Male reproductive tract malformations in rats following gestational and lactational exposure to di(n-butyl) phthalate: An antiandrogenic mechanism?

Toxicological Sciences

Volumn 43, Issue 1, 1998, Pages 47-60

  Mylchreest, Eve ^a   Cattley, Russell C ^a   Foster, Paul M D ^a  

^a CIIT CENTERS FOR HEALTH RESEARCH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIANDROGEN; FLUTAMIDE; PHTHALIC ACID DIBUTYL ESTER; PLASTICIZER;

AGENESIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; FEMALE; HYPOSPADIAS; LACTATION; MALE; MALE GENITAL TRACT MALFORMATION; NONHUMAN; PRENATAL EXPOSURE; PROSTATE; RAT; SEMINAL VESICLE; TESTIS ATROPHY;

ANIMALIA;

EID: 0031860360     PISSN: 10966080     EISSN: None     Source Type: Journal    
DOI: 10.1006/toxs.1998.2436     Document Type: Article

References (33)

1. Agency for Toxic Substances and Disease Registry (ATSDR) (1990). Toxicological Profile for Di-n-bntylphthalate, TP-90-10. U.S. Department of Health and Human Services, Public Health Service, Atlanta, GA.
2. Cater, B. R., Cook, M. W., Gangolli, S. D., and Grasso, P. (1977). Studies on dibutyl phthalate-induced testicular atrophy in the rat: Effect on zinc metabolism. Toxicol. Appl. Pharmacol. 41, 609-618.
3. Cooper, R. L., Goldman, J. M., and Vandenbergh, J. G. (1993). Monitoring of the estrous cycle in the laboratory rodent by vaginal lavage. In Methods in Toxicology: Female Reproductive Toxicology (J. J. Heindel and R. E. Chapin, Ed.), Vol. 3B, pp. 45-55. Academic Press, San Diego.
4. Dostal, L. A., Chapin, R. E., Stefanski, S. A., Harris, M. W., and Schwetz, B. A. (1988). Testicular toxicity and reduced Sertoli cell numbers in neonatal rats by di(2-ethylhexyl) phthalate and the recovery of fertility as adults. Toxicol. Appl. Pharmacol. 95, 104-121.
5. Dostal, L. A., Weaver, R. P., and Schwetz, B. A. (1987). Transfer of di(2-ethylhexyl) phthalate through rat milk and effects on milk composition and the mammary gland. Toxicol. Appl. Pharmacol. 91, 315-325.
6. Ema, M., Amano, H., Itami, T., and Kawasaki, H. (1993). Teratogenic evaluation of di-n-butyl phthalate in rats. Toxicol. Lett. 69, 197-203.
7. Ema, M., Amano, H., and Ogawa, Y. (1994). Characterization of the developmental toxicity of di-n-butyl phthalate. Toxicology 86, 163-174.
8. Ema, M., Kurosaka, R., Amano, H., and Ogawa, Y. (1995). Developmental toxicity evaluation of mono-n-butyl phthalate in rats. Toxicol. Lett. 78, 101-106.
9. Gondos, B., and Berndtson, W. E. (1993). Postnatal and pubertal development. In The Sertoli Cell (L. D. Russell and M. D. Griswold, Ed.), pp. 115-154. Cache River Press, Clearwater, FL.
10. Gray, L. E., Ostby, J., Ferrell, J., Rehnberg, G., Linder, R., Cooper, R., Goldman, J., Slott, V., and Laskey, J. (1989). A dose-response analysis of methoxychlor-induced alterations of reproductive development and function in the rat. Fundam. Appl. Toxicol. 12, 92-108.
11. Gray, T. J. B., and Gangolli, S. D. (1986). Aspects of the testicular toxicity of phthalate esters. Environ. Health Perspect. 65, 229-235.
12. Imperato-McGinley, J., Binienda, Z., Arthur, A., Mininberg, D. T., Vaughan, E. D., and Quimby, F. W. (1985). The development of a male pseudohermaphroditic rat using an inhibitor of the enzyme 5α-reductase. Endocrinology 116, 807-812.
13. Imperato-McGinley, J., Sanchez, R. S., Spencer, J. R., Yee, B., and Vaughan, E. D. (1992). Comparison of the effects of the 5α-reductase inhibitor finasteride and the antiandrogen flutamide on prostate and genital differentiation: Dose-response studies. Endocrinology 131, 1149-1156.
14. Jobling, S., Reynolds, T., White, R., Parker, M. G., and Sumpter, J. P. (1995). A variety of environmentally persistent chemicals, including some phthalate plasticizers, are weakly estrogenic. Environ. Health Perspect. 103, 582-587.
15. Kelce, W. R., Lambright, C. R., Gray, L. E., and Roberts, K. P. (1997). Vinclozlin and p,p′-DDE alter androgen-dependent gene expression: In vivo confirmation of an androgen receptor-mediated mechanism. Toxicol. Appl. Pharmacol. 142, 192-200.
16. Kelce, W. R., Stone, C. R., Laws, S. C., Gray, L. E., Kemppainen, J. A., and Wilson, E. M. (1995). Persistent DDT metabolite p,p′-DDE is a potent androgen receptor antagonist. Nature 375, 581-585.
17. Kluwe, W. M. (1982). Overview of phthalate ester pharmacokinetics in mammalian species. Environ. Health Perspect. 45, 3-10.
18. Lloyd, S. C., and Foster, P. M. D. (1988). Effect of mono-(2-ethylhexyl)phthalate on follicle-stimulating hormone responsiveness of cultured rat Sertoli cells. Toxicol. Appl. Pharmacol. 95, 484-489.
19. Manson, J. M., and Yang, Y. J. (1994). Test methods for assessing female reproductive and developmental toxicology. In Principles and Methods of Toxicology (A. W. Hayes, Ed.), pp. 989-1037. Raven Press, New York.
20. Meek, M. D., Clemons, J., Wu, Z. F., Fielden, M. R., and Zacharewski, T. (1997). In vitro and in vivo assessments of the alleged estrogen receptormediated activities of phthalate esters. Toxicologist 36, 295.
21. National Research Council (NRC) (1996). Guide for the Care and Use of Laboratory Animals. National Academy Press, Washington, DC.
22. National Toxicology Program (NTP) (1991). Final report on the reproductive toxicity of di-n-butyl phthalate (CAS No. 84-74-2) in Sprague-Dawley rats. Report # T-0035C. NTIS Publication No. PB92111996. Naitonal Technical Information Service (NTIS), Department of Commerce, Springfield, VA.
23. National Toxicology Program (NTP) (1995). The Toxicokinetics and Metabolism of Di-n-butyl phthalate. Research Triangle Institute, NTP Chemistry Support Services, Research Triangle Park, NC.
24. Sharpe, R. M., Fisher, J. S., Miller, M. M., Jobling, S., and Sumpter, J. P. (1995). Gestational and lactational exposure of rats to xenoestrogens results in reduced testicular size and sperm production. Environ. Health Perspect. 103, 1136-1143.
25. Sharpe, R. M., and Skakkebæk, N. E. (1993). Are oestrogens involved in falling sperm counts and disorders of the male reproductive tract? Lancet 341, 1392-1395.
26. Shiota, K., and Nishimura, H. (1982). Teratogenicity of di(2-ethylhexyl) phthalate (DEHP) and di-n-butyl phthalate (DBP) in mice. Environ. Health Perspect. 45, 65-70.
27. Singh, A. R., Lawrence, W. H., and Autian, J. (1972). Teratogenicity of phthalate esters in rats. J. Pharm. Sci. 61, 51-55.
28. Tandon, R., Chowdhary, S. R., Seth, P. K., and Srivastava, S. P. (1990). Altered development of testis of rat exposed to di(2-ethylhexyl) phthalate (DEHP) during lactation. J. Environ. Biol. 11, 345-354.
29. Tandon, R., Seth, P. K., and Srivastava, S. P. (1991). Effect of in utero exposure to di(2-ethylhexyl)phthalate on rat testes. Indian J. Exp. Biol. 29, 1044-1046.
30. Teirlynck, O., Kaufman, J. M., Bogaert, M. G., and Roels, H. (1988). Testicular toxicity induced by single dosing of di- and mono-(2-ethylhexyl) phthalate in the rat. Toxicol Lett. 40, 85-91.
31. Toppari, J., Larsen, J. C., Christiansen, P., Giwercman, A., Grandjean, P., Guillette, L. J., Jégou, B., Jensen, T. K., Jouannet, P., Keiding, N., Leffers, H., McLachlan, J. A., Meyer, O., Müller, J., Rajpert-De Meyts, E., Scheike, T., Sharpe, R., Sumpter, J., and Skakkebæk, N. E. (1996). Male reproductive health and environmental xenoestrogens. Environ. Health Perspect. 104,Suppl. 4, 741-803.
32. Wine, R. N., Li, L. H., Hommel Barnes, L., Gulati, D. K., and Chapin, R. E. (1997). Reproductive toxicity of di-n-butylphthalate in a continuous breeding protocol in Sprague-Dawley rats. Environ. Health. Perspect. 105, 102-107.
33. Working, P. K., and Hurtt, M. E. (1987). Computerized videomicrographic analysis of rat sperm motility. J. Androl. 8, 330-337.