WNK1, the kinase mutated in an inherited high-blood-pressure syndrome, is a novel PKB (protein kinase B)/Akt substrate

Biochemical Journal

Volumn 378, Issue 1, 2004, Pages 257-268

  Vitari, Alberto C ^a   Deak, Maria ^a   Collins, Barry J ^a   Morrice, Nick ^a   Prescott, Alan R ^a   Phelan, Anne ^b   Humphreys, Sian ^b   Alessi, Dario R ^a  

^a UNIVERSITY OF DUNDEE   (United Kingdom)

^b PFIZER GLOBAL RESEARCH AND DEVELOPMENT   (United Kingdom)

Author keywords

3 phosphoinositide dependent protein kinase 1 (PDK1); Gordon's syndrome; Hypertension; Mass spectrometry (MS); Phosphoinositide 3 kinase (PI 3 kinase); Pseudohypoaldosteronism type II (PHAII)

Indexed keywords

ANTIBODIES; BLOOD; CATALYSIS; CELLS; ENZYME INHIBITION; INSULIN;

CELLULAR LOCALIZATION; HIGH BLOOD-PRESSURE SYNDROME; HYPERTENSION; PHOSPHORYLATION;

ENZYMES;

2 (2 CHLORO 4 IODOANILINO) N CYCLOPROPYLMETHOXY 3,4 DIFLUOROBENZAMIDE; 2 MORPHOLINO 8 PHENYLCHROMONE; MITOGEN ACTIVATED PROTEIN KINASE 1; MUTANT PROTEIN; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3 KINASE INHIBITOR; PROTEIN KINASE; PROTEIN KINASE B; PROTEIN KINASE WNK1; RAPAMYCIN; SOMATOMEDIN BINDING PROTEIN 1; THREONINE; UNCLASSIFIED DRUG; WORTMANNIN;

AMINO TERMINAL SEQUENCE; ARTICLE; BLOOD PRESSURE REGULATION; CELLULAR DISTRIBUTION; CONTROLLED STUDY; DRUG EFFECT; DRUG TARGETING; EMBRYO; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME LOCALIZATION; ENZYME PHOSPHORYLATION; ENZYME SUBSTRATE; GENE MUTATION; GENETIC DISORDER; HUMAN; HUMAN CELL; HYPERTENSION; IN VIVO STUDY; MAMMAL CELL; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION;

ANTIBODY SPECIFICITY; CATALYSIS; CELL LINE; HUMANS; HYPERTENSION; INSULIN-LIKE GROWTH FACTOR I; MUTATION; PHOSPHORYLATION; PHOSPHOTHREONINE; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-AKT; PSEUDOHYPOALDOSTERONISM; RIBOSOMAL PROTEIN S6 KINASES, 90-KDA; SYNDROME;

MAMMALIA;

EID: 1542314814     PISSN: 02646021     EISSN: None     Source Type: Journal    
DOI: 10.1042/BJ20031692     Document Type: Article

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