Characterization of peroxisome proliferator-Activated receptor α-Independent effects of PPARα activators in the rodent liver: Di-(2-ethylhexyl) phthalate also activates the constitutive-activated receptor

Toxicological Sciences

Volumn 113, Issue 1, 2009, Pages 45-59

  Ren, Hongzu ^a   Aleksunes, Lauren M ^b   Wood, Carmen ^c   Vallanat, Beena ^a   George, Michael H ^c   Klaassen, Curtis D ^b   Corton, J Christopher ^c  

^a U S ENVIRONMENTAL PROTECTION AGENCY   (United States)

^b UNIVERSITY OF KANSAS SCHOOL OF MEDICINE   (United States)

^c U S ENVIRONMENTAL PROTECTION AGENCY   (United States)

Author keywords

Constitutive activated receptor; Di (2 ethylhexyl) phthalate; Liver cancer; Peroxisome proliferator activated receptor ; Pregnane X receptor; Transcript profiling

Indexed keywords

CELL NUCLEUS RECEPTOR; CLOFIBRATE; CONSTITUTIVE ANDROSTANE RECEPTOR; CYTOCHROME P450 2B; CYTOCHROME P450 3A11; GLUTATHIONE TRANSFERASE; GLUTATHIONE TRANSFERASE M4; GLUTATHIONE TRANSFERASE M7; METALLOTHIONEIN I; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA; PHENOBARBITAL; PHTHALIC ACID BIS(2 ETHYLHEXYL) ESTER; PLASTICIZER; UNCLASSIFIED DRUG; VALPROIC ACID;

ARTICLE; CELL GROWTH; GENE INDUCTION; GENETIC TRANSCRIPTION; LIVER CANCER; LIVER CELL; LIVER PARENCHYMA; MALE; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PROTEIN FAMILY; RAT; RECEPTOR UPREGULATION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; WILD TYPE;

ANIMALS; CLOFIBRATE; DIETHYLHEXYL PHTHALATE; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; LIVER; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PEROXISOME PROLIFERATORS; PHENOBARBITAL; PLASTICIZERS; PPAR ALPHA; RATS; RECEPTORS, CYTOPLASMIC AND NUCLEAR; RECEPTORS, STEROID; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; TRANSCRIPTION, GENETIC; VALPROIC ACID;

MUS; RATTUS; RODENTIA;

EID: 75249083175     PISSN: 10966080     EISSN: 10960929     Source Type: Journal    
DOI: 10.1093/toxsci/kfp251     Document Type: Article

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