Developmental and functional biology of the primate fetal adrenal cortex

Endocrine Reviews

Volumn 18, Issue 3, 1997, Pages 378-403

  Mesiano, Sam ^a   Jaffe, Robert B ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BASIC FIBROBLAST GROWTH FACTOR; CORTICOTROPIN; CORTICOTROPIN RELEASING FACTOR; ESTROGEN; SOMATOMEDIN B; SOMATOMEDIN C;

ADRENAL CORTEX; ANIMAL EXPERIMENT; CORTICOTROPIN RELEASE; EMBRYO DEVELOPMENT; FETUS; FETUS DEVELOPMENT; GROWTH REGULATION; HORMONAL REGULATION; NONHUMAN; ONTOGENY; POSTNATAL DEVELOPMENT; PRIMATE; PRIORITY JOURNAL; REVIEW; STEROIDOGENESIS;

ADRENAL CORTEX; ADRENOCORTICOTROPIC HORMONE; ANIMALS; EMBRYONIC AND FETAL DEVELOPMENT; GROWTH SUBSTANCES; HUMANS; INFANT, NEWBORN; PRIMATES; RECEPTORS, CYTOPLASMIC AND NUCLEAR; TRANSCRIPTION FACTORS;

EID: 0030926557     PISSN: 0163769X     EISSN: None     Source Type: Journal    
DOI: 10.1210/er.18.3.378     Document Type: Review

References (253)

1. Liggins GC 1976 Adrenocortical-related maturational events in the fetus. Am J Obstet Gynecol 126:931-941
2. Liggins GC, Fairclough RJ, Grieves SA, Kendall JZ, Knox BS 1973 The mechanism of initiation of parturition in the ewe. Recent Prog Horm Res 29:111-159
3. Liggins GC 1981 Endocrinology of parturition. In: Novy MJ, Resko JA (eds) Fetal Endocrinology. Academic Press, Inc., New York, pp 211-237
4. Jirasek J 1980 Human Fetal Endocrines. Martinus Nijhoff, London, pp 69-82
5. Hornsby PJ 1985 The regulation of adrenocortical function by control of growth and structure. In: Anderson DC Winter JSD (eds) Adrenal Cortex. Butterworths, London, pp 1-31
6. Jaffe RB, Serón-Ferré M, Crickard K, Koritnik D, Mitchell BF, Huhtaniemi IT 1981 Regulation and function of the primate fetal adrenal gland and gonad. Recent Prog Horm Res 37:41-103
7. Winter JSD 1985 The adrenal cortex in the fetus and neonate. In: Anderson DC, Winter JSD (eds) Adrenal Cortex. Butterworths, London, pp 32-56
8. Liggins GC, Kennedy PC, Holm LW 1967 Failure of initiation of parturition after electrocoagulation of the pituitary of the fetal lamb. Am J Obstet Gynecol 98:1080-1086
9. Gray ES, Abramovich DR 1980 Morphologic features of the anencephalic adrenal gland in early pregnancy. Am J Obstet Gynecol 137:491-495
10. Benirschke K 1956 Adrenals in anencephaly and hydrocephaly. Obstet Gynecol 8:412-425
11. Sucheston ME, Cannon MS 1970 Microscopic comparison of the normal and anencephalic human adrenal gland with emphasis on the transient-zone. Obstet Gynecol 35:544-553
12. Walsh SW, Norman RL, Novy MJ 1979 In utero regulation of rhesus monkey fetal adrenals: effects of dexamethasone, adrenocorticotropin, thyrotropin-releasing hormone, prolactin, human chorionic gonadotropin, and alpha-melanocyte-stimulating hormone on fetal and maternal plasma steroids. Endocrinology 104: 1805-1813
13. Challis JRG, Davies IJ, Benirschke K, Hendrickx AG, Ryan KJ 1974 The effects of dexamethasone on plasma steroid levels and fetal adrenal histology in the pregnant rhesus monkey. Endocrinology 95:1300-1305
14. Winters AJ, Oliver C, Colston C, MacDonald PC, Porter JC 1974 Plasma ACTH levels in the human fetus and neonate as related to age and parturition. J Clin Endocrinol Metab 39:269-273
15. Serón-Ferré M, Lawrence CC, Jaffe RB 1978 Role of hCG in regulation of the fetal zone of the human fetal adrenal gland. J Clin Endocrinol Metab 46:834-837
16. Mesiano S, Mellon SH, Gospodarowicz D, Di Blasio AM, Jaffe RB 1991 Basic fibroblast growth factor expression is regulated by ACTH in the human fetal adrenal: A model for adrenal growth regulation. Proc Natl Acad Sci USA 88:5428-5431
17. Burris TP, Guo W, McCabe ER 1996 The gene responsible for adrenal hypoplasia congenita, DAX-1, encodes a nuclear hormone receptor that defines a new class within the superfamily. Recent Prog Horm Res 51:241-259
18. Luo X, Ikeda Y, Parker KL 1994 A cell-specific nuclear receptor is essential for adrenal and gonadal development and sexual differentiation. Cell 77:481-490
19. Sucheston ME, Cannon MS 1968 Development of zonular patterns in the human adrenal gland. J Morphol 126:477-491
20. Keene MFL, Hewer EE 1927 Observations on the development of the human suprarenal gland. J Anat 61:302-324
21. Hatano O, Takakusu A, Nomura M, Morohashi KI 1996 Identical origin of adrenal cortex and gonad revealed by expression profiles of Ad4BP/SF-1. Genes Cells 1:663-671
22. Uotila UU 1940 The early embryological development of the fetal and permanent adrenal cortex in man. Anat Rec 76:183-203
23. Crowder RE 1957 The development of the adrenal gland in man, with special reference to origin and ultimate location of cell types and evidence in favor of the "cell migration" theory. Contemp Embryol 251:195-209
24. Benner MC 1940 Studies on the involution of the fetal cortex of the adrenal glands. Am J Pathol 16:787-798
25. Lanman JT 1953 Fetal zone of the adrenal gland; its developmental course, comparative anatomy, and possible physiological functions. Medicine 32:389-430
26. McClellan M, Brenner RM 1981 Development of the fetal adrenals in nonhuman primates: electron microscopy. In: Novy MJ, Resko JA (eds) Fetal Endocrinology. Academic Press, New York, pp 383-403
27. McNutt NS, Jones AL 1970 Observations of the ultrastructure of cytodifferentiation in the human fetal adrenal cortex. Lab Invest 11:513
28. Mesiano S, Coulter CL, Jaffe RB 1992 Localization of cytochrome P450 cholesterol side chain cleavage, cytchrome P450 17α-hydroxylase/17,20-lyase, and 3β-hydroxysteroid dehydrogenase isomerase steroidogenic enzymes in the human and rhesus fetal adrenal gland: reappraisal of functional zonation. J Clin Endocrinol Metab 77:1184-1189
29. McNulty WP 1981 Postnatum evolution of the adrenal glands of rhesus macaques. In: Novy MJ, Resko JA (eds) Fetal Endocrinology. Academic Press, New York, pp 53-64
30. Spencer SJ, Mesiano S, Jaffe RB 1995 Programmed cell death in remodelling of the human fetal adrenal cortex: possible role of activin-A. Program of the 42nd Annual Meeting of the Society for Gynecological Investigation, Chicago, IL, 1995, Abstract O27
31. Johannisson E 1968 The foetal adrenal cortex in the human. Its ultrastructure at different stages of development and in different functional states. Acta Endocrinol (Copenh) 130[Suppl]:1-107
32. Coulter CL, Goldsmith PC, Mesiano S, Voytek CC, Martin MC, Han VKM, Jaffe RB 1996 Functional maturation of the primate fetal adrenal in vivo: 1. Role of insulin-like growth factors, IGF-I receptor and IGF binding proteins in growth regulation. Endocrinology 137:4487-4498
33. Ford JK, Young RW 1963 Cell proliferation and displacement in the adrenal cortex of young rats injected with tritiated thymidine. Anat Rec 146:125-133
34. Belloni AS, Mazzocchi G, Meneghelli V, Nussdorfer GG 1978 Cytogenesis in the rat adrenal cortex: evidence for an ACTH-induced centripetal cell migration from the zona glomerulosa. Arch Anat Histol Embryol 61:195-206
35. Wright NA 1971 Cell proliferation in the prepubertal male rat adrenal cortex: an autoradiographic study. J Endocrinol 49:599-609
36. Wright NA, Voncima D, Morley AR 1973 An attempt to demonstrate cell migration from the zona glomerulosa in the prepubertal male rat adrenal cortex. J Endocrinol 59:451-459
37. Morley SD, Viard I, Chung BC, Ikeda Y, Parker KL, Mullins JJ 1996 Variegated expression of a mouse steroid 21-hydroxylase/ beta-galactosidase transgene suggests centripetal migration of adrenocortical cells. Mol Endocrinol 10:585-598
38. Iannaccone PM, Weinberg WC 1987 The histogenesis of the rat adrenal cortex: a study based on histological analysis of mosaic pattern in chimeras. J Exp Zool 243:217-223
39. Albrecht ED, Aberdeen GW, Babischkin JS, Tilly JL, Pepe GJ 1996 Biphasic developmental expression of adrenocorticotropin receptor messenger ribonucleic acid levels in the baboon fetal adrenal gland. Endocrinology 137:1292-1298
40. Partsch CJ, Sippell WG, Mackenzie IZ, Aynsley-Green A 1991 The steroid hormonal milieu of the undisturbed human fetus and mother at 16-20 weeks gestation. J Clin Endocrinol Metab 73:969-974
41. Murphy BE 1973 Steroid arteriovenous differences in umbilical cord plasma: evidence of cortisol production by the human fetus in early gestation. J Clin Endocrinol Metab 36:1037-1038
42. Campbell AL, Murphy BE 1977 The maternal-fetal cortisol gradient during pregnancy and at delivery. J Clin Endocrinol Metab 45:435-440
43. Pasqualini JR, Lowy J, Wiqvist N, Diczfalusy E 1968 Biosynthesis of cortisol from 3β, 17α,21-trihydroxypregn-5-en-20-one by the intact human foetus at midpregnancy. Biochim Biophy Acta 152: 648-650
44. Solomon S, Bird CE, Ling W, Iwamiya M, Young PCM 1967 Formation and metabolism of steroids in the fetus and placenta. Recent Prog Horm Res 23:297-335
45. 14C]-progesterone by the previable human fetus. J Steroid Biochem 8:499-504
46. Blankstein J, Fujieda K, Reyes FI, Faiman C, Winter JSD 1980 Aldosterone and corticosterone in amniotic fluid during various stages of pregnancy. Steroids 36:161-165
47. Bayard F, Ances IG, Tapper AJ, Weldon VV, Kowarski A, Migeon CJ 1970 Transplacental passage and fetal secretion of aldosterone. J Clin Invest 49:1389-1393
48. Pasqualini JR, Wiqvist N, Diczfalusy E 1966 Biosynthesis of aldosterone by human foetuses perfused with corticosterone at midterm. Biochim Biophys Acta 121:430-431
49. Siiteri PK, MacDonald PC 1963 The utilization of circulating dehydroepiandrosterone sulfate for estrogen synthesis during human pregnancy. Steroids 2:713-730
50. Yen SSC 1991 Endocrine-metabolic adaptations in pregnancy. In: Yen SSC, Jaffe RB (eds) Reproductive Endocrinology. W.B. Saunders, Philadelphia, pp 936-981
51. Baker BL, Jaffe RB 1975 The genesis of cell types in the adenohypophysis of the human fetus as observed with immunocytochemistry. Am J Anat 143:137-161
52. Fransden VA, Stakemann G 1961 The site of production of oestrogenic hormones in human pregnancy. Hormone excretion in pregnancy with anencephalic foetus. Acta Endocrinol (Copenh) 38:383-391
53. France JT, Seddon RJ, Liggins GC 1973 A study of pregnancy with low estrogen production due to placental sulfatase deficiency. J Clin Endocrinol Metab 36:1-9
54. France JT, Liggins GC 1969 Placental sulfatase deficiency. J Clin Endocrinol Metab 29:138-141
55. Morel Y, Miller WL 1991 Clinical and molecular genetics of congenital adrenal hyperplasia due to 21-hydroxylase deficiency. Adv Hum Genet 20:1-68
56. George FW, Wilson JD 1988 Sex determination and differentiation. In: Knobil E, Neill JD (eds) The Physiology of Reproduction. Raven Press, New York, pp 3-26
57. Bloch E, Benirschke K 1959 Synthesis in vitro of steroids by human fetal adrenal slices. J Biol Chem 234:1085-1089
58. Dufau ML, Villee DB 1969 Aldosterone biosynthesis by human fetal adrenal in vitro. Biochim Biophys Acta 176:637-641
59. Villee DB, Engel LL, Loring JM, Villee CA 1961 Steroid hydroxylation in human fetal adrenals: Formation of 16α-hydroxyprogesterone, 17-hydroxyprogesterone and deoxycorticosterone. Endocrinology 69:354-372
60. Serón-Ferré M, Lawrence CC, Siiteri PK, Jaffe RB 1978 Steroid production by definitive and fetal zones of the human fetal adrenal gland. J Clin Endocrinol Metab 47:603-609
61. Serón-Ferré M, Biglieri EG, Jaffe RB 1990 Regulation of mineralocorticoid secretion by the superfused fetal monkey adrenal gland: lack of stimulation of aldosterone by ACTH. J Dev Physiol 13:33-36
62. Nelson HP, Kuhn RW, Deyman ME, Jaffe RB 1990 Human fetal adrenal definitive and fetal zone metabolism of pregnenolone and corticosterone: Alternate biosynthetic pathways and absence of detectable aldosterone synthesis. J Clin Endocrinol Metab 70:693-698
63. 2 receptor is present in the human fetal adrenal gland throughout the second trimester of gestation. J Clin Endocrinol Metab 81:3914-3922
64. Simonian MH, Gill GN 1981 Regulation of the fetal human adrenal cortex: Effects of adrenocorticotropin on growth and function of monolayer cultures of fetal and definitive zone cells. Endocrinology 108:1769-1779
65. Branchaud CL, Goodyer CG, Hall CG, Arato JS, Silman RE, Giroud CJP 1978 Steroidogenic activity of hACTH and related peptides on the human neocortex and fetal adrenal cortex in organ culture. Steroids 31:557-571
66. Ducsay CA, Stanczyk FZ, Novy MJ 1985 Maternal and fetal production rates of progesterone in rhesus macaques: placental transfer and conversion to cortisol. Endocrinology 117:1253-1258
67. Pepe GJ, Albrecht ED 1980 The utilization of placental substrates for cortisol synthesis by the baboon placenta near term. Steroids 35:591
68. Goldman AS, Yakovac WC, Bongiovanni AM 1966 Development of activity of 3β-hydroxysteroid dehydrogenase in human fetal tissues and in two anencephalic newborns. J Clin Endocrinol Metab 26:14-22
69. Voutilainen R, Ilveskmaki V, Miettinen P 1991 Low expression of 3β-hydroxy-5-ene steroid dehydrogenase gene in human fetal adrenals in vivo; adrenocorticotropin and protein kinase C-dependent regulation in adrenocortical cultures. J Clin Endocrinol Metab 72:761-767
70. Parker Jr CR, Faye-Petersen O, Stankovic AK, Mason JI, Grizzle WE 1995 Immunohistochemical evaluation of the cellular localization and ontogeny of 3β-hydroxysteroid dehydrogenase/delta 5-4 isomerase in the human fetal adrenal gland. Endocr Res 21:69-80
71. Doody KM, Carr BR, Rainey WE, Byrd W, Murry BA, Strickler RC, Thomas JL, Mason JI 1990 3β-Hydroxysteroid dehydrogenase/isomerase in the fetal zone and neocortex of the human fetal adrenal gland. Endocrinology 126:2487-2492
72. Dupont E, Luu-The V, Labrie F, Pelletier G 1990 Ontogeny of 3β-hydroxysteroid/Δ5-Δ4 isomerase (3β-HSD) in human adrenal gland performed by immunocytochemistry. Mol Cell Endocrinol 75:R7-R10
73. Coulter CL, Goldsmith PC, Mesiano S, Voytek CC, Martin MC, Mason JI, Jaffe RB 1996 Functional maturation of the primate fetal adrenal in vivo: 2. Ontogeny of corticosteroid synthesis is dependent upon specific zonal expression of 3β-hydroxysteroid dehydrogenase/isomerase (3βHSD). Endocrinology 137:4953-4959
74. Mesiano S, Katz SL, Lee JY, Jaffe RB 1997 Insulin-like growth factors augment steroid production and expression of steroidogenic enzymes in human fetal adrenal cortical cells: Implications for adrenal androgen regulation. J Clin Endocrinol Metab 82:1390-1396
75. Glickman JA, Challis JRG 1980 The changing response pattern of sheep fetal adrenal cells throughout the course of gestation. Endocrinology 106:1371-1376
76. Durand P, Cathiard A, Locatelli A, Dazord A, Saez JM 1981 Spontaneous and adrenocorticotropin (ACTH)-induced maturation of the responsiveness of ovine fetal adrenal cells to in vitro stimulation by ACTH and cholera toxin. Endocrinology 109:2117-2123
77. Jacobs RA, Young IR, Hollingworth SA, Thorburn GD 1994 Chronic administration of low doses of adrenocorticotropin to hypophysectomized fetal sheep leads to normal term labor. Endocrinology 134:1389-1394
78. Magyar DM, Devaskar J, Fridshal D, Buster JE, Nathanielsz PW 1980 Responsiveness and maximum secretory capacity of isolated fetal lamb adrenocortical cells throughout the last third of gestation. Endocrinology 107:1582-1586
79. Di Blasio AM, Jaffe RB 1988 Adrenocorticotropic hormone does not induce desensitization in human adrenal cells during fetal life. Biol Reprod 39:617-621
80. Rainey WE, McAllister JM, Byrd EW, Mason JI, Carr BR 1991 Regulation of corticotropin responsiveness in human fetal adrenal cells. Am J Obstet Gynecol 165:1649-1654
81. Mesiano S, Fujimoto VY, Nelson LR, Lee JY, Voytek CC, Jaffe RB 1996 Localization and regulation of corticotropin receptor expression in the midgestation human fetal adrenal cortex: implications for in utero homeostasis. J Clin Endocrinol Metab 81:340-345
82. Kolanowski J, Esselinckx W, Nagent de Deuxchaisnes C, Crabbe J 1977 Adrenocortical response upon repeated stimulation with corticotropin in patients lacking endogenous corticotropin secretion. Acta Endocrinol (Copenh) 85:595-607
83. Bransome EJ 1968 Regulation of adrenal growth. Differences in the effects of ACTH in normal and dexamethasone-suppressed guinea pigs. Endocrinology 83:956-964
84. Cuthrell WV, Rose JC, Meis PJ 1990 The effect of adrenocorticotropic hormone infusion on subsequent pituitary response in the sheep fetus. Am J Obstet Gynecol 163:170-174
85. Siler-Khodr TM, Morgenstern LL, Greenwood FC 1974 Hormone synthesis and release from the human fetal adenohypophysis in vitro. J Clin Endocrinol Metab 39:891-905
86. Pepe GJ, Davies WA, Albrecht ED 1994 Activation of the baboon fetal pituitary-adrenocortical axis at midgestation by estrogen: enhancement of fetal pituitary proopiomelanocortin messenger ribonucleic acid expression. Endocrinology 135:2581-2587
87. Pepe GJ, Albrecht ED 1990 Regulation of the primate fetal adrenal cortex. Endocr Rev 11:151-176
88. Easterling Jr WE, Simmer HH, Dignam WJ, Frankland MV, Naftolin F 1966 Neutral C19-steroids and steroid sulfates in human pregnancy. II. Dehydroepiandrosterone sulfate, 16-alpha-hydroxydehydroepiandrosterone, and 16-alpha-hydroxydehydroepiandrosterone sulfate in maternal and fetal blood of pregnancies with anencephalic and normal fetuses. Steroids 8:157-178
89. Honnebier WJ, Jobis AC, Swaab DF 1974 The effect of hypophyseal hormones and human chorionic gonadotropin (HCG) on the anencephalic fetal adrenal cortex and parturition in the human. J Obstet Gynaecol Br Common 81:423-438
90. Nichols J, Lescure OL, Migeon CJ 1958 Levels of 17-hydroxycorticosteroids and 17-ketosteroids in maternal and cord plasma in term anencephaly. J Clin Endocrinol Metab 18:444-452
91. Aria K, Kuwabara Y, Okinaga S 1972 The effect of adrenocorticotropic hormone and dexamethasone, administered to the fetus in utero, upon maternal and fetal estrogens. Am J Obstet Gynecol 113:316-322
92. Novy MJ, Walsh SW, Kittinger GW 1977 Experimental fetal anencephaly in the rhesus monkey: effect on gestational length and fetal and maternal plasma steroids. J Clin Endocrinol Metab 45:1031-1038
93. Miller WL, Levine LS 1987 Molecular and clinical advances in congenital adrenal hyperplasia. J Pediatr 111:1-71
94. Mountjoy KG, Robbins LS, Mortrud MT, Cone RD 1992 The cloning of a family of genes that encode the melanocortin receptors. Science 257:1248-1251
95. Di Blasio AM, Fujii DK, Yamamoto M, Martin MC, Jaffe RB 1990 Maintenance of cell proliferation and steroidogenesis in cultured human fetal adrenal cells chronically exposed to adrenocorticotropic hormone: Rationalization of in vitro and in vivo findings. Biol Reprod 42:683-691
96. Ramachandran J, Suyama AT 1975 Inhibition of replication of normal adrenocortical cells in culture by adrenocorticotropin. Proc Natl Acad Sci USA 72:113-117
97. Goldfarb M 1990 The fibroblast growth factor family. Cell Growth Diff 1:439-445
98. Johnson DE, Lee PL, Williams LT 1990 Diverse forms of a receptor for acidic and basic fibroblast growth factor. Mol Cell Biol 10:4728-4736
99. Gospodarowicz D, Handley HH 1975 Stimulation of division of Y1 adrenal cells by a growth factor isolated from bovine pituitary glands. Endocrinology 97:102-107
100. Gospodarowicz D, Ill CR, Hornsby PJ, Gill GN 1977 Control of bovine adrenal cortical cell proliferation by fibroblast growth factor. Lack of effect of epidermal growth factor. Endocrinology 100: 1080-1089
101. Hornsby PJ, Gill GN 1977 Hormonal control of adrenocortical cell proliferation. Desensitization to ACTH and interaction between ACTH and fibroblast growth factor in bovine adrenocortical cell cultures. J Clin Invest 60:342-352
102. Gospodarowicz D, Baird A, Cheng J, Lui G-M, Esch F, Bohlen P 1986 Isolation of fibroblast growth factor from bovine adrenal gland: physicochemical and biological characterization. Endocrinology 118:82-90
103. Schweigerer L, Neufeld G, Friedman J, Abraham JA, Fiddes JC, Gospodarowicz D 1987 Basic fibroblast growth factor: production and growth stimulation in cultured adrenal cortex cells. Endocrinology 120:796-800
104. Basile DP, Holzwarth MA 1994 Basic fibroblast growth factor receptor in the rat adrenal cortex: effects of suramin and unilateral adrenalectomy on receptor numbers. Endocrinology 134:2482-2489
105. Crickard K, Ill CR, Jaffe RB 1981 Control of proliferation of human fetal adrenal cells in vitro. J Clin Endocrinol Metab 53:790-796
106. Hornsby PJ, Sturek M, Harris SE, Simonian MH 1983 Serum and growth factor requirements for proliferation of human adrenocortical cells in culture: Comparison with bovine adrenocortical cells. In Vitro 19:863-869
107. Gospodarowicz D, Cheng J, Lui G-M, Bohlen P 1985 Corpus luteum angiogenic factor is related to fibroblast growth factor. Endocrinology 117:2383-2391
108. Shifren JL, Lee JY, Mesiano S, Taylor RN, Jaffe RB 1996 ACTH increases vascular endothelial growth factor expression in human fetal adrenal cortical cells. Program of the 43nd Annual Meeting of the Society for Gynecological Investigation, Philadelphia, PA, 1996, Abstract 131
109. Gospodarowicz D, Ill CR, Birdwell CR 1977 Effects of fibroblast and epidermal growth factors on ovarian cell proliferation in vitro: I. Characterization of the response of granulosa cells to FGF and EGF. Endocrinology 100:1108-1120
110. Coulter CL, Read LC, Carr BR, Tarantal AF, Barry S, Styne DM 1996 A role for epidermal growth factor in the morphological and functional maturation of the adrenal gland in the fetal rhesus monkey in vivo. J Clin Endocrinol Metab 81:1254-1260
111. Luger A, Calogero AE, Kalogeras K, Gallucci WT, Gold PW, Loriaux DL, Chrousos GP 1988 Interaction of epidermal growth factor with the hypothalamic-pituitary-adrenal axis: potential physiologic relevance. J Clin Endocrinol Metab 66:334-337
112. Polk DH, Ervin MG, Padbury JF, Lam RW, Reviczky AL, Fisher DA 1987 Epidermal growth factor acts as a corticotropin-releasing factor in chronically catheterized fetal lambs. J Clin Invest 79:984-988
113. Prigent SA, Lemoine NR 1992 The type 1 (EGFR-related) family of growth factor receptors and their ligands. Prog Growth Factor Res 4:1-24
114. Sasano H, Suzuki T, Shizawa S, Kato K, Nagura H 1994 Transforming growth factor alpha, epidermal growth factor, and epidermal growth factor receptor expression in normal and diseased human adrenal cortex by immunohistochemistry and in situ hybridization. Mod Pathol 7:741-746
115. Smikle CB, Kim HS, Mesiano S, Jaffe RB 1996 Identification of the ligands for the epidermal growth factor receptor in human fetal and adult adrenal glands. Program of the 10th International Congress of Endocrinology, San Francisco, CA, 1996, Abstract OR6-3
116. Guyda HJ 1991 Concepts of IGF physiology. In: Spencer E (ed) Modern Concepts of Insulin-Like Growth Factors. Elsevier, New York, pp 99-110
117. 4 incorporation by cartilage. J Lab Clin Med 49:825-836
118. D'Ercole AJ 1991 The insulin-like growth factors and fetal growth. In: Spencer E (ed) Modern Concepts of Insulin-Like Growth Factors. Elsevier, New York, pp 9-23
119. Rosenfeld RG, Hintz RL 1986 Somatomedin receptors; structure, function and regulation. In: Conn P (ed) The Receptors. Academic Press, New York, pp 281-329
120. Baxter RC 1991 Physiological roles of IGF binding proteins. In: Spencer E (ed) Modern Concepts of Insulin-Like Growth Factors. Elsevier, New York, pp 371-380
121. Ilvesmaki V, Kahri AI, Miettinen PJ, Voutilainen R 1993 Insulin-like growth factors (IGFs) and their receptors in adrenal tumors: high IGF-II expression in functional adrenocortical carcinomas. J Clin Endocrinol Metab 77:852-858
122. Adashi EY, Resnick CE, D'Ercole AJ, Svoboda ME, Van Wyk JJ 1985 Insulin-like growth factors as intraovarian regulators of granulosa cell growth and function. Endocr Rev 6:400-420
123. Mondschein JS, Canning SF, Miller DQ, Hammond JM 1989 Insulin-like growth factors (IGFs) as autocrine/paracrine regulators of granulosa cell differentiation and growth: studies with a neutralizing monoclonal antibody to IGF-I. Biol Reprod 41:79-85
124. Perrard-Sapori MH, Chatelain PG, Jaillard C, Saez JM 1987 Characterization and regulation of somatomedin-C/insulin-like growth factor I (Sm-C/IGF-I) receptors on cultured pig Leydig cells. Effects of Sm-C/IGF-I on luteotropin receptors and steroidogenesis. Eur J Biochem 165:209-214
125. Bernier M, Chatelain P, Mather JP, Saez JM 1986 Regulation of gonadotropin receptors, gonadotropin responsiveness, and cell multiplication by somatomedin-C and insulin in cultured pig Leydig cells. J Cell Physiol 129:257-263
126. Penhoat A, Chatelain PG, Jaillard C, Saez JM 1988 Characterization of insulin-like growth factor I and insulin receptors on cultured bovine adrenal fasciculata cells. Role of these peptides on adrenal cell function. Endocrinology 122:2518-2526
127. Penhoat A, Jaillard C, Saez JM 1989 Synergistic effects of corticotropin and insulin-like growth factor I on corticotropin receptors and corticotropin responsiveness in cultured bovine adrenalocortical cells. Biochem Biophys Res Commun 165:355-359
128. Naaman E, Chatelain P, Saez JM, Durand P 1989 In vitro effect of insulin and insulin-like growth factor-I on cell multiplication and adrenocorticotropin responsiveness in fetal adrenal cells. Biol Reprod 40:570-577
129. Pham-Huu-Trung MT, Villette JM, Bogyo A, Duclos JM, Fiet J, Binoux M 1991 Effects of insulin-like growth factor I (IGF-I) on enzymatic activity in human adrenocortical cells. Interactions with ACTH. J Steroid Biochem Mol Biol 39:903-909
130. Pillion DJ, Arnold P, Yang M, Stockard CR, Grizzle WE 1989 Receptors for insulin and insulin-like growth factor-I in the human adrenal gland. Biochem Biophys Res Commun 165:204-211
131. Shigematsu K, Niwa M, Kurihara M, Yamashita K, Kawai K, Tsuchiyama H 1989 Receptor autoradiographic localization of insulin-like growth factor-I (IGF-I) binding sites in human fetal and adult adrenal glands. Life Sci 45:3033-3042
132. Penhoat A, Naville D, Jaillard C, Chatelain PG, Saez JM 1989 Hormonal regulation of insulin-like growth factor I secretion by bovine adrenal cels. J Biol Chem 264:6858-6862
133. Han VKM, D'Ercole AJ, Lund PK 1987 Cellular localization of somatomedin (insulin-like growth factor) messenger RNA in the human fetus. Science 236:193-197
134. Han VKM, Lund PK, Lee DC, D'Ercole AJ 1988 Expression of somatomedin/insulin-like growth factor messenger ribonucleic acids in the human fetus: Identification, characterization, and tissue distribution. J Clin Endocrinol Metab 66:422-429
135. Ilvesmaki V, Blum WF, Voutilainen R 1993 Insulin-like growth factor binding proteins in the human adrenal gland. Mol Cell Endocrinol 97:71-79
136. Voutilainen R, Miller WL 1987 Coordinate tropic hormone regulation of mRNAs for insulin-like growth factor II and cholesterol side-chain-cleavage enzyme, P450 ssc, in steroidogenic tissues. Proc Natl Acad Sci USA 84:1590-1594
137. Mesiano S, Mellon SH, Jaffe RB 1992 Mitogenic action, regulation and localization of insulin-like growth factors in the human fetal adrenal gland. J Clin Endocrinol Metab 76:968-976
138. Mesiano S, Jaffe RB 1992 Regulation of growth and function of the human fetal adrenal. In: Saez JM, Brownie AC, Capponi A, Chambaz EF, Mantero F (eds) Cellular and Molecular Biology of the Adrenal Cortex. John Libby and Company, London, pp 235-245
139. Osborne CK, Coronado EB, Kitten LJ, Arteaga CI, Fuqua SA, Ramasharma K, Marshall M, Li CH 1989 Insulin-like growth factor-II (IGF-II): a potential autocrine/paracrine growth factor for human breast cancer acting via the IGF-I receptor. Mol Endocrinol 3:1710-1719
140. Rosenfeld RG, Beukers MW, Oh Y, Zhang H, Ling N 1991 Insulin-like growth factor receptor physiology: use of IGF-II analogs as probes of receptor function. In: Spencer E (ed) Modern Concepts of Insulin-Like Growth Factors. Elsevier, New York, pp 439-448
141. Mesiano S, Jaffe RB 1993 Interaction of insulin-like growth factor-II and estradiol directs steroidogenesis in the human fetal adrenal toward dehydroepiandrosterone sulfate production. J Clin Endocrinol Metab 77:754-758
142. L'Alleman D, Penhoat A, Lebrethon MC, Ardevol R, Baehr V, Oelkers W, Saez JM 1996 Insulin-like growth factors enhance steroidogenic enzyme and corticotropin receptor messenger ribonucleic acid levels and corticotropin responsiveness in cultured human adrenocortical cells. J Clin Endocrinol Metab 81:3892-3897
143. Bala RM, Lopatka J, Leung A, McCoy E, McArthur RG 1981 Serum immunoreactive somatomedin levels in normal adults, pregnant women at term, children at various ages, and children with constitutionally delayed growth. J Clin Endocrinol Metab 52:508-512
144. Cutler GB, Glenn M, Bush M, Hodgen GD, Graham CE, Loriaux DL 1978 Adrenarche: a survey of rodents, domestic animals, and primates. Endocrinology 103:2112-2118
145. Ying SY 1988 Inhibins, activins, and follistatins: gonadal proteins modulating the secretion of follicle-stimulating hormone. Endocr Rev 9:267-293
146. Thomsen G, Woolf T, Whitman M, Sokol S, Vaughan J, Vale W, Melton DA 1990 Activins are expressed early in Xenopus embryogenesis and can induce axial mesoderm structures. Cell 63:485-493
147. Dye RB, Rabinovici J, Jaffe RB 1992 Inhibin and activin in reproductive biology. Obstet Gynecol Surv 47:173-185
148. Mathews LS 1994 Activin receptors and cellular signaling by the receptor serine kinase family. Endocr Rev 15:310-325
149. Rabinovici J, Spencer SJ, Doldi N, Goldsmith PC, Schwall R, Jaffe RB 1992 Activin-A as an intraovarian modulator: actions, localization, and regulation of the intact dimer in human ovarian cells. J Clin Invest 89:1528-1536
150. Meunier H, Rivier C, Evans RM, Vale W 1988 Gonadal and extragonadal expression of inhibin alpha, beta A, and beta B subunits in various tissues predicts diverse functions. Proc Nat Acad Sci USA 85:247-251
151. Crawford RJ, Hammond VE, Evans BA, Coghlan JP, Haralambidis J, Hudson B, Penschow JD, Richards RI, Tregear GW 1987 Alpha-inhibin gene expression occurs in the ovine adrenal cortex, and is regulated by adrenocorticotropin. Mol Endocrinol 1:699-706
152. Matzuk MM, Finegold MJ, Mather JP, Krummen L, Lu H, Bradley A 1994 Development of cancer cachexia-like syndrome and adrenal tumors in inhibin-deficient mice. Proc Natl Acad Sci USA 91:8817-8821
153. Spencer SJ, Rabinovici J, Jaffe RB 1990 Human recombinant activin-A inhibits proliferation of human fetal adrenal cells in vitro. J Clin Endocrinol Metab 71:1678-1680
154. Spencer SJ, Rabinovici J, Mesiano S, Goldsmith PC, Jaffe RB 1992 Activin and inhibin in the human adrenal gland: Regulation and differential effects in fetal and adult cells. J Clin Invest 90:142-149
155. Massague J 1990 The transforming growth factor β family. Annu Rev Cell Biol 6:597-641
156. Roberts AB, Flanders KC, Kondaiah P, Thompson NL, van Obberghen-Schilling E, Wakefield LM, Rossi P, de Crombrugghe B, Heine U, Sporn MB 1990 Transforming growth factor beta: biochemistry and roles in embryogenesis, tissue repair and remodeling and carcinogenesis. Recent Prog Horm Res 44:157-197
157. Rainey WE, Viard I, Mason JI, Cochet C, Chambaz EM, Saez JM 1988 Effects of transforming growth factor beta on ovine adrenocortical cells. Mol Cell Endocrinol 60:189-198
158. Gupta P, Franco-Saenz R, Gentry LE, Mulrow PJ 1992 Transforming growth factor-beta 1 inhibits aldosterone and stimulates adrenal renin in cultured bovine zona glomerulosa cells. Endocrinology 131:631-363
159. Hotta M, Baird A 1986 Differential effects of transforming growth factor type beta on the growth and function of adrenocortical cells in vitro. Proc Natl Acad Sci USA 83:7795-7799
160. Feige JJ, Cochet C, Chambaz EM 1986 Type beta transforming growth factor is a potent modulator of differentiated adrenocortical cell functions. Biochem Biophys Res Commun 139:693-700
161. Rainey WE, Viard I, Saez JM 1989 Transforming growth factor beta treatment decreases ACTH receptors on ovine adrenocortical cells. J Biol Chem 264:21474-21477
162. Cochet C, Feige JJ, Chambaz EM 1988 Bovine adrenocortical cells exhibit high affinity transforming growth factor-beta receptors which are regulated by adrenocorticotropin. J Biol Chem 263:5707-5713
163. Riopel L, Branchaud CL, Goodyer CG, Adkar V, Lefebvre Y 1989 Growth-inhibitory effect of TGF-β on human fetal adrenal cells in primary monolayer culture. J Cell Physiol 140:233-238
164. Parker Jr CR, Stankovic AK, Harlin C, Garden L 1992 Adrenocorticotropin interferes with transforming growth factor-beta-induced growth inhibition of neocortical cells from the human fetal adrenal gland. J Clin Endocrinol Metab 75:1519-1521
165. Stankovic AK, Dion LD, Parker Jr CR 1994 Effects of transforming growth factor-beta on human fetal adrenal steroid production. Mol Cell Endocrinol 99:145-151
166. Stankovic AK, Parker Jr CR 1995 Receptor binding of transforming growth factor-beta by human total adrenal cells. Mol Cell Endocrinol 109:159-165
167. Lebrethon MC, Jaillard C, Naville D, Begeot M, Saez JM 1994 Regulation of corticotropin and steroidogenic enzyme mRNAs in human fetal adrenal cells by corticotropin, angiotensin-II and transforming growth factor-β1. Mol Cell Endocrinol 106:137-143
168. Enmark E, Gustafsson J 1996 Orphan nuclear receptors - the first eight years. Mol Endocrinol 10:1293-1307
169. Ikeda Y, Lala DS, Luo X, Kim E, Moisan MP, Parker KL 1993 Characterization of the mouse FTZ-F1 gene, which encodes a key regulator of steroid hydroxylase gene expression. Mol Endocrinol 7:852-860
170. Lala DS, Rice DA, Parker KL 1992 Steroidogenic factor I, a key regulator of steroidogenic enzyme expression, is the mouse homolog of fushi tarazu-factor I. Mol Endocrinol 6:1249-1258
171. 170a. Parker KL, Schimmer BP 1997 Steroidogenic factor 1: a key determinant of endocrine development and function. Endocr Rev 18:361-377
172. Muscatelli F, Strom TM, Walker AP, Zanaria E, Recan D, Meindl A, Bardoni B, Guioli S, Zehetner G, Rabl W, Schwarz HP, Kaplan J, Camerino G, Meitinger T, Monaco AP 1994 Mutations in the DAX-1 gene give rise to both X-linked adrenal hypoplasia congenita and hypogonadotropic hypogonadism. Nature 372:672-676
173. Guo W, Mason JS, Stone Jr CG, Morgan SA, Madu SI, Baldini A, Lindsay EA, Biesecker LG, Copeland KC, Horlick MN, Pettigrew AL, Zanaria E, McCabe ERB 1995 Diagnosis of X-linked adrenal hypoplasia congenita by mutation analysis of the DAX1 gene. JAMA 274:324-330
174. Zanaria E, Muscatelli F, Bardoni B, Strom TM, Guioli S, Guo W, Lalli E, Moser C, Walker AP, McCabe ER, Meitinger T, Monaco AP, Sassone-Corsi P, Camerino G 1994 An unusual member of the nuclear hormone receptor superfamily responsible for X-linked adrenal hypoplasia congenita. Nature 372:635-641
175. Ikeda Y, Shen WH, Ingraham HA, Parker KL 1994 Developmental expression of mouse steroidogenic factor-1, an essential regulator of the steroid hydroxylases. Mol Endocrinol 8:654-662
176. Guo W, Burris TP, Zhang YH, Huang BL, Mason J, Copeland KC, Kupfer SR, Pagon RA, McCabe ER 1996 Genomic sequence of the DAX1 gene: an orphan nuclear receptor responsible for X-linked adrenal hypoplasia congenita and hypogonadotropic hypogonadism. J Clin Endocrinol Metab 81:2481-2486
177. Burris TP, Guo W, Le T, McCabe ER 1995 Identification of a putative steroidogenic factor-1 response element in the DAX-1 promoter. Biochem Biophys Res Commun 214:576-581
178. Goustin AS, Betsholtz C, Pfeifer-Ohlsson S, Persson H, Rydnert J, Bywater M, Holmgren G, Heldin CH, Westermark B, Ohlsson R 1985 Co-expression of the sis and myc proto-oncogenes in developing human placenta suggests autocrine control of trophoblast growth. Cell 41:301-312
179. Gospodarowicz D, Cheng J, Lui G-M, Fujii DK, Baird A, Bohlen P 1985 Fibroblast growth factor in the human placenta. Biochem Biophys Res Commun 128:554-562
180. Fant M, Munro H, Moses AC 1986 An autocrine/paracrine role for insulin-like growth factors in the regulation of human placental growth. J Clin Endocrinol Metab 63:499-505
181. Casey ML, MacDonald PC, Simpson ER 1992 Endocrinological changes of pregnancy. In: Wilson JD, Foster DW (eds) Williams Textbook of Endocrinology. W.B. Saunders Company, Philadelphia, pp 977-991
182. Lanman JT 1957 The adrenal fetal zone: its occurrence in primates and a possible relationship to chorionic gonadotropin. Endocrinology 61:684-691
183. Lauritzen C, Lehmann WD 1967 Levels of chorionic gonadotropin in the newborn infant and their relationship to adrenal dehydroepiandrosterone. J Endocrinol 39:173-182
184. Pabon JE, Li X, Lei ZM, Sanfilippo JS, Yussman MA, Rao CV 1996 Novel presence of luteinizing hormone/chorionic gonadotropin receptors in human adrenal glands. J Clin Endocrinol Metab 81: 2397-2400
185. Lehmann WD, Lauritzen CH 1975 HCG + ACTH stimulation of in vitro dehydroepiandrosterone production in human fetal adrenals from precursor cholesterol and delta5-pregnenolone. J Perinat Med 3:231-236
186. Abu-Hakima M, Branchaud CL, Goodyer CG, Murphy BE 1987 The effects of human chorionic gonadotropin on growth and steroidogenesis of the human fetal adrenal gland in vitro. Am J Obstet Gynecol 156:681-687
187. Sasaki A, Tempst P, Liotta AS, Margioris AN, Hood LE, Kent SB, Sato S, Shinkawa O, Yoshinaga K, Krieger DT 1988 Isolation and characterization of a corticotropin-releasing hormone-like peptide from human placenta. J Clin Endocrinol Metab 67:768-773
188. Schulte HM, Healy DL 1987 Corticotropin releasing hormone- and adrenocorticotropin-like immunoreactivity in human placenta, peripheral and uterine vein plasma. Horm Metab Res 16[Suppl]:44-46
189. Shibasaki T, Odagiri E, Shizume K, Ling N 1982 Corticotropin-releasing factor-like activity in human placental extracts. J Clin Endocrinol Metab 55:384-386
190. Frim DM, Emanuel RL, Robinson BG, Smas CM, Adler GK, Majzoub JA 1988 Characterization and gestational regulation of corticotropin-releasing hormone messenger RNA in human placenta. J Clin Invest 82:287-292
191. Saijonmaa O, Laatikainen T, Wahlstrom T 1988 Corticotrophin-releasing factor in human placenta: localization, concentration and release in vitro. Placenta 9:373-385
192. Riley SC, Walton JC, Herlick JM, Challis JRG 1991 The localization and distribution of corticotropin-releasing hormone in the human placenta and fetal membranes throughout gestation. J Clin Endocrinol Metab 72:1001-1007
193. Grino M, Chrousos GP, Margioris AN 1987 The corticotropin releasing hormone gene is expressed in human placenta. Biochem Biophys Res Commun 148:1208-1214
194. Margioris AN, Grino M, Protos P, Gold PW, Chrousos GP 1988 Corticotropin-releasing hormone and oxytocin stimulate the release of placental proopiomelanocortin peptides. J Clin Endocrinol Metab 66:922-926
195. Petraglia F, Sawchenko PE, Rivier J, Vale W 1987 Evidence for local stimulation of ACTH secretion by corticotropin-releasing factor in human placenta. Nature 328:717-719
196. Liotta A, Osathanondh R, Ryan KJ, Krieger DT 1977 Presence of corticotropin in human placenta: demonstration of in vitro synthesis. Endocrinology 101:1522-1528
197. Liotta AS, Krieger DT 1980 In vitro biosynthesis and comparative posttranslational processing of immunoreactive precursor corticotropin/beta-endorphin by human placental and pituitary cells. Endocrinology 106:1504-1511
198. Goland RS, Wardlaw SL, Stark RI, Brown Jr LS, Frantz AG 1986 High levels of corticotropin-releasing hormone immunoactivity in maternal and fetal plasma during pregnancy. J Clin Endocrinol Metab 63:1199-1203
199. Goland RS, Wardlaw SL, Blum M, Tropper PJ, Stark RI 1988 Biologically active corticotropin-releasing hormone in maternal and fetal plasma during pregnancy. Am J Obstet Gynecol 159:884-890
200. Pepe GJ, Albrecht ED 1995 Actions of placental and fetal adrenal steroid hormones in primate pregnancy. Endocr Rev 16:608-648
201. Mitchell BF, Serón-Ferré M, Jaffe RB 1982 Cortisol-cortisone interrelationship in the late gestation rhesus monkey fetus in utero. Endocrinology 111:1837-1842
202. Kittinger GW, Beamer NB, Hagemenas F, Hill JD, Baughman WL, Ochsner AJ 1972 Evidence for autonomous pituitary-adrenal function in the near-term fetal rhesus (Macaca mulatta). Endocrinology 91:1037-1044
203. Murphy BE, Clark SJ, Donald IR, Pinsky M, Vedady D 1974 Conversion of maternal cortisol to cortisone during placental transfer to the human fetus. Am J Obstet Gynecol 118:538-541
204. 14C cortisol during late pregnancy. J Clin Invest 36:1350-1362
205. Beitins IZ, Bayard F, Ances IG, Kowarski A, Migeon CJ 1973 The metabolic clearance rate, blood production, interconversion and transplacental passage of cortisol and cortisone in pregnancy near term. Pediat Res 7:509-519
206. Pepe GJ, Albrecht ED 1984 Transuteroplacental metabolism of cortisol and cortisone during mid- and late gestation in the baboon. Endocrinology 115:1946-1951
207. Waddell BJ, Albrecht ED, Pepe GJ 1988 Effect of estrogen on the metabolism of cortisol and cortisone in the baboon fetus at midgestation. Biol Reprod 38:1006-1011
208. Pepe GJ, Waddell BJ, Stahl SJ, Albrecht ED 1988 The regulation of transplacental cortisol-cortisone metabolism by estrogen in pregnant baboons. Endocrinology 122:78-83
209. Voutilainen R, Kahri AI 1980 Placental origin of the suppression of 3 beta-hydroxysteroid dehydrogenase in the fetal zone cells of human fetal adrenals. J Steroid Biochem 13:39-43
210. Voutilainen R, Kahri AI, Salmenpera M 1979 The effects of progesterone, pregnenolone, estriol, ACTH and hCG on steroid secretion of cultured human fetal adrenals. J Steroid Biochem 10: 695-700
211. Fujieda K, Faiman C, Reyes FI, Winter JSD 1982 The control of steroidogenesis by human fetal adrenal cells in tissue culture. IV. The effects of exposure to placental steroids. J Clin Endocrinol Metab 54:89-94
212. Hirst JJ, West NB, Brenner RM, Novy MJ 1992 Steroid hormone receptors in the adrenal glands of fetal and adult rhesus monkeys. J Clin Endocrinol Metab 75:308-314
213. Pepe GJ, Waddell BJ, Albrecht ED 1989 Effect of estrogen on pituitary peptide-induced dehydroepiandrosterone secretion in the baboon fetus at midgestation, Endocrinology 125:1519-1524
214. Albrecht ED, Pepe GJ 1987 Effect of estrogen on dehydroepiandrosterone formation by baboon fetal adrenal cells in vitro. Am J Obstet Gynecol 156:1275-1278
215. Albrecht ED, Henson MC, Walker ML, Pepe GJ 1990 Modulation of adrenocorticotropin-stimulated baboon fetal adrenal dehydroepiandrosterone formation in vitro by estrogen at mid- and late gestation. Endocrinology 126:3083-3088
216. Coulter CL, Martin MC, Voytek CC, Hofmann JI, Jaffe RB 1993 Response to hemorrhagic stress in the rhesus monkey fetus in utero: effects on the pituitary-adrenal axis. J Clin Endocrinol Metab 76: 1234-1240
217. Ryan KJ 1959 Metabolism of C-16 oxygenated steroids by human placenta. The formation of estriol. J Biol Chem 234:2006-2008
218. Villee CA, Tsai SC 1969 The de novo synthesis of steroids by the placenta. In: Pecile A, Finzi C (eds) The Foetal-Placental Unit. Excerpta Medica Foundation, Amsterdam, pp 110-119
219. Diczfalusy E 1969 Steroid metabolism in the foeto-placental unit. In: Pecile A, Finzi C (eds) The Foetal-Placental Unit. Excerpta Medica Foundation, Amsterdam, pp 65-109
220. Siiteri PK, Serón-Ferré M 1981 Some new thoughts on the fetoplacental unit and parturition in primates. In: Novy MJ, Resko JA (eds) Fetal Endocrinology. Academic Press, Inc., New York, pp 1-34
221. Cassmer O 1959 Hormone production of the isolated human placenta. Acta Endocrinol (Copenh) 45[Suppl]):9-12
222. Bolté E, Mancuso S, Eriksson G 1964 Studies on the aromatization of neutral steroids in pregnant women: I. Aromatization of C-19 steroids by placenta perfused in situ. Acta Endocrinol (Copenh) 45:535-559
223. 3H-estrogens in normal pregnant women. J Clin Endocrinol Metab 23:1298-1301
224. Diczfalusy E 1964 Endocrine functions of the human fetoplacental unit. Fed Proc 23:791-798
225. Serón-Ferré M, Jaffe RB 1981 The fetal adrenal gland. Annu Rev Physiol 43:141-162
226. Ryan KJ 1969 Theoretical basis for endocrine control of gestation - A comparative approach. In: Pecile A, Finzi C (eds) The Foetal-Placental Unit. Excerpta Medica Foundation, Amsterdam, pp 120-131
227. Tulchinsky D, Hobel CJ, Yeager E, Marshall JR 1972 Plasma estrone, estradiol, estriol, progesterone, and 17-hydroxyprogesterone in human pregnancy. I. Normal pregnancy. Am J Obstet Gynecol 112:1095-1100
228. Townsley JD 1972 Steroid hormones in pregnancy: the baboon as a model for studies on oestrogen synthesis. Acta Endocrinol (Copenh) [Suppl] 166:191-197
229. Nathanielsz PW 1976 Fetal Endocrinology: An Experimental Approach. Elsevier/North-Holland, Amsterdam
230. Honnebier WJ, Swaab DF 1973 The influence of anencephaly upon intrauterine growth of fetus and placenta and upon gestation length. J Obstet Gynaecol Br Comm 80:577-588
231. Mueller-Heubach E, Myers RE, Adamsons K 1972 Effects of adrenalectomy on pregnancy length in the rhesus monkey. Am J Obstet Gynecol 112:221-226
232. Novy MJ, Walsh SW 1983 Dexamethasone and estradiol treatment in pregnant rhesus macaques: effects on gestational length, maternal plasma hormones, and fetal growth. Am J Obstet Gynecol 145:920-931
233. Nathanielsz PW, Figueroa JP, Honnebier MB 1992 In the rhesus monkey placental retention after fetectomy at 121 to 130 days' gestation outlasts the normal duration of pregnancy. Am J Obstet Gynecol 166:1529-1535
234. Umezaki H, Valenzuela GJ, Hess DL, Ducsay CA 1993 Fetectomy alters maternal endocrine and uterine activity rhythms in rhesus macaques during late gestation. Am J Obstet Gynecol 169:1435-1441
235. Mecenas CA, Giussani DA, Owiny JR, Jenkins SL, Wu WX, Honnebier BO, Lockwood CJ, Kong L, Guller S, Nathanielsz PW 1996 Production of premature delivery in pregnant rhesus monkeys by androstenedione infusion. Nat Med 2:443-448
236. Albrecht ED, Crenshaw Jr MC, Pepe GJ 1989 The effect of estrogen on placental delivery after fetectomy in baboons. Am J Obstet Gynecol 160:237-241
237. Shozu M, Akasofu K, Harada T, Kubota Y 1991 A new cause of female pseudohermaphroditism: Placental aromatase deficiency. J Clin Endocrinol Metab 72:560-566
238. Campbell EA, Linton EA, Wolfe CDA, Scragge PR, Jones MT, Lowry PJ 1987 Plasma corticotropin-releasing hormone concentrations during pregnancy and parturition. J Clin Endocrinol Metab 64:1054-1059
239. Sasaki A, Shinkawa O, Margioris AN, Liotta AS, Sato S, Murakami O, Go M, Shimizu Y, Hanew K, Yoshinaga K 1987 Immunoreactive corticotropin-releasing hormone in human plasma during pregnancy, labor, and delivery. J Clin Endocrinol Metab 64:224-229
240. Sasaki A, Liotta AS, Luckey MM, Margioris AN, Suda T, Krieger DT 1984 Immunoreactive corticotropin-releasing factor is present in human plasma during the third trimester of pregnancy. J Clin Endocrinol Metab 59:812-814
241. McLean M, Bisits A, Davies J, Woods R, Lowry P, Smith R 1995 A placental clock controlling the length of human pregnancy. Nat Med 1:460-463
242. Robinson BG, Emanuel RL, Frim DM, Majzoub JA 1988 Glucocorticoid stimulates expression of corticotropin-releasing hormone gene in human placenta. Proc Natl Acad Sci USA 85:5244-5248
243. Karalis K, Goodwin G, Majzoub JA 1996 Cortisol blockade of progesterone: a possible molecular mechanism involved in the initiation of human labor. Nat Med 2:556-560
244. Blumenfeld Z, Jaffe RB 1986 Hypophysiotropic and neuromodulatory regulation of adrenocorticotropin in the human fetal pituitary gland. J Clin Invest 78:288-294
245. Gibbs DM, Stewart RD, Liu JH, Vale W, Rivier J, Yen SS 1982 Effects of synthetic corticotropin-releasing factor and dopamine on the release of immunoreactive beta-endorphin/beta-lipotropin and alpha-melanocyte-stimulating hormone from human fetal pituitaries in vitro. J Clin Endocrinol Metab 55:1149-1152
246. Gibbs DM, Stewart RD, Vale W, Rivier J, Yen SS 1983 Synthetic corticotropin-releasing factor stimulates secretion of immunoreactive beta-endorphin/beta-lipotropin and ACTH by human fetal pituitaries in vitro. Life Sci 32:547-550
247. Petraglia F, Giardino L, Coukos G, Calza L, Vale W, Genazzani AR 1990 Corticotropin releasing factor and parturition: plasma and amniotic fluid levels and placental binding sites. Obstet Gynecol 75:784-789
248. Hillhouse EW, Grammatopoulos D, Milton NG, Quartero HW 1993 The identification of a human myometrial corticotropin-releasing hormone receptor that increases in affinity during pregnancy. J Clin Endocrinol Metab 76:736-741
249. Jones SA, Challis JR 1989 Local stimulation of prostaglandin production by corticotropin-releasing hormone in human fetal membranes and placenta. Biochem Biophys Res Commun 159:192-199
250. Benedetto C, Petraglia F, Marozio L, Chiarolini L, Florio P, Genazzani AR, Massobrio M 1994 Corticotropin-releasing hormone increases prostaglandin F2 alpha activity on human myometrium in vitro. Am J Obstet Gynecol 171:126-131
251. Quartero HWP, Fry CH 1989 Placental corticotropin releasing factor may modulate human parturition. Placenta 10:439-443
252. McLean M, Thompson D, Zhang HP, Brinsmead M, Smith R 1994 Corticotrophin-releasing hormone and beta-endorphin in labour. Eur J Endocrinol 131:167-172
253. Neville AM, O'Hare MJ 1982 The Human Adrenal Cortex. Springer-Verlag, Berlin, pp 11-15