Molecular basis of cannabinoid CB1 receptor coupling to the G protein heterotrimer Gαiβγ; Identification of key CB1 contacts with the C-terminal helix α5 of Gαi

Journal of Biological Chemistry

Volumn 288, Issue 45, 2013, Pages 32449-32465

  Shim, Joong Youn ^a   Ahn, Kwang H ^b   Kendall, Debra A ^b  

^a NORTH CAROLINA CENTRAL UNIVERSITY   (United States)

^b UNIVERSITY OF CONNECTICUT   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADRENERGIC RECEPTORS; CONFORMATIONAL CHANGE; COUPLING ACTIVITIES; G PROTEIN ACTIVATION; G PROTEIN COUPLED RECEPTORS; INTRACELLULAR LOOP; MOLECULAR DYNAMICS SIMULATIONS; STRUCTURAL MODELING;

ENZYME INHIBITION; MOLECULAR DYNAMICS;

PROTEINS;

2 OLEOYL 1 PALMITOYLPHOSPHATIDYLCHOLINE; ALANINE; ARGININE; ASPARTIC ACID; BETA 2 ADRENERGIC RECEPTOR; CANNABINOID 1 RECEPTOR; INHIBITORY GUANINE NUCLEOTIDE BINDING PROTEIN; INHIBITORY GUANINE NUCLEOTIDE BINDING PROTEIN BETA GAMMA; ISOLEUCINE; LEUCINE; RADIOLIGAND; THREONINE; TYROSINE; UNCLASSIFIED DRUG;

ARTICLE; CARBOXY TERMINAL SEQUENCE; CONFORMATIONAL TRANSITION; HUMAN; LIGAND BINDING; MOLECULAR DYNAMICS; MUTATION; PLASMID; PRIORITY JOURNAL; SIGNAL TRANSDUCTION;

CANNABINOID RECEPTORS; COMPUTER MODELING; G PROTEIN-COUPLED RECEPTORS (GPCR); G PROTEINS; MOLECULAR DYNAMICS; MUTAGENESIS; PROTEIN-PROTEIN INTERACTIONS; SIGNALING;

GTP-BINDING PROTEIN ALPHA SUBUNITS; GTP-BINDING PROTEIN BETA SUBUNITS; GTP-BINDING PROTEIN GAMMA SUBUNITS; HEK293 CELLS; HUMANS; MODELS, MOLECULAR; PROTEIN STRUCTURE, QUATERNARY; PROTEIN STRUCTURE, SECONDARY; RECEPTOR, CANNABINOID, CB1;

EID: 84887443683     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M113.489153     Document Type: Article

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