Dynamic Epigenetic Changes Involved in Testicular Toxicity Induced by Di-2-(Ethylhexyl) Phthalate in Mice

Basic and Clinical Pharmacology and Toxicology

Volumn 106, Issue 2, 2010, Pages 118-123

  Wu, Shengde ^a   Zhu, Jing ^b   Li, Yasha ^b   Lin, Tao ^a   Gan, Liqiang ^a   Yuan, Xingang ^a   Xiong, Jing ^a   Liu, Xing ^a   Xu, Mingdeng ^a   Zhao, Dan ^a   Ma, Chao ^a   Li, Xuliang ^a   Wei, Guanghui ^a  

^a CHONGQING MEDICAL UNIVERSITY   (China)

^b CHILDREN S HOSPITAL OF CHONGQING MEDICAL UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

COMPLEMENTARY DNA; DNA METHYLTRANSFERASE; PHTHALIC ACID 2 ETHYLHEXYL MONOESTER;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DNA METHYLATION; ENVIRONMENTAL EXPOSURE; ENVIRONMENTAL FACTOR; EPIGENETICS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MALE; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; QUANTITATIVE ANALYSIS; REAL TIME POLYMERASE CHAIN REACTION; TESTIS FUNCTION; TESTIS INJURY; WESTERN BLOTTING;

ANIMALS; BLOTTING, WESTERN; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DIETHYLHEXYL PHTHALATE; DNA METHYLATION; DNA MODIFICATION METHYLASES; EPIGENESIS, GENETIC; FEMALE; GENE EXPRESSION REGULATION; GONADAL DYSGENESIS; MALE; MATERNAL EXPOSURE; MICE; PLASTICIZERS; POLYMERASE CHAIN REACTION; PREGNANCY; TESTIS;

MUS;

EID: 74549123299     PISSN: 17427835     EISSN: 17427843     Source Type: Journal    
DOI: 10.1111/j.1742-7843.2009.00483.x     Document Type: Article

References (52)

1. Toppari J, Larsen JC, Christiansen P, Giwercman A, Grandjean P, Guillette LJ Jr. et al. Male reproductive health and environmental xenoestrogens. Environ Health Perspect 1996 104 (Suppl. 4 741 803.
2. Irvine S, Cawood E, Richardson D, MacDonald E, Aitken J. Evidence of deteriorating semen quality in the United Kingdom: birth cohort study in 577 men in Scotland over 11 years. Br Med J 1996 312 : 467 471.
3. Paulozzi LJ. International trends in rates of hypospadias and cryptorchidism. Environ Health Perspect 1999 107 : 297 302.
4. Skakkebaek NE, Rajpert-De Meyts E, Main KM. Testicular dysgenesis syndrome: an increasingly common developmental disorder with environmental aspects. Hum Reprod 2001 16 : 972 978. (Pubitemid 32451837)
5. Sharpe RM. Hormones and testis development and the possible adverse effects of environmental chemicals. Toxicol Lett 2001 120 : 221 232.
6. Fisher JS. Environmental anti-androgens and male reproductive health: focus on phthalates and testicular dysgenesis syndrome. Reproduction 2004 127 : 305 315.
7. Kavlock R, Boekelheide K, Chapin R, Cunningham M, Faustman E, Foster P et al. NTP Center for the evaluation of risks to human reproduction: phthalates expert panel report on the reproductive and developmental toxicity of di(2-ethylhexyl) phthalate. Reprod Toxicol 2002 16 : 529 653.
8. Koch HM, Drexler H, Angerer J. An estimation of the daily intake of di(2-ethylhexyl)phthalate (DEHP) and other phthalates in the general population. Int J Hyg Environ Health 2003 206 : 77 83.
9. Koch HM, Preuss R, Angerer J. Di(2-ethylhexyl)phthalate (DEHP): human metabolism and internal exposure - an update and latest results. Int J Androl 2006 29 : 155 165.
10. Silva MJ, Barr DB, Reidy JA, Malek NA, Hodge CC, Caudill SP et al. Urinary levels of seven phthalate metabolites in the U.S. population from the National Health and Nutrition Examination Survey (NHANES) 1999-2000. Environ Health Perspect 2004 112 : 331 338.
11. Fisher JS, Macpherson S, Marchetti N, Sharpe RM. Human 'testicular dysgenesis syndrome': a possible model using in-utero exposure of the rat to dibutyl phthalate. Hum Reprod 2003 18 : 1383 1394.
12. Foster PM. Disruption of reproductive development in male rat offspring following in utero exposure to phthalate esters. Int J Androl 2006 29 : 140 147.
13. Corton JC, Lapinskas PJ. Peroxisome proliferator-activated receptors: mediators of phthalate ester-induced effects in the male reproductive tract? Toxicol Sci 2005 83 : 4 17.
14. Ward JM, Peters JM, Perella CM, Gonzalez FJ. Receptor and nonreceptor-mediated organ-specific toxicity of di(2-ethylhexyl)phthalate (DEHP) in peroxisome proliferator-activated receptor alpha-null mice. Toxicol Pathol 1998 26 : 240 246.
15. Holliday R, Pugh JE. DNA modification mechanisms and gene activity during development. Science 1975 187 : 226 232.
16. Li E, Bestor TH, Jaenisch R. Targeted mutation of the DNA methyltransferase gene results in embryonic lethality. Cell 1992 69 : 915 926.
17. Lei H, Oh SP, Okano M, Juttermann R, Goss KA, Jaenisch R et al. De novo DNA cytosine methyltransferase activities in mouse embryonic stem cells. Development 1996 122 : 3195 3205.
18. Okano M, Xie S, Li E. Cloning and characterization of a family of novel mammalian DNA (cytosine-5) methyltransferases. Nat Genet 1998 19 : 219 220.
19. Gowher H, Jeltsch A. Enzymatic properties of recombinant Dnmt3a DNA methyltransferase from mouse: the enzyme modifies DNA in a non-processive manner and also methylates non-CpG [correction of non-CpA] sites. J Mol Biol 2001 309 : 1201 1208. (Pubitemid 32623318)
20. Okano M, Bell DW, Haber DA, Li E. DNA methyltransferases Dnmt3a and Dnmt3b are essential for de novo methylation and mammalian development. Cell 1999 99 : 247 257.
21. Aoki A, Suetake I, Miyagawa J, Fujio T, Chijiwa T, Sasaki H et al. Enzymatic properties of de novo-type mouse DNA (cytosine-5) methyltransferases. Nucleic Acids Res 2001 29 : 3506 3512.
22. Zheng YG, Wu J, Chen Z, Goodman M. Chemical regulation of epigenetic modifications: opportunities for new cancer therapy. Med Res Rev 2008 28 : 645 687.
23. Aagaard-Tillery KM, Grove K, Bishop J, Ke X, Fu Q, McKnight R et al. Developmental origins of disease and determinants of chromatin structure: maternal diet modifies the primate fetal epigenome. J Mol Endocrinol 2008 41 : 91 102.
24. Martin DI, Cropley JE, Suter CM. Environmental influence on epigenetic inheritance at the Avy allele. Nutr Rev 2008 66 (Suppl. 1 S12 4.
25. Pogribny IP, Tryndyak VP, Boureiko A, Melnyk S, Bagnyukova TV, Montgomery B et al. Mechanisms of peroxisome proliferator-induced DNA hypomethylation in rat liver. Mutat Res 2008 644 : 17 23.
26. Ledwith BJ, Manam S, Troilo P, Joslyn DJ, Galloway SM, Nichols WW. Activation of immediate-early gene expression by peroxisome proliferators in vitro. Mol Carcinog 1993 8 : 20 7.
27. Magana AA, Wrobel K, Caudillo YA, Zaina S, Lund G. High-performance liquid chromatography determination of 5-methyl-2′-deoxycytidine, 2′-deoxycytidine, and other deoxynucleosides and nucleosides in DNA digests. Anal Biochem 2008 374 : 378 385.
28. Shang H, Wei H, Yue B, Xu P, Huang H. Microsatellite analysis in two populations of Kunming mice. Lab Anim 2009 43 : 34 40.
29. Gray LE Jr., Ostby J, Furr J, Price M, Veeramachaneni DN, Parks L. Perinatal exposure to the phthalates DEHP, BBP, and DINP, but not DEP, DMP, or DOTP, alters sexual differentiation of the male rat. Toxicol Sci 2000 58 : 350 365.
30. Fuke C, Shimabukuro M, Petronis A, Sugimoto J, Oda T, Miura K et al. Age related changes in 5-methylcytosine content in human peripheral leukocytes and placentas: an HPLC-based study. Ann Hum Genet 2004 68 : 196 204.
31. Young JI, Smith JR. DNA methyltransferase inhibition in normal human fibroblasts induces a p21-dependent cell cycle withdrawal. J Biol Chem 2001 276 : 19610 19616.
32. Livak KJ, Schmittgen TD. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods 2001 25 : 402 408.
33. Rein T, DePamphilis ML, Zorbas H. Identifying 5-methylcytosine and related modifications in DNA genomes. Nucleic Acids Res 1998 26 : 2255 2264.
34. Kanai Y, Hirohashi S. Alterations of DNA methylation associated with abnormalities of DNA methyltransferases in human cancers during transition from a precancerous to a malignant state. Carcinogenesis 2007 28 : 2434 2442.
35. Lin IG, Han L, Taghva A, O'Brien LE, Hsieh CL. Murine de novo methyltransferase Dnmt3a demonstrates strand asymmetry and site preference in the methylation of DNA in vitro. Mol Cell Biol 2002 22 : 704 723.
36. Barlow DP. Methylation and imprinting: from host defense to gene regulation? Science 1993 260 : 309 310.
37. Li E, Beard C, Jaenisch R. Role for DNA methylation in genomic imprinting. Nature 1993 366 : 362 365.
38. Grant SG, Chapman VM. Mechanisms of X-chromosome regulation. Annu Rev Genet 1988 22 : 199 233.
39. Okano M, Takebayashi S, Okumura K, Li E. Assignment of cytosine-5 DNA methyltransferases Dnmt3a and Dnmt3b to mouse chromosome bands 12A2-A3 and 2H1 by in situ hybridization. Cytogenet Cell Genet 1999 86 : 333 334.
40. Li S, Washburn KA, Moore R, Uno T, Teng C, Newbold RR et al. Developmental exposure to diethylstilbestrol elicits demethylation of estrogen-responsive lactoferrin gene in mouse uterus. Cancer Res 1997 57 : 4356 4359.
41. Alworth LC, Howdeshell KL, Ruhlen RL, Day JK, Lubahn DB, Huang TH et al. Uterine responsiveness to estradiol and DNA methylation are altered by fetal exposure to diethylstilbestrol and methoxychlor in CD-1 mice: effects of low versus high doses. Toxicol Appl Pharmacol 2002 183 : 10 22.
42. Anway MD, Cupp AS, Uzumcu M, Skinner MK. Epigenetic transgenerational actions of endocrine disruptors and male fertility. Science 2005 308 : 1466 1469.
43. Dolinoy DC, Weidman JR, Waterland RA, Jirtle RL. Maternal genistein alters coat color and protects Avy mouse offspring from obesity by modifying the fetal epigenome. Environ Health Perspect 2006 114 : 567 572.
44. Moore RW, Rudy TA, Lin TM, Ko K, Peterson RE. Abnormalities of sexual development in male rats with in utero and lactational exposure to the antiandrogenic plasticizer di(2-ethylhexyl) phthalate. Environ Health Perspect 2001 109 : 229 237.
45. Monk M, Boubelik M, Lehnert S. Temporal and regional changes in DNA methylation in the embryonic, extraembryonic and germ cell lineages during mouse embryo development. Development 1987 99 : 371 382.
46. Surani MA. Imprinting and the initiation of gene silencing in the germ line. Cell 1998 93 : 309 312.
47. Reik W, Dean W, Walter J. Epigenetic reprogramming in mammalian development. Science 2001 293 : 1089 1093.
48. Kafri T, Ariel M, Brandeis M, Shemer R, Urven L, McCarrey J et al. Developmental pattern of gene-specific DNA methylation in the mouse embryo and germ line. Genes Dev 1992 6 : 705 714.
49. Brandeis M, Kafri T, Ariel M, Chaillet JR, McCarrey J, Razin A et al. The ontogeny of allele-specific methylation associated with imprinted genes in the mouse. EMBO J 1993 12 : 3669 3677.
50. Coffigny H, Bourgeois C, Ricoul M, Bernardino J, Vilain A, Niveleau A et al. Alterations of DNA methylation patterns in germ cells and Sertoli cells from developing mouse testis. Cytogenet Cell Genet 1999 87 : 175 181.
51. Robertson KD, Wolffe AP. DNA methylation in health and disease. Nat Rev Genet 2000 1 : 11 9.
52. Jones PA, Takai D. The role of DNA methylation in mammalian epigenetics. Science 2001 293 : 1068 1070.