Hrk1 plays both Hog1-dependent and -independent roles in controlling stress response and antifungal drug resistance in Cryptococcus neoformans

PLoS ONE

Volumn 6, Issue 4, 2011, Pages

  Kim, Seo Young ^a   Ko, Young Joon ^a   Jung, Kwang Woo ^a   Strain, Anna ^b   Nielsen, Kirsten ^b   Bahn, Yong Sun ^a  

^a Yonsei University   (South Korea)

^b UNIVERSITY OF MINNESOTA MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMPHOTERICIN B; CHLORPHENOTANE; FLUCONAZOLE; FUNGAL PROTEIN; GLYCEROL; HIGH OSMOLARITY GLYCEROL 1 PROTEIN; HIGH OSMOLARITY GLYCEROL 1 REGULATED KINASE 1; KETOCONAZOLE; MITOGEN ACTIVATED PROTEIN KINASE; UNCLASSIFIED DRUG; ANTIFUNGAL AGENT; CAENORHABDITIS ELEGANS PROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIFUNGAL RESISTANCE; ARTICLE; BIOSYNTHESIS; CELLULAR STRESS RESPONSE; CONTROLLED STUDY; CRYPTOCOCCUS NEOFORMANS; DOWNSTREAM PROCESSING; FEMALE; FUNGAL VIRULENCE; GENE MUTATION; MITOCHONDRION SWELLING; MOUSE; NONHUMAN; NORTHERN BLOTTING; OSMOTIC STRESS; OXIDATIVE STRESS; PROTEIN DETERMINATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; SENSITIVITY ANALYSIS; AMINO ACID SEQUENCE; ANIMAL; ANTIBIOTIC RESISTANCE; CHEMISTRY; DRUG EFFECT; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; MOLECULAR GENETICS; OSMOTIC PRESSURE; PHYSIOLOGY; SEQUENCE HOMOLOGY; VIRULENCE;

FILOBASIDIELLA NEOFORMANS; SACCHAROMYCES CEREVISIAE; SCHIZOSACCHAROMYCES POMBE;

AMINO ACID SEQUENCE; ANIMALS; ANTIFUNGAL AGENTS; CAENORHABDITIS ELEGANS PROTEINS; CRYPTOCOCCUS NEOFORMANS; DRUG RESISTANCE, MICROBIAL; GENE EXPRESSION REGULATION; GLYCEROL; MITOGEN-ACTIVATED PROTEIN KINASES; MOLECULAR SEQUENCE DATA; OSMOTIC PRESSURE; OXIDATIVE STRESS; SEQUENCE HOMOLOGY, AMINO ACID; VIRULENCE;

EID: 79954576036     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0018769     Document Type: Article

References (31)

1. Hohmann S, Krantz M, Nordlander B, (2007) Yeast osmoregulation. Methods Enzymol 428: 29-45.
2. Bahn YS, (2008) Master and Commander in fungal pathogens: The two-component system and the HOG signaling pathway. Eukaryot Cell 7: 2017-2036.
3. Barone FC, Irving EA, Ray AM, Lee JC, Kassis S, et al. (2001) Inhibition of p38 mitogen-activated protein kinase provides neuroprotection in cerebral focal ischemia. Med Res Rev 21: 129-145.
4. Lee JC, Kumar S, Griswold DE, Underwood DC, Votta BJ, et al. (2000) Inhibition of p38 MAP kinase as a therapeutic strategy. Immunopharmacology 47: 185-201.
5. Bahn YS, Kojima K, Cox GM, Heitman J, (2005) Specialization of the HOG pathway and its impact on differentiation and virulence of Cryptococcus neoformans. Mol Biol Cell 16: 2285-2300.
6. Bahn YS, Kojima K, Cox GM, Heitman J, (2006) A unique fungal two-component system regulates stress responses, drug sensitivity, sexual development, and virulence of Cryptococcus neoformans. Mol Biol Cell 17: 3122-3135.
7. Kojima K, Bahn YS, Heitman J, (2006) Calcineurin, Mpk1 and Hog1 MAPK pathways independently control fludioxonil antifungal sensitivity in Cryptococcus neoformans. Microbiology 152: 591-604.
8. Bahn YS, Geunes-Boyer S, Heitman J, (2007) Ssk2 mitogen-activated protein kinase kinase kinase governs divergent patterns of the stress-activated Hog1 signaling pathway in Cryptococcus neoformans. Eukaryot Cell 6: 2278-2289.
9. Ko YJ, Yu YM, Kim GB, Lee GW, Maeng PJ, et al. (2009) Remodeling of global transcription patterns of Cryptococcus neoformans genes mediated by the stress-activated HOG signaling pathways. Eukaryot Cell 8: 1197-1217.
10. Sanchez-Piris M, Posas F, Alemany V, Winge I, Hidalgo E, et al. (2002) The serine/threonine kinase Cmk2 is required for oxidative stress response in fission yeast. J Biol Chem 277: 17722-17727.
11. Smith DA, Toone WM, Chen D, Bahler J, Jones N, et al. (2002) The Srk1 protein kinase is a target for the Sty1 stress-activated MAPK in fission yeast. J Biol Chem 277: 33411-33421.
12. Lopez-Aviles S, Grande M, Gonzalez M, Helgesen AL, Alemany V, et al. (2005) Inactivation of the Cdc25 phosphatase by the stress-activated Srk1 kinase in fission yeast. Mol Cell 17: 49-59.
13. Dahlkvist A, Kanter-Smoler G, Sunnerhagen P, (1995) The RCK1 and RCK2 protein kinase genes from Saccharomyces cerevisiae suppress cell cycle checkpoint mutations in Schizosaccharomyces pombe. Mol Gen Genet 246: 316-326.
14. Bilsland-Marchesan E, Arino J, Saito H, Sunnerhagen P, Posas F, (2000) Rck2 kinase is a substrate for the osmotic stress-activated mitogen-activated protein kinase Hog1. Mol Cell Biol 20: 3887-3895.
15. Teige M, Scheikl E, Reiser V, Ruis H, Ammerer G, (2001) Rck2, a member of the calmodulin-protein kinase family, links protein synthesis to high osmolarity MAP kinase signaling in budding yeast. Proc Natl Acad Sci USA 98: 5625-5630.
16. Bilsland E, Molin C, Swaminathan S, Ramne A, Sunnerhagen P, (2004) Rck1 and Rck2 MAPKAP kinases and the HOG pathway are required for oxidative stress resistance. Mol Microbiol 53: 1743-1756.
17. Ramne A, Bilsland-Marchesan E, Erickson S, Sunnerhagen P, (2000) The protein kinases Rck1 and Rck2 inhibit meiosis in budding yeast. Mol Gen Genet 263: 253-261.
18. Lopez-Aviles S, Lambea E, Moldon A, Grande M, Fajardo A, et al. (2008) Activation of Srk1 by the mitogen-activated protein kinase Sty1/Spc1 precedes its dissociation from the kinase and signals its degradation. Mol Biol Cell 19: 1670-1679.
19. Maeng S, Ko YJ, Kim GB, Jung KW, Floyd A, et al. (2010) Comparative transcriptome analysis reveals novel roles of the Ras and cyclic AMP signaling pathways in environmental stress response and antifungal drug sensitivity in Cryptococcus neoformans. Eukaryot Cell 9: 360-378.
20. Asp E, Sunnerhagen P, (2003) Mkp1 and Mkp2, two MAPKAP-kinase homologues in Schizosaccharomyces pombe, interact with the MAP kinase Sty1. Mol Genet Genomics 268: 585-597.
21. Wemmie JA, Steggerda SM, Moye-Rowley WS, (1997) The Saccharomyces cerevisiae AP-1 protein discriminates between oxidative stress elicited by the oxidants H2O2 and diamide. J Biol Chem 272: 7908-7914.
22. Hughes AL, Friedman R, (2003) Parallel evolution by gene duplication in the genomes of two unicellular fungi. Genome Res 13: 794-799.
23. Chen D, Toone WM, Mata J, Lyne R, Burns G, et al. (2003) Global transcriptional responses of fission yeast to environmental stress. Mol Biol Cell 14: 214-229.
24. Dahlkvist A, Sunnerhagen P, (1994) Two novel deduced serine/threonine protein kinases from Saccharomyces cerevisiae. Gene 139: 27-33.
25. Bahn YS, Hicks JK, Giles SS, Cox GM, Heitman J, (2004) Adenylyl cyclase-associated protein Aca1 regulates virulence and differentiation of Cryptococcus neoformans via the cyclic AMP-protein kinase A cascade. Eukaryot Cell 3: 1476-1491.
26. Livak KJ, Schmittgen TD, (2001) Analysis of relative gene expression data using real-time quantitative PCR and the 2-ΔΔCT Method. Methods 25: 402-408.
27. Davidson RC, Blankenship JR, Kraus PR, de Jesus Berrios M, Hull CM, et al. (2002) A PCR-based strategy to generate integrative targeting alleles with large regions of homology. Microbiology 148: 2607-2615.
28. Jung KW, Kim SY, Okagaki LH, Nielsen K, Bahn YS, (2011) Ste50 adaptor protein governs sexual differentiation of Cryptococcus neoformans via the pheromone-response MAPK signaling pathway. Fungal Genet Biol 48: 154-165.
29. Hicks JK, D'Souza CA, Cox GM, Heitman J, (2004) Cyclic AMP-dependent protein kinase catalytic subunits have divergent roles in virulence factor production in two varieties of the fungal pathogen Cryptococcus neoformans. Eukaryot Cell 3: 14-26.
30. Perfect JR, Ketabchi N, Cox GM, Ingram CW, Beiser CL, (1993) Karyotyping of Cryptococcus neoformans as an epidemiological tool. J Clin Microbiol 31: 3305-3309.
31. Nielsen K, Cox GM, Wang P, Toffaletti DL, Perfect JR, et al. (2003) Sexual cycle of Cryptococcus neoformans var. grubii and virulence of congenic a and a isolates. Infect Immun 71: 4831-4841.