Calcineurin regulatory subunit is essential for virulence and mediates interactions with FKBP12-FK506 in Cryptococcus neoformans

Molecular Microbiology

Volumn 39, Issue 4, 2001, Pages 835-849

  Fox, Deborah S ^a   Cruz, M Cristina ^a   Sia, Rey A L ^a   Ke, Hengming ^b   Cox, Gary M ^a   Cardenas, Maria E ^a   Heitman, Joseph ^a  

^a DUKE UNIVERSITY MEDICAL CENTER   (United States)

^b UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID; CALCINEURIN; CYCLOSPORIN A; FK 506 BINDING PROTEIN; PROTEIN SUBUNIT; TACROLIMUS;

ANTIFUNGAL ACTIVITY; ARTICLE; CRYPTOCOCCUS NEOFORMANS; CRYSTAL STRUCTURE; DRUG PROTEIN BINDING; FUNGAL GENETICS; FUNGUS GROWTH; FUNGUS MUTATION; GENE DUPLICATION; GENE INSERTION; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; VIRULENCE;

AMINO ACID SEQUENCE; ANIMALS; BASE SEQUENCE; CALCINEURIN; CRYPTOCOCCOSIS; CRYPTOCOCCUS NEOFORMANS; DISEASE MODELS, ANIMAL; DNA, FUNGAL; FUNGAL PROTEINS; GENES, FUNGAL; HEATING; HUMANS; MICE; MICE, INBRED DBA; MOLECULAR SEQUENCE DATA; MUTAGENESIS; PROTEIN STRUCTURE, SECONDARY; RECOMBINATION, GENETIC; SEQUENCE HOMOLOGY, AMINO ACID; TACROLIMUS; TACROLIMUS BINDING PROTEIN 1A; VIRULENCE;

FILOBASIDIELLA NEOFORMANS; FUNGI;

EID: 0035114113     PISSN: 0950382X     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2958.2001.02295.x     Document Type: Article

References (47)

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4. Targets of immunophilin-immunosuppressant complexes are distinct highly conserved regions of calcineurin A
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