologues of CSBP/p38 MAP kinase: activation, substrate specificity and sensitivity to inhibition by pyridinyl imidazoles. Biochem. Biophys. Res. Commun. 235:1997;533-538.
-
(1997)
Biochem. Biophys. Res. Commun.
, vol.235
, pp. 533-538
-
-
Kumar, S.1
McDonnell, P.C.2
Gum, R.J.3
Hand, A.T.4
Lee, J.C.5
Young, P.R.6
-
66
-
-
0033527443
-
Pyridinylimidazole compound SB 203580 inhibits the activity but not the activation of p38 mitogen-activated protein kinase
-
Kumar S., Jiang M.S., Adams J.L., Lee J.C. Pyridinylimidazole compound SB 203580 inhibits the activity but not the activation of p38 mitogen-activated protein kinase. Biochem. Biophys. Res. Commun. 263:1999;825-831.
-
(1999)
Biochem. Biophys. Res. Commun.
, vol.263
, pp. 825-831
-
-
Kumar, S.1
Jiang, M.S.2
Adams, J.L.3
Lee, J.C.4
-
67
-
-
0029365005
-
Modulation of actin dynamics during stress and physiological stimulation by a signaling pathway involving p38 MAP kinase and heat-shock protein 27
-
Landry J., Huot J. Modulation of actin dynamics during stress and physiological stimulation by a signaling pathway involving p38 MAP kinase and heat-shock protein 27. Biochem. Cell Biol. 73:1995;703-707.
-
(1995)
Biochem. Cell Biol.
, vol.73
, pp. 703-707
-
-
Landry, J.1
Huot, J.2
-
68
-
-
0029664650
-
Role of CSB/p38/RK stress response kinase in LPS and cytokine signaling mechanisms
-
Lee J.C., Young P.R. Role of CSB/p38/RK stress response kinase in LPS and cytokine signaling mechanisms. J. Leukocyte Biol. 59:1996;152-157.
-
(1996)
J. Leukocyte Biol.
, vol.59
, pp. 152-157
-
-
Lee, J.C.1
Young, P.R.2
-
69
-
-
0027761036
-
Bicyclic imidazoles as a novel class of cytokine biosynthesis inhibitors
-
Lee J.C., Badger A.M., Griswold D.E., Dunnington D., Truneh A., Votta B., White J.R., Young P.R., Bender P.E. Bicyclic imidazoles as a novel class of cytokine biosynthesis inhibitors. Ann. N. Y. Acad. Sci. 696:1993;149-170.
-
(1993)
Ann. N. Y. Acad. Sci.
, vol.696
, pp. 149-170
-
-
Lee, J.C.1
Badger, A.M.2
Griswold, D.E.3
Dunnington, D.4
Truneh, A.5
Votta, B.6
White, J.R.7
Young, P.R.8
Bender, P.E.9
-
70
-
-
0023740078
-
Inhibition of monocyte IL-1 production by the anti-inflammatory compound SK&F 86002
-
Lee J.C., Griswold D.E., Votta B., Hanna N. Inhibition of monocyte IL-1 production by the anti-inflammatory compound SK&F 86002. Int. J. Immunopharmacol. 10:1988;835-843.
-
(1988)
Int. J. Immunopharmacol.
, vol.10
, pp. 835-843
-
-
Lee, J.C.1
Griswold, D.E.2
Votta, B.3
Hanna, N.4
-
71
-
-
0033030207
-
P38 mitogen-activated protein kinase inhibitors - mechanisms and therapeutic potentials
-
Lee J.C., Kassis S., Kumar S., Badger A., Adams J.L. p38 mitogen-activated protein kinase inhibitors - mechanisms and therapeutic potentials. Pharmacol. Ther. 82:1999;389-397.
-
(1999)
Pharmacol. Ther.
, vol.82
, pp. 389-397
-
-
Lee, J.C.1
Kassis, S.2
Kumar, S.3
Badger, A.4
Adams, J.L.5
-
72
-
-
0028605318
-
A protein kinase involved in the regulation of inflammatory cytokine biosynthesis
-
Lee J.C., Laydon J.T., McDonnell P.C., Gallagher T.F., Kumar S., Green D., McNulty D., Blumenthal M.J., Heys J.R., Landvatter S.W., Strickler J.E., McLaughlin M.M., Siemens I.R., Fisher S.M., Livi G.P., White J.R., Adams J.L., Young P.R. A protein kinase involved in the regulation of inflammatory cytokine biosynthesis. Nature. 372:1994;739-746.
-
(1994)
Nature
, vol.372
, pp. 739-746
-
-
Lee, J.C.1
Laydon, J.T.2
McDonnell, P.C.3
Gallagher, T.F.4
Kumar, S.5
Green, D.6
McNulty, D.7
Blumenthal, M.J.8
Heys, J.R.9
Landvatter, S.W.10
Strickler, J.E.11
McLaughlin, M.M.12
Siemens, I.R.13
Fisher, S.M.14
Livi, G.P.15
White, J.R.16
Adams, J.L.17
Young, P.R.18
-
73
-
-
0030581626
-
The primary structure of p38 gamma: A new member of p38 group of MAP kinases
-
Li Z., Jiang Y., Ulevitch R.J., Han J. The primary structure of p38 gamma: a new member of p38 group of MAP kinases. Biochem. Biophys. Res. Commun. 228:1996;334-340.
-
(1996)
Biochem. Biophys. Res. Commun.
, vol.228
, pp. 334-340
-
-
Li, Z.1
Jiang, Y.2
Ulevitch, R.J.3
Han, J.4
-
74
-
-
0032564311
-
Molecular basis for p38 kinase inhibitor specificity
-
Lisnock J.M., Tebben A., Frantz B., O'Neill E.A., Croft G., O'Keffe S.J., Li B., Hacker C., de Laszlo S., Smith A., Libby B., Liverton N., Hermes J., LoGrasso P. Molecular basis for p38 kinase inhibitor specificity. Biochemistry. 37:1998;16573-16581.
-
(1998)
Biochemistry
, vol.37
, pp. 16573-16581
-
-
Lisnock, J.M.1
Tebben, A.2
Frantz, B.3
O'Neill, E.A.4
Croft, G.5
O'Keffe, S.J.6
Li, B.7
Hacker, C.8
De Laszlo, S.9
Smith, A.10
Libby, B.11
Liverton, N.12
Hermes, J.13
Lograsso, P.14
-
75
-
-
0030868682
-
Kinetic mechanism for p38 MAP kinase
-
LoGrasso P.V., Frantz B., Rolando A.M., O'Keefe S.J., Hermes J.D., O'Neill E.A. Kinetic mechanism for p38 MAP kinase. Biochemistry. 36:1997;10422-10427.
-
(1997)
Biochemistry
, vol.36
, pp. 10422-10427
-
-
Lograsso, P.V.1
Frantz, B.2
Rolando, A.M.3
O'Keefe, S.J.4
Hermes, J.D.5
O'Neill, E.A.6
-
76
-
-
0033118982
-
Defective IL-12 production in mitogen-activated protein (MAP) kinase kinase 3 (Mkk3)-deficient mice
-
Lu H.T., Yang D.D., Wysk M., Gatti E., Mellman I., Davis R.J., Flavell R.A. Defective IL-12 production in mitogen-activated protein (MAP) kinase kinase 3 (Mkk3)-deficient mice. EMBO J. 18:1999;1845-1857.
-
(1999)
EMBO J.
, vol.18
, pp. 1845-1857
-
-
Lu, H.T.1
Yang, D.D.2
Wysk, M.3
Gatti, E.4
Mellman, I.5
Davis, R.J.6
Flavell, R.A.7
-
77
-
-
0027930046
-
Pathophysiology of cor pulmonale in chronic obstructive pulmonary disease, state-of-the-art: Parts 1 and 2
-
and 1158-1168
-
MacNee, W., 1994. Pathophysiology of cor pulmonale in chronic obstructive pulmonary disease, state-of-the-art: Parts 1 and 2. Am. J. Respir. Crit. Care Med. 150, 833-852 and 1158-1168.
-
(1994)
Am. J. Respir. Crit. Care Med.
, vol.150
, pp. 833-852
-
-
MacNee, W.1
-
78
-
-
0032400931
-
Inhibitors of the p38 mitogen-activated kinase modulate IL-4 induction of low affinity IgE receptor (CD23) in human monocytes
-
Marshall L.A., Hansbury M.J., Bolognese B.J., Gum R.J., Young P.R., Mayer R.J. Inhibitors of the p38 mitogen-activated kinase modulate IL-4 induction of low affinity IgE receptor (CD23) in human monocytes. J. Immunol. 161:1998;6005-6013.
-
(1998)
J. Immunol.
, vol.161
, pp. 6005-6013
-
-
Marshall, L.A.1
Hansbury, M.J.2
Bolognese, B.J.3
Gum, R.J.4
Young, P.R.5
Mayer, R.J.6
-
79
-
-
0032570051
-
Rapid and long-lasting suppression of the ATF-2 transcription factor is a common response to neuronal injury
-
Martin-Villalba A., Winter C., Brecht S., Buschmann T., Zimmermann M., Herdegen T. Rapid and long-lasting suppression of the ATF-2 transcription factor is a common response to neuronal injury. Brain Res. Mol. Brain Res. 62:1998;158-166.
-
(1998)
Brain Res. Mol. Brain Res.
, vol.62
, pp. 158-166
-
-
Martin-Villalba, A.1
Winter, C.2
Brecht, S.3
Buschmann, T.4
Zimmermann, M.5
Herdegen, T.6
-
80
-
-
0032524919
-
T lymphocyte activation signals for interleukin-2 production involve activation of MKK6-p38 and MKK7-SAPK/JNK signaling pathways sensitive to cyclosporin A
-
Matsuda S., Moriguchi T., Koyasu S., Nishida E. T lymphocyte activation signals for interleukin-2 production involve activation of MKK6-p38 and MKK7-SAPK/JNK signaling pathways sensitive to cyclosporin A. J. Biol. Chem. 273:1998;12378-12382.
-
(1998)
J. Biol. Chem.
, vol.273
, pp. 12378-12382
-
-
Matsuda, S.1
Moriguchi, T.2
Koyasu, S.3
Nishida, E.4
-
81
-
-
0031815078
-
Proinflammatory cytokine-induced and chemical mediator-induced IL-8 expression in human bronchial epithelial cells through p38 mitogen-activated protein kinase-dependent pathway
-
Matsumoto K., Hashimoto S., Gon Y., Nakayama T., Horie T. Proinflammatory cytokine-induced and chemical mediator-induced IL-8 expression in human bronchial epithelial cells through p38 mitogen-activated protein kinase-dependent pathway. J. Allergy Clin. Immunol. 101:1998;825-831.
-
(1998)
J. Allergy Clin. Immunol.
, vol.101
, pp. 825-831
-
-
Matsumoto, K.1
Hashimoto, S.2
Gon, Y.3
Nakayama, T.4
Horie, T.5
-
82
-
-
0029097750
-
Localization of the human stress responsive MAP kinase-like CSAIDs binding protein (CSBP) gene to chromosome 6q21.3/21.2
-
McDonnell P.C., DiLella A.G., Lee J.C., Young P.R. Localization of the human stress responsive MAP kinase-like CSAIDs binding protein (CSBP) gene to chromosome 6q21.3/21.2. Genomics. 29:1995;301-302.
-
(1995)
Genomics
, vol.29
, pp. 301-302
-
-
McDonnell, P.C.1
Dilella, A.G.2
Lee, J.C.3
Young, P.R.4
-
83
-
-
0029923193
-
Identification of mitogen-activated protein (MAP) kinase-activated protein kinase-3, a novel substrate of CSBP p38 MAP kinase
-
McLaughlin M.M., Kumar S., McDonnell P.C., Van Horn S., Lee J.C., Livi G.P., Young P.R. Identification of mitogen-activated protein (MAP) kinase-activated protein kinase-3, a novel substrate of CSBP p38 MAP kinase. J. Biol. Chem. 271:1996;8488-8492.
-
(1996)
J. Biol. Chem.
, vol.271
, pp. 8488-8492
-
-
McLaughlin, M.M.1
Kumar, S.2
McDonnell, P.C.3
Van Horn, S.4
Lee, J.C.5
Livi, G.P.6
Young, P.R.7
-
84
-
-
0029913458
-
SAP kinase-3, a new member of the family of mammalian stress-activated protein kinases
-
Mertens S., Craxton M., Goedert M. SAP kinase-3, a new member of the family of mammalian stress-activated protein kinases. FEBS Lett. 383:1996;273-276.
-
(1996)
FEBS Lett.
, vol.383
, pp. 273-276
-
-
Mertens, S.1
Craxton, M.2
Goedert, M.3
-
85
-
-
0030656997
-
Signalling through either the p38 or ERK mitogen-activated protein (MAP) kinase pathway is obligatory for phorbol ester and T cell receptor complex (TCR-CD3)-stimulated for phorbol ester and T cell receptor complex (TCR-CD3)-stimulated phosphorylation of initiation factor (eIF) 4E in Jurkat T cells
-
Morley S.J. Signalling through either the p38 or ERK mitogen-activated protein (MAP) kinase pathway is obligatory for phorbol ester and T cell receptor complex (TCR-CD3)-stimulated for phorbol ester and T cell receptor complex (TCR-CD3)-stimulated phosphorylation of initiation factor (eIF) 4E in Jurkat T cells. FEBS Lett. 418:1997;327-332.
-
(1997)
FEBS Lett.
, vol.418
, pp. 327-332
-
-
Morley, S.J.1
-
86
-
-
0030760725
-
Involvement of stress-activated protein kinase and p38/RK mitogen-activated protein kinase signaling pathways in the enhanced phosphorylation of initiation factor 4E in NIH 3T3 cells
-
Morley S.J., McKendrick L. Involvement of stress-activated protein kinase and p38/RK mitogen-activated protein kinase signaling pathways in the enhanced phosphorylation of initiation factor 4E in NIH 3T3 cells. J. Biol. Chem. 272:1997;17887-17893.
-
(1997)
J. Biol. Chem.
, vol.272
, pp. 17887-17893
-
-
Morley, S.J.1
McKendrick, L.2
-
87
-
-
0032526694
-
PRAK, a novel protein kinase regulated by the p38 MAP kinase
-
New L., Jiang Y., Zhao M., Liu K., Zhu W., Flood L.J., Kato Y., Parry G.C., Han J. PRAK, a novel protein kinase regulated by the p38 MAP kinase. EMBO J. 17:1998;3372-3384.
-
(1998)
EMBO J.
, vol.17
, pp. 3372-3384
-
-
New, L.1
Jiang, Y.2
Zhao, M.3
Liu, K.4
Zhu, W.5
Flood, L.J.6
Kato, Y.7
Parry, G.C.8
Han, J.9
-
88
-
-
0032512546
-
MAPKAPK5, a novel mitogen-activated protein kinase (MAPK)-activated protein kinase, is a substrate of the extracellular-regulated kinase (ERK) and p38 kinase
-
Ni H., Wang X.S., Diener K., Yao Z. MAPKAPK5, a novel mitogen-activated protein kinase (MAPK)-activated protein kinase, is a substrate of the extracellular-regulated kinase (ERK) and p38 kinase. Biochem. Biophys. Res. Commun. 243:1998;92-96.
-
(1998)
Biochem. Biophys. Res. Commun.
, vol.243
, pp. 92-96
-
-
Ni, H.1
Wang, X.S.2
Diener, K.3
Yao, Z.4
-
89
-
-
0029967151
-
Activation of a p38 mitogen-activated protein kinase in human neutrophils by lipopolysaccharide
-
Nick J.A., Avdi N.J., Gerwins P., Johnson G.L., Worthen G.S. Activation of a p38 mitogen-activated protein kinase in human neutrophils by lipopolysaccharide. J. Immunol. 156:1996;4867-4875.
-
(1996)
J. Immunol.
, vol.156
, pp. 4867-4875
-
-
Nick, J.A.1
Avdi, N.J.2
Gerwins, P.3
Johnson, G.L.4
Worthen, G.S.5
-
90
-
-
0033537965
-
Activation of p38 mitogen-activated protein kinase by PYK2/related adhesion focal tyrosine kinase-dependent mechanism
-
Pandey P., Avraham S., Kumar S., Nakazawa A., Place A., Ghanem L., Rana A., Kumar V., Majumder P.K., Avraham H., Davis R.J., Kharbanda S. Activation of p38 mitogen-activated protein kinase by PYK2/related adhesion focal tyrosine kinase-dependent mechanism. J. Biol. Chem. 274:1999;10140-10144.
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 10140-10144
-
-
Pandey, P.1
Avraham, S.2
Kumar, S.3
Nakazawa, A.4
Place, A.5
Ghanem, L.6
Rana, A.7
Kumar, V.8
Majumder, P.K.9
Avraham, H.10
Davis, R.J.11
Kharbanda, S.12
-
91
-
-
0032575568
-
Identification of stathmin as a novel substrate for p38δ
-
Parker C.G., Hunt J., Diener K., Mcginley M., Soriano B., Kessler G.A., Bray J., Yao Z.B., Wang X.S., Kohno T., Lichenstein H.S. Identification of stathmin as a novel substrate for p38δ Biochem. Biophys. Res. Commun. 249:1998;791-796.
-
(1998)
Biochem. Biophys. Res. Commun.
, vol.249
, pp. 791-796
-
-
Parker, C.G.1
Hunt, J.2
Diener, K.3
McGinley, M.4
Soriano, B.5
Kessler, G.A.6
Bray, J.7
Yao, Z.B.8
Wang, X.S.9
Kohno, T.10
Lichenstein, H.S.11
-
92
-
-
0032491440
-
RSK-B, a novel ribosomal S6 kinase family member, is a CREB kinase under dominant control of p38alpha mitogen-activated protein kinase (p38alphaMAPK)
-
Pierrat B., Correia J.S., Mary J.L., Tomas-Zuber M., Lesslauer W. RSK-B, a novel ribosomal S6 kinase family member, is a CREB kinase under dominant control of p38alpha mitogen-activated protein kinase (p38alphaMAPK). J. Biol. Chem. 273:1998;29661-29671.
-
(1998)
J. Biol. Chem.
, vol.273
, pp. 29661-29671
-
-
Pierrat, B.1
Correia, J.S.2
Mary, J.L.3
Tomas-Zuber, M.4
Lesslauer, W.5
-
93
-
-
0026656362
-
Kinetic model of the epidermal growth factor (EGF) receptor tyrosine kinase and a possible mechanism of its activation by EGF
-
Posner I., Engel M., Levitzki Kinetic model of the epidermal growth factor (EGF) receptor tyrosine kinase and a possible mechanism of its activation by EGF. J. Biol. Chem. 267:1992;20638-20647.
-
(1992)
J. Biol. Chem.
, vol.267
, pp. 20638-20647
-
-
Posner, I.1
Engel, M.2
Levitzki3
-
94
-
-
0039171658
-
Analysis of the role of Hsp25 phosphorylation reveals the importance of the oligomerization state of this small heat shock protein in its protective function against TNFalpha- And hydrogen peroxide-induced cell death
-
Preville X., Schultz H., Knauf U., Gaestel M., Arrigo A.P. Analysis of the role of Hsp25 phosphorylation reveals the importance of the oligomerization state of this small heat shock protein in its protective function against TNFalpha- and hydrogen peroxide-induced cell death. J. Cell. Biochem. 69:1998;436-452.
-
(1998)
J. Cell. Biochem.
, vol.69
, pp. 436-452
-
-
Preville, X.1
Schultz, H.2
Knauf, U.3
Gaestel, M.4
Arrigo, A.P.5
-
95
-
-
0031715855
-
Phosphorylation is not essential for protection of L929 cells by Hsp25 against H2O2-mediated disruption actin cytoskeleton, a protection which appears related to the redox change mediated by Hsp25
-
Preville X., Gaestel M., Arrigo A.P. Phosphorylation is not essential for protection of L929 cells by Hsp25 against H2O2-mediated disruption actin cytoskeleton, a protection which appears related to the redox change mediated by Hsp25. Cell Stress Chaperones. 3:1998;177-187.
-
(1998)
Cell Stress Chaperones
, vol.3
, pp. 177-187
-
-
Preville, X.1
Gaestel, M.2
Arrigo, A.P.3
-
96
-
-
0029827366
-
The p38 and ERK MAP kinase pathways cooperate to activate ternary complex factors and c-fos transcription in response to UV light
-
Price M.A., Cruzalegui F.H., Treisman R. The p38 and ERK MAP kinase pathways cooperate to activate ternary complex factors and c-fos transcription in response to UV light. EMBO J. 15:1996;6552-6563.
-
(1996)
EMBO J.
, vol.15
, pp. 6552-6563
-
-
Price, M.A.1
Cruzalegui, F.H.2
Treisman, R.3
-
97
-
-
0028935270
-
Pro-inflammatory cytokines and environmental stress cause p38 mitogen-activated protein kinase activation by dual phosphorylation on tyrosine and threonine
-
Raingeaud J., Gupta S., Rogers J.S., Dickens M., Han J., Ulevitch R.J., Davis R.J. Pro-inflammatory cytokines and environmental stress cause p38 mitogen-activated protein kinase activation by dual phosphorylation on tyrosine and threonine. J. Biol. Chem. 270:1995;7420-7426.
-
(1995)
J. Biol. Chem.
, vol.270
, pp. 7420-7426
-
-
Raingeaud, J.1
Gupta, S.2
Rogers, J.S.3
Dickens, M.4
Han, J.5
Ulevitch, R.J.6
Davis, R.J.7
-
98
-
-
0030051528
-
MKK3- And MKK6-regulated gene expression is mediated by the p38 mitogen-activated protein kinase signal transduction pathway
-
Raingeaud J., Whitmarsh A.J., Barrett T., Derijard B., Davis R.J. MKK3- and MKK6-regulated gene expression is mediated by the p38 mitogen-activated protein kinase signal transduction pathway. Mol. Cell Biol. 16:1996;1247-1255.
-
(1996)
Mol. Cell Biol.
, vol.16
, pp. 1247-1255
-
-
Raingeaud, J.1
Whitmarsh, A.J.2
Barrett, T.3
Derijard, B.4
Davis, R.J.5
-
99
-
-
0032525233
-
Interferon-gamma expression by Th1 effector T cells mediated by the p38 MAP kinase signaling pathway
-
Rincon M., Enslen H., Raingeaud J., Recht M., Zapton T., Su M.S., Penix L.A., Davis R.J., Flavell R.A. Interferon-gamma expression by Th1 effector T cells mediated by the p38 MAP kinase signaling pathway. EMBO J. 17:1998;2817-2829.
-
(1998)
EMBO J.
, vol.17
, pp. 2817-2829
-
-
Rincon, M.1
Enslen, H.2
Raingeaud, J.3
Recht, M.4
Zapton, T.5
Su, M.S.6
Penix, L.A.7
Davis, R.J.8
Flavell, R.A.9
-
100
-
-
0028022750
-
A novel kinase cascade triggered by stress and heat shock that stimulates MAPKAP kinase-2 and phosphorylation of the small heat shock proteins
-
Rouse J., Cohen P., Trigon S., Morange M., Alonso-Llamazares A., Zamanillo D., Hunt T., Nebreda A.R. A novel kinase cascade triggered by stress and heat shock that stimulates MAPKAP kinase-2 and phosphorylation of the small heat shock proteins. Cell. 78:1994;1027-1037.
-
(1994)
Cell
, vol.78
, pp. 1027-1037
-
-
Rouse, J.1
Cohen, P.2
Trigon, S.3
Morange, M.4
Alonso-Llamazares, A.5
Zamanillo, D.6
Hunt, T.7
Nebreda, A.R.8
-
101
-
-
0032862832
-
Inhibitors of p38 MAP kinase: Therapeutic intervention in cytokine-mediated diseases
-
Salituro F.G., Germann U.A., Wilson K.P., Bemis G.W., Fox T., Su M.S. Inhibitors of p38 MAP kinase: therapeutic intervention in cytokine-mediated diseases. Curr. Med. Chem. 6:1999;807-823.
-
(1999)
Curr. Med. Chem.
, vol.6
, pp. 807-823
-
-
Salituro, F.G.1
Germann, U.A.2
Wilson, K.P.3
Bemis, G.W.4
Fox, T.5
Su, M.S.6
-
102
-
-
0033120111
-
Extracellular signal-regulated kinase, stress-activated protein kinase c-Jun N-terminal kinase, and p38(mapk) are involved in IL-10-mediated selective repression of TNF-alpha-induced activation and maturation of human peripheral blood monocyte-derived dendritic cells
-
Sato K., Nagayama H., Tadokoro K., Juji T., Takahashi T.A. Extracellular signal-regulated kinase, stress-activated protein kinase c-Jun N-terminal kinase, and p38(mapk) are involved in IL-10-mediated selective repression of TNF-alpha-induced activation and maturation of human peripheral blood monocyte-derived dendritic cells. J. Immunol. 162:1999;3865-3872.
-
(1999)
J. Immunol.
, vol.162
, pp. 3865-3872
-
-
Sato, K.1
Nagayama, H.2
Tadokoro, K.3
Juji, T.4
Takahashi, T.A.5
-
103
-
-
0031783189
-
Hypoxic stimulation of the stress-activated protein kinases in pulmonary artery fibroblasts
-
Scott P.H., Paul A., Belham C.M., Peacock A.J., Wadsworth R.M., Gould G.W., Welsh D., Plevin R. Hypoxic stimulation of the stress-activated protein kinases in pulmonary artery fibroblasts. Am. J. Respir. Crit. Care Med. 158:1998;958-962.
-
(1998)
Am. J. Respir. Crit. Care Med.
, vol.158
, pp. 958-962
-
-
Scott, P.H.1
Paul, A.2
Belham, C.M.3
Peacock, A.J.4
Wadsworth, R.M.5
Gould, G.W.6
Welsh, D.7
Plevin, R.8
-
104
-
-
0029992125
-
Intrathymic signals in thymocytes are mediated by p38 mitogen-activated protein kinase
-
Sen J., Kapeller R., Fragoso R., Sen R., Zon L.I., Burakoff S.J. Intrathymic signals in thymocytes are mediated by p38 mitogen-activated protein kinase. J. Immunol. 156:1996;4535-4538.
-
(1996)
J. Immunol.
, vol.156
, pp. 4535-4538
-
-
Sen, J.1
Kapeller, R.2
Fragoso, R.3
Sen, R.4
Zon, L.I.5
Burakoff, S.J.6
-
105
-
-
0023058975
-
A conserved AU sequence from the 3′ untranslated region of GM-CSF mRNA mediates selective mRNA degradation
-
Shaw G., Kamen R. A conserved AU sequence from the 3′ untranslated region of GM-CSF mRNA mediates selective mRNA degradation. Cell. 46:1986;659-667.
-
(1986)
Cell
, vol.46
, pp. 659-667
-
-
Shaw, G.1
Kamen, R.2
-
106
-
-
0029940355
-
TAB1: An activator of the TAK1 MAPKKK in TGF-β signal transduction
-
Shibuya H., Yamaguchi K., Shirakabe K., Tonegawa A., Gotoh Y., Ueno N., Irie K., Nishida E., Matsumoto K. TAB1: an activator of the TAK1 MAPKKK in TGF-β signal transduction. Science. 272:1996;1179-1182.
-
(1996)
Science
, vol.272
, pp. 1179-1182
-
-
Shibuya, H.1
Yamaguchi, K.2
Shirakabe, K.3
Tonegawa, A.4
Gotoh, Y.5
Ueno, N.6
Irie, K.7
Nishida, E.8
Matsumoto, K.9
-
107
-
-
9044220225
-
3pK, a new mitogen-activated protein kinase-activated protein kinase located in the small cell lung cancer tumor suppressor gene
-
Sithanandam G., Latif F., Duh F.M., Bernal R., Smola U., Li H., Kuzmin I., Wixler V., Geil L., Shrestha S. 3pK, a new mitogen-activated protein kinase-activated protein kinase located in the small cell lung cancer tumor suppressor gene. Mol. Cell Biol. 16:1996;868-876.
-
(1996)
Mol. Cell Biol.
, vol.16
, pp. 868-876
-
-
Sithanandam, G.1
Latif, F.2
Duh, F.M.3
Bernal, R.4
Smola, U.5
Li, H.6
Kuzmin, I.7
Wixler, V.8
Geil, L.9
Shrestha, S.10
-
108
-
-
0033613857
-
Identification of an extracellular signal-regulated kinase (ERK) docking site in ribosomal S6 kinase, a sequence critical for activation by ERK in vivo
-
Smith J.A., Poteet-Smith C.E., Malarkey K., Sturgill T.W. Identification of an extracellular signal-regulated kinase (ERK) docking site in ribosomal S6 kinase, a sequence critical for activation by ERK in vivo. J. Biol. Chem. 274:1999;2893-2898.
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 2893-2898
-
-
Smith, J.A.1
Poteet-Smith, C.E.2
Malarkey, K.3
Sturgill, T.W.4
-
109
-
-
0030805915
-
P38-2, a novel mitogen-activated protein kinase with distinct properties
-
Stein B., Yang M.X., Young D.B., Janknecht R., Hunter T., Murray B.W., Barbosa M.S. p38-2, a novel mitogen-activated protein kinase with distinct properties. J. Biol. Chem. 272:1997;19509-19517.
-
(1997)
J. Biol. Chem.
, vol.272
, pp. 19509-19517
-
-
Stein, B.1
Yang, M.X.2
Young, D.B.3
Janknecht, R.4
Hunter, T.5
Murray, B.W.6
Barbosa, M.S.7
-
110
-
-
0026457201
-
Identification of MAPKAP kinase 2 as a major enzyme responsible for the phosphorylation of the small mammalian heat shock proteins
-
Stokoe D., Engel K., Campbell D.G., Cohen P., Gaestel M. Identification of MAPKAP kinase 2 as a major enzyme responsible for the phosphorylation of the small mammalian heat shock proteins. FEBS Lett. 313:1992;307-313.
-
(1992)
FEBS Lett.
, vol.313
, pp. 307-313
-
-
Stokoe, D.1
Engel, K.2
Campbell, D.G.3
Cohen, P.4
Gaestel, M.5
-
111
-
-
0027508290
-
Phosphorylation and activation of human tyrosine hydroxylase in vitro by mitogen-activated protein (MAP) kinase and MAP-kinase-activated kinases 1 and 2
-
Sutherland C., Alterio J., Campbell D.G., Le Bourdelles B., Mallet J., Haavik J., Cohen P. Phosphorylation and activation of human tyrosine hydroxylase in vitro by mitogen-activated protein (MAP) kinase and MAP-kinase-activated kinases 1 and 2. Eur. J. Biochem. 217:1993;715-722.
-
(1993)
Eur. J. Biochem.
, vol.217
, pp. 715-722
-
-
Sutherland, C.1
Alterio, J.2
Campbell, D.G.3
Le Bourdelles, B.4
Mallet, J.5
Haavik, J.6
Cohen, P.7
-
112
-
-
0030851904
-
A human homolog of the yeast Ssk2/Ssk22 MAP kinase kinase kinases, MTK1, mediates stress-induced activation of the p38 and JNK pathways
-
Takekawa M., Posas F., Saito H. A human homolog of the yeast Ssk2/Ssk22 MAP kinase kinase kinases, MTK1, mediates stress-induced activation of the p38 and JNK pathways. EMBO J. 16:1997;4973-4982.
-
(1997)
EMBO J.
, vol.16
, pp. 4973-4982
-
-
Takekawa, M.1
Posas, F.2
Saito, H.3
-
113
-
-
0032514967
-
A family of stress-inducible GADD45-like proteins mediate activation of the stress-responsive MTK1/MEKK4 MAPKKK
-
Takekawa M., Saito H. A family of stress-inducible GADD45-like proteins mediate activation of the stress-responsive MTK1/MEKK4 MAPKKK. Cell. 95:1998;521-550.
-
(1998)
Cell
, vol.95
, pp. 521-550
-
-
Takekawa, M.1
Saito, H.2
-
114
-
-
0031828315
-
P38 mitogen-activated protein kinase inhibition attenuates intercellular adhesion molecule-1 up-regulation on human pulmonary microvascular endothelial cells
-
Tamura D.Y., Moore E.E., Johnson J.L., Zallen G., Aiboshi J., Silliman C.C. p38 mitogen-activated protein kinase inhibition attenuates intercellular adhesion molecule-1 up-regulation on human pulmonary microvascular endothelial cells. Surgery. 124:1998;403-407.
-
(1998)
Surgery
, vol.124
, pp. 403-407
-
-
Tamura, D.Y.1
Moore, E.E.2
Johnson, J.L.3
Zallen, G.4
Aiboshi, J.5
Silliman, C.C.6
-
115
-
-
0029790656
-
FGF and stress regulate CREB and ATF-1 via a pathway involving p38 MAP kinase and MAPKAP kinase-2
-
Tan Y., Rouse J., Zhang A., Cariati S., Cohen P., Comb M.J. FGF and stress regulate CREB and ATF-1 via a pathway involving p38 MAP kinase and MAPKAP kinase-2. EMBO J. 15:1996;4629-4642.
-
(1996)
EMBO J.
, vol.15
, pp. 4629-4642
-
-
Tan, Y.1
Rouse, J.2
Zhang, A.3
Cariati, S.4
Cohen, P.5
Comb, M.J.6
-
116
-
-
0032493662
-
P38 Mitogen-activated protein kinase mediates the transcriptional induction of the atrial natriuretic factor gene through a serum response element. A potential role for the transcription factor ATF6
-
Thuerauf D.J., Arnold N.D., Zechner D., Hanford D.S., DeMartin K.M., McDonough P.M., Prywes R., Glembotski C.C. p38 Mitogen-activated protein kinase mediates the transcriptional induction of the atrial natriuretic factor gene through a serum response element. A potential role for the transcription factor ATF6. J. Biol. Chem. 273:1998;20636-20643.
-
(1998)
J. Biol. Chem.
, vol.273
, pp. 20636-20643
-
-
Thuerauf, D.J.1
Arnold, N.D.2
Zechner, D.3
Hanford, D.S.4
Demartin, K.M.5
McDonough, P.M.6
Prywes, R.7
Glembotski, C.C.8
-
117
-
-
0030954172
-
A highly specific inhibitor of human p38 MAP kinase binds in the ATP pocket
-
Tong L., Pav S., White D.H., Rogers S., Crane K.M., Cywin C.L., Brown M.L., Pargellis C.A. A highly specific inhibitor of human p38 MAP kinase binds in the ATP pocket. Nat. Struct. Biol. 4:1997;311-316.
-
(1997)
Nat. Struct. Biol.
, vol.4
, pp. 311-316
-
-
Tong, L.1
Pav, S.2
White, D.H.3
Rogers, S.4
Crane, K.M.5
Cywin, C.L.6
Brown, M.L.7
Pargellis, C.A.8
-
118
-
-
0032926898
-
The MKK7 gene encodes a group of c-Jun NH2-terminal kinase kinases
-
Tournier C., Whitmarsh A.J., Cavanagh J., Barrett T., Davis R.J. The MKK7 gene encodes a group of c-Jun NH2-terminal kinase kinases. Mol. Cell Biol. 19:1999;1569-1581.
-
(1999)
Mol. Cell Biol.
, vol.19
, pp. 1569-1581
-
-
Tournier, C.1
Whitmarsh, A.J.2
Cavanagh, J.3
Barrett, T.4
Davis, R.J.5
-
119
-
-
0029030855
-
ATF-2 is preferentially activated by stress-activated protein kinases to mediate c-jun induction in response to genotoxic agents
-
van Dam H., Wilhelm D., Herr I., Steffen A., Herrlich P., Angel P. ATF-2 is preferentially activated by stress-activated protein kinases to mediate c-jun induction in response to genotoxic agents. EMBO J. 14:1995;1798-1811.
-
(1995)
EMBO J.
, vol.14
, pp. 1798-1811
-
-
Van Dam, H.1
Wilhelm, D.2
Herr, I.3
Steffen, A.4
Herrlich, P.5
Angel, P.6
-
120
-
-
0029938805
-
Stress-induced phosphorylation and activation of the transcription factor CHOP (GADD153) by p38 MAP
-
Wang X.Z., Ron D. Stress-induced phosphorylation and activation of the transcription factor CHOP (GADD153) by p38 MAP. Science. 272:1996;1347-1349.
-
(1996)
Science
, vol.272
, pp. 1347-1349
-
-
Wang, X.Z.1
Ron, D.2
-
121
-
-
0030756286
-
Molecular cloning and characterization of a novel p38 mitogen-activated protein kinase
-
Wang X.S., Diener K., Manthey C.L., Wang S., Rosenzweig B., Bray J., Delaney J., Cole C.N., Chan-Hui P.Y., Mantlo N., Lichenstein H.S., Zukowski M., Yao Z. Molecular cloning and characterization of a novel p38 mitogen-activated protein kinase. J. Biol. Chem. 272:1997;23668-23674.
-
(1997)
J. Biol. Chem.
, vol.272
, pp. 23668-23674
-
-
Wang, X.S.1
Diener, K.2
Manthey, C.L.3
Wang, S.4
Rosenzweig, B.5
Bray, J.6
Delaney, J.7
Cole, C.N.8
Chan-Hui, P.Y.9
Mantlo, N.10
Lichenstein, H.S.11
Zukowski, M.12
Yao, Z.13
-
122
-
-
0030911867
-
The structure of mitogen activated protein kinase p38 at 2.1 A resolution
-
Wang X.Z., Harkins P.C., Ulevitch R.J., Han J., Cobb M.H., Goldsmith E.J. The structure of mitogen activated protein kinase p38 at 2.1 A resolution. Proc. Natl. Acad. Sci. 94:1997;2327-2332.
-
(1997)
Proc. Natl. Acad. Sci.
, vol.94
, pp. 2327-2332
-
-
Wang, X.Z.1
Harkins, P.C.2
Ulevitch, R.J.3
Han, J.4
Cobb, M.H.5
Goldsmith, E.J.6
-
123
-
-
0032530336
-
Structural basis of inhibitor selectivity in MAP kinases
-
Wang Z.L., Canagarajah B.J., Boehm J.C., Kassis S., Cobb M.H., Young P.R., Abdel-Meguid S., Adams J.L., Goldsmith E.J. Structural basis of inhibitor selectivity in MAP kinases. Structure. 6:1998;1117-1128.
-
(1998)
Structure
, vol.6
, pp. 1117-1128
-
-
Wang, Z.L.1
Canagarajah, B.J.2
Boehm, J.C.3
Kassis, S.4
Cobb, M.H.5
Young, P.R.6
Abdel-Meguid, S.7
Adams, J.L.8
Goldsmith, E.J.9
-
124
-
-
0032540244
-
The phosphorylation of eukaryotic initiation factor eIF4E in response to phorbol esters, cell stresses, and cytokines is mediated by distinct MAP kinase pathways
-
Wang X., Flynn A., Waskiewicz A.J., Webb B.L., Vries R.G., Baines I.A., Cooper J.A., Proud C.G. The phosphorylation of eukaryotic initiation factor eIF4E in response to phorbol esters, cell stresses, and cytokines is mediated by distinct MAP kinase pathways. J. Biol. Chem. 273:1998;9373-9377.
-
(1998)
J. Biol. Chem.
, vol.273
, pp. 9373-9377
-
-
Wang, X.1
Flynn, A.2
Waskiewicz, A.J.3
Webb, B.L.4
Vries, R.G.5
Baines, I.A.6
Cooper, J.A.7
Proud, C.G.8
-
125
-
-
17444438194
-
A p38 MAP kinase inhibitor SB 203580 inhibits CD28-dependent T cell proliferation and IL-2 production
-
Ward S.G., Parry R.V., Matthews J., O'Neill L. A p38 MAP kinase inhibitor SB 203580 inhibits CD28-dependent T cell proliferation and IL-2 production. Biochem. Soc. Trans. 25:1997;304S.
-
(1997)
Biochem. Soc. Trans.
, vol.25
, pp. 304S
-
-
Ward, S.G.1
Parry, R.V.2
Matthews, J.3
O'Neill, L.4
-
126
-
-
0029806856
-
Tumor necrosis factor-alpha-induced phosphorylation and activation of cytosolic phospholipase A2 are abrogated by an inhibitor of the cascade in human neutrophils
-
Waterman W.H., Molski T.F., Huang C.K., Adams J.L., Sha'afi R.I. Tumor necrosis factor-alpha-induced phosphorylation and activation of cytosolic phospholipase A2 are abrogated by an inhibitor of the cascade in human neutrophils. Biochem. J. 319:1996;17-20.
-
(1996)
Biochem. J.
, vol.319
, pp. 17-20
-
-
Waterman, W.H.1
Molski, T.F.2
Huang, C.K.3
Adams, J.L.4
Sha'Afi, R.I.5
-
127
-
-
0032981328
-
Phosphorylation of the cap-binding protein eukaryotic translation initiation factor 4E by protein kinase Mnk1 in vivo
-
Waskiewicz A.J., Johnson J.C., Penn B., Mahalingam M., Kimball S.R., Cooper J.A. Phosphorylation of the cap-binding protein eukaryotic translation initiation factor 4E by protein kinase Mnk1 in vivo. Mol. Cell Biol. 19:1999;1871-1880.
-
(1999)
Mol. Cell Biol.
, vol.19
, pp. 1871-1880
-
-
Waskiewicz, A.J.1
Johnson, J.C.2
Penn, B.3
Mahalingam, M.4
Kimball, S.R.5
Cooper, J.A.6
-
128
-
-
0029998541
-
Crystal structure of p38 mitogen-activated protein kinase
-
Wilson K.P., Fitzgibbon M.J., Caron P.N., Griffith J.P., Chen W.Y., McCaffrey P.G., Chambers S.P., Su M.S.S. Crystal structure of p38 mitogen-activated protein kinase. J. Biol. Chem. 271:1996;27696-27700.
-
(1996)
J. Biol. Chem.
, vol.271
, pp. 27696-27700
-
-
Wilson, K.P.1
Fitzgibbon, M.J.2
Caron, P.N.3
Griffith, J.P.4
Chen, W.Y.5
McCaffrey, P.G.6
Chambers, S.P.7
Su, M.S.S.8
-
129
-
-
12644277392
-
The structural basis for the specificity of pyridinylimidazole inhibitors of p38 MAP kinase
-
Wilson K.P., McCaffrey P.G., Hsiao K., Pazhanisamy S., Galullo V., Bemis G.W., Fitzgibbon M.J., Caron P.R., Murcko H.A., Su M.S.S. The structural basis for the specificity of pyridinylimidazole inhibitors of p38 MAP kinase. Chem. Biol. 4:1997;423-431.
-
(1997)
Chem. Biol.
, vol.4
, pp. 423-431
-
-
Wilson, K.P.1
McCaffrey, P.G.2
Hsiao, K.3
Pazhanisamy, S.4
Galullo, V.5
Bemis, G.W.6
Fitzgibbon, M.J.7
Caron, P.R.8
Murcko, H.A.9
Su, M.S.S.10
-
130
-
-
0033568608
-
The p38 MAP kinase pathway signals for cytokine-induced mRNA stabilization via MAP kinase-activated protein kinase 2 and an AU-rich region-targeted mechanism
-
Winzen R., Kracht M., Ritter B., Wilhelm A., Chen C.-Y.A, Shyu A.-B., Muller M., Gaestel M., Resch K., Holtmann H. The p38 MAP kinase pathway signals for cytokine-induced mRNA stabilization via MAP kinase-activated protein kinase 2 and an AU-rich region-targeted mechanism. EMBO J. 18:1999;4969-4980.
-
(1999)
EMBO J.
, vol.18
, pp. 4969-4980
-
-
Winzen, R.1
Kracht, M.2
Ritter, B.3
Wilhelm, A.4
Chen, C.-Y.A.5
Shyu, A.-B.6
Muller, M.7
Gaestel, M.8
Resch, K.9
Holtmann, H.10
-
131
-
-
15144349962
-
Activation of stress-activated protein kinases/c-Jun N-terminal protein kinases (SAPKs/JNKs) by a novel mitogen-activated protein kinase kinase
-
Yao Z., Diener K., Wang X.S., Zukowski M., Matsumoto G., Zhou G., Mo R., Sasaki T., Nishina H., Hui C.C., Tan T.H., Woodgett J.P., Penninger J.M. Activation of stress-activated protein kinases/c-Jun N-terminal protein kinases (SAPKs/JNKs) by a novel mitogen-activated protein kinase kinase. J. Biol. Chem. 272:1997;32378-32383.
-
(1997)
J. Biol. Chem.
, vol.272
, pp. 32378-32383
-
-
Yao, Z.1
Diener, K.2
Wang, X.S.3
Zukowski, M.4
Matsumoto, G.5
Zhou, G.6
Mo, R.7
Sasaki, T.8
Nishina, H.9
Hui, C.C.10
Tan, T.H.11
Woodgett, J.P.12
Penninger, J.M.13
-
132
-
-
0030924833
-
Pyridinyl imidazole inhibitors of p38 MAP kinase bind in the ATP site
-
Young P.R., McLaughlin M.M., Kumar S., Kassis S., Doyle M.L., McNulty D., Gallagher T.F., Fisher S., McDonnell P.C., Carr S.A., Huddleston M.J., Seibel G., Porter T.G., Livi G.P., Adams J.L., Lee J.C. Pyridinyl imidazole inhibitors of p38 MAP kinase bind in the ATP site. J. Biol. Chem. 272:1997;12116-12121.
-
(1997)
J. Biol. Chem.
, vol.272
, pp. 12116-12121
-
-
Young, P.R.1
McLaughlin, M.M.2
Kumar, S.3
Kassis, S.4
Doyle, M.L.5
McNulty, D.6
Gallagher, T.F.7
Fisher, S.8
McDonnell, P.C.9
Carr, S.A.10
Huddleston, M.J.11
Seibel, G.12
Porter, T.G.13
Livi, G.P.14
Adams, J.L.15
Lee, J.C.16
-
133
-
-
0028818395
-
Mxi2, a mitogen-activated protein kinase that recognizes and phosphorylates Max protein
-
Zervos A.S., Faccio L., Gatto J.P., Kyriakis J.M., Brent R. Mxi2, a mitogen-activated protein kinase that recognizes and phosphorylates Max protein. Proc. Natl. Acad. Sci. U. S. A. 92(23):1995;10531-10534.
-
(1995)
Proc. Natl. Acad. Sci. U. S. A.
, vol.92
, Issue.23
, pp. 10531-10534
-
-
Zervos, A.S.1
Faccio, L.2
Gatto, J.P.3
Kyriakis, J.M.4
Brent, R.5
-
134
-
-
0028820587
-
Rho family GTPases regulate p38 mitogen-activated protein kinase through the downstream mediator Pak1
-
Zhang S., Han J., Sells M.A., Chernoff J., Knaus U.G., Ulevitch R.J., Bokoch G.M. Rho family GTPases regulate p38 mitogen-activated protein kinase through the downstream mediator Pak1. J. Biol. Chem. 270:1995;23934-23936.
-
(1995)
J. Biol. Chem.
, vol.270
, pp. 23934-23936
-
-
Zhang, S.1
Han, J.2
Sells, M.A.3
Chernoff, J.4
Knaus, U.G.5
Ulevitch, R.J.6
Bokoch, G.M.7
-
135
-
-
0032953307
-
Regulation of the MEF2 family of transcription factors by p38
-
Zhao M., New L., Kravchenko V.V., Kato Y., Gram H., di Padova F., Olson E.N., Ulevitch R.J., Han J. Regulation of the MEF2 family of transcription factors by p38. Mol. Cell Biol. 19:1999;21-30.
-
(1999)
Mol. Cell Biol.
, vol.19
, pp. 21-30
-
-
Zhao, M.1
New, L.2
Kravchenko, V.V.3
Kato, Y.4
Gram, H.5
Di Padova, F.6
Olson, E.N.7
Ulevitch, R.J.8
Han, J.9
-
136
-
-
0031214070
-
High expression and activation of MAP kinase-activated protein kinase 2 in cardiac muscle cells
-
Zu Y.L., Ai Y., Gilchrist A., Maulik N., Watras J., Sha'afi R.I., Das D.K., Huang C.K. High expression and activation of MAP kinase-activated protein kinase 2 in cardiac muscle cells. J. Mol. Cell. Cardiol. 29:1997;2159-2168.
-
(1997)
J. Mol. Cell. Cardiol.
, vol.29
, pp. 2159-2168
-
-
Zu, Y.L.1
Ai, Y.2
Gilchrist, A.3
Maulik, N.4
Watras, J.5
Sha'Afi, R.I.6
Das, D.K.7
Huang, C.K.8
-
137
-
-
0032519736
-
P38 mitogen-activated protein kinase activation is required for human neutrophil function triggered by TNF-α Or FMLP stimulation
-
Zu Y.L., Qi J., Gilchrist A., Fernandez G.A., Vazquez-Abad D., Kreutzer D.L., Huang C.K., Sha'afi R.I. p38 mitogen-activated protein kinase activation is required for human neutrophil function triggered by TNF-α or FMLP stimulation. J. Immunol. 160:1998;1982-1999.
-
(1998)
J. Immunol.
, vol.160
, pp. 1982-1999
-
-
Zu, Y.L.1
Qi, J.2
Gilchrist, A.3
Fernandez, G.A.4
Vazquez-Abad, D.5
Kreutzer, D.L.6
Huang, C.K.7
Sha'Afi, R.I.8
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