Ccr4 promotes resolution of the endoplasmic reticulum stress response during host temperature adaptation in Cryptococcus neoformans

Eukaryotic Cell

Volumn 10, Issue 7, 2011, Pages 895-901

  Havel, Virginia E ^a   Wool, Nathan K ^a   Ayad, David ^a   Downey, Kurtis M ^a   Wilson, Christabel F ^b   Larsen, Peter ^c   Djordjevic, Julianne T ^b   Panepinto, John C ^a  

^a UNIVERSITY AT BUFFALO   (United States)

^b UNIVERSITY OF SYDNEY   (Australia)

^c UNIVERSITY OF ILLINOIS   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHEMOKINE RECEPTOR CCR4; FUNGAL PROTEIN; MESSENGER RNA;

ADAPTATION; ARTICLE; BODY TEMPERATURE; CRYPTOCOCCUS NEOFORMANS; DNA MICROARRAY; ENDOPLASMIC RETICULUM; FLUORESCENCE MICROSCOPY; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GENE INACTIVATION; GENETICS; METABOLISM; MUTATION; PHENOTYPE; PHYSIOLOGICAL STRESS; POLYMERASE CHAIN REACTION; UNFOLDED PROTEIN RESPONSE;

ADAPTATION, PHYSIOLOGICAL; BODY TEMPERATURE; CRYPTOCOCCUS NEOFORMANS; ENDOPLASMIC RETICULUM; FUNGAL PROTEINS; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION, FUNGAL; GENE KNOCKOUT TECHNIQUES; MICROSCOPY, FLUORESCENCE; MUTATION; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PHENOTYPE; POLYMERASE CHAIN REACTION; RECEPTORS, CCR4; RNA, MESSENGER; STRESS, PHYSIOLOGICAL; UNFOLDED PROTEIN RESPONSE;

FILOBASIDIELLA NEOFORMANS;

EID: 79960136702     PISSN: 15359778     EISSN: None     Source Type: Journal    
DOI: 10.1128/EC.00006-11     Document Type: Article

References (29)

1. Ammar, R., A. M. Smith, L. E. Heisler, G. Giaever, and C. Nislow. 2009. A comparative analysis of DNA barcode microarray feature size. BMC Genomics 10:471.
2. Bicanic, T., and T. S. Harrison. 2004. Cryptococcal meningitis. Br. Med. Bull. 72:99-118.
3. Chen, S. C., L. C. Wright, J. C. Golding, and T. C. Sorrell. 2000. Purification and characterization of secretory phospholipase B, lysophospholipase and lysophospholipase/transacylase from a virulent strain of the pathogenic fungus Cryptococcus neoformans. Biochem. J. 347:431-439.
4. Chen, Y., et al. 2005. Identification of mitogen-activated protein kinase signaling pathways that confer resistance to endoplasmic reticulum stress in Saccharomyces cerevisiae. Mol. Cancer Res. 3:669-677.
5. Chow, E. D., O. W. Liu, S. O'Brien, and H. D. Madhani. 2007. Exploration of whole-genome responses of the human AIDS-associated yeast pathogen Cryptococcus neoformans var grubii: nitric oxide stress and body temperature. Curr. Genet. 52:137-148.
6. Dixit, A., S. F. Carroll, and S. T. Qureshi.2009. Cryptococcus gattii: an emerging cause of fungal disease in North America. Interdiscip. Perspect. Infect. Dis. 2009:840452.
7. Elson, S. L., S. M. Noble, N. V. Solis, S. G. Filler, and A. D. Johnson. 2009. An RNA transport system in Candida albicans regulates hyphal morphology and invasive growth. PLoS Genet. 5:e1000664.
8. Fan, J., et al. 2002. Global analysis of stress-regulated mRNA turnover by using cDNA arrays. Proc. Natl. Acad. Sci. U. S. A. 99:10611-10616.
9. Gasch, A. P., et al. 2004. Conservation and evolution of cis-regulatory systems in ascomycete fungi. PLoS Biol. 2:e398.
10. Gerik, K. J., et al. 2005. Cell wall integrity is dependent on the PKC1 signal transduction pathway in Cryptococcus neoformans. Mol. Microbiol. 58:393-408.
11. Gilbert, N. M., et al. KRE genes are required for beta-1,6-glucan synthesis, maintenance of capsule architecture and cell wall protein anchoring in Cryptococcus neoformans. Mol. Microbiol. 76:517-534.
12. Goldstrohm, A. C., D. J. Seay, B. A. Hook, and M. Wickens. 2007. PUF protein-mediated deadenylation is catalyzed by Ccr4p. J. Biol. Chem. 282: 109-114.
13. Grigull, J., S. Mnaimneh, J. Pootoolal, M. D. Robinson, and T. R. Hughes. 2004. Genome-wide analysis of mRNA stability using transcription inhibitors and microarrays reveals posttranscriptional control of ribosome biogenesis factors. Mol. Cell. Biol. 24:5534-5547.
14. Jiang, H., W. Guan, and Z. Gu. Tinkering evolution of post-transcriptional RNA regulons: puf3p in fungi as an example. PLoS Genet. 6:e1001030.
15. Kapteyn, J. C., et al. 2000. The cell wall architecture of Candida albicans wild-type cells and cell wall-defective mutants. Mol. Microbiol. 35:601-611.
16. Keene, J. D. 2007. RNA regulons: coordination of post-transcriptional events. Nat. Rev. Genet. 8:533-543.
17. Kimata, Y., Y. Ishiwata-Kimata, S. Yamada, and K. Kohno. 2006. Yeast unfolded protein response pathway regulates expression of genes for antioxidative stress and for cell surface proteins. Genes Cells 11:59-69.
18. Kincaid, M. M., and A. A. Cooper. 2007. ERADicate ER stress or die trying. Antioxid. Redox Signal 9:2373-2387.
19. Kraus, P. R., et al. 2004. Identification of Cryptococcus neoformans temperature-regulated genes with a genomic-DNA microarray. Eukaryot. Cell 3:1249-1260.
20. Liu, O. W., et al. 2008. Systematic genetic analysis of virulence in the human fungal pathogen Cryptococcus neoformans. Cell 135:174-188.
21. Livak, K. J., and T. D. Schmittgen. 2001. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T) Method. Methods 25:402-408.
22. Morris, A. R., N. Mukherjee, and J. D. Keene. 2008. Ribonomic analysis of human Pum1 reveals cis-trans conservation across species despite evolution of diverse mRNA target sets. Mol. Cell. Biol. 28:4093-4103.
23. Panepinto, J., et al. 2005. The DEAD-box RNA helicase Vad1 regulates multiple virulence-associated genes in Cryptococcus neoformans. J. Clin. Invest. 115:632-641.
24. Panepinto, J. C., et al. 2007. Binding of serum mannan binding lectin to a cell integrity-defective Cryptococcus neoformans ccr4{increment} mutant. Infect. Immun. 75:4769-4779.
25. Richie, D. L., et al. 2009. A role for the unfolded protein response (UPR) in virulence and antifungal susceptibility in Aspergillus fumigatus. PLoS Pathog. 5:e1000258.
26. Scrimale, T., L. Didone, K. L. de Mesy Bentley, and D. J. Krysan. 2009. The unfolded protein response is induced by the cell wall integrity mitogenactivated protein kinase signaling cascade and is required for cell wall integrity in Saccharomyces cerevisiae. Mol. Biol. Cell 20:164-175.
27. Siafakas, A. R., et al. 2007. Cell wall-linked cryptococcal phospholipase B1 is a source of secreted enzyme and a determinant of cell wall integrity. J. Biol. Chem. 282:37508-37514.
28. Simons, J. F., M. Ebersold, and A. Helenius. 1998. Cell wall 1,6-beta-glucan synthesis in Saccharomyces cerevisiae depends on ER glucosidases I and II, and the molecular chaperone BiP/Kar2p. EMBO J. 17:396-405.
29. Steen, B. R., et al. 2002. Temperature-regulated transcription in the pathogenic fungus Cryptococcus neoformans. Genome Res. 12:1386-1400.