메뉴 건너뛰기




Volumn 520, Issue , 2013, Pages 337-355

Functional residues essential for the activation of the CB1 cannabinoid Receptor

Author keywords

CB1; functional residues; GPCR; homology modeling; hydrophobic patch; Keywords; molecular dynamics simulation; receptor activation; toggle switch

Indexed keywords

BETA 2 ADRENERGIC RECEPTOR; CANNABINOID 1 RECEPTOR; DEXANABINOL; LYSINE; VALINE;

EID: 84872546888     PISSN: 00766879     EISSN: 15577988     Source Type: Book Series    
DOI: 10.1016/B978-0-12-391861-1.00016-2     Document Type: Chapter
Times cited : (8)

References (36)
  • 2
    • 69549108193 scopus 로고    scopus 로고
    • Multiple switches in G protein-coupled receptor activation
    • S. Ahuja, and S.O. Smith Multiple switches in G protein-coupled receptor activation Trends in Pharmacological Sciences 30 2009 494 502
    • (2009) Trends in Pharmacological Sciences , vol.30 , pp. 494-502
    • Ahuja, S.1    Smith, S.O.2
  • 3
    • 0031565726 scopus 로고    scopus 로고
    • An alpha-carbon template for the transmembrane helices in the rhodopsin family of G-protein-coupled receptors
    • DOI 10.1006/jmbi.1997.1240
    • J.M. Baldwin, G.F. Schertler, and V.M. Unger An alpha-carbon template for the transmembrane helices in the rhodopsin family of G-protein-coupled receptors Journal of Molecular Biology 272 1997 144 164 (Pubitemid 27395544)
    • (1997) Journal of Molecular Biology , vol.272 , Issue.1 , pp. 144-164
    • Baldwin, J.M.1    Schertler, G.F.X.2    Unger, V.M.3
  • 4
    • 0035800850 scopus 로고    scopus 로고
    • Activation of the beta 2-adrenergic receptor involves disruption of an ionic lock between the cytoplasmic ends of transmembrane segments 3 and 6
    • J.A. Ballesteros, A.D. Jensen, G. Liapakis, S.G. Rasmussen, L. Shi, and U. Gether Activation of the beta 2-adrenergic receptor involves disruption of an ionic lock between the cytoplasmic ends of transmembrane segments 3 and 6 The Journal of Biological Chemistry 276 2001 29171 29177
    • (2001) The Journal of Biological Chemistry , vol.276 , pp. 29171-29177
    • Ballesteros, J.A.1    Jensen, A.D.2    Liapakis, G.3    Rasmussen, S.G.4    Shi, L.5    Gether, U.6
  • 5
    • 77957055780 scopus 로고
    • Integrated methods for modeling G-protein coupled receptors
    • S.C. Sealfon, P.M. Conn, Academic Press San Francisco
    • J.A. Ballesteros, and H. Weinstein Integrated methods for modeling G-protein coupled receptors S.C. Sealfon, P.M. Conn, Methods in neuroscience 1995 Academic Press San Francisco 366 428
    • (1995) Methods in Neuroscience , pp. 366-428
    • Ballesteros, J.A.1    Weinstein, H.2
  • 6
    • 33747759025 scopus 로고    scopus 로고
    • A cannabinoid receptor 1 mutation proximal to the DRY motif results in constitutive activity and reveals intramolecular interactions involved in receptor activation
    • DOI 10.1016/j.brainres.2006.05.042, PII S0006899306013904
    • A.M. D'Antona, K.H. Ahn, L. Wang, D.F. Mierke, J. Lucas-Lenard, and D.A. Kendall A cannabinoid receptor 1 mutation proximal to the DRY motif results in constitutive activity and reveals intramolecular interactions involved in receptor activation Brain Research 1108 2006 1 11 (Pubitemid 44278001)
    • (2006) Brain Research , vol.1108 , Issue.1 , pp. 1-11
    • D'Antona, A.M.1    Ahn, K.H.2    Wang, L.3    Mierke, D.F.4    Lucas-Lenard, J.5    Kendall, D.A.6
  • 7
    • 0035935802 scopus 로고    scopus 로고
    • Calculating free energies using average force
    • DOI 10.1063/1.1410978
    • E. Darve, and A. Pohorille Calculating free energies using average force The Journal of Chemical Physics 115 2001 9169 9183 (Pubitemid 33128021)
    • (2001) Journal of Chemical Physics , vol.115 , Issue.20 , pp. 9169-9183
    • Darve, E.1    Pohorille, A.2
  • 8
    • 50249156843 scopus 로고    scopus 로고
    • Selective structure-based virtual screening for full and partial agonists of the beta2 adrenergic receptor
    • C. de Graaf, and D. Rognan Selective structure-based virtual screening for full and partial agonists of the beta2 adrenergic receptor Journal of Medicinal Chemistry 51 2008 4978 4985
    • (2008) Journal of Medicinal Chemistry , vol.51 , pp. 4978-4985
    • De Graaf, C.1    Rognan, D.2
  • 15
    • 67650239912 scopus 로고    scopus 로고
    • Analysis of full and partial agonists binding to beta2-adrenergic receptor suggests a role of transmembrane helix v in agonist-specific conformational changes
    • V. Katritch, K.A. Reynolds, V. Cherezov, M.A. Hanson, C.B. Roth, and M. Yeager Analysis of full and partial agonists binding to beta2-adrenergic receptor suggests a role of transmembrane helix V in agonist-specific conformational changes Journal of Molecular Recognition 22 2009 307 318
    • (2009) Journal of Molecular Recognition , vol.22 , pp. 307-318
    • Katritch, V.1    Reynolds, K.A.2    Cherezov, V.3    Hanson, M.A.4    Roth, C.B.5    Yeager, M.6
  • 16
    • 0032973339 scopus 로고    scopus 로고
    • Relationships between ligand affinities for the cerebellar cannabinoid receptor CB1 and the induction of GDP/GTP exchange
    • DOI 10.1046/j.1471-4159.1999.0722379.x
    • C.S. Kearn, M.J. Greenberg, R. DiCamelli, K. Kurzawa, and C.J. Hillard Relationships between ligand affinities for the cerebellar cannabinoid receptor CB1 and the induction of GDP/GTP exchange Journal of Neurochemistry 72 1999 2379 2387 (Pubitemid 29242188)
    • (1999) Journal of Neurochemistry , vol.72 , Issue.6 , pp. 2379-2387
    • Kearn, C.S.1    Greenberg, M.J.2    DiCamelli, R.3    Kurzawa, K.4    Hillard, C.J.5
  • 17
    • 2142823785 scopus 로고    scopus 로고
    • Agonist binding: A multistep process
    • DOI 10.1124/mol.65.5.1060
    • B. Kobilka Agonist binding: A multistep process Molecular Pharmacology 65 2004 1060 1062 (Pubitemid 38543476)
    • (2004) Molecular Pharmacology , vol.65 , Issue.5 , pp. 1060-1062
    • Kobilka, B.1
  • 18
    • 34447633368 scopus 로고    scopus 로고
    • Conformational complexity of G-protein-coupled receptors
    • DOI 10.1016/j.tips.2007.06.003, PII S0165614707001459, Allosterism and Collateral Efficacy
    • B.K. Kobilka, and X. Deupi Conformational complexity of G-protein-coupled receptors Trends in Pharmacological Sciences 28 2007 397 406 (Pubitemid 47087966)
    • (2007) Trends in Pharmacological Sciences , vol.28 , Issue.8 , pp. 397-406
    • Kobilka, B.K.1    Deupi, X.2
  • 19
    • 79959564813 scopus 로고    scopus 로고
    • Agonist-bound adenosine A2A receptor structures reveal common features of GPCR activation
    • G. Lebon, T. Warne, P.C. Edwards, K. Bennett, C.J. Langmead, and A.G. Leslie Agonist-bound adenosine A2A receptor structures reveal common features of GPCR activation Nature 474 2011 521 525
    • (2011) Nature , vol.474 , pp. 521-525
    • Lebon, G.1    Warne, T.2    Edwards, P.C.3    Bennett, K.4    Langmead, C.J.5    Leslie, A.G.6
  • 20
  • 21
    • 0034333417 scopus 로고    scopus 로고
    • Inverse agonist properties of N-(piperidin-1-yl)-5-(4-chlorophenyl)-1-(2, 4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxamide HCl (SR141716A) and 1-(2-chlorophenyl)-4-cyano-5-(4-methoxyphenyl)-1H-pyrazole-3-carboxylic acid phenylamide (CP-272871) for the CB(1) cannabinoid receptor
    • J.P. Meschler, D.M. Kraichely, G.H. Wilken, and A.C. Howlett Inverse agonist properties of N-(piperidin-1-yl)-5-(4-chlorophenyl)-1-(2,4- dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxamide HCl (SR141716A) and 1-(2-chlorophenyl)-4-cyano-5-(4-methoxyphenyl)-1H-pyrazole-3-carboxylic acid phenylamide (CP-272871) for the CB(1) cannabinoid receptor Biochemical Pharmacology 60 2000 1315 1323
    • (2000) Biochemical Pharmacology , vol.60 , pp. 1315-1323
    • Meschler, J.P.1    Kraichely, D.M.2    Wilken, G.H.3    Howlett, A.C.4
  • 22
    • 0037452868 scopus 로고    scopus 로고
    • Sequence analyses of G-protein-coupled receptors: Similarities to rhodopsin
    • DOI 10.1021/bi027224+
    • T. Mirzadegan, G. Benkö, S. Filipek, and K. Palczewski Sequence analyses of G-protein-coupled receptors: similarities to rhodopsin Biochemistry 42 2003 2759 2767 (Pubitemid 36331518)
    • (2003) Biochemistry , vol.42 , Issue.10 , pp. 2759-2767
    • Mirzadegan, T.1    Benko, G.2    Filipek, S.3    Palczewski, K.4
  • 23
    • 78651411166 scopus 로고    scopus 로고
    • Structure of a nanobody-stabilized active state of the β(2) adrenoceptor
    • S.G. Rasmussen, H.J. Choi, J.J. Fung, E. Pardon, P. Casarosa, and P.S. Chae Structure of a nanobody-stabilized active state of the β(2) adrenoceptor Nature 469 2011 175 180
    • (2011) Nature , vol.469 , pp. 175-180
    • Rasmussen, S.G.1    Choi, H.J.2    Fung, J.J.3    Pardon, E.4    Casarosa, P.5    Chae, P.S.6
  • 26
    • 78751487961 scopus 로고    scopus 로고
    • A structural insight into the reorientation of transmembrane domains 3 and 5 during family A G protein-coupled receptor activation
    • K. Sansuk, X. Deupi, I.R. Torrecillas, A. Jongejan, S. Nijmeijer, and R.A. Bakker A structural insight into the reorientation of transmembrane domains 3 and 5 during family A G protein-coupled receptor activation Molecular Pharmacology 79 2011 262 269
    • (2011) Molecular Pharmacology , vol.79 , pp. 262-269
    • Sansuk, K.1    Deupi, X.2    Torrecillas, I.R.3    Jongejan, A.4    Nijmeijer, S.5    Bakker, R.A.6
  • 27
    • 0037174606 scopus 로고    scopus 로고
    • β2 adrenergic receptor activation: Modulation of the proline kink in transmembrane 6 by a rotamer toggle switch
    • DOI 10.1074/jbc.M206801200
    • L. Shi, G. Liapakis, R. Xu, F. Guarnieri, J.A. Ballesteros, and J.A. Javitch Beta2 adrenergic receptor activation. Modulation of the proline kink in transmembrane 6 by a rotamer toggle switch The Journal of Biological Chemistry 277 2002 40989 40996 (Pubitemid 35215688)
    • (2002) Journal of Biological Chemistry , vol.277 , Issue.43 , pp. 40989-40996
    • Shi, L.1    Liapakis, G.2    Xu, R.3    Guarnieri, F.4    Ballesteros, J.A.5    Javitch, J.A.6
  • 28
    • 80053038272 scopus 로고    scopus 로고
    • Identification of essential cannabinoid-binding domains: Structural insights into early dynamic events in receptor activation
    • J.-Y. Shim, A.C. Bertalovitz, and D.A. Kendall Identification of essential cannabinoid-binding domains: Structural insights into early dynamic events in receptor activation The Journal of Biological Chemistry 286 2011 33422 33435
    • (2011) The Journal of Biological Chemistry , vol.286 , pp. 33422-33435
    • Shim, J.-Y.1    Bertalovitz, A.C.2    Kendall, D.A.3
  • 31
    • 79953242234 scopus 로고    scopus 로고
    • The structural basis of agonist-induced activation in constitutively active rhodopsin
    • J. Standfuss, P.C. Edwards, A. D'Antona, M. Fransen, G. Xie, and D.D. Oprian The structural basis of agonist-induced activation in constitutively active rhodopsin Nature 471 2011 656 660
    • (2011) Nature , vol.471 , pp. 656-660
    • Standfuss, J.1    Edwards, P.C.2    D'Antona, A.3    Fransen, M.4    Xie, G.5    Oprian, D.D.6
  • 32
    • 20444499405 scopus 로고    scopus 로고
    • 2 adrenoceptor binding site with catechol reveals differences in binding and activation by agonists and partial agonists
    • DOI 10.1074/jbc.M502352200
    • G. Swaminath, X. Deupi, T.W. Lee, W. Zhu, F.S. Thian, and T.S. Kobilka Probing the beta2 adrenoceptor binding site with catechol reveals differences in binding and activation by agonists and partial agonists The Journal of Biological Chemistry 280 2005 22165 22171 (Pubitemid 40827872)
    • (2005) Journal of Biological Chemistry , vol.280 , Issue.23 , pp. 22165-22171
    • Swaminath, G.1    Deupi, X.2    Lee, T.W.3    Zhu, W.4    Thian, F.S.5    Kobilka, T.S.6    Kobilka, B.7
  • 33
    • 84871579031 scopus 로고    scopus 로고
    • PheVI:09 (Phe6.44) as a sliding micro-switch in 7TM G protein-coupled receptor activation
    • published online 7 November
    • Valentin-Hansen, L., Holst, B., Frimurer, T. M., & Schwartz, T. W. PheVI:09 (Phe6.44) as a sliding micro-switch in 7TM G protein-coupled receptor activation. The Journal of Biological Chemistry, http://www.jbc.org/cgi/doi/10. 1074/jbc.M112.395137; published online 7 November 2012.
    • (2012) The Journal of Biological Chemistry
    • Valentin-Hansen, L.1    Holst, B.2    Frimurer, T.M.3    Schwartz, T.W.4
  • 34
    • 0038729670 scopus 로고    scopus 로고
    • Measurement of the millisecond activation switch of G protein-coupled receptors in living cells
    • DOI 10.1038/nbt838
    • J.P. Vilardaga, M. Bünemann, C. Krasel, M. Castro, and M.J. Lohse Measurement of the millisecond activation switch of G protein-coupled receptors in living cells Nature Biotechnology 21 2003 807 812 (Pubitemid 36791401)
    • (2003) Nature Biotechnology , vol.21 , Issue.7 , pp. 807-812
    • Vilardaga, J.-P.1    Bunemann, M.2    Krasell, C.3    Castro, M.4    Lohse, M.J.5
  • 35
    • 84861064804 scopus 로고    scopus 로고
    • Crystal structures of a stabilized β1-adrenoceptor bound to the biased agonists bucindolol and carvedilol
    • T. Warne, P.C. Edwards, A.G. Leslie, and C.G. Tate Crystal structures of a stabilized β1-adrenoceptor bound to the biased agonists bucindolol and carvedilol Structure 20 2012 841 849
    • (2012) Structure , vol.20 , pp. 841-849
    • Warne, T.1    Edwards, P.C.2    Leslie, A.G.3    Tate, C.G.4
  • 36
    • 78651405537 scopus 로고    scopus 로고
    • The structural basis for agonist and partial agonist action on a β(1)-adrenergic receptor
    • T. Warne, R. Moukhametzianov, J.G. Baker, R. Nehmé, P.C. Edwards, and A.G. Leslie The structural basis for agonist and partial agonist action on a β(1)-adrenergic receptor Nature 469 2011 241 244
    • (2011) Nature , vol.469 , pp. 241-244
    • Warne, T.1    Moukhametzianov, R.2    Baker, J.G.3    Nehmé, R.4    Edwards, P.C.5    Leslie, A.G.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.