Collaborative work on evaluation of ovarian toxicity 10) Two- or four-week repeated dose studies and fertility study of di-(2-ethylhexyl) phthalate (DEHP) in female rats

Journal of Toxicological Sciences

Volumn 34, Issue 1 SPEC. ISS., 2009, Pages

  Takai, Ryo ^a   Hayashi, Shuji ^a   Kiyokawa, Junpei ^a   Iwata, Yoshika ^a   Matsuo, Saori ^a   Suzuki, Masami ^a   Mizoguchi, Keiji ^a   Chiba, Shuichi ^a   Deki, Toshiaki ^a  

^a CHUGAI PHARMACEUTICAL CO LTD   (Japan)

Author keywords

Di (2 ethylhexyl) phthalate (DEHP); Female fertility study; Ovarian toxicity; Rat study; Repeated dose toxicity study

Indexed keywords

PHTHALIC ACID BIS(2 ETHYLHEXYL) ESTER; PLASTICIZER;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL VACUOLE; CESAREAN SECTION; CONTROLLED STUDY; CORPUS LUTEUM; ESTRUS CYCLE; EVALUATION; FEMALE; FEMALE FERTILITY; HISTOPATHOLOGY; MALE; MORPHOLOGY; NONHUMAN; OVARY; OVARY FOLLICLE ATRESIA; PREGNANCY; PREGNANCY RATE; RAT; REPRODUCTIVE TOXICITY; STROMA CELL; ANIMAL; ANIMAL EMBRYO; CHEMICALLY INDUCED DISORDER; DRUG ADMINISTRATION; DRUG EFFECT; EMBRYO DEATH; EMBRYO DEVELOPMENT; FERTILITY; HEALTH CARE ORGANIZATION; JAPAN; METHODOLOGY; OVARY FOLLICLE; PATHOLOGY; SPRAGUE DAWLEY RAT; TOXICITY TESTING;

RATTUS;

ANIMALS; DIETHYLHEXYL PHTHALATE; DRUG ADMINISTRATION SCHEDULE; EMBRYO LOSS; EMBRYO, MAMMALIAN; EMBRYONIC DEVELOPMENT; ESTROUS CYCLE; FEMALE; FERTILITY; JAPAN; MALE; OVARIAN FOLLICLE; OVARY; PLASTICIZERS; PREGNANCY; PUBLIC-PRIVATE SECTOR PARTNERSHIPS; RATS; RATS, SPRAGUE-DAWLEY; SOCIETIES, SCIENTIFIC; STROMAL CELLS; TOXICITY TESTS; VACUOLES;

EID: 64949120427     PISSN: 03881350     EISSN: 18803989     Source Type: Journal    
DOI: 10.2131/jts.34.s111     Document Type: Article

References (11)

1. Davis, B.J., Maronpot, R.R. and Heindel, J.J. (1994): Di-(2-ethylhexyl) phthalate suppresses estradiol and ovulation in cycling rats. Toxicol. Appl. Pharmacol., 128, 216-223.
2. Dirven, H.A., van den Broek, P.H. and Jongeneelen, F.J. (1990): Effect of di(2-ethylhexyl)phthalate on enzyme activity levels in liver and serum of rats. Toxicology, 65, 199-207.
3. Froment, P., Gizard, F., Defever, D., Staels, B., Dupont, J. and Monget, P. (2006): Peroxisome proliferator-activated receptors in reproductive tissues: from gametogenesis to parturition. J. Endocrinol., 189, 199-209.
4. Heaney, A.P., Fernando, M. and Melmed, S. (2003): PPAR-gamma receptor ligands: novel therapy for pituitary adenomas. J. Clin. Invest., 111, 1381-1388.
5. Hirosawa, N., Yano, K., Suzuki, Y. and Sakamoto, Y. (2006): Endocrine disrupting effect of di-(2-ethylhexyl)phthalate on female rats and proteome analyses of their pituitaries. Proteomics, 6, 958-971.
6. Klimisch, H.J., Gamer, A.O., Hellwig, J., Kaufmann, W. and Jackh, R. (1992): Di-(2-ethylhexyl) phthalate: A short-term repeated inhalation toxicity study including fertility assessment. Food Chem. Toxicol., 30, 915-919.
7. Komar, C.M., Braissant, O., Wahli, W. and Curry, T.E.Jr. (2001): Expression and localization of PPARs in the rat ovary during follicular development and the periovulatory period. Endocrinology, 142, 4831-4838.
8. Lake, B.G., Gray, T.J., Lewis, D.F., Beamand, J.A., Hodder, K.D., Purchase, R. and Gangolli, SD. (1987): Structure-activity relationships for induction of peroxisomal enzyme activities by phthalate monoesters in primary rat hepatocyte cultures. Toxcol. Ind. Health, 3, 165-183.
9. Lovekamp-Swan, T., Jetten, A.M. and Davis, B.J. (2003): Dual activation of PPARalpha and PPARgamma by mono-(2-ethylhexyl) phthalate in rat ovarian granulosa cells. Mol. Cell. Endcrinol., 201, 133-141.
10. Mouihate, A., Boissé L. and Pittman, Q.J. (2004): A novel antipyretic action of 15-deoxy-delta12,14-prostaglandin J2 in the rat brain. J. Neurosci., 24, 1312-1308.
11. Reddy, J.K. and Lalwai, N.D. (1983): Carcinogenesis by hepatic peroxisome proliferators: evaluation of the risk of hypolipidemic drugs and industrial plasticizers to humans. Crit. Rev. Toxicol., 12, 1-58.