The receptor-bound "empty pocket" state of the heterotrimeric G-protein α-subunit is conformationally dynamic

Biochemistry

Volumn 45, Issue 43, 2006, Pages 12986-12997

  Abdulaev, Najmoutin G ^a   Ngo, Tony ^b   Ramon, Eva ^b   Brabazon, Danielle M ^c   Marino, John P ^a   Ridge, Kevin D ^b  

^a UNIVERSITY OF MARYLAND BIOTECHNOLOGY INSTITUTE   (United States)

^b UNIVERSITY OF TEXAS MEDICAL SCHOOL   (United States)

^c LOYOLA UNIVERSITY MARYLAND   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVATION ANALYSIS; CONFORMATIONS; DETERGENTS; ISOTOPES; NUCLEAR MAGNETIC RESONANCE; POLYPEPTIDES; WAVE PROPAGATION;

NUCLEOTIDES; RECEPTOR INTERACTING REGIONS; STRUCTURAL SIGNALS; TRANSDUCINS;

PROTEINS;

DETERGENT; G PROTEIN COUPLED RECEPTOR; GUANINE NUCLEOTIDE; GUANINE NUCLEOTIDE BINDING PROTEIN ALPHA SUBUNIT; GUANOSINE DIPHOSPHATE; ISOTOPE; MAGNESIUM ION; NITROGEN 15; RHODOPSIN; TRANSDUCIN;

ARTICLE; COMPLEX FORMATION; CONFORMATIONAL TRANSITION; DYNAMICS; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PHOTOREACTIVITY; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN CONFORMATION; REACTION ANALYSIS; SIGNAL TRANSDUCTION;

ANIMALS; CATTLE; GTP-BINDING PROTEIN ALPHA SUBUNITS; GUANINE NUCLEOTIDES; GUANOSINE DIPHOSPHATE; GUANOSINE TRIPHOSPHATE; HETEROTRIMERIC GTP-BINDING PROTEINS; LIGHT; MAGNETIC RESONANCE SPECTROSCOPY; MODELS, BIOLOGICAL; MODELS, CHEMICAL; MODELS, MOLECULAR; PROTEIN BINDING; PROTEIN CONFORMATION; RECEPTORS, G-PROTEIN-COUPLED; RHODOPSIN; TRANSDUCIN;

EID: 33751119043     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi061088h     Document Type: Article

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