Fetal origin of endocrine dysfunction in the adult: The phthalate model

Journal of Steroid Biochemistry and Molecular Biology

Volumn 137, Issue , 2013, Pages 5-17

  Martinez Arguelles, D B ^a   Campioli, E ^a   Culty, M ^a,b   Zirkin, B R ^c   Papadopoulos, V ^a,b  

^a RESEARCH INSTITUTE OF THE MCGILL UNIVERSITY HEALTH CENTRE   (Canada)

^b MCGILL UNIVERSITY   (Canada)

^c JOHNS HOPKINS UNIVERSITY   (United States)

Author keywords

Endocrine disruptor; Environment; Phthalate; Sex differences; Steroid hormones

Indexed keywords

ALDOSTERONE; CHOLESTEROL; CHOLESTEROL MONOOXYGENASE (SIDE CHAIN CLEAVING); CORTICOSTERONE; DEOXYCORTICOSTERONE; ENDOCRINE DISRUPTOR; FOLLITROPIN; LUTEINIZING HORMONE; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PHTHALIC ACID BIS(2 ETHYLHEXYL) ESTER; PRASTERONE; PRASTERONE SULFATE; PREGNENOLONE; PROGESTERONE; STEROIDOGENIC ACUTE REGULATORY PROTEIN; TESTOSTERONE; THYROTROPIN;

ADULT DISEASE; ANDROGEN SYNTHESIS; BIOGENESIS; BIOSYNTHESIS; CHOLESTEROL TRANSPORT; ENDOCRINE DISEASE; FREE LIOTHYRONINE INDEX; GENE EXPRESSION; GRANULOSA CELL; LEYDIG CELL; LIVER CARCINOGENESIS; MITOCHONDRIAL MEMBRANE; MUELLERIAN DUCT; NERVE CELL DIFFERENTIATION; NONHUMAN; OVARY DEVELOPMENT; PRIMORDIAL GERM CELL; RENIN ANGIOTENSIN ALDOSTERONE SYSTEM; REVIEW; SERTOLI CELL; SEXUAL DEVELOPMENT; STEM CELL; STEROIDOGENESIS; TESTIS DEVELOPMENT; TESTOSTERONE BLOOD LEVEL; TESTOSTERONE SYNTHESIS; ZONA GLOMERULOSA;

2-ETHYLHEXANOIC ACID; 22R-HYDROXYCHOLESTEROL; 22R-OHC; ACTH; ADRENOCORTICOTROPIC HORMONE; ADULT LEYDIG CELLS; ALC; ANGIOTENSIN RECEPTOR; ATIIR; DEHP; DEHYDROEPIANDROSTERONE; DHEA; DHEAS; DI-(2-ETHYLHEXYL) PHTHALATE; EHXA; ENDOCRINE DISRUPTOR; ENVIRONMENT; FOLLICLE-STIMULATING HORMONE; FSH; GD; GESTATIONAL DAY; GNRH; GONADOTROPIN-RELEASING HORMONE; LH; LUTEINIZING HORMONE; MEHP; METHYLATION-SENSITIVE RESTRICTION FINGER PRINTING; MINERALOCORTICOID RECEPTOR; MIS; MONO(2-ETHYLHEXYL) PHTHALATE; MR; MSRF; MÜLLERIAN INHIBITORY SUBSTANCE; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR; PHTHALATE; PND; POLYVINYL CHLORIDE; POSTNATAL DAY; PPAR; PVC; REACTIVE OXYGEN SPECIES; ROS; SEX-DETERMINING REGION OF THE Y CHROMOSOME; SEX-DIFFERENCES; SRY; STAR; STEROID HORMONES; STEROIDOGENIC ACUTE REGULATORY PROTEIN; SULFATED DEHYDROEPIANDROSTERONE; T3; T4; TDS; TESTICULAR DYSGENESIS SYNDROME; THYROID STIMULATING HORMONE; THYROXINE; TRANSLOCATOR PROTEIN (18-KDA); TRIIODOTHYRONINE; TSH; TSPO; ZF; ZG; ZONA FASCICULATA; ZONA GLOMERULOSA; ZONA RETICULARIS; ZR;

ADULT; DIETHYLHEXYL PHTHALATE; ENDOCRINE DISRUPTORS; ENDOCRINE GLANDS; FEMALE; FETUS; HUMANS; MALE; MODELS, BIOLOGICAL; PREGNANCY; PRENATAL EXPOSURE DELAYED EFFECTS; STEROIDS;

ANIMALIA; RODENTIA;

EID: 84886585120     PISSN: 09600760     EISSN: 18791220     Source Type: Journal    
DOI: 10.1016/j.jsbmb.2013.01.007     Document Type: Review

References (184)

1. R. Kavlock, D. Barr, K. Boekelheide, W. Breslin, P. Breysse, R. Chapin, K. Gaido, E. Hodgson, M. Marcus, K. Shea, and P. Williams NTP-CERHR expert panel update on the reproductive and developmental toxicity of di(2-ethylhexyl) phthalate Reproductive Toxicology 22 2006 291 399
2. T. Schettler Human exposure to phthalates via consumer products International Journal of Andrology 29 2006 134 139
3. R. Hauser, and A.M. Calafat Phthalates and human health Occupational and Environmental Medicine 62 2005 806 818 (Pubitemid 41565017)
4. R.H. McKee, J.H. Butala, R.M. David, and G. Gans NTP center for the evaluation of risks to human reproduction reports on phthalates: addressing the data gaps Reproductive Toxicology 18 2004 1 22 (Pubitemid 38175443)
5. A.M. Calafat, L.L. Needham, M.J. Silva, and G. Lambert Exposure to di-(2-ethylhexyl) phthalate among premature neonates in a neonatal intensive care unit Pediatrics 113 2004 e429 e434
6. R. Green, R. Hauser, A.M. Calafat, J. Weuve, T. Schettler, S. Ringer, K. Huttner, and H. Hu Use of di(2-ethylhexyl) phthalate-containing medical products and urinary levels of mono(2-ethylhexyl) phthalate in neonatal intensive care unit infants Environmental Health Perspectives 113 2005 1222 1225 (Pubitemid 41387663)
7. J. Weuve, B.N. Sanchez, A.M. Calafat, T. Schettler, R.A. Green, H. Hu, and R. Hauser Exposure to phthalates in neonatal intensive care unit infants: urinary concentrations of monoesters and oxidative metabolites Environmental Health Perspectives 114 2006 1424 1431 (Pubitemid 44314769)
8. S. Bizzari, B. Oppenberg, and Y. Iskikawa Plasticizers 2000
9. M. Wormuth, M. Scheringer, M. Vollenweider, and K. Hungerbuhler What are the sources of exposure to eight frequently used phthalic acid esters in Europeans? Risk Analysis: An Official Publication of the Society for Risk Analysis 26 2006 803 824 (Pubitemid 43948196)
10. N.R. Janjua, H. Frederiksen, N.E. Skakkebaek, H.C. Wulf, and A.M. Andersson Urinary excretion of phthalates and paraben after repeated whole-body topical application in humans International Journal of Andrology 31 2008 118 130
11. H. Frederiksen, N.E. Skakkebaek, and A.M. Andersson Metabolism of phthalates in humans Molecular Nutrition & Food Research 51 2007 899 911 (Pubitemid 47173700)
12. U. Heudorf, V. Mersch-Sundermann, and J. Angerer Phthalates: toxicology and exposure International Journal of Hygiene and Environmental Health 210 2007 623 634 (Pubitemid 47539285)
13. L.P. Huang, C.C. Lee, P.C. Hsu, and T.S. Shih The association between semen quality in workers and the concentration of di(2-ethylhexyl) phthalate in polyvinyl chloride pellet plant air Fertility and Sterility 96 2011 90 94
14. J.J. Adibi, R. Hauser, P.L. Williams, R.M. Whyatt, A.M. Calafat, H. Nelson, R. Herrick, and S.H. Swan Maternal urinary metabolites of di-(2-ethylhexyl) phthalate in relation to the timing of labor in a US multicenter pregnancy cohort study American Journal of Epidemiology 169 2009 1015 1024
15. J.J. Adibi, F.P. Perera, W. Jedrychowski, D.E. Camann, D. Barr, R. Jacek, and R.M. Whyatt Prenatal exposures to phthalates among women in New York City and Krakow, Poland Environmental Health Perspectives 111 2003 1719 1722 (Pubitemid 37407930)
16. G. Latini, C. De Felice, G. Presta, A. Del Vecchio, I. Paris, F. Ruggieri, and P. Mazzeo In utero exposure to di-(2-ethylhexyl)phthalate and duration of human pregnancy Environmental Health Perspectives 111 2003 1783 1785 (Pubitemid 37419903)
17. S.H. Swan, K.M. Main, F. Liu, S.L. Stewart, R.L. Kruse, A.M. Calafat, C.S. Mao, J.B. Redmon, C.L. Ternand, S. Sullivan, J.L. Teague Study for Future Families Research Team Decrease in anogenital distance among male infants with prenatal phthalate exposure Environmental Health Perspectives 113 2005 1056 1061 (Pubitemid 41149638)
18. M.J. Silva, J.A. Reidy, A.R. Herbert, J.L. Preau Jr., L.L. Needham, and A.M. Calafat Detection of phthalate metabolites in human amniotic fluid Bulletin of Environmental Contamination and Toxicology 72 2004 1226 1231 (Pubitemid 38691464)
19. M.J. Silva, J.A. Reidy, E. Samandar, A.R. Herbert, L.L. Needham, and A.M. Calafat Detection of phthalate metabolites in human saliva Archives of Toxicology 79 2005 647 652 (Pubitemid 41618947)
20. A.M. Calafat, A.R. Slakman, M.J. Silva, A.R. Herbert, and L.L. Needham Automated solid phase extraction and quantitative analysis of human milk for 13 phthalate metabolites Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences 805 2004 49 56 (Pubitemid 38534402)
21. K.M. Main, G.K. Mortensen, M.M. Kaleva, K.A. Boisen, I.N. Damgaard, M. Chellakooty, I.M. Schmidt, A.M. Suomi, H.E. Virtanen, D.V. Petersen, A.M. Andersson, J. Toppari, and N.E. Skakkebaek Human breast milk contamination with phthalates and alterations of endogenous reproductive hormones in infants three months of age Environmental Health Perspectives 114 2006 270 276 (Pubitemid 43193651)
22. J. Zhu, S.P. Phillips, Y.L. Feng, and X. Yang Phthalate esters in human milk: concentration variations over a 6-month postpartum time Environmental Science & Technology 40 2006 5276 5281 (Pubitemid 44373087)
23. G.K. Mortensen, K.M. Main, A.M. Andersson, H. Leffers, and N.E. Skakkebaek Determination of phthalate monoesters in human milk, consumer milk, and infant formula by tandem mass spectrometry (LC-MS-MS) Analytical and Bioanalytical Chemistry 382 2005 1084 1092 (Pubitemid 40890969)
24. J.H. Petersen, and T. Breindahl Plasticizers in total diet samples, baby food and infant formulae Food Additives and Contaminants 17 2000 133 141 (Pubitemid 30160630)
25. J. Doull, R. Cattley, C. Elcombe, B.G. Lake, J. Swenberg, C. Wilkinson, G. Williams, and M. van Gemert A cancer risk assessment of di(2-ethylhexyl) phthalate: application of the new U.S. EPA Risk Assessment Guidelines Regulatory Toxicology and Pharmacology: RTP 29 1999 327 357 (Pubitemid 29323788)
26. H.M. Koch, H. Drexler, and J. Angerer An estimation of the daily intake of di(2-ethylhexyl)phthalate (DEHP) and other phthalates in the general population International Journal of Hygiene and Environmental Health 206 2003 77 83 (Pubitemid 36356389)
27. H. Frederiksen, L. Aksglaede, K. Sorensen, N.E. Skakkebaek, A. Juul, and A.M. Andersson Urinary excretion of phthalate metabolites in 129 healthy Danish children and adolescents: estimation of daily phthalate intake Environmental Research 111 2011 656 663
28. G. Pan, T. Hanaoka, M. Yoshimura, S. Zhang, P. Wang, H. Tsukino, K. Inoue, H. Nakazawa, S. Tsugane, and K. Takahashi Decreased serum free testosterone in workers exposed to high levels of di-n-butyl phthalate (DBP) and di-2-ethylhexyl phthalate (DEHP): a cross-sectional study in China Environmental Health Perspectives 114 2006 1643 1648 (Pubitemid 44718267)
29. N. Pant, M. Shukla, P.D. Kumar, Y. Shukla, N. Mathur, G.Y. Kumar, and D.K. Saxena Correlation of phthalate exposures with semen quality Toxicology and Applied Pharmacology 231 2008 112 116
30. R. Hauser, J.D. Meeker, N.P. Singh, M.J. Silva, L. Ryan, S. Duty, and A.M. Calafat DNA damage in human sperm is related to urinary levels of phthalate monoester and oxidative metabolites Human Reproduction 22 2007 688 695
31. K.P. Phillips, and N. Tanphaichitr Human exposure to endocrine disrupters and semen quality Journal of Toxicology and Environmental Health. Part B: Critical Reviews 11 2008 188 220 (Pubitemid 351451258)
32. H.O. Adami, R. Bergstrom, M. Mohner, W. Zatonski, H. Storm, A. Ekbom, S. Tretli, L. Teppo, H. Ziegler, and M. Rahu Testicular cancer in nine northern European countries Journal international du cancer International Journal of Cancer 59 1994 33 38
33. J.S. Fisher, S. Macpherson, N. Marchetti, and R.M. Sharpe Human 'testicular dysgenesis syndrome': a possible model using in-utero exposure of the rat to dibutyl phthalate Human Reproduction 18 2003 1383 1394 (Pubitemid 36840943)
34. N.E. Skakkebaek, E. Rajpert-De Meyts, and K.M. Main Testicular dysgenesis syndrome: an increasingly common developmental disorder with environmental aspects Human Reproduction 16 2001 972 978 (Pubitemid 32451837)
35. J.S. Fisher Environmental anti-androgens and male reproductive health: focus on phthalates and testicular dysgenesis syndrome Reproduction 127 2004 305 315 (Pubitemid 38425690)
36. K.A. Boisen, M. Chellakooty, I.M. Schmidt, C.M. Kai, I.N. Damgaard, A.M. Suomi, J. Toppari, N.E. Skakkebaek, and K.M. Main Hypospadias in a cohort of 1072 Danish newborn boys: prevalence and relationship to placental weight, anthropometrical measurements at birth, and reproductive hormone levels at three months of age Journal of Clinical Endocrinology and Metabolism 90 2005 4041 4046 (Pubitemid 41058169)
37. K.A. Boisen, M. Kaleva, K.M. Main, H.E. Virtanen, A.M. Haavisto, I.M. Schmidt, M. Chellakooty, I.N. Damgaard, C. Mau, M. Reunanen, N.E. Skakkebaek, and J. Toppari Difference in prevalence of congenital cryptorchidism in infants between two Nordic countries Lancet 363 2004 1264 1269 (Pubitemid 38496487)
38. E. Huyghe, P. Plante, and P.F. Thonneau Testicular cancer variations in time and space in Europe European Urology 51 2007 621 628 (Pubitemid 46097270)
39. R.T. Preiksa, B. Zilaitiene, V. Matulevicius, N.E. Skakkebaek, J.H. Petersen, N. Jorgensen, and J. Toppari Higher than expected prevalence of congenital cryptorchidism in Lithuania: a study of 1204 boys at birth and 1 year follow-up Human Reproduction 20 2005 1928 1932 (Pubitemid 40932379)
40. E. Carlsen, A. Giwercman, N. Keiding, and N.E. Skakkebaek Evidence for decreasing quality of semen during past 50 years BMJ 305 1992 609 613
41. N. Jorgensen, C. Asklund, E. Carlsen, and N.E. Skakkebaek Coordinated European investigations of semen quality: results from studies of Scandinavian young men is a matter of concern International Journal of Andrology 29 2006 54 61
42. N. Jorgensen, E. Carlsen, I. Nermoen, M. Punab, J. Suominen, A.G. Andersen, A.M. Andersson, T.B. Haugen, A. Horte, T.K. Jensen, O. Magnus, J.H. Petersen, M. Vierula, J. Toppari, and N.E. Skakkebaek East-West gradient in semen quality in the Nordic-Baltic area: a study of men from the general population in Denmark, Norway, Estonia and Finland Human Reproduction 17 2002 2199 2208
43. D.B. Martinez-Arguelles, T. Guichard, M. Culty, B.R. Zirkin, and V. Papadopoulos In utero exposure to the antiandrogen di-(2-ethylhexyl) phthalate decreases adrenal aldosterone production in the adult rat Biology of Reproduction 85 2011 51 61
44. E.E. Baulieu Neurosteroids: a novel function of the brain Psychoneuroendocrinology 23 1998 963 987 (Pubitemid 29049302)
45. R.C. Brown, C. Cascio, and V. Papadopoulos Pathways of neurosteroid biosynthesis in cell lines from human brain: regulation of dehydroepiandrosterone formation by oxidative stress and beta-amyloid peptide Journal of Neurochemistry 74 2000 847 859 (Pubitemid 30053759)
46. S.H. Mellon, and L.D. Griffin Neurosteroids: biochemistry and clinical significance Trends in Endocrinology and Metabolism: TEM 13 2002 35 43 (Pubitemid 36734014)
47. K.M. Kayes-Wandover, and P.C. White Steroidogenic enzyme gene expression in the human heart Journal of Clinical Endocrinology and Metabolism 85 2000 2519 2525 (Pubitemid 32269210)
48. P.C. White Aldosterone: direct effects on and production by the heart Journal of Clinical Endocrinology and Metabolism 88 2003 2376 2383 (Pubitemid 36733544)
49. M.J. Young, C.D. Clyne, T.J. Cole, and J.W. Funder Cardiac steroidogenesis in the normal and failing heart Journal of Clinical Endocrinology and Metabolism 86 2001 5121 5126 (Pubitemid 33070224)
50. C.R. Jefcoate Liver, X receptor opens a new gateway to StAR and to steroid hormones Journal of Clinical Investigation 116 2006 1832 1835 (Pubitemid 44033305)
51. M.B. Rone, J. Fan, and V. Papadopoulos Cholesterol transport in steroid biosynthesis: role of protein-protein interactions and implications in disease states Biochimica et Biophysica Acta 1791 2009 646 658
52. H.A. Lavoie, and S.R. King Transcriptional regulation of steroidogenic genes: STARD1, CYP11A1 and HSD3B Experimental Biology and Medicine 234 2009 880 907
53. B.J. Brock, and M.R. Waterman Biochemical differences between rat and human cytochrome P450c17 support the different steroidogenic needs of these two species Biochemistry 38 1999 1598 1606
54. G. Pelletier, S. Li, V. Luu-The, Y. Tremblay, A. Belanger, and F. Labrie Immunoelectron microscopic localization of three key steroidogenic enzymes (cytochrome P450(scc), 3 beta-hydroxysteroid dehydrogenase and cytochrome P450(c17)) in rat adrenal cortex and gonads Journal of Endocrinology 171 2001 373 383 (Pubitemid 33061715)
55. L.M. Perkins, and A.H. Payne Quantification of P450scc, P450(17) alpha, and iron sulfur protein reductase in Leydig cells and adrenals of inbred strains of mice Endocrinology 123 1988 2675 2682 (Pubitemid 19012780)
56. M. Saitou, S.C. Barton, and M.A. Surani A molecular programme for the specification of germ cell fate in mice Nature 418 2002 293 300 (Pubitemid 34790674)
57. M. Ginsburg, M.H. Snow, and A. McLaren Primordial germ cells in the mouse embryo during gastrulation Development 110 1990 521 528 (Pubitemid 20330528)
58. T. Jiang, C.C. Hou, Z.Y. She, W.X. Yang, The SOX gene family: function and regulation in testis determination and male fertility maintenance, Molecular Biology Reports (2012), in press, PMID: 23184044.
59. P. Koopman, A. Munsterberg, B. Capel, N. Vivian, and R. Lovell-Badge Expression of a candidate sex-determining gene during mouse testis differentiation Nature 348 1990 450 452 (Pubitemid 120015087)
60. P. Koopman Gonad development: signals for sex Current Biology: CB 11 2001 R481 R483
61. D.W. Lording, and D.M. De Kretser Comparative ultrastructural and histochemical studies of the interstitial cells of the rat testis during fetal and postnatal development Journal of Reproduction and Fertility 29 1972 261 269
62. E.C. Roosen-Runge, and D. Anderson The development of the interstitial cells in the testis of the albino rat Acta Anatomica 37 1959 125 137
63. R.P. Vergouwen, S.G. Jacobs, R. Huiskamp, J.A. Davids, and D.G. de Rooij Proliferative activity of gonocytes, Sertoli cells and interstitial cells during testicular development in mice Journal of Reproduction and Fertility 93 1991 233 243
64. A.G. Byskov Differentiation of mammalian embryonic gonad Physiological Reviews 66 1986 71 117
65. M.P. Hardy, B.R. Zirkin, and L.L. Ewing Kinetic studies on the development of the adult population of Leydig cells in testes of the pubertal rat Endocrinology 124 1989 762 770 (Pubitemid 19057066)
66. G. Majdic, P.T. Saunders, and K.J. Teerds Immunoexpression of the steroidogenic enzymes 3-beta hydroxysteroid dehydrogenase and 17 alpha-hydroxylase, C17,20 lyase and the receptor for luteinizing hormone (LH) in the fetal rat testis suggests that the onset of Leydig cell steroid production is independent of LH action Biology of Reproduction 58 1998 520 525 (Pubitemid 28099119)
67. H.B. Ariyaratne, and S. Chamindrani Mendis-Handagama Changes in the testis interstitium of Sprague Dawley rats from birth to sexual maturity Biology of Reproduction 62 2000 680 690 (Pubitemid 30118309)
68. M.E. Pepling, and A.C. Spradling Female mouse germ cells form synchronously dividing cysts Development 125 1998 3323 3328 (Pubitemid 28458332)
69. C.R. Nicholas, K.M. Haston, and R.A. Pera Intact fetal ovarian cord formation promotes mouse oocyte survival and development BMC Developmental Biology 10 2010 2
70. M.E. Pepling, and A.C. Spradling Mouse ovarian germ cell cysts undergo programmed breakdown to form primordial follicles Developmental Biology 234 2001 339 351 (Pubitemid 32552663)
71. M.A. Sarraj, and A.E. Drummond Mammalian foetal ovarian development: consequences for health and disease Reproduction 143 2012 151 163
72. A.M. Zama, and M. Uzumcu Epigenetic effects of endocrine-disrupting chemicals on female reproduction: an ovarian perspective Frontiers in Neuroendocrinology 31 2010 420 439
73. O. Hatano, A. Takakusu, M. Nomura, and K. Morohashi Identical origin of adrenal cortex and gonad revealed by expression profiles of Ad4BP/SF-1 Genes to Cells: Devoted to Molecular & Cellular Mechanisms 1 1996 663 671 (Pubitemid 126673156)
74. T.B. Dunn Normal and pathologic anatomy of the adrenal gland of the mouse, including neoplasms Journal of the National Cancer Institute 44 1970 1323 1389
75. S. Tanaka, and A. Matsuzawa Comparison of adrenocortical zonation in C57BL/6J and DDD mice Experimental Animals 44 1995 285 291
76. S. Mesiano, and R.B. Jaffe Developmental and functional biology of the primate fetal adrenal cortex Endocrine Reviews 18 1997 378 403 (Pubitemid 27246882)
77. A.M. Calafat, X. Ye, M.J. Silva, Z. Kuklenyik, and L.L. Needham Human exposure assessment to environmental chemicals using biomonitoring International Journal of Andrology 29 2006 166 171
78. J.E. Klaunig, M.A. Babich, K.P. Baetcke, J.C. Cook, J.C. Corton, R.M. David, J.G. DeLuca, D.Y. Lai, R.H. McKee, J.M. Peters, R.A. Roberts, and P.A. Fenner-Crisp PPARalpha agonist-induced rodent tumors: modes of action and human relevance Critical Reviews in Toxicology 33 2003 655 780 (Pubitemid 38037444)
79. I. Rusyn, J.M. Peters, and M.L. Cunningham Modes of action and species-specific effects of di-(2-ethylhexyl)phthalate in the liver Critical Reviews in Toxicology 36 2006 459 479 (Pubitemid 43904319)
80. H.M. Koch, H.M. Bolt, R. Preuss, and J. Angerer New metabolites of di(2-ethylhexyl)phthalate (DEHP) in human urine and serum after single oral doses of deuterium-labelled DEHP Archives of Toxicology 79 2005 367 376 (Pubitemid 41040172)
81. M.J. Silva, E. Samandar, J.L. Preau Jr., L.L. Needham, and A.M. Calafat Urinary oxidative metabolites of di(2-ethylhexyl) phthalate in humans Toxicology 219 2006 22 32 (Pubitemid 43120703)
82. W.W. Huber, B. Grasl-Kraupp, and R. Schulte-Hermann Hepatocarcinogenic potential of di(2-ethylhexyl)phthalate in rodents and its implications on human risk Critical Reviews in Toxicology 26 1996 365 481 (Pubitemid 26242495)
83. R.K. Gupta, J.M. Singh, T.C. Leslie, S. Meachum, J.A. Flaws, and H.H. Yao Di-(2-ethylhexyl) phthalate and mono-(2-ethylhexyl) phthalate inhibit growth and reduce estradiol levels of antral follicles in vitro Toxicology and Applied Pharmacology 242 2010 224 230
84. H.M. Koch, H.M. Bolt, and J. Angerer Di(2-ethylhexyl)phthalate, (DEHP) metabolites in human urine and serum after a single oral dose of deuterium-labelled DEHP Archives of Toxicology 78 2004 123 130 (Pubitemid 38657193)
85. H.M. Koch, R. Preuss, and J. Angerer Di(2-ethylhexyl)phthalate, (DEHP): human metabolism and internal exposure - an update and latest results International Journal of Andrology 29 2006 155 165
86. M.J. Silva, D.B. Barr, J.A. Reidy, K. Kato, N.A. Malek, C.C. Hodge, D. Hurtz III, A.M. Calafat, L.L. Needham, and J.W. Brock Glucuronidation patterns of common urinary and serum monoester phthalate metabolites Archives of Toxicology 77 2003 561 567 (Pubitemid 37378476)
87. H.J. Koo, and B.M. Lee Toxicokinetic relationship between di(2-ethylhexyl) phthalate (DEHP) and mono(2-ethylhexyl) phthalate in rats Journal of Toxicology and Environmental Health. Part A 70 2007 383 387 (Pubitemid 46514943)
88. W. Kessler, W. Numtip, W. Volkel, E. Seckin, G.A. Csanady, C. Putz, D. Klein, H. Fromme, and J.G. Filser Kinetics of di(2-ethylhexyl) phthalate (DEHP) and mono(2-ethylhexyl) phthalate in blood and of DEHP metabolites in urine of male volunteers after single ingestion of ring-deuterated DEHP Toxicology and Applied Pharmacology 264 2012 284 291
89. W.A. Anderson, L. Castle, M.J. Scotter, R.C. Massey, and C. Springall A biomarker approach to measuring human dietary exposure to certain phthalate diesters Food Additives and Contaminants 18 2001 1068 1074 (Pubitemid 33107596)
90. R. Hauser, J.D. Meeker, S. Park, M.J. Silva, and A.M. Calafat Temporal variability of urinary phthalate metabolite levels in men of reproductive age Environmental Health Perspectives 112 2004 1734 1740 (Pubitemid 40017296)
91. J. Berger, and D.E. Moller The mechanisms of action of PPARs Annual Review of Medicine 53 2002 409 435 (Pubitemid 34177889)
92. E.K. Maloney, and D.J. Waxman trans-Activation of PPARalpha and PPARgamma by structurally diverse environmental chemicals Toxicology and Applied Pharmacology 161 1999 209 218
93. R.B. Clark The role of PPARs in inflammation and immunity Journal of Leukocyte Biology 71 2002 388 400
94. M.R. Hill, S. Clarke, K. Rodgers, B. Thornhill, J.M. Peters, F.J. Gonzalez, and J.M. Gimble Effect of peroxisome proliferator-activated receptor alpha activators on tumor necrosis factor expression in mice during endotoxemia Infection and Immunity 67 1999 3488 3493 (Pubitemid 29291520)
95. C.H. Hurst, and D.J. Waxman Activation of PPARalpha and PPARgamma by environmental phthalate monoesters Toxicological Sciences: An Official Journal of the Society of Toxicology 74 2003 297 308 (Pubitemid 36958298)
96. C. Cheung, T.E. Akiyama, J.M. Ward, C.J. Nicol, L. Feigenbaum, C. Vinson, and F.J. Gonzalez Diminished hepatocellular proliferation in mice humanized for the nuclear receptor peroxisome proliferator-activated receptor alpha Cancer Research 64 2004 3849 3854 (Pubitemid 38697295)
97. B.D. Astill, R. Gingell, D. Guest, J. Hellwig, J.R. Hodgson, K. Kuettler, W. Mellert, S.R. Murphy, R.L. Sielken Jr., and T.R. Tyler Oncogenicity testing of 2-ethylhexanol in Fischer 344 rats and B6C3F1 mice Fundamental and Applied Toxicology: Official Journal of the Society of Toxicology 31 1996 29 41
98. W.M. Kluwe, J.E. Huff, H.B. Matthews, R. Irwin, and J.K. Haseman Comparative chronic toxicities and carcinogenic potentials of 2-ethylhexyl-containing compounds in rats and mice Carcinogenesis 6 1985 1577 1583 (Pubitemid 16251949)
99. Y. Ito, T. Nakamura, Y. Yanagiba, D.H. Ramdhan, N. Yamagishi, H. Naito, M. Kamijima, F.J. Gonzalez, and T. Nakajima Plasticizers may activate human hepatic peroxisome proliferator-activated receptor alpha less than that of a mouse but may activate constitutive androstane receptor in liver PPAR Research 2012 2012 201284
100. H. Ren, L.M. Aleksunes, C. Wood, B. Vallanat, M.H. George, C.D. Klaassen, and J.C. Corton Characterization of peroxisome proliferator-activated receptor alpha-independent effects of PPARalpha activators in the rodent liver: di-(2-ethylhexyl) phthalate also activates the constitutive-activated receptor Toxicological Sciences: An Official Journal of the Society of Toxicology 113 2010 45 59
101. J.M. Ward, J.M. Peters, C.M. Perella, and F.J. Gonzalez Receptor and nonreceptor-mediated organ-specific toxicity of di(2-ethylhexyl)phthalate (DEHP) in peroxisome proliferator-activated receptor alpha-null mice Toxicologic Pathology 26 1998 240 246 (Pubitemid 28155330)
102. A. Eveillard, L. Mselli-Lakhal, A. Mogha, F. Lasserre, A. Polizzi, J.M. Pascussi, H. Guillou, P.G. Martin, and T. Pineau Di-(2-ethylhexyl)-phthalate, (DEHP) activates the constitutive androstane receptor (CAR): a novel signalling pathway sensitive to phthalates Biochemical Pharmacology 77 2009 1735 1746
103. Y. Ito, O. Yamanoshita, N. Asaeda, Y. Tagawa, C.H. Lee, T. Aoyama, G. Ichihara, K. Furuhashi, M. Kamijima, F.J. Gonzalez, and T. Nakajima Di(2-ethylhexyl)phthalate induces hepatic tumorigenesis through a peroxisome proliferator-activated receptor alpha-independent pathway Journal of Occupational Health 49 2007 172 182 (Pubitemid 47036465)
104. P. Sjoberg, U. Bondesson, T.J. Gray, and L. Ploen Effects of di-(2-ethylhexyl) phthalate and five of its metabolites on rat testis in vivo and in in vitro Acta Pharmacologica et Toxicologica 58 1986 225 233 (Pubitemid 16080515)
105. L.E. Gray Jr., J. Ostby, J. Furr, M. Price, D.N. Veeramachaneni, and L. Parks Perinatal exposure to the phthalates DEHP, BBP, and DINP, but not DEP, DMP, or DOTP, alters sexual differentiation of the male rat Toxicological Sciences: An Official Journal of the Society of Toxicology 58 2000 350 365 (Pubitemid 32042433)
106. D.J. Macleod, R.M. Sharpe, M. Welsh, M. Fisken, H.M. Scott, G.R. Hutchison, A.J. Drake, and S. van den Driesche Androgen action in the masculinization programming window and development of male reproductive organs International Journal of Andrology 33 2010 279 287
107. E. Mylchreest, R.C. Cattley, and P.M. Foster Male reproductive tract malformations in rats following gestational and lactational exposure to Di(n-butyl) phthalate: an antiandrogenic mechanism? Toxicological Sciences: An Official Journal of the Society of Toxicology 43 1998 47 60 (Pubitemid 28255935)
108. L.E. Gray, J. Ostby, J. Furr, C.J. Wolf, C. Lambright, L. Parks, D.N. Veeramachaneni, V. Wilson, M. Price, A. Hotchkiss, E. Orlando, and L. Guillette Effects of environmental antiandrogens on reproductive development in experimental animals Human Reproduction Update 7 2001 248 264 (Pubitemid 32440287)
109. C. Wolf Jr., C. Lambright, P. Mann, M. Price, R.L. Cooper, J. Ostby, and L.E. Gray Jr. Administration of potentially antiandrogenic pesticides (procymidone, linuron, iprodione, chlozolinate, p,p′-DDE, and ketoconazole) and toxic substances (dibutyl- and diethylhexyl phthalate, PCB 169, and ethane dimethane sulphonate) during sexual differentiation produces diverse profiles of reproductive malformations in the male rat Toxicology and Industrial Health 15 1999 94 118 (Pubitemid 30484120)
110. C.J. Wolf, G.A. LeBlanc, J.S. Ostby, and L.E. Gray Jr. Characterization of the period of sensitivity of fetal male sexual development to vinclozolin Toxicological Sciences: An Official Journal of the Society of Toxicology 55 2000 152 161 (Pubitemid 30252446)
111. M. Culty, R. Thuillier, W. Li, Y. Wang, D.B. Martinez-Arguelles, C.G. Benjamin, K.M. Triantafilou, B.R. Zirkin, and V. Papadopoulos In utero exposure to di-(2-ethylhexyl) phthalate exerts both short-term and long-lasting suppressive effects on testosterone production in the rat Biology of Reproduction 78 2008 1018 1028 (Pubitemid 351749307)
112. V.D. Shultz, S. Phillips, M. Sar, P.M. Foster, and K.W. Gaido Altered gene profiles in fetal rat testes after in utero exposure to di(n-butyl) phthalate Toxicological Sciences: An Official Journal of the Society of Toxicology 64 2001 233 242 (Pubitemid 33130315)
113. D.B. Martinez-Arguelles, M. Culty, B.R. Zirkin, and V. Papadopoulos In utero exposure to di-(2-ethylhexyl) phthalate decreases mineralocorticoid receptor expression in the adult testis Endocrinology 150 2009 5575 5585
114. J. Jiang, L. Ma, L. Yuan, X. Wang, and W. Zhang Study on developmental abnormalities in hypospadiac male rats induced by maternal exposure to di-n-butyl phthalate (DBP) Toxicology 232 2007 286 293 (Pubitemid 46441619)
115. R.S. Ge, Q. Dong, C.M. Sottas, S.A. Latif, D.J. Morris, and M.P. Hardy Stimulation of testosterone production in rat Leydig cells by aldosterone is mineralocorticoid receptor mediated Molecular and Cellular Endocrinology 243 2005 35 42 (Pubitemid 41573681)
116. H.P. Brun, J.F. Leonard, V. Moronvalle, J.M. Caillaud, C. Melcion, and A. Cordier Pig Leydig cell culture: a useful in vitro test for evaluating the testicular toxicity of compounds Toxicology and Applied Pharmacology 108 1991 307 320
117. R.H. Menard, D.L. Loriaux, F.C. Bartter, and J.R. Gillette The effect of the administration of spironolactone on the concentration of plasma testosterone, estradiol and cortisol in male dogs (1) Steroids 31 1978 771 782 (Pubitemid 9119854)
118. R.S. Ge, Q. Dong, C.M. Sottas, H. Chen, B.R. Zirkin, and M.P. Hardy Gene expression in rat leydig cells during development from the progenitor to adult stage: a cluster analysis Biology of Reproduction 72 2005 1405 1415 (Pubitemid 40696083)
119. V. Supornsilchai, O. Soder, and K. Svechnikov Stimulation of the pituitary-adrenal axis and of adrenocortical steroidogenesis ex vivo by administration of di-2-ethylhexyl phthalate to prepubertal male rats Journal of Endocrinology 192 2007 33 39 (Pubitemid 46444393)
120. N.G. Hattangady, L.O. Olala, W.B. Bollag, and W.E. Rainey Acute and chronic regulation of aldosterone production Molecular and Cellular Endocrinology 350 2012 151 162
121. J.H. Dees, M. Gazouli, and V. Papadopoulos Effect of mono-ethylhexyl phthalate on MA-10 Leydig tumor cells Reproductive Toxicology 15 2001 171 187 (Pubitemid 32377809)
122. G.G. Botelho, M. Golin, A.C. Bufalo, R.N. Morais, P.R. Dalsenter, and A.J. Martino-Andrade Reproductive effects of di(2-ethylhexyl)phthalate in immature male rats and its relation to cholesterol, testosterone, and thyroxin levels Archives of Environmental Contamination and Toxicology 57 2009 777 784
123. K. Svechnikov, I. Svechnikova, and O. Soder Inhibitory effects of mono-ethylhexyl phthalate on steroidogenesis in immature and adult rat Leydig cells in vitro Reproductive Toxicology 25 2008 485 490
124. I. Svechnikova, K. Svechnikov, and O. Soder The influence of di-(2-ethylhexyl) phthalate on steroidogenesis by the ovarian granulosa cells of immature female rats Journal of Endocrinology 194 2007 603 609 (Pubitemid 47471228)
125. K. Liu, K.P. Lehmann, M. Sar, S.S. Young, and K.W. Gaido Gene expression profiling following in utero exposure to phthalate esters reveals new gene targets in the etiology of testicular dysgenesis Biology of Reproduction 73 2005 180 192 (Pubitemid 40863613)
126. K.J. Johnson, E.N. McDowell, M.P. Viereck, and J.Q. Xia Species-specific dibutyl phthalate fetal testis endocrine disruption correlates with inhibition of SREBP2-dependent gene expression pathways Toxicological Sciences 120 2011 460 474
127. D. Gunnarsson, P. Leffler, E. Ekwurtzel, G. Martinsson, K. Liu, and G. Selstam Mono-(2-ethylhexyl) phthalate stimulates basal steroidogenesis by a cAMP-independent mechanism in mouse gonadal cells of both sexes Reproduction 135 2008 693 703 (Pubitemid 351698616)
128. J. Fan, K. Traore, W. Li, H. Amri, H. Huang, C. Wu, H. Chen, B. Zirkin, and V. Papadopoulos Molecular mechanisms mediating the effect of mono-(2-ethylhexyl) phthalate on hormone-stimulated steroidogenesis in MA-10 mouse tumor Leydig cells Endocrinology 151 2010 3348 3362
129. H. Lin, R.S. Ge, G.R. Chen, G.X. Hu, L. Dong, Q.Q. Lian, D.O. Hardy, C.M. Sottas, X.K. Li, and M.P. Hardy Involvement of testicular growth factors in fetal Leydig cell aggregation after exposure to phthalate in utero Proceedings of the National Academy of Sciences of the United States of America 105 2008 7218 7222 (Pubitemid 351754458)
130. D.B. Martinez-Arguelles, R.H. McKee, C.V. Rohlicek, M. Culty, B.R. Zirkin, and V. Papadopoulos Maternal in utero exposure to the endocrine disruptor di-(2-ethylhexyl) phthalate affects the blood pressure of adult male offspring Toxicology and Applied Pharmacology 266 2013 95 100
131. T. Tanida, K. Warita, K. Ishihara, S. Fukui, T. Mitsuhashi, T. Sugawara, Y. Tabuchi, T. Nanmori, W.M. Qi, T. Inamoto, T. Yokoyama, H. Kitagawa, and N. Hoshi Fetal and neonatal exposure to three typical environmental chemicals with different mechanisms of action: mixed exposure to phenol, phthalate, and dioxin cancels the effects of sole exposure on mouse midbrain dopaminergic nuclei Toxicology Letters 189 2009 40 47
132. C.R. Dhanya, A.R. Indu, K.V. Deepadevi, and P.A. Kurup Inhibition of membrane Na(+)-K+ Atpase of the brain, liver and RBC in rats administered di(2-ethyl hexyl) phthalate (DEHP) a plasticizer used in polyvinyl chloride (PVC) blood storage bags Indian Journal of Experimental Biology 41 2003 814 820 (Pubitemid 36953550)
133. Y. Xu, S. Agrawal, T.J. Cook, and G.T. Knipp Di-(2-ethylhexyl)-phthalate affects lipid profiling in fetal rat brain upon maternal exposure Archives of Toxicology 81 2007 57 62 (Pubitemid 46115458)
134. Y. Masuo, M. Morita, S. Oka, and M. Ishido Motor hyperactivity caused by a deficit in dopaminergic neurons and the effects of endocrine disruptors: a study inspired by the physiological roles of PACAP in the brain Regulatory Peptides 123 2004 225 234 (Pubitemid 39424171)
135. C. Voss, H. Zerban, P. Bannasch, and M.R. Berger Lifelong exposure to di-(2-ethylhexyl)-phthalate induces tumors in liver and testes of Sprague-Dawley rats Toxicology 206 2005 359 371 (Pubitemid 39601021)
136. P. Englebienne The serum steroid transport proteins: biochemistry and clinical significance Molecular Aspects of Medicine 7 1984 313 396 (Pubitemid 15207794)
137. J.D. Meeker, A.M. Calafat, and R. Hauser Di(2-ethylhexyl) phthalate metabolites may alter thyroid hormone levels in men Environmental Health Perspectives 115 2007 1029 1034 (Pubitemid 47317067)
138. P.C. Huang, P.L. Kuo, Y.L. Guo, P.C. Liao, and C.C. Lee Associations between urinary phthalate monoesters and thyroid hormones in pregnant women Human Reproduction 22 2007 2715 2722
139. J.A. Howarth, S.C. Price, M. Dobrota, P.A. Kentish, and R.H. Hinton Effects on male rats of di-(2-ethylhexyl) phthalate and di-n-hexylphthalate administered alone or in combination Toxicology Letters 121 2001 35 43 (Pubitemid 32324123)
140. R. Poon, P. Lecavalier, R. Mueller, V.E. Valli, B.G. Procter, and I. Chu Subchronic oral toxicity of di-n-octyl phthalate and di(2-Ethylhexyl) phthalate in the rat Food and Chemical Toxicology 35 1997 225 239 (Pubitemid 27187457)
141. R.H. Hinton, F.E. Mitchell, A. Mann, D. Chescoe, S.C. Price, A. Nunn, P. Grasso, and J.W. Bridges Effects of phthalic acid esters on the liver and thyroid Environmental Health Perspectives 70 1986 195 210 (Pubitemid 17034351)
142. D.J. Barker The fetal and infant origins of adult disease BMJ 301 1990 1111 (Pubitemid 20387183)
143. S. Wu, J. Zhu, Y. Li, T. Lin, L. Gan, X. Yuan, J. Xiong, X. Liu, M. Xu, D. Zhao, C. Ma, X. Li, and G. Wei Dynamic epigenetic changes involved in testicular toxicity induced by di-2-(ethylhexyl) phthalate in mice Basic & Clinical Pharmacology & Toxicology 106 2010 118 123
144. S. Wu, J. Zhu, Y. Li, T. Lin, L. Gan, X. Yuan, M. Xu, and G. Wei Dynamic effect of di-2-(ethylhexyl) phthalate on testicular toxicity: epigenetic changes and their impact on gene expression International Journal of Toxicology 29 2010 193 200
145. D.B. Martinez-Arguelles, and V. Papadopoulos Epigenetic regulation of the expression of genes involved in steroid hormone biosynthesis and action Steroids 75 2010 467 476
146. S.M. Rifka, G.B. Cutler Jr., M.A. Sauer, and D.L. Loriaux Rat adrenal androgen receptor: a possible mediator of androgen-induced decreased in rat adrenal weight Endocrinology 103 1978 1103 1110 (Pubitemid 9047995)
147. M.M. Kau, M.J. Lo, S.W. Wang, S.C. Tsai, J.J. Chen, Y.C. Chiao, J.Y. Yeh, H. Lin, A.Y. Shum, V.S. Fang, L.T. Ho, and P.S. Wang Inhibition of aldosterone production by testosterone in male rats Metabolism: Clinical and Experimental 48 1999 1108 1114 (Pubitemid 29418279)
148. S. Gallant, J. Alfano, M. Charpin, and A.C. Brownie Expression of adrenal cytochromes P-450 in testosterone-induced hypertension Hypertension 18 1991 523 528
149. A.J. Martino-Andrade, and I. Chahoud Reproductive toxicity of phthalate esters Molecular Nutrition & Food Research 54 2010 148 157
150. J.L. Lyche, A.C. Gutleb, A. Bergman, G.S. Eriksen, A.J. Murk, E. Ropstad, M. Saunders, and J.U. Skaare Reproductive and developmental toxicity of phthalates Journal of Toxicology and Environmental Health. Part B: Critical Reviews 12 2009 225 249
151. T. Lovekamp-Swan, and B.J. Davis Mechanisms of phthalate ester toxicity in the female reproductive system Environmental Health Perspectives 111 2003 139 145 (Pubitemid 36305308)
152. G. Toft, B.A. Jonsson, C.H. Lindh, T.K. Jensen, N.H. Hjollund, A. Vested, and J.P. Bonde Association between pregnancy loss and urinary phthalate levels around the time of conception Environmental Health Perspectives 120 2012 458 463
153. R.M. Whyatt, J.J. Adibi, A.M. Calafat, D.E. Camann, V. Rauh, H.K. Bhat, F.P. Perera, H. Andrews, A.C. Just, L. Hoepner, D. Tang, and R. Hauser Prenatal di(2-ethylhexyl)phthalate exposure and length of gestation among an inner-city cohort Pediatrics 124 2009 e1213 e1220
154. L. Cobellis, G. Latini, C. De Felice, S. Razzi, I. Paris, F. Ruggieri, P. Mazzeo, and F. Petraglia High plasma concentrations of di-(2-ethylhexyl)- phthalate in women with endometriosis Human Reproduction 18 2003 1512 1515 (Pubitemid 36840962)
155. I. Colon, D. Caro, C.J. Bourdony, and O. Rosario Identification of phthalate esters in the serum of young Puerto Rican girls with premature breast development Environmental Health Perspectives 108 2000 895 900
156. R.H. McKee Toxicology Research Task Group Phthalate exposure and early thelarche Environmental Health Perspectives 112 2004 A541 A543
157. B.J. Davis, R.R. Maronpot, and J.J. Heindel Di-(2-ethylhexyl) phthalate suppresses estradiol and ovulation in cycling rats Toxicology and Applied Pharmacology 128 1994 216 223 (Pubitemid 24330842)
158. B.J. Davis, R. Weaver, L.J. Gaines, and J.J. Heindel Mono-(2-ethylhexyl) phthalate suppresses estradiol production independent of FSH-cAMP stimulation in rat granulosa cells Toxicology and Applied Pharmacology 128 1994 224 228 (Pubitemid 24330843)
159. T.N. Lovekamp, and B.J. Davis Mono-(2-ethylhexyl) phthalate suppresses aromatase transcript levels and estradiol production in cultured rat granulosa cells Toxicology and Applied Pharmacology 172 2001 217 224 (Pubitemid 32406029)
160. L.Q. Fan, R.C. Cattley, and J.C. Corton Tissue-specific induction of 17 beta-hydroxysteroid dehydrogenase type IV by peroxisome proliferator chemicals is dependent on the peroxisome proliferator-activated receptor alpha Journal of Endocrinology 158 1998 237 246 (Pubitemid 28342068)
161. T. Lovekamp-Swan, A.M. Jetten, and B.J. Davis Dual activation of PPARalpha and PPARgamma by mono-(2-ethylhexyl) phthalate in rat ovarian granulosa cells Molecular and Cellular Endocrinology 201 2003 133 141 (Pubitemid 36434289)
162. C. Xu, J.A. Chen, Z. Qiu, Q. Zhao, J. Luo, L. Yang, H. Zeng, Y. Huang, L. Zhang, J. Cao, and W. Shu Ovotoxicity and PPAR-mediated aromatase downregulation in female Sprague-Dawley rats following combined oral exposure to benzo[a]pyrene and di-(2-ethylhexyl) phthalate Toxicology Letters 199 2010 323 332
163. J.W. Laskey, and E. Berman Steroidogenic assessment using ovary culture in cycling rats: effects of bis(2-diethylhexyl)phthalate on ovarian steroid production Reproductive Toxicology 7 1993 25 33
164. S. Lenie, and J. Smitz Steroidogenesis-disrupting compounds can be effectively studied for major fertility-related endpoints using in vitro cultured mouse follicles Toxicology Letters 185 2009 143 152
165. H. Inada, K. Chihara, A. Yamashita, I. Miyawaki, C. Fukuda, Y. Tateishi, T. Kunimatsu, J. Kimura, H. Funabashi, and T. Miyano Evaluation of ovarian toxicity of mono-(2-ethylhexyl) phthalate (MEHP) using cultured rat ovarian follicles Journal of Toxicological Sciences 37 2012 483 490
166. M. Ma, Y. Zhang, X. Pei, and Z. Duan Effects of di-(2-ethylhexyl) phthalate exposure on reproductive development and PPARs in prepubertal female rats Wei sheng yan jiu Journal of Hygiene Research 40 2011 688 692 697
167. R. Takai, S. Hayashi, J. Kiyokawa, Y. Iwata, S. Matsuo, M. Suzuki, K. Mizoguchi, S. Chiba, and T. Deki Collaborative work on evaluation of ovarian toxicity. 10. Two- or four-week repeated dose studies and fertility study of di-(2-ethylhexyl) phthalate (DEHP) in female rats Journal of Toxicological Sciences 34 Suppl. 1 2009 SP111 SP119
168. J.S. Schmidt, K. Schaedlich, N. Fiandanese, P. Pocar, and B. Fischer Effects of di(2-ethylhexyl) phthalate (DEHP) on female fertility and adipogenesis in C3H/N mice Environmental Health Perspectives 120 2012 1123 1129
169. P. Pocar, N. Fiandanese, C. Secchi, A. Berrini, B. Fischer, J.S. Schmidt, K. Schaedlich, and V. Borromeo Exposure to di(2-ethyl-hexyl) phthalate (DEHP) in utero and during lactation causes long-term pituitary-gonadal axis disruption in male and female mouse offspring Endocrinology 153 2012 937 948
170. B. Moyer, and M.L. Hixon Reproductive effects in F1 adult females exposed in utero to moderate to high doses of mono-2-ethylhexylphthalate (MEHP) Reproductive Toxicology 34 2012 43 50
171. S.W. Grande, A.J. Andrade, C.E. Talsness, K. Grote, and I. Chahoud A dose-response study following in utero and lactational exposure to di(2-ethylhexyl)phthalate: effects on female rat reproductive development Toxicological Sciences: An Official Journal of the Society of Toxicology 91 2006 247 254
172. S.W. Grande, A.J. Andrade, C.E. Talsness, K. Grote, A. Golombiewski, A. Sterner-Kock, and I. Chahoud A dose-response study following in utero and lactational exposure to di-(2-ethylhexyl) phthalate (DEHP): reproductive effects on adult female offspring rats Toxicology 229 2007 114 122 (Pubitemid 44889269)
173. Y. Ding, Y. Gao, R. Shi, Y.J. Zhou, and Y. Tian Effects of in utero exposure to di(2-ethylhexyl) phthalate on sexual development in female offspring Zhonghua yu fang yi xue za zhi Chinese Journal of Preventive Medicine 44 2010 150 153
174. C.J. Thompson, S.M. Ross, J. Hensley, K. Liu, S.C. Heinze, S.S. Young, and K.W. Gaido Differential steroidogenic gene expression in the fetal adrenal gland versus the testis and rapid and dynamic response of the fetal testis to di(n-butyl) phthalate Biology of Reproduction 73 2005 908 917 (Pubitemid 41507493)
175. N.C. Noriega, K.L. Howdeshell, J. Furr, C.R. Lambright, V.S. Wilson, and L.E. Gray Jr. Pubertal administration of DEHP delays puberty, suppresses testosterone production, and inhibits reproductive tract development in male Sprague-Dawley and Long-Evans rats Toxicological Sciences: An Official Journal of the Society of Toxicology 111 2009 163 178
176. T.T. Vo, E.M. Jung, V.H. Dang, Y.M. Yoo, K.C. Choi, F.H. Yu, and E.B. Jeung Di-(2 ethylhexyl) phthalate and flutamide alter gene expression in the testis of immature male rats Reproductive Biology and Endocrinology: RB&E 7 2009 104
177. B.T. Akingbemi, R.T. Youker, C.M. Sottas, R. Ge, E. Katz, G.R. Klinefelter, B.R. Zirkin, and M.P. Hardy Modulation of rat Leydig cell steroidogenic function by di(2-ethylhexyl)phthalate Biology of Reproduction 65 2001 1252 1259 (Pubitemid 32927595)
178. N. Hirosawa, K. Yano, Y. Suzuki, and Y. Sakamoto Endocrine disrupting effect of di-(2-ethylhexyl)phthalate on female rats and proteome analyses of their pituitaries Proteomics 6 2006 958 971 (Pubitemid 43260220)
179. R.C. Cattley, J.G. Conway, and J.A. Popp Association of persistent peroxisome proliferation and oxidative injury with hepatocarcinogenicity in female F-344 rats fed di(2-ethylhexyl)phthalate for 2 years Cancer Letters 38 1987 15 22 (Pubitemid 18005830)
180. K.E. Tomaszewski, D.K. Agarwal, and R.L. Melnick In vitro steady-state levels of hydrogen peroxide after exposure of male F344 rats and female B6C3F1 mice to hepatic peroxisome proliferators Carcinogenesis 7 1986 1871 1876
181. Y. Zhao, H. Ao, L. Chen, C.M. Sottas, R.S. Ge, L. Li, and Y. Zhang Mono-(2-ethylhexyl) phthalate affects the steroidogenesis in rat Leydig cells through provoking ROS perturbation Toxicology In Vitro: An International Journal Published in Association with BIBRA 26 2012 950 955
182. W. Wang, Z.R. Craig, M.S. Basavarajappa, R.K. Gupta, and J.A. Flaws Di (2-ethylhexyl) phthalate inhibits growth of mouse ovarian antral follicles through an oxidative stress pathway Toxicology and Applied Pharmacology 258 2012 288 295
183. P. Erkekoglu, W. Rachidi, O.G. Yuzugullu, B. Giray, M. Ozturk, A. Favier, and F. Hincal Induction of ROS, p53, p21 in DEHP- and MEHP-exposed LNCaP cells-protection by selenium compounds Food and Chemical Toxicology: An International Journal Published for the British Industrial Biological Research Association 49 2011 1565 1571
184. P. Erkekoglu, W. Rachidi, O.G. Yuzugullu, B. Giray, A. Favier, M. Ozturk, and F. Hincal Evaluation of cytotoxicity and oxidative DNA damaging effects of di(2-ethylhexyl)-phthalate (DEHP) and mono(2-ethylhexyl)-phthalate (MEHP) on MA-10 Leydig cells and protection by selenium Toxicology and Applied Pharmacology 248 2010 52 62