Ovotoxicity and PPAR-mediated aromatase downregulation in female Sprague-Dawley rats following combined oral exposure to benzo[a]pyrene and di-(2-ethylhexyl) phthalate

Toxicology Letters

Volumn 199, Issue 3, 2010, Pages 323-332

  Xu, Chuan ^a,b   Chen, Ji An ^a   Qiu, Zhiqun ^a   Zhao, Qing ^a   Luo, Jiaohua ^a   Yang, Lan ^a   Zeng, Hui ^a   Huang, Yujing ^a   Zhang, Liang ^a   Cao, Jia ^a   Shu, Weiqun ^a  

^a THIRD MILITARY MEDICAL UNIVERSITY   (China)

^b CHENGDU MILITARY GENERAL HOSPITAL   (China)

Author keywords

Benzo a pyrene (B a P); Combination; Di (2 ethylhexyl) phthalate (DEHP); Granulosa cells; Mechanism; Ovotoxicity

Indexed keywords

AROMATASE; BENZO[A]PYRENE; ESTRADIOL; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PHTHALIC ACID BIS(2 ETHYLHEXYL) ESTER;

ANIMAL EXPERIMENT; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CONTROLLED STUDY; DOWN REGULATION; ESTRADIOL BLOOD LEVEL; ESTRUS CYCLE; FEMALE; GENE EXPRESSION; GENE EXPRESSION PROFILING; GRANULOSA CELL; HOMEOSTASIS; HORMONE RELEASE; NONHUMAN; NUCLEOTIDE SEQUENCE; ORGAN WEIGHT; OVARY; OVARY FOLLICLE; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; REPRODUCTIVE TOXICITY; SIGNAL TRANSDUCTION;

ADMINISTRATION, ORAL; ANIMALS; APOPTOSIS; AROMATASE; BENZO(A)PYRENE; DIETHYLHEXYL PHTHALATE; DOWN-REGULATION; ESTRADIOL; ESTRUS; FEMALE; OVARY; PEROXISOME PROLIFERATOR-ACTIVATED RECEPTORS; RATS; RATS, SPRAGUE-DAWLEY;

RATTUS; ZEA MAYS;

EID: 78650514297     PISSN: 03784274     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.toxlet.2010.09.015     Document Type: Article

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