Multiple roles of Ypd1 phosphotransfer protein in viability, stress response, and virulence factor regulation in cryptococcus neoformans

Eukaryotic Cell

Volumn 10, Issue 7, 2011, Pages 998-1002

  Lee, Jang Won ^a   Ko, Young Joon ^a   Kim, Seo Young ^a   Bahn, Yong Sun ^a  

^a Yonsei University   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

FUNGAL PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHOTRANSFERASE; PROTEIN KINASE; SIGNAL PEPTIDE; VIRULENCE FACTOR;

AMINO ACID SEQUENCE; CRYPTOCOCCUS NEOFORMANS; DNA SEQUENCE; GENE INACTIVATION; GENETICS; METABOLISM; NOTE; PHYSIOLOGICAL STRESS; SEQUENCE ALIGNMENT; SIGNAL TRANSDUCTION;

AMINO ACID SEQUENCE; CRYPTOCOCCUS NEOFORMANS; FUNGAL PROTEINS; GENE KNOCKOUT TECHNIQUES; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHOTRANSFERASES; PROTEIN KINASES; SEQUENCE ALIGNMENT; SEQUENCE ANALYSIS, DNA; SIGNAL TRANSDUCTION; STRESS, PHYSIOLOGICAL; VIRULENCE FACTORS;

EUKARYOTA; FILOBASIDIELLA NEOFORMANS;

EID: 79960130013     PISSN: 15359778     EISSN: None     Source Type: Journal    
DOI: 10.1128/EC.05124-11     Document Type: Note

References (24)

1. Aoyama, K., Y. Mitsubayashi, H. Aiba, and T. Mizuno. 2000. Spy1, a histidine-containing phosphotransfer signaling protein, regulates the fission yeast cell cycle through the Mcs4 response regulator. J. Bacteriol. 182:4868-4874.
2. Bahn, Y. S. 2008. Master and commander in fungal pathogens: the twocomponent system and the HOG signaling pathway. Eukaryot. Cell 7:2017-2036.
3. Bahn, Y. S., S. Geunes-Boyer, and J. Heitman. 2007. Ssk2 mitogen-activated protein kinase kinase kinase governs divergent patterns of the stress-activated Hog1 signaling pathway in Cryptococcus neoformans. Eukaryot. Cell 6:2278-2289.
4. Bahn, Y. S., K. Kojima, G. M. Cox, and J. Heitman. 2005. Specialization of the HOG pathway and its impact on differentiation and virulence of Cryptococcus neoformans. Mol. Biol. Cell 16:2285-2300.
5. Bahn, Y. S., K. Kojima, G. M. Cox, and J. Heitman. 2006. A unique fungal two-component system regulates stress responses, drug sensitivity, sexual development, and virulence of Cryptococcus neoformans. Mol. Biol. Cell 17:3122-3135.
6. Bahn, Y. S., et al. 2007. Sensing the environment: lessons from fungi. Nat. Rev. Microbiol. 5:57-69.
7. Burbulys, D., K. A. Trach, and J. A. Hoch. 1991. Initiation of sporulation in B. subtilis is controlled by a multicomponent phosphorelay. Cell 64:545-552.
8. Davidson, R. C., et al. 2002. A PCR-based strategy to generate integrative targeting alleles with large regions of homology. Microbiology 148:2607-2615.
9. Hwang, I., H. C. Chen, and J. Sheen. 2002. Two-component signal transduction pathways in Arabidopsis. Plant Physiol. 129:500-515.
10. 2 sensing pathway via differential expression of carbonic anhydrase in Cryptococcus neoformans. Genetics 185:1207-1219.
11. Ko, Y. J., et al. 2009. Remodeling of global transcription patterns of Cryptococcus neoformans genes mediated by the stress-activated HOG signaling pathways. Eukaryot. Cell 8:1197-1217.
12. Kojima, K., Y. S. Bahn, and J. Heitman. 2006. Calcineurin, Mpk1 and Hog1 MAPK pathways independently control fludioxonil antifungal sensitivity in Cryptococcus neoformans. Microbiology 152:591-604.
13. Krantz, M., E. Becit, and S. Hohmann. 2006. Comparative analysis of HOG pathway proteins to generate hypotheses for functional analysis. Curr. Genet. 49:152-165.
14. Kruppa, M., and R. Calderone. 2006. Two-component signal transduction in human fungal pathogens. FEMS Yeast Res. 6:149-159.
15. Laub, M. T., and M. Goulian. 2007. Specificity in two-component signal transduction pathways. Annu. Rev. Genet. 41:121-145.
16. Lu, J. M., R. J. Deschenes, and J. S. Fassler. 2003. Saccharomyces cerevisiae histidine phosphotransferase Ypd1p shuttles between the nucleus and cytoplasm for SLN1-dependent phosphorylation of Ssk1p and Skn7p. Eukaryot. Cell 2:1304-1314.
17. Mizuno, T. 2005. Two-component phosphorelay signal transduction systems in plants: from hormone responses to circadian rhythms. Biosci. Biotechnol. Biochem. 69:2263-2276.
18. Nguyen, A. N., A. Lee, W. Place, and K. Shiozaki. 2000. Multistep phosphorelay proteins transmit oxidative stress signals to the fission yeast stressactivated protein kinase. Mol. Biol. Cell 11:1169-1181.
19. Ory, J. J., C. L. Griffith, and T. L. Doering. 2004. An efficiently regulated promoter system for Cryptococcus neoformans utilizing the CTR4 promoter. Yeast 21:919-926.
20. Porter, S. W., and A. H. West. 2005. A common docking site for response regulators on the yeast phosphorelay protein YPD1. Biochim. Biophys. Acta 1748:138-145.
21. Porter, S. W., Q. Xu, and A. H. West. 2003. Ssk1p response regulator binding surface on histidine-containing phosphotransfer protein Ypd1p. Eukaryot. Cell 2:27-33.
22. Posas, F., et al. 1996. Yeast HOG1 MAP kinase cascade is regulated by a multistep phosphorelay mechanism in the SLN1-YPD1-SSK1 "two-component" osmosensor. Cell 86:865-875.
23. Song, H. K., et al. 1999. Insights into eukaryotic multistep phosphorelay signal transduction revealed by the crystal structure of Ypd1p from Saccharomyces cerevisiae. J. Mol. Biol. 293:753-761.
24. Xu, Q., and A. H. West. 1999. Conservation of structure and function among histidine-containing phosphotransfer (HPt) domains as revealed by the crystal structure of YPD1. J. Mol. Biol. 292:1039-1050.