Plasticizers may activate human hepatic peroxisome proliferator-activated receptor α less than that of a mouse but may activate constitutive androstane receptor in liver

PPAR Research

Volumn , Issue , 2012, Pages

  Ito, Yuki ^a,b   Nakamura, Toshiki ^b   Yanagiba, Yukie ^b   Ramdhan, Doni Hikmat ^b   Yamagishi, Nozomi ^b   Naito, Hisao ^b   Kamijima, Michihiro ^a   Gonzalez, Frank J ^c   Nakajima, Tamie ^b  

^a NAGOYA CITY UNIVERSITY GRADUATE SCHOOL OF MEDICAL SCIENCES   (Japan)

^b NAGOYA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^c NATIONAL CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADIPIC ACID; ADIPIC ACID BIS(2 ETHYLHEXYL) ESTER; CONSTITUTIVE ANDROSTANE RECEPTOR; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA; PHTHALIC ACID BIS(2 ETHYLHEXYL) ESTER; PHTHALIC ACID DIBUTYL ESTER; PLASTICIZER; TRIACYLGLYCEROL; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DIETARY INTAKE; ENVIRONMENTAL EXPOSURE; FATTY ACID OXIDATION; GENOTYPE; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; HUMAN VERSUS ANIMAL COMPARISON; LIVER; MALE; MOUSE; NONHUMAN; SPECIES DIFFERENCE; TRIACYLGLYCEROL BLOOD LEVEL;

EID: 84863661947     PISSN: 16874757     EISSN: 16874765     Source Type: Journal    
DOI: 10.1155/2012/201284     Document Type: Article

References (46)

1. Gonzalez F. J., Peters J. M., Cattley R. C., Mechanism of action of the nongenotoxic peroxisome proliferators: role of the peroxisome proliferator-activated receptor Journal of the National Cancer Institute 1998 90 22 1702 1709 (Pubitemid 28539089)
2. Maloney E. K., Waxman D. J., trans-Activation of PPARalpha and PPARgamma by structurally diverse environmental chemicals Toxicology and Appllied Pharmacology 1999 161 2 209 218
3. Hurst C. H., Waxman D. J., Activation of PPAR and PPAR by environmental phthalate monoesters Toxicological Sciences 2003 74 2 297 308 (Pubitemid 36958298)
4. Bility M. T., Thompson J. T., McKee R. H., David R. M., Butala J. H., Vanden Heuvel J. P., Peters J. M., Activation of mouse and human peroxisome proliferator-activated receptors (PPARs) by phthalate monoesters Toxicological Sciences 2004 82 1 170 182 (Pubitemid 39485332)
5. Mandard S., Muller M., Kersten S., Peroxisome proliferator-activated receptor target genes Cellular and Molecular Life Sciences 2004 61 4 393 416 (Pubitemid 38316578)
6. Klaunig J. E., Babich M. A., Baetcke K. P., Cook J. C., Corton J. C., David R. M., DeLuca J. G., Lai D. Y., McKee R. H., Peters J. M., Roberts R. A., Fenner-Crisp P. A., PPAR agonist-induced rodent tumors: modes of action and human relevance Critical Reviews in Toxicology 2003 33 6 655 780 (Pubitemid 38037444)
7. Palmer C. N. A., Hsu M. H., Griffin K. J., Raucy J. L., Johnson E. F., Peroxisome proliferator activated receptor- expression in human liver Molecular Pharmacology 1998 53 1 14 22 (Pubitemid 28068368)
8. Rusyn I., Corton J. C., Mechanistic considerations for human relevance of cancer hazard of di(2-ethylhexyl) phthalate Mutation Research 2012 750 2 141 158
9. Melnick R. L., Is peroxisome proliferation an obligatory precursor step in the carcinogenicity of di(2-ethylhexyl)phthalate (DEHP)? Environmental Health Perspectives 2001 109 5 437 442 (Pubitemid 32998799)
10. Guyton K. Z., Chiu W. A., Bateson T. F., Jinot J., Scott C. S., Brown R. C., Caldwell J. C., A reexamination of the PPAR- activation mode of action as a basis for assessing human cancer risks of environmental contaminants Environmental Health Perspectives 2009 117 11 1664 1672
11. Melnick R. L., Brody C., DiGangi J., Huff J., The IARC evaluation of DEHP excludes key papers demonstrating carcinogenic effects International Journal of Occupational and Environmental Health 2003 9 4 400 402 (Pubitemid 40287975)
12. Melnick R. L., The IARC evaluation of di(2-ethylhexyl)phthalate (DEHP): a flawed decision based on an untested hypothesis International Journal of Occupational and Environmental Health 2002 8 3 284 286
13. Huff J., IARC and the DEHP quagmire International Journal of Occupational and Environmental Health 2003 9 4 402 404 (Pubitemid 40287976)
14. Grosse Y., Baan R., Secretan-Lauby B., El Ghissassi F., Bouvard V., Benbrahim-Tallaa L., Guha N., Islami F., Galichet L., Straif K., WHO International Agency for Research on Cancer Monograph Working Group, Carcinogenicity of chemicals in industrial and consumer products, food contaminants and flavourings, and water chlorination byproducts. The lancet oncology 2011 12 4 328 329
15. Ramdhan D. H., Kamijima M., Wang D., Ito Y., Naito H., Yanagiba Y., Hayashi Y., Tanaka N., Aoyama T., Gonzalez F. J., Nakajima T., Differential response to trichloroethylene-induced hepatosteatosis in wild-type and PPAR -humanized mice Environmental Health Perspectives 2010 118 11 1557 1563
16. Nakamura T., Ito Y., Yanagiba Y., Ramdhan D. H., Kono Y., Naito H., Hayashi Y., Li Y., Aoyama T., Gonzalez F. J., Nakajima T., Microgram-order ammonium perfluorooctanoate may activate mouse peroxisome proliferator-activated receptor, but not human PPAR Toxicology 2009 265 1-2 27 33
17. Shah Y. M., Morimura K., Yang Q., Tanabe T., Takagi M., Gonzalez F. J., Peroxisome proliferator-activated receptor regulates a microRNA-mediated signaling cascade responsible for hepatocellular proliferation Molecular and Cellular Biology 2007 27 12 4238 4247 (Pubitemid 46906549)
18. Cheung C., Akiyama T. E., Ward J. M., Nicol C. J., Feigenbaum L., Vinson C., Gonzalez F. J., Diminished hepatocellular proliferation in mice humanized for the nuclear receptor peroxisome proliferator-activated receptor Cancer Research 2004 64 11 3849 3854 (Pubitemid 38697295)
19. Morimura K., Cheung C., Ward J. M., Reddy J. K., Gonzalez F. J., Differential susceptibility of mice humanized for peroxisome proliferator-activated receptor to Wy-14,643-induced liver tumorigenesis Carcinogenesis 2006 27 5 1074 1080
20. Perrone C. E., Shao L., Williams G. M., Effect of rodent hepatocarcinogenic peroxisome proliferators on fatty acyl-CoA oxidase, DNA synthesis, and apoptosis in cultured human and rat hepatocytes Toxicology and Applied Pharmacology 1998 150 2 277 286 (Pubitemid 28302511)
21. Tzameli I., Pissios P., Schuetz E. G., Moore D. D., The xenobiotic compound 1,4-bis[2-(3,5-dichloropyridyloxy)]benzene is an agonist ligand for the nuclear receptor CAR Molecular and Cellular Biology 2000 20 9 2951 2958 (Pubitemid 30215008)
22. Zelko I., Negishi M., Phenobarbital-elicited activation of nuclear receptor CAR in induction of cytochrome P450 genes Biochemical and Biophysical Research Communications 2000 277 1 1 6
23. Honkakoski P., Zelko I., Sueyoshi T., Negishi M., The nuclear orphan receptor CAR-retinoid X receptor heterodimer activates the phenobarbital- responsive enhancer module of the CYP2B gene Molecular and Cellular Biology 1998 18 10 5652 5658 (Pubitemid 28450516)
24. Eveillard A., Mselli-Lakhal L., Mogha A., Lasserre F., Polizzi A., Pascussi J. M., Guillou H., Martin P. G. P., Pineau T., Di-(2-ethylhexyl)- phthalate (DEHP) activates the constitutive androstane receptor (CAR): a novel signalling pathway sensitive to phthalates Biochemical Pharmacology 2009 77 11 1735 1746
25. Cheng X., Klaassen C. D., Perfluorocarboxylic acids induce cytochrome P450 enzymes in mouse liver through activation of PPAR- and CAR transcription factors Toxicological Sciences 2008 106 1 29 36
26. Maglich J. M., Lobe D. C., Moore J. T., The nuclear receptor CAR (NR1I3) regulates serum triglyceride levels under conditions of metabolic stress Journal of Lipid Research 2009 50 3 439 445
27. Rezen T., Tamasi V., Lovgren-Sandblom A., Bjorkhem I., Meyer U. A., Rozman D., Effect of CAR activation on selected metabolic pathways in normal and hyperlipidemic mouse livers BMC Genomics 2009 10, article 384
28. Zhang J., Huang W., Chua S. S., Wei P., Moore D. D., Modulation of acetaminophen-induced hepatotoxicity by the xenobiotic receptor CAR Science 2002 298 5592 422 424 (Pubitemid 35176352)
29. Huang W., Zhang J., Washington M., Liu J., Parant J. M., Lozano G., Moore D. D., Xenobiotic stress induces hepatomegaly and liver tumors via the nuclear receptor constitutive androstane receptor Molecular Endocrinology 2005 19 6 1646 1653 (Pubitemid 41002992)
30. Yamamoto Y., Moore R., Goldsworthy T. L., Negishi M., Maronpot R. R., The orphan nuclear receptor constitutive active/androstane receptor is essential for liver tumor promotion by phenobarbital in mice Cancer Research 2004 64 20 7197 7200 (Pubitemid 39372050)
31. Folch J., Lees M., Sloane Stanley G. H., A simple method for the isolation and purification of total lipides from animal tissues The Journal of Biological Chemistry 1957 226 1 497 509
32. Ameen C., Edvardsson U., Ljungberg A., Activation of peroxisome proliferator-activated receptor alpha increases the expression and activity of microsomal triglyceride transfer protein in the liver The Journal of Biological Chemistry 2005 280 2 1224 1229
33. Yanagiba Y., Ito Y., Kamijima M., Gonzalez F. J., Nakajima T., Octachlorostyrene induces cytochrome P450, UDP-glucuronosyltransferase, and sulfotransferase via the aryl hydrocarbon receptor and constitutive androstane receptor Toxicological Sciences 2009 111 1 19 26
34. Ito Y., Yamanoshita O., Kurata Y., Kamijima M., Aoyama T., Nakajima T., Induction of peroxisome proliferator-activated receptor alpha (PPAR )-related enzymes by di(2-ethylhexyl) phthalate (DEHP) treatment in mice and rats, but not marmosets Archives of Toxicology 2007 81 3 219 226 (Pubitemid 46364907)
35. Ito Y., Yamanoshita O., Asaeda N., Tagawa Y., Lee C. H., Aoyama T., Ichihara G., Furuhashi K., Kamijima M., Gonzalez F. J., Nakajima T., Di(2-ethylhexyl)phthalate induces hepatic tumorigenesis through a peroxisome proliferator-activated receptor -independent pathway Journal of Occupational Health 2007 49 3 172 182 (Pubitemid 47036465)
36. Furuta S., Mayazawa S., Hashimoto T., Purification and properties of rat liver Acyl-CoA dehydrogenases and electron transfer flavoprotein Journal of Biochemistry 1981 90 6 1739 1750
37. Miyazawa S., Osumi T., Hashimoto T., The presence of a new 3-oxoacyl-CoA thiolase in rat liver peroxisomes European Journal of Biochemistry 1980 103 3 589 596
38. Izai K., Uchida Y., Orii T., Yamamoto S., Hashimoto T., Novel fatty acid -oxidation enzymes in rat liver mitochondria: I. Purification and properties of very-long-chain acyl-coenzyme A dehydrogenase The Journal of Biological Chemistry 1992 267 2 1027 1033
39. Osumi T., Hashimoto T., Purification and properties of mitochondrial and peroxisomal 3-hydroxyacyl-CoA dehydrogenase from rat liver Archives of Biochemistry and Biophysics 1980 203 1 372 383
40. Kim J., Min G., Kemper B., Chromatin assembly enhances binding to the CYP2B1 phenobarbital-responsive unit (PBRU) of nuclear factor-1, which binds simultaneously with constitutive androstane receptor (CAR)/retinoid X receptor (RXR) and enhances CAR/RXR-mediated activation of the PBRU The Journal of Biological Chemistry 2001 276 10 7559 7567
41. Ren H., Aleksunes L. M., Wood C., Characterization of peroxisome proliferator-activated receptor independent effects of PPAR activators in the rodent liver: di-(2-ethylhexyl) phthalate also activates the constitutive-activated receptor Toxicological Sciences 2010 113 1 45 59
42. Eveillard A., Lasserre F., de Tayrac M., Polizzi A., Claus S., Canlet C., Mselli-Lakhal L., Gotardi G., Paris A., Guillou H., Martin P. G. P., Pineau T., Identification of potential mechanisms of toxicity after di-(2-ethylhexyl)- phthalate (DEHP) adult exposure in the liver using a systems biology approach Toxicology and Applied Pharmacology 2009 236 3 282 292
43. Wyde M. E., Kirwan S. E., Zhang F., Laughter A., Hoffman H. B., Bartolucci-Page E., Gaido K. W., Yan B., You L., Di-n-butyl phthalate activates constitutive androstane receptor and pregnane X receptor and enhances the expression of steroid-metabolizing enzymes in the liver of rat fetuses Toxicological Sciences 2005 86 2 281 290 (Pubitemid 41418641)
44. DeKeyser J. G., Stagliano M. C., Auerbach S. S., Prabhu K. S., Jones A. D., Omiecinski C. J., Di(2-ethylhexyl) phthalate is a highly potent agonist for the human constitutive androstane receptor splice variant CAR2 Molecular Pharmacology 2009 75 5 1005 1013
45. Wu C., Gilroy R., Taylor R., Alteration of hepatic nuclear receptor-mediated signaling pathways in HCV patients with and without a history of alcohol drinking Hepatology 2011 54 6 1966 1974
46. Dirven H. A. A. M., van den Broek P. H. H., Peeters M. C. E., Peters J. G. P., Mennes W. C., Blaauboer B. J., Noordhoek J., Jongeneelen F. J., Effects of the peroxisome proliferator mono(2-ethylhexyl)phthalate in primary hepatocyte cultures derived from rat, guinea pig, rabbit and monkey. Relationship between interspecies differences in biotransformation and peroxisome proliferating potencies Biochemical Pharmacology 1993 45 12 2425 2434 (Pubitemid 23189535)