메뉴 건너뛰기




Volumn 9, Issue 4, 2006, Pages 352-358

Lipid signaling in pathogenic fungi

Author keywords

[No Author keywords available]

Indexed keywords

AEROBASIDIN A; CYCLOHEXIMIDE; DIACYLGLYCEROL; ENZYME INHIBITOR; FARNESOL; FLUCONAZOLE; GALBONOLIDE A; ICOSANOID; KAFREFUNGIN; LIPID; NYSTATIN; SPHINGOLIPID; UNCLASSIFIED DRUG; VIRULENCE FACTOR;

EID: 33746297857     PISSN: 13695274     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.mib.2006.06.003     Document Type: Review
Times cited : (70)

References (42)
  • 1
    • 0018803639 scopus 로고
    • Unsaturated diacylglycerol as a possible messenger for the activation of calcium-activated, phospholipid-dependent protein kinase system
    • Takai Y., Kishimoto A., Kikkawa U., Mori T., and Nishizuka Y. Unsaturated diacylglycerol as a possible messenger for the activation of calcium-activated, phospholipid-dependent protein kinase system. Biochem Biophys Res Commun 91 (1979) 1218-1224
    • (1979) Biochem Biophys Res Commun , vol.91 , pp. 1218-1224
    • Takai, Y.1    Kishimoto, A.2    Kikkawa, U.3    Mori, T.4    Nishizuka, Y.5
  • 2
    • 21544470248 scopus 로고    scopus 로고
    • Protein kinase C and phospholipase D: intimate interactions in intracellular signaling
    • Becker K.P., and Hannun Y.A. Protein kinase C and phospholipase D: intimate interactions in intracellular signaling. Cell Mol Life Sci 62 (2005) 1448-1461
    • (2005) Cell Mol Life Sci , vol.62 , pp. 1448-1461
    • Becker, K.P.1    Hannun, Y.A.2
  • 3
    • 0036303786 scopus 로고    scopus 로고
    • The therapeutic potential of modulating the ceramide/sphingomyelin pathway
    • Kolesnick R. The therapeutic potential of modulating the ceramide/sphingomyelin pathway. J Clin Invest 110 (2002) 3-8
    • (2002) J Clin Invest , vol.110 , pp. 3-8
    • Kolesnick, R.1
  • 4
    • 0023919129 scopus 로고
    • Regulation of protein kinase C by lysophospholipids. Potential role in signal transduction
    • Oishi K., Raynor R.L., Charp P.A., and Kuo J.F. Regulation of protein kinase C by lysophospholipids. Potential role in signal transduction. J Biol Chem 263 (1988) 6865-6871
    • (1988) J Biol Chem , vol.263 , pp. 6865-6871
    • Oishi, K.1    Raynor, R.L.2    Charp, P.A.3    Kuo, J.F.4
  • 5
    • 0037135626 scopus 로고    scopus 로고
    • The ceramide-centric universe of lipid-mediated cell regulation: stress encounters of the lipid kind
    • Hannun Y.A., and Obeid L.M. The ceramide-centric universe of lipid-mediated cell regulation: stress encounters of the lipid kind. J Biol Chem 277 (2002) 25847-25850
    • (2002) J Biol Chem , vol.277 , pp. 25847-25850
    • Hannun, Y.A.1    Obeid, L.M.2
  • 6
    • 0037071871 scopus 로고    scopus 로고
    • Sphingolipid functions in Saccharomyces cerevisiae
    • Dickson R.C., and Lester R.L. Sphingolipid functions in Saccharomyces cerevisiae. Biochim Biophys Acta 1583 (2002) 13-25
    • (2002) Biochim Biophys Acta , vol.1583 , pp. 13-25
    • Dickson, R.C.1    Lester, R.L.2
  • 7
    • 23844502040 scopus 로고    scopus 로고
    • Sphingolipids in infectious diseases
    • Hanada K. Sphingolipids in infectious diseases. Jpn J Infect Dis 58 (2005) 131-148
    • (2005) Jpn J Infect Dis , vol.58 , pp. 131-148
    • Hanada, K.1
  • 8
    • 29644447465 scopus 로고    scopus 로고
    • Role of sphingolipids in microbial pathogenesis
    • A current and comprehensive review of the role sphingolipids play in mediating the interactions between host and pathogen during infection.
    • Heung L.J., Luberto C., and Del Poeta M. Role of sphingolipids in microbial pathogenesis. Infect Immun 74 (2006) 28-39. A current and comprehensive review of the role sphingolipids play in mediating the interactions between host and pathogen during infection.
    • (2006) Infect Immun , vol.74 , pp. 28-39
    • Heung, L.J.1    Luberto, C.2    Del Poeta, M.3
  • 9
    • 0038107709 scopus 로고    scopus 로고
    • Production of eicosanoids and other oxylipins by pathogenic eukaryotic microbes
    • Noverr M.C., Erb-Downward J.R., and Huffnagle G.B. Production of eicosanoids and other oxylipins by pathogenic eukaryotic microbes. Clin Microbiol Rev 16 (2003) 517-533
    • (2003) Clin Microbiol Rev , vol.16 , pp. 517-533
    • Noverr, M.C.1    Erb-Downward, J.R.2    Huffnagle, G.B.3
  • 13
    • 2442701773 scopus 로고    scopus 로고
    • The sphingolipid pathway regulates Pkc1 through the formation of diacylglycerol in Cryptococcus neoformans
    • This is the first study to show diacylglycerol activation of PKC in a fungal pathogen.
    • Heung L.J., Luberto C., Plowden A., Hannun Y.A., and Del Poeta M. The sphingolipid pathway regulates Pkc1 through the formation of diacylglycerol in Cryptococcus neoformans. J Biol Chem 279 (2004) 21144-21153. This is the first study to show diacylglycerol activation of PKC in a fungal pathogen.
    • (2004) J Biol Chem , vol.279 , pp. 21144-21153
    • Heung, L.J.1    Luberto, C.2    Plowden, A.3    Hannun, Y.A.4    Del Poeta, M.5
  • 15
    • 0028309762 scopus 로고
    • Saccharomyces cerevisiae PKC1 encodes a protein kinase C (PKC) homolog with a substrate specificity similar to that of mammalian PKC
    • Watanabe M., Chen C.Y., and Levin D.E. Saccharomyces cerevisiae PKC1 encodes a protein kinase C (PKC) homolog with a substrate specificity similar to that of mammalian PKC. J Biol Chem 269 (1994) 16829-16836
    • (1994) J Biol Chem , vol.269 , pp. 16829-16836
    • Watanabe, M.1    Chen, C.Y.2    Levin, D.E.3
  • 16
    • 0037626943 scopus 로고    scopus 로고
    • Evolution, biochemistry and genetics of protein kinase C in fungi
    • Schmitz H.P., and Heinisch J.J. Evolution, biochemistry and genetics of protein kinase C in fungi. Curr Genet 43 (2003) 245-254
    • (2003) Curr Genet , vol.43 , pp. 245-254
    • Schmitz, H.P.1    Heinisch, J.J.2
  • 18
    • 23344448602 scopus 로고    scopus 로고
    • The role and mechanism of diacylglycerol-protein kinase C1 signaling in melanogenesis by Cryptococcus neoformans
    • The diacylglycerol-binding C1 domain of Pkc1 mediates the effects of Ipc1-generated diacylglycerol on virulence factors such as melanization and capsule formation.
    • Heung L.J., Kaiser A.E., Luberto C., and Del Poeta M. The role and mechanism of diacylglycerol-protein kinase C1 signaling in melanogenesis by Cryptococcus neoformans. J Biol Chem 280 (2005) 28547-28555. The diacylglycerol-binding C1 domain of Pkc1 mediates the effects of Ipc1-generated diacylglycerol on virulence factors such as melanization and capsule formation.
    • (2005) J Biol Chem , vol.280 , pp. 28547-28555
    • Heung, L.J.1    Kaiser, A.E.2    Luberto, C.3    Del Poeta, M.4
  • 19
    • 26944477777 scopus 로고    scopus 로고
    • Cell wall integrity is dependent on the PKC1 signal transduction pathway in Cryptococcus neoformans
    • A comprehensive study in which putative members of the Pkc1 signaling pathway in C. neoformans were identified and partially characterized.
    • Gerik K.J., Donlin M.J., Soto C.E., Banks A.M., Banks I.R., Maligie M.A., Selitrennikoff C.P., and Lodge J.K. Cell wall integrity is dependent on the PKC1 signal transduction pathway in Cryptococcus neoformans. Mol Microbiol 58 (2005) 393-408. A comprehensive study in which putative members of the Pkc1 signaling pathway in C. neoformans were identified and partially characterized.
    • (2005) Mol Microbiol , vol.58 , pp. 393-408
    • Gerik, K.J.1    Donlin, M.J.2    Soto, C.E.3    Banks, A.M.4    Banks, I.R.5    Maligie, M.A.6    Selitrennikoff, C.P.7    Lodge, J.K.8
  • 20
    • 27744507812 scopus 로고    scopus 로고
    • APP1 transcription is regulated by IPC1-DAG pathway and is controlled by ATF2 transcription factor in Cryptococcus neoformans
    • A new cryptococcal transcription factor, Atf2, was found to induce the transcription of the virulence factor App1 in the presence of increased diacylglycerol.
    • Mare L., Iatta R., Montagna M.T., Luberto C., and Del Poeta M. APP1 transcription is regulated by IPC1-DAG pathway and is controlled by ATF2 transcription factor in Cryptococcus neoformans. J Biol Chem 280 (2005) 36055-36064. A new cryptococcal transcription factor, Atf2, was found to induce the transcription of the virulence factor App1 in the presence of increased diacylglycerol.
    • (2005) J Biol Chem , vol.280 , pp. 36055-36064
    • Mare, L.1    Iatta, R.2    Montagna, M.T.3    Luberto, C.4    Del Poeta, M.5
  • 22
    • 0035836681 scopus 로고    scopus 로고
    • Purification and characterization of an autoregulatory substance capable of regulating the morphological transition in Candida albicans
    • Oh K.B., Miyazawa H., Naito T., and Matsuoka H. Purification and characterization of an autoregulatory substance capable of regulating the morphological transition in Candida albicans. Proc Natl Acad Sci USA 98 (2001) 4664-4668
    • (2001) Proc Natl Acad Sci USA , vol.98 , pp. 4664-4668
    • Oh, K.B.1    Miyazawa, H.2    Naito, T.3    Matsuoka, H.4
  • 23
    • 29444447659 scopus 로고    scopus 로고
    • Enhanced pathogenicity of Candida albicans pre-treated with subinhibitory concentrations of fluconazole in a mouse model of disseminated candidiasis
    • One of the first studies to indirectly address the role of farnesol in a murine model of infection. Azole-exposed C. albicans produced higher amounts of farnesol and were hypervirulent in mice.
    • Navarathna D.H., Hornby J.M., Hoerrmann N., Parkhurst A.M., Duhamel G.E., and Nickerson K.W. Enhanced pathogenicity of Candida albicans pre-treated with subinhibitory concentrations of fluconazole in a mouse model of disseminated candidiasis. J Antimicrob Chemother 56 (2005) 1156-1159. One of the first studies to indirectly address the role of farnesol in a murine model of infection. Azole-exposed C. albicans produced higher amounts of farnesol and were hypervirulent in mice.
    • (2005) J Antimicrob Chemother , vol.56 , pp. 1156-1159
    • Navarathna, D.H.1    Hornby, J.M.2    Hoerrmann, N.3    Parkhurst, A.M.4    Duhamel, G.E.5    Nickerson, K.W.6
  • 24
    • 23744445246 scopus 로고    scopus 로고
    • Farnesol concentrations required to block germ tube formation in Candida albicans in the presence and absence of serum
    • This study systemically characterized the concentrations of farnesol needed to block hyphal formation under a number of inducing conditions. The authors provide evidence that lipid-binding albumin in serum might play a significant role in attenuating the effects of farnesol.
    • Mosel D.D., Dumitru R., Hornby J.M., Atkin A.L., and Nickerson K.W. Farnesol concentrations required to block germ tube formation in Candida albicans in the presence and absence of serum. Appl Environ Microbiol 71 (2005) 4938-4940. This study systemically characterized the concentrations of farnesol needed to block hyphal formation under a number of inducing conditions. The authors provide evidence that lipid-binding albumin in serum might play a significant role in attenuating the effects of farnesol.
    • (2005) Appl Environ Microbiol , vol.71 , pp. 4938-4940
    • Mosel, D.D.1    Dumitru, R.2    Hornby, J.M.3    Atkin, A.L.4    Nickerson, K.W.5
  • 25
    • 22444445262 scopus 로고    scopus 로고
    • Release from quorum-sensing molecules triggers hyphal formation during Candida albicans resumption of growth
    • Enjalbert B., and Whiteway M. Release from quorum-sensing molecules triggers hyphal formation during Candida albicans resumption of growth. Eukaryot Cell 4 (2005) 1203-1210
    • (2005) Eukaryot Cell , vol.4 , pp. 1203-1210
    • Enjalbert, B.1    Whiteway, M.2
  • 27
    • 0034458993 scopus 로고    scopus 로고
    • Crk1, a novel Cdc2-related protein kinase, is required for hyphal development and virulence in Candida albicans
    • Chen J., Zhou S., Wang Q., Chen X., Pan T., and Liu H. Crk1, a novel Cdc2-related protein kinase, is required for hyphal development and virulence in Candida albicans. Mol Cell Biol 20 (2000) 8696-8708
    • (2000) Mol Cell Biol , vol.20 , pp. 8696-8708
    • Chen, J.1    Zhou, S.2    Wang, Q.3    Chen, X.4    Pan, T.5    Liu, H.6
  • 28
    • 2442548488 scopus 로고    scopus 로고
    • Hgc1, a novel hypha-specific G1 cyclin-related protein regulates Candida albicans hyphal morphogenesis
    • Zheng X., Wang Y., and Wang Y. Hgc1, a novel hypha-specific G1 cyclin-related protein regulates Candida albicans hyphal morphogenesis. EMBO J 23 (2004) 1845-1856
    • (2004) EMBO J , vol.23 , pp. 1845-1856
    • Zheng, X.1    Wang, Y.2    Wang, Y.3
  • 29
    • 4143061348 scopus 로고    scopus 로고
    • The two-component signal transduction protein Chk1p regulates quorum sensing in Candida albicans
    • Kruppa M., Krom B.P., Chauhan N., Bambach A.V., Cihlar R.L., and Calderone R.A. The two-component signal transduction protein Chk1p regulates quorum sensing in Candida albicans. Eukaryot Cell 3 (2004) 1062-1065
    • (2004) Eukaryot Cell , vol.3 , pp. 1062-1065
    • Kruppa, M.1    Krom, B.P.2    Chauhan, N.3    Bambach, A.V.4    Cihlar, R.L.5    Calderone, R.A.6
  • 30
    • 33645079654 scopus 로고    scopus 로고
    • Farnesol-induced apoptosis in Aspergillus nidulans reveals a possible mechanism for antagonistic interactions between fungi
    • A. nidulans exposed to physiological concentrations of farnesol undergoes an apoptotic-like death. This study unveiled a novel role for farnesol as an antifungal agent.
    • Semighini C.P., Hornby J.M., Dumitru R., Nickerson K.W., and Harris S.D. Farnesol-induced apoptosis in Aspergillus nidulans reveals a possible mechanism for antagonistic interactions between fungi. Mol Microbiol 59 (2006) 753-764. A. nidulans exposed to physiological concentrations of farnesol undergoes an apoptotic-like death. This study unveiled a novel role for farnesol as an antifungal agent.
    • (2006) Mol Microbiol , vol.59 , pp. 753-764
    • Semighini, C.P.1    Hornby, J.M.2    Dumitru, R.3    Nickerson, K.W.4    Harris, S.D.5
  • 32
    • 0038650921 scopus 로고    scopus 로고
    • Farnesol biosynthesis in Candida albicans: cellular response to sterol inhibition by zaragozic acid B
    • Hornby J.M., Kebaara B.W., and Nickerson K.W. Farnesol biosynthesis in Candida albicans: cellular response to sterol inhibition by zaragozic acid B. Antimicrob Agents Chemother 47 (2003) 2366-2369
    • (2003) Antimicrob Agents Chemother , vol.47 , pp. 2366-2369
    • Hornby, J.M.1    Kebaara, B.W.2    Nickerson, K.W.3
  • 33
    • 2542454811 scopus 로고    scopus 로고
    • Enhanced production of farnesol by Candida albicans treated with four azoles
    • Hornby J.M., and Nickerson K.W. Enhanced production of farnesol by Candida albicans treated with four azoles. Antimicrob Agents Chemother 48 (2004) 2305-2307
    • (2004) Antimicrob Agents Chemother , vol.48 , pp. 2305-2307
    • Hornby, J.M.1    Nickerson, K.W.2
  • 34
    • 33746313518 scopus 로고    scopus 로고
    • Farnesol and geraniol chemopreventive activities during the initial phases of hepatocarcinogenesis involve similar actions on cell proliferation and DNA damage, but distinct actions on apoptosis, plasma cholesterol and HMGCoA reductase
    • Ong T.P., Heidor R., de Conti A., Dagli M.L., and Moreno F.S. Farnesol and geraniol chemopreventive activities during the initial phases of hepatocarcinogenesis involve similar actions on cell proliferation and DNA damage, but distinct actions on apoptosis, plasma cholesterol and HMGCoA reductase. Carcinogenesis (2005)
    • (2005) Carcinogenesis
    • Ong, T.P.1    Heidor, R.2    de Conti, A.3    Dagli, M.L.4    Moreno, F.S.5
  • 35
    • 27844543339 scopus 로고    scopus 로고
    • Membrane raft lipid constituents affect drug susceptibilities of Candida albicans
    • Ergosterol and complex sphingolipid synthesis were found to be necessary to develop drug resistance in C. albicans. This might be as a result of the formation of lipid microdomains which stabilize the membrane drug efflux pump Cdr1p.
    • Pasrija R., Prasad T., and Prasad R. Membrane raft lipid constituents affect drug susceptibilities of Candida albicans. Biochem Soc Trans 33 (2005) 1219-1223. Ergosterol and complex sphingolipid synthesis were found to be necessary to develop drug resistance in C. albicans. This might be as a result of the formation of lipid microdomains which stabilize the membrane drug efflux pump Cdr1p.
    • (2005) Biochem Soc Trans , vol.33 , pp. 1219-1223
    • Pasrija, R.1    Prasad, T.2    Prasad, R.3
  • 36
    • 0032994127 scopus 로고    scopus 로고
    • Farnesol-induced growth inhibition in Saccharomyces cerevisiae by a cell cycle mechanism
    • Machida K., Tanaka T., Yano Y., Otani S., and Taniguchi M. Farnesol-induced growth inhibition in Saccharomyces cerevisiae by a cell cycle mechanism. Microbiol 145 (1999) 293-299
    • (1999) Microbiol , vol.145 , pp. 293-299
    • Machida, K.1    Tanaka, T.2    Yano, Y.3    Otani, S.4    Taniguchi, M.5
  • 37
    • 26944437020 scopus 로고    scopus 로고
    • Candida albicans-conditioned medium protects yeast cells from oxidative stress: a possible link between quorum sensing and oxidative stress resistance
    • The link between farnesol and resistance to oxidative stress is established. This study also partially characterizes another secreted molecule in cultures that is able to induce the transcription of oxidative stress-protective genes.
    • Westwater C., Balish E., and Schofield D.A. Candida albicans-conditioned medium protects yeast cells from oxidative stress: a possible link between quorum sensing and oxidative stress resistance. Eukaryot Cell 4 (2005) 1654-1661. The link between farnesol and resistance to oxidative stress is established. This study also partially characterizes another secreted molecule in cultures that is able to induce the transcription of oxidative stress-protective genes.
    • (2005) Eukaryot Cell , vol.4 , pp. 1654-1661
    • Westwater, C.1    Balish, E.2    Schofield, D.A.3
  • 38
    • 0035055325 scopus 로고    scopus 로고
    • Pathogenic yeasts Cryptococcus neoformans and Candida albicans produce immunomodulatory prostaglandins
    • Noverr M.C., Phare S.M., Toews G.B., Coffey M.J., and Huffnagle G.B. Pathogenic yeasts Cryptococcus neoformans and Candida albicans produce immunomodulatory prostaglandins. Infect Immun 69 (2001) 2957-2963
    • (2001) Infect Immun , vol.69 , pp. 2957-2963
    • Noverr, M.C.1    Phare, S.M.2    Toews, G.B.3    Coffey, M.J.4    Huffnagle, G.B.5
  • 39
    • 27644599133 scopus 로고    scopus 로고
    • Prostaglandin production during growth of Candida albicans biofilms
    • Alem M.A., and Douglas L.J. Prostaglandin production during growth of Candida albicans biofilms. J Med Microbiol 54 (2005) 1001-1005
    • (2005) J Med Microbiol , vol.54 , pp. 1001-1005
    • Alem, M.A.1    Douglas, L.J.2
  • 40
    • 0036139219 scopus 로고    scopus 로고
    • Production of prostaglandins and leukotrienes by pathogenic fungi
    • Noverr M.C., Toews G.B., and Huffnagle G.B. Production of prostaglandins and leukotrienes by pathogenic fungi. Infect Immun 70 (2002) 400-402
    • (2002) Infect Immun , vol.70 , pp. 400-402
    • Noverr, M.C.1    Toews, G.B.2    Huffnagle, G.B.3
  • 41
    • 21344467963 scopus 로고    scopus 로고
    • Three putative oxylipin biosynthetic genes integrate sexual and asexual development in Aspergillus nidulans
    • Tsitsigiannis D.I., Kowieski T.M., Zarnowski R., and Keller N.P. Three putative oxylipin biosynthetic genes integrate sexual and asexual development in Aspergillus nidulans. Microbiol 151 (2005) 1809-1821
    • (2005) Microbiol , vol.151 , pp. 1809-1821
    • Tsitsigiannis, D.I.1    Kowieski, T.M.2    Zarnowski, R.3    Keller, N.P.4
  • 42
    • 23344437309 scopus 로고    scopus 로고
    • Aspergillus cyclooxygenase-like enzymes are associated with prostaglandin production and virulence
    • The first enzymes involved in eicosanoid production in pathogenic fungi are identified. Suppressing the expression of these enzymes results in a hypervirulent strain.
    • Tsitsigiannis D.I., Bok J.W., Andes D., Nielsen K.F., Frisvad J.C., and Keller N.P. Aspergillus cyclooxygenase-like enzymes are associated with prostaglandin production and virulence. Infect Immun 73 (2005) 4548-4559. The first enzymes involved in eicosanoid production in pathogenic fungi are identified. Suppressing the expression of these enzymes results in a hypervirulent strain.
    • (2005) Infect Immun , vol.73 , pp. 4548-4559
    • Tsitsigiannis, D.I.1    Bok, J.W.2    Andes, D.3    Nielsen, K.F.4    Frisvad, J.C.5    Keller, N.P.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.