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Volumn , Issue , 2013, Pages 489-514

Ergosterol Biosynthesis for the Specific Treatment of Chagas Disease: From Basic Science to Clinical Trials

Author keywords

14 demethylase; Chagas disease; Clinical trials; Ergosterol biosynthesis inhibitor; Posaconazole; Ravuconazole

Indexed keywords


EID: 84886486052     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1002/9783527670383.ch26     Document Type: Chapter
Times cited : (2)

References (158)
  • 1
    • 0000921923 scopus 로고
    • Nova entidade morbida do homen. Resumo greal dos estudos etiológicos e clínicos
    • Chagas, C. (1911) Nova entidade morbida do homen. Resumo greal dos estudos etiológicos e clínicos. Mem. Inst. Oswaldo Cruz, 3, 219-275.
    • (1911) Mem. Inst. Oswaldo Cruz , vol.3 , pp. 219-275
    • Chagas, C.1
  • 3
    • 56249089380 scopus 로고    scopus 로고
    • The neglected tropical diseases of Latin America and the Caribbean: a review of disease burden and distribution and a roadmap for control and elimination
    • Hotez, P.J., Bottazzi, M.E., Franco-Paredes, C., Ault, S.K., and Periago, M.R. (2008) The neglected tropical diseases of Latin America and the Caribbean: a review of disease burden and distribution and a roadmap for control and elimination. PLoS Negl. Trop. Dis., 2, e300.
    • (2008) PLoS Negl. Trop. Dis. , vol.2
    • Hotez, P.J.1    Bottazzi, M.E.2    Franco-Paredes, C.3    Ault, S.K.4    Periago, M.R.5
  • 6
    • 70449591251 scopus 로고    scopus 로고
    • The unfinished public health agenda of Chagas disease in the era of globalization
    • Franco-Paredes, C., Bottazzi, M.E., and Hotez, P.J. (2009) The unfinished public health agenda of Chagas disease in the era of globalization. PLoS Negl. Trop. Dis., 3, e470.
    • (2009) PLoS Negl. Trop. Dis. , vol.3
    • Franco-Paredes, C.1    Bottazzi, M.E.2    Hotez, P.J.3
  • 7
    • 48349098874 scopus 로고    scopus 로고
    • Commentary: Chagas disease: 100 years since discovery and lessons for the future
    • Gurtler, R.E., Diotaiuti, L., and Kitron, U. (2008) Commentary: Chagas disease: 100 years since discovery and lessons for the future. Int. J. Epidemiol., 37, 698-701.
    • (2008) Int. J. Epidemiol. , vol.37 , pp. 698-701
    • Gurtler, R.E.1    Diotaiuti, L.2    Kitron, U.3
  • 10
    • 34249650285 scopus 로고    scopus 로고
    • Chagas disease in the United States: a cause for concern in Louisiana?
    • Diaz, J.H. (2007) Chagas disease in the United States: a cause for concern in Louisiana? J. La. State Med. Soc., (21-3), 25-29.
    • (2007) J. La. State Med. Soc. , vol.21-23 , pp. 25-29
    • Diaz, J.H.1
  • 11
    • 50849110476 scopus 로고    scopus 로고
    • Seroprevalence of Trypanosoma cruzi infection in at-risk blood donors in Catalonia (Spain)
    • Piron, M., Verges, M., Munoz, J., Casamitjana, N., Sanz, S., Maymo, R.M., Hernandez, J.M. et al. (2008) Seroprevalence of Trypanosoma cruzi infection in at-risk blood donors in Catalonia (Spain). Transfusion, 48, 1862- L 1868.
    • (2008) Transfusion , vol.48
    • Piron, M.1    Verges, M.2    Munoz, J.3    Casamitjana, N.4    Sanz, S.5    Maymo, R.M.6    Hernandez, J.M.7
  • 12
    • 34247855091 scopus 로고    scopus 로고
    • Diagnosis, management and treatment of chronic Chagas' heart disease in areas where Trypanosoma cruzi infection is not endemic
    • Gascon, J., Albajar, P., Canas, E., Flores, M., Gomez Prat, J., Herrera, R.N., Lafuente, C.A. et al. (2007) Diagnosis, management and treatment of chronic Chagas' heart disease in areas where Trypanosoma cruzi infection is not endemic. Rev. Esp. Cardiol., 60, 285-293.
    • (2007) Rev. Esp. Cardiol. , vol.60 , pp. 285-293
    • Gascon, J.1    Albajar, P.2    Canas, E.3    Flores, M.4    Gomez Prat, J.5    Herrera, R.N.6    Lafuente, C.A.7
  • 14
    • 0036637084 scopus 로고    scopus 로고
    • The impact of Chagas disease control in Latin America: a review
    • Dias, J.C., Silveira, A.C., and Schofield, C. J. (2002) The impact of Chagas disease control in Latin America: a review. Mem. Inst. Oswaldo Cruz, 97, 603-612.
    • (2002) Mem. Inst. Oswaldo Cruz , vol.97 , pp. 603-612
    • Dias, J.C.1    Silveira, A.C.2    Schofield, C.J.3
  • 15
    • 64749110340 scopus 로고    scopus 로고
    • Challenges and opportunities for primary, secondary, and tertiary prevention of Chagas disease
    • Rassi, A.Jr., Dias, J.C., Marin-Neto, J.A., and Rassi, A. (2009) Challenges and opportunities for primary, secondary, and tertiary prevention of Chagas disease. Heart., 95, 524-534.
    • (2009) Heart. , vol.95 , pp. 524-534
    • Rassi Jr., A.1    Dias, J.C.2    Marin-Neto, J.A.3    Rassi, A.4
  • 16
    • 0142227145 scopus 로고    scopus 로고
    • Specific chemotherapy of Chagas disease: controversies and advances
    • Urbina, J.A. and Docampo, R. (2003) Specific chemotherapy of Chagas disease: controversies and advances. Trends Parasitol., 19, 495-501.
    • (2003) Trends Parasitol. , vol.19 , pp. 495-501
    • Urbina, J.A.1    Docampo, R.2
  • 17
    • 33646833207 scopus 로고    scopus 로고
    • The treatment of Chagas disease (South American trypanosomiasis)
    • Pinto Dias, J.C. (2006) The treatment of Chagas disease (South American trypanosomiasis). Ann. Intern. Med., 144, 772-774.
    • (2006) Ann. Intern. Med. , vol.144 , pp. 772-774
    • Pinto Dias, J.C.1
  • 19
    • 77953082627 scopus 로고    scopus 로고
    • Specific chemotherapy of Chagas disease: relevance, current limitations and new approaches
    • Urbina, J.A. (2009) Specific chemotherapy of Chagas disease: relevance, current limitations and new approaches. Acta Trop., 115, 55-68.
    • (2009) Acta Trop. , vol.115 , pp. 55-68
    • Urbina, J.A.1
  • 20
    • 70349967303 scopus 로고    scopus 로고
    • The role of parasite persistence in pathogenesis of Chagas heart disease
    • Gutierrez, F.R., Guedes, P.M., Gazzinelli, R.T., and Silva, J.S. (2009) The role of parasite persistence in pathogenesis of Chagas heart disease. Parasite Immunol., 31, 673-685.
    • (2009) Parasite Immunol. , vol.31 , pp. 673-685
    • Gutierrez, F.R.1    Guedes, P.M.2    Gazzinelli, R.T.3    Silva, J.S.4
  • 21
    • 0030870893 scopus 로고    scopus 로고
    • Immunological control of Trypanosoma cruzi infection and pathogenesis of Chagas' disease
    • Brener, Z. and Gazzinelli, R.T. (1997) Immunological control of Trypanosoma cruzi infection and pathogenesis of Chagas' disease. Int. Arch. Allergy Immunol., 114, 103-110.
    • (1997) Int. Arch. Allergy Immunol. , vol.114 , pp. 103-110
    • Brener, Z.1    Gazzinelli, R.T.2
  • 26
    • 17544400692 scopus 로고    scopus 로고
    • Long term evaluation of etiological treatment of Chagas disease with benznidazole
    • CanScado, J.R. (2002) Long term evaluation of etiological treatment of Chagas disease with benznidazole. Rev. Inst. Med. Trop. Sao Paulo, 44, 29-37.
    • (2002) Rev. Inst. Med. Trop. Sao Paulo , vol.44 , pp. 29-37
    • CanScado, J.R.1
  • 27
    • 0033253710 scopus 로고    scopus 로고
    • Criteria of Chagas disease cure
    • CanScado, J.R. (1999) Criteria of Chagas disease cure. Mem. Inst. Oswaldo Cruz, (Suppl. 1), 331-336.
    • (1999) Mem. Inst. Oswaldo Cruz , Issue.SUPPL. 1 , pp. 331-336
    • CanScado, J.R.1
  • 28
    • 64749110340 scopus 로고    scopus 로고
    • Challenges and opportunities for primary, secondary, and tertiary prevention of Chagas' disease
    • Rassi, A.Jr., Dias, J.C., Marin-Neto, J.A., and Rassi, A. (2009) Challenges and opportunities for primary, secondary, and tertiary prevention of Chagas' disease. Heart, 95, 524-534.
    • (2009) Heart , vol.95 , pp. 524-534
    • Rassi Jr., A.1    Dias, J.C.2    Marin-Neto, J.A.3    Rassi, A.4
  • 30
    • 0023609713 scopus 로고
    • Susceptibility and natural resistance of Trypanosoma cruzi strains to drugs used clinically in Chagas disease
    • Filardi, L.S. and Brener, Z. (1987) Susceptibility and natural resistance of Trypanosoma cruzi strains to drugs used clinically in Chagas disease. Trans. R. Soc. Trop. Med. Hyg., 81, 755-759.
    • (1987) Trans. R. Soc. Trop. Med. Hyg. , vol.81 , pp. 755-759
    • Filardi, L.S.1    Brener, Z.2
  • 31
    • 17344379918 scopus 로고    scopus 로고
    • Molecular characterization of susceptible and naturally resistant strains of Trypanosoma cruzi to benznidazole and nifurtimox
    • Murta, S.M., Gazzinelli, R.T., Brener, Z., and Romanha, A.J. (1998) Molecular characterization of susceptible and naturally resistant strains of Trypanosoma cruzi to benznidazole and nifurtimox. Mol. Biochem. Parasitol., 93, 203-214.
    • (1998) Mol. Biochem. Parasitol. , vol.93 , pp. 203-214
    • Murta, S.M.1    Gazzinelli, R.T.2    Brener, Z.3    Romanha, A.J.4
  • 32
    • 70449566766 scopus 로고    scopus 로고
    • Feasibility, drug safety, and effectiveness of etiological treatment programs for Chagas disease in Honduras, Guatemala, and Bolivia: 10-year experience of Medecins sans Frontieres
    • Yun, O., Lima, M.A., Ellman, T., Chambi, W., Castillo, S., Flevaud, L., Roddy, P. et al. (2009) Feasibility, drug safety, and effectiveness of etiological treatment programs for Chagas disease in Honduras, Guatemala, and Bolivia: 10-year experience of Medecins sans Frontieres. PLoS. Negl. Trop. Dis., 3, e488.
    • (2009) PLoS. Negl. Trop. Dis. , vol.3
    • Yun, O.1    Lima, M.A.2    Ellman, T.3    Chambi, W.4    Castillo, S.5    Flevaud, L.6    Roddy, P.7
  • 33
    • 0037105691 scopus 로고    scopus 로고
    • Experimental chemotherapy against Trypanosoma cruzi infection: essential role of endogenous interferongamma in mediating parasitologic cure
    • Romanha, A.J., Alves, R.O., Murta, S.M., Silva, J.S., Ropert, C., and Gazzinelli, R.T. (2002) Experimental chemotherapy against Trypanosoma cruzi infection: essential role of endogenous interferongamma in mediating parasitologic cure. J. Infect. Dis., 186, 823-828.
    • (2002) J. Infect. Dis. , vol.186 , pp. 823-828
    • Romanha, A.J.1    Alves, R.O.2    Murta, S.M.3    Silva, J.S.4    Ropert, C.5    Gazzinelli, R.T.6
  • 34
    • 0033836587 scopus 로고    scopus 로고
    • Immunological and clinical evaluation of chagasic patients subjected to chemotherapy during the acute phase of Trypanosoma cruzi infection 14-30 years ago
    • Bahia-Oliveira, L.M., Gomes, J.A., Cancado, J.R., Ferrari, T.C., Lemos, E.M., Luz, Z.M., Moreira, M.C. et al. (2000) Immunological and clinical evaluation of chagasic patients subjected to chemotherapy during the acute phase of Trypanosoma cruzi infection 14-30 years ago. J. Infect. Dis., 182, 634-638.
    • (2000) J. Infect. Dis. , vol.182 , pp. 634-638
    • Bahia-Oliveira, L.M.1    Gomes, J.A.2    Cancado, J.R.3    Ferrari, T.C.4    Lemos, E.M.5    Luz, Z.M.6    Moreira, M.C.7
  • 37
    • 33750503607 scopus 로고    scopus 로고
    • Etiological treatment in patients infected by Trypanosoma cruzi: experiences in Argentina
    • Sosa-Estani, S. and Segura, E.L. (2006) Etiological treatment in patients infected by Trypanosoma cruzi: experiences in Argentina. Curr. Opin. Infect. Dis., 19, 583-587.
    • (2006) Curr. Opin. Infect. Dis. , vol.19 , pp. 583-587
    • Sosa-Estani, S.1    Segura, E.L.2
  • 38
    • 0034153419 scopus 로고    scopus 로고
    • Evaluation of an specific treatment for Trypanosoma cruzi in children, in the evolution of the indeterminate phase
    • Silveira, C.A., Castillo, E., and Castro, C. (2000) Evaluation of an specific treatment for Trypanosoma cruzi in children, in the evolution of the indeterminate phase. Rev. Soc. Bras. Med. Trop., 33, 191-196.
    • (2000) Rev. Soc. Bras. Med. Trop. , vol.33 , pp. 191-196
    • Silveira, C.A.1    Castillo, E.2    Castro, C.3
  • 40
    • 44449142382 scopus 로고    scopus 로고
    • Persistence of PCRpositive tissue in benznidazole-treatedmice with negative blood parasitological and serological tests in dual infections with Trypanosoma cruzi stocks from different genotypes
    • Martins, H.R., Figueiredo, L.M., Valamiel-Silva, J.C., Carneiro, C.M., Machado-Coelho, G.L., Vitelli-Avelar, D.M., Bahia, M.T. et al. (2008) Persistence of PCRpositive tissue in benznidazole-treatedmice with negative blood parasitological and serological tests in dual infections with Trypanosoma cruzi stocks from different genotypes. J. Antimicrob. Chemother., 61, 1319-1327.
    • (2008) J. Antimicrob. Chemother. , vol.61 , pp. 1319-1327
    • Martins, H.R.1    Figueiredo, L.M.2    Valamiel-Silva, J.C.3    Carneiro, C.M.4    Machado-Coelho, G.L.5    Vitelli-Avelar, D.M.6    Bahia, M.T.7
  • 46
    • 62549113879 scopus 로고    scopus 로고
    • Efficacy of benznidazol treatment for asymptomatic chagasic patients from state of Rio Grande do Sul evaluated during a three years follow-up
    • Fernandes, C.D., Tiecher, F.M., Balbinot, M.M., Liarte, D.B., Scholl, D., Steindel, M., and Romanha, A. (2009) Efficacy of benznidazol treatment for asymptomatic chagasic patients from state of Rio Grande do Sul evaluated during a three years follow-up. Mem. Inst. Oswaldo Cruz, 104, 27-32.
    • (2009) Mem. Inst. Oswaldo Cruz , vol.104 , pp. 27-32
    • Fernandes, C.D.1    Tiecher, F.M.2    Balbinot, M.M.3    Liarte, D.B.4    Scholl, D.5    Steindel, M.6    Romanha, A.7
  • 47
    • 0033963255 scopus 로고    scopus 로고
    • The targets of the lytic antibody response against Trypanosoma cruzi
    • Krautz, G.M., Kissinger, J.C., and Krettli, A.U. (2000) The targets of the lytic antibody response against Trypanosoma cruzi. Parasitol. Today, 16, 31-34.
    • (2000) Parasitol. Today , vol.16 , pp. 31-34
    • Krautz, G.M.1    Kissinger, J.C.2    Krettli, A.U.3
  • 49
    • 0141675203 scopus 로고    scopus 로고
    • Enzyme-linked immunoassay using recombinant transsialidase of Trypanosoma cruzi can be employed for monitoring of patients with Chagas' disease after drug treatment
    • Pereira-Chioccola, V.L., Fragata-Filho, A. A., Levy, A.M., Rodrigues, M.M., and Schenkman, S. (2003) Enzyme-linked immunoassay using recombinant transsialidase of Trypanosoma cruzi can be employed for monitoring of patients with Chagas' disease after drug treatment. Clin. Diagn. Lab. Immunol., 10, 826-830.
    • (2003) Clin. Diagn. Lab. Immunol. , vol.10 , pp. 826-830
    • Pereira-Chioccola, V.L.1    Fragata-Filho, A.A.2    Levy, A.M.3    Rodrigues, M.M.4    Schenkman, S.5
  • 50
    • 84934440537 scopus 로고    scopus 로고
    • Sterol 14-demethylase inhibitors for Trypanosoma cruzi infections
    • Buckner, F.S. (2008) Sterol 14-demethylase inhibitors for Trypanosoma cruzi infections. Adv. Exp. Med. Biol., 625, 61-80.
    • (2008) Adv. Exp. Med. Biol. , vol.625 , pp. 61-80
    • Buckner, F.S.1
  • 51
    • 34547905013 scopus 로고    scopus 로고
    • Etiological treatment of chronic Chagas disease: neglected 'evidence' by evidencebased medicine
    • Viotti, R. and Vigliano, C. (2007) Etiological treatment of chronic Chagas disease: neglected 'evidence' by evidencebased medicine. Expert Rev. Anti Infect. Ther., 5, 717-726.
    • (2007) Expert Rev. Anti Infect. Ther. , vol.5 , pp. 717-726
    • Viotti, R.1    Vigliano, C.2
  • 52
    • 33646847271 scopus 로고    scopus 로고
    • Long-term cardiac outcomes of treating chronic Chagas disease with benznidazole versus no treatment: a nonrandomized trial
    • Viotti, R., Vigliano, C., Lococo, B., Bertocchi, G., Petti, M., Alvarez, M.G., Postan, M. et al. (2006) Long-term cardiac outcomes of treating chronic Chagas disease with benznidazole versus no treatment: a nonrandomized trial. Ann. Intern. Med., 144, 724-734.
    • (2006) Ann. Intern. Med. , vol.144 , pp. 724-734
    • Viotti, R.1    Vigliano, C.2    Lococo, B.3    Bertocchi, G.4    Petti, M.5    Alvarez, M.G.6    Postan, M.7
  • 54
    • 0025166484 scopus 로고
    • Sensitivity of parasites to free radical damage by antiparasitic drugs
    • Docampo, R. (1990) Sensitivity of parasites to free radical damage by antiparasitic drugs. Chem. Biol. Interact., 73, 1-27.
    • (1990) Chem. Biol. Interact. , vol.73 , pp. 1-27
    • Docampo, R.1
  • 56
    • 77955436769 scopus 로고    scopus 로고
    • New insights in Chagas' disease treatment
    • Urbina, J.A. (2010) New insights in Chagas' disease treatment. Drugs Future, 35, 409-419.
    • (2010) Drugs Future , vol.35 , pp. 409-419
    • Urbina, J.A.1
  • 57
    • 77953082627 scopus 로고    scopus 로고
    • Specific chemotherapy of Chagas disease: relevance, current limitations and new approaches
    • Urbina, J.A. (2010) Specific chemotherapy of Chagas disease: relevance, current limitations and new approaches. Acta Trop., 115, 55-68.
    • (2010) Acta Trop. , vol.115 , pp. 55-68
    • Urbina, J.A.1
  • 58
    • 68949212150 scopus 로고    scopus 로고
    • Chagas heart disease: pathophysiologic mechanisms, prognostic factors and risk stratification
    • Rassi, A.Jr., Rassi, A., and Marin-Neto, J. A. (2009) Chagas heart disease: pathophysiologic mechanisms, prognostic factors and risk stratification. Mem. Inst. Oswaldo Cruz, 104 (Suppl. 1), 152-158.
    • (2009) Mem. Inst. Oswaldo Cruz , vol.104 , Issue.SUPPL. 1 , pp. 152-158
    • Rassi Jr., A.1    Rassi, A.2    Marin-Neto, J.A.3
  • 59
    • 0030271981 scopus 로고    scopus 로고
    • Autoimmunity in Chagas disease cardiomyopathy: fullfilling the criteria at last?
    • Kalil, J. and Cunha-Neto, E. (1996) Autoimmunity in Chagas disease cardiomyopathy: fullfilling the criteria at last? Parasitol. Today, 12, 396-399.
    • (1996) Parasitol. Today , vol.12 , pp. 396-399
    • Kalil, J.1    Cunha-Neto, E.2
  • 60
    • 0028939403 scopus 로고
    • Autoinmunity in Chagas disease cardiopathy: biological relevance of a cardiac myosin-specific epitope crossreactive to an inmunodominant Trypanosoma cruzi antigen
    • Cunha-Neto, E., Duranti, M., Gruber, A., Zingales, B., De Messias, I., Stolf, N., Bellotti, G. et al. (1995) Autoinmunity in Chagas disease cardiopathy: biological relevance of a cardiac myosin-specific epitope crossreactive to an inmunodominant Trypanosoma cruzi antigen. Proc. Natl. Acad. Sci. USA, 92, 3541-3545.
    • (1995) Proc. Natl. Acad. Sci. USA , vol.92 , pp. 3541-3545
    • Cunha-Neto, E.1    Duranti, M.2    Gruber, A.3    Zingales, B.4    De Messias, I.5    Stolf, N.6    Bellotti, G.7
  • 61
    • 0033256630 scopus 로고    scopus 로고
    • Parasitological cure of Chagas disease: is it possible? Is it relevant?
    • Urbina, J.A. (1999) Parasitological cure of Chagas disease: is it possible?, Is it relevant? Mem. Inst. Oswaldo Cruz, (Suppl. 1), 349-355.
    • (1999) Mem. Inst. Oswaldo Cruz , Issue.SUPPL. 1 , pp. 349-355
    • Urbina, J.A.1
  • 62
    • 26844461073 scopus 로고    scopus 로고
    • Chemotherapy of trypanosomiases and leishmaniasis
    • Croft, S.L., Barrett, M.P., and Urbina, J.A. (2005) Chemotherapy of trypanosomiases and leishmaniasis. Trends Parasitol., 21, 508-512.
    • (2005) Trends Parasitol. , vol.21 , pp. 508-512
    • Croft, S.L.1    Barrett, M.P.2    Urbina, J.A.3
  • 63
    • 0035340666 scopus 로고    scopus 로고
    • Parasite persistence in the aetiology of Chagas disease
    • Tarleton, R.L. (2001) Parasite persistence in the aetiology of Chagas disease. Int. J. Parasitol., 31, 550-554.
    • (2001) Int. J. Parasitol. , vol.31 , pp. 550-554
    • Tarleton, R.L.1
  • 65
    • 45549100534 scopus 로고    scopus 로고
    • Rationale and design of a randomized placebocontrolled trial assessing the effects of etiologic treatment in Chagas' cardiomyopathy: the BENznidazole Evaluation For Interrupting Trypanosomiasis (BENEFIT)
    • Marin-Neto, J.A., Rassi, A.Jr., Morillo, C. A., Avezum, A., Connolly, S.J., Sosa-Estani, S., Rosas, F. et al. (2008) Rationale and design of a randomized placebocontrolled trial assessing the effects of etiologic treatment in Chagas' cardiomyopathy: the BENznidazole Evaluation For Interrupting Trypanosomiasis (BENEFIT). Am. Heart J., 156, 37-43.
    • (2008) Am. Heart J. , vol.156 , pp. 37-43
    • Marin-Neto, J.A.1    Rassi Jr., A.2    Morillo, C.A.3    Avezum, A.4    Connolly, S.J.5    Sosa-Estani, S.6    Rosas, F.7
  • 66
    • 0032412784 scopus 로고    scopus 로고
    • Biochemistry, cell biology and molecular biology of lipids of Saccharomyces cerevisiae
    • Daum, G., Lees, N.D., Bard, M., and Dickson, R. (1998) Biochemistry, cell biology and molecular biology of lipids of Saccharomyces cerevisiae. Yeast, 14, 1471-1510.
    • (1998) Yeast , vol.14 , pp. 1471-1510
    • Daum, G.1    Lees, N.D.2    Bard, M.3    Dickson, R.4
  • 67
    • 0024672966 scopus 로고
    • Sterols of parasitic protozoa and helminths
    • Furlong, S.T. (1989) Sterols of parasitic protozoa and helminths. Exp. Parasitol., 68, 482-485.
    • (1989) Exp. Parasitol. , vol.68 , pp. 482-485
    • Furlong, S.T.1
  • 68
    • 0014678296 scopus 로고
    • The sterols of Trypanosoma cruzi and Crithidia fasciculata
    • Korn, E.D., Von Brand, T., and Tobie, E.J. (1969) The sterols of Trypanosoma cruzi and Crithidia fasciculata. Comp. Biochem. Physiol., 30, 601-610.
    • (1969) Comp. Biochem. Physiol. , vol.30 , pp. 601-610
    • Korn, E.D.1    Von Brand, T.2    Tobie, E.J.3
  • 69
    • 0031941787 scopus 로고    scopus 로고
    • In-vitro antiproliferative effects and mechanism of action of the bis-triazole D0870 and its S(-) enantiomer against Trypanosoma cruzi
    • Liendo, A., Lazardi, K., and Urbina, J.A. (1998) In-vitro antiproliferative effects and mechanism of action of the bis-triazole D0870 and its S(-) enantiomer against Trypanosoma cruzi. J. Antimicrob. Chemother., 41, 197-205.
    • (1998) J. Antimicrob. Chemother. , vol.41 , pp. 197-205
    • Liendo, A.1    Lazardi, K.2    Urbina, J.A.3
  • 71
    • 69049116505 scopus 로고    scopus 로고
    • Ergosterol biosynthesis and drug development for Chagas disease
    • Urbina, J.A. (2009) Ergosterol biosynthesis and drug development for Chagas disease. Mem. Inst. Oswaldo Cruz, (Suppl. 1), 311-318.
    • (2009) Mem. Inst. Oswaldo Cruz , Issue.SUPPL. 1 , pp. 311-318
    • Urbina, J.A.1
  • 72
    • 0023793225 scopus 로고
    • Alteration of lipid order profile and permeability of plasma membranes from Trypanosoma cruzi epimastigotes grown in the presence of ketoconazole
    • Urbina, J.A., Vivas, J., Ramos, H., Larralde, G., Aguilar, Z., and Avilan, L. (1988) Alteration of lipid order profile and permeability of plasma membranes from Trypanosoma cruzi epimastigotes grown in the presence of ketoconazole. Mol. Biochem. Parasitol., 30, 185-195.
    • (1988) Mol. Biochem. Parasitol. , vol.30 , pp. 185-195
    • Urbina, J.A.1    Vivas, J.2    Ramos, H.3    Larralde, G.4    Aguilar, Z.5    Avilan, L.6
  • 73
    • 0030973599 scopus 로고    scopus 로고
    • Altered lipid composition and enzyme activities of plasma membranes from Trypanosoma (Schizotrypanum) cruzi epimastigotes grown in the presence of sterol biosynthesis inhibitors
    • Contreras, L.M., Vivas, J., and Urbina, J.A. (1997) Altered lipid composition and enzyme activities of plasma membranes from Trypanosoma (Schizotrypanum) cruzi epimastigotes grown in the presence of sterol biosynthesis inhibitors. Biochem. Pharmacol., 53, 697-704.
    • (1997) Biochem. Pharmacol. , vol.53 , pp. 697-704
    • Contreras, L.M.1    Vivas, J.2    Urbina, J.A.3
  • 75
    • 0029047470 scopus 로고
    • Molecular order and dynamics of phosphatidylcholine bilayer membranes in the presence of cholesterol, ergosterol and lanosterol: a comparative study using 2H-, 13C- and 31P-NMR spectroscopy
    • Urbina, J.A., Pekerar, S., Le, H.B., Patterson, J., Montez, B., and Oldfield, E. (1995) Molecular order and dynamics of phosphatidylcholine bilayer membranes in the presence of cholesterol, ergosterol and lanosterol: a comparative study using 2H-, 13C- and 31P-NMR spectroscopy. Biochim. Biophys. Acta, 1238, 163-176.
    • (1995) Biochim. Biophys. Acta , vol.1238 , pp. 163-176
    • Urbina, J.A.1    Pekerar, S.2    Le, H.B.3    Patterson, J.4    Montez, B.5    Oldfield, E.6
  • 76
    • 0031658230 scopus 로고    scopus 로고
    • A carbon-13 nuclear magnetic resonance spectroscopic study of interproton pair order parameters: a new approach to study order and dynamics in phospholipid membrane systems
    • Urbina, J.A., Moreno, B., Arnold, W., Taron, C.H., Orlean, P., and Oldfield, E. (1998) A carbon-13 nuclear magnetic resonance spectroscopic study of interproton pair order parameters: a new approach to study order and dynamics in phospholipid membrane systems. Biophys. J., 75, 1372-1383.
    • (1998) Biophys. J. , vol.75 , pp. 1372-1383
    • Urbina, J.A.1    Moreno, B.2    Arnold, W.3    Taron, C.H.4    Orlean, P.5    Oldfield, E.6
  • 77
    • 0025114817 scopus 로고
    • Ultrastructural alterations induced by two ergosterol biosynthesis inhibitors, ketoconazole and terbinafine, on epimastigotes and amastigotes of Trypanosoma (Schizotrypanum) cruzi
    • Lazardi, K., Urbina, J.A., and de Souza,W. (1990) Ultrastructural alterations induced by two ergosterol biosynthesis inhibitors, ketoconazole and terbinafine, on epimastigotes and amastigotes of Trypanosoma (Schizotrypanum) cruzi. Antimicrob. Agents Chemother., 34, 2097-2105.
    • (1990) Antimicrob. Agents Chemother. , vol.34 , pp. 2097-2105
    • Lazardi, K.1    Urbina, J.A.2    de Souza, W.3
  • 78
    • 0025872450 scopus 로고
    • Ultrastructural alterations induced by ICI 195,739, a bis-triazole derivative with strong antiproliferative action against Trypanosoma (Schizotrypanum) cruzi
    • Lazardi, K., Urbina, J.A., and de Souza,W. (1991) Ultrastructural alterations induced by ICI 195,739, a bis-triazole derivative with strong antiproliferative action against Trypanosoma (Schizotrypanum) cruzi. Antimicrob. Agents Chemother., 35, 736-740.
    • (1991) Antimicrob. Agents Chemother. , vol.35 , pp. 736-740
    • Lazardi, K.1    Urbina, J.A.2    De Souza, W.3
  • 79
    • 0034806092 scopus 로고    scopus 로고
    • The sterol composition of Trypanosoma cruzi changes after growth in different culture media and results in different sensitivity to digitonin-permeabilization
    • Rodrigues, C.O., Catisti, R., Uyemura, S. A., Vercesi, A.E., Lira, R., Rodriguez, C., Urbina, J.A. et al. (2001) The sterol composition of Trypanosoma cruzi changes after growth in different culture media and results in different sensitivity to digitonin-permeabilization. J. Eukaryot. Microbiol., 48, 588-594.
    • (2001) J. Eukaryot. Microbiol. , vol.48 , pp. 588-594
    • Rodrigues, C.O.1    Catisti, R.2    Uyemura, S.A.3    Vercesi, A.E.4    Lira, R.5    Rodriguez, C.6    Urbina, J.A.7
  • 81
    • 0031807492 scopus 로고    scopus 로고
    • Antiproliferative effects and mechanism of action of SCH 56592 against Trypanosoma (Schizotrypanum) cruzi: in vitro and in vivo studies
    • Urbina, J.A., Payares, G., Contreras, L.M., Liendo, A., Sanoja, C., Molina, J., Piras, M. et al. (1998) Antiproliferative effects and mechanism of action of SCH 56592 against Trypanosoma (Schizotrypanum) cruzi: in vitro and in vivo studies. Antimicrob. Agents Chemother., 42, 1771-1777.
    • (1998) Antimicrob. Agents Chemother. , vol.42 , pp. 1771-1777
    • Urbina, J.A.1    Payares, G.2    Contreras, L.M.3    Liendo, A.4    Sanoja, C.5    Molina, J.6    Piras, M.7
  • 82
    • 33645639221 scopus 로고    scopus 로고
    • CYP51 from Trypanosoma cruzi: a phyla-specific residue in the B0 helix defines substrate preferences of sterol 14alpha-demethylase
    • Lepesheva, G.I., Zaitseva, N.G., Nes, W. D., Zhou,W., Arase, M., Liu, J., Hill, G.C. et al. (2006) CYP51 from Trypanosoma cruzi: a phyla-specific residue in the B0 helix defines substrate preferences of sterol 14alpha-demethylase. J. Biol. Chem., 281, 3577-3585.
    • (2006) J. Biol. Chem. , vol.281 , pp. 3577-3585
    • Lepesheva, G.I.1    Zaitseva, N.G.2    Nes, W.D.3    Zhou, W.4    Arase, M.5    Liu, J.6    Hill, G.C.7
  • 83
    • 0024430490 scopus 로고
    • Mechanistic studies of lanosterol 14 alpha-methyl demethylase: substrate requirements for the component reactions catalyzed by a single cytochrome P-450 isozyme
    • Fischer, R.T., Stam, S.H., Johnson, P.R., Ko, S.S., Magolda, R.L., Gaylor, J.L., and Trzaskos, J.M. (1989) Mechanistic studies of lanosterol 14 alpha-methyl demethylase: substrate requirements for the component reactions catalyzed by a single cytochrome P-450 isozyme. J. Lipid. Res., 30, 1621-1632.
    • (1989) J. Lipid. Res. , vol.30 , pp. 1621-1632
    • Fischer, R.T.1    Stam, S.H.2    Johnson, P.R.3    Ko, S.S.4    Magolda, R.L.5    Gaylor, J.L.6    Trzaskos, J.M.7
  • 84
    • 79960975304 scopus 로고    scopus 로고
    • Targeting Trypanosoma cruzi sterol 14alphademethylase (CYP51)
    • Lepesheva, G.I., Villalta, F., and Waterman, M.R. (2011) Targeting Trypanosoma cruzi sterol 14alphademethylase (CYP51). Adv. Parasitol., 75, 65-87.
    • (2011) Adv. Parasitol. , vol.75 , pp. 65-87
    • Lepesheva, G.I.1    Villalta, F.2    Waterman, M.R.3
  • 85
    • 0027184261 scopus 로고
    • Selective inhibition of mammalian lanosterol 14 alpha-demethylase: a possible strategy for cholesterol lowering
    • Walker, K.A., Kertesz, D.J., Rotstein, D. M., Swinney, D.C., Berry, P.W., So, O.Y., Webb, A.S. et al. (1993) Selective inhibition of mammalian lanosterol 14 alpha-demethylase: a possible strategy for cholesterol lowering. J. Med. Chem., 36, 2235-2237.
    • (1993) J. Med. Chem. , vol.36 , pp. 2235-2237
    • Walker, K.A.1    Kertesz, D.J.2    Rotstein, D.M.3    Swinney, D.C.4    Berry, P.W.5    So, O.Y.6    Webb, A.S.7
  • 86
    • 77955477571 scopus 로고    scopus 로고
    • Structural insights into inhibition of sterol 14alpha-demethylase in the human pathogen Trypanosoma cruzi
    • Lepesheva, G.I., Hargrove, T.Y., Anderson, S., Kleshchenko, Y., Furtak, V., Wawrzak, Z., Villalta, F. et al. (2010) Structural insights into inhibition of sterol 14alpha-demethylase in the human pathogen Trypanosoma cruzi. J. Biol. Chem., 285, 25582-25590.
    • (2010) J. Biol. Chem. , vol.285 , pp. 25582-25590
    • Lepesheva, G.I.1    Hargrove, T.Y.2    Anderson, S.3    Kleshchenko, Y.4    Furtak, V.5    Wawrzak, Z.6    Villalta, F.7
  • 87
    • 77952358375 scopus 로고    scopus 로고
    • Structural characterization of CYP51 from Trypanosoma cruzi and Trypanosoma brucei bound to the antifungal drugs posaconazole and fluconazole
    • Chen, C.K., Leung, S.S., Guilbert, C., Jacobson, M.P., McKerrow, J.H., and Podust, L.M. (2010) Structural characterization of CYP51 from Trypanosoma cruzi and Trypanosoma brucei bound to the antifungal drugs posaconazole and fluconazole. PLoS Negl. Trop. Dis., 4, e651.
    • (2010) PLoS Negl. Trop. Dis. , vol.4
    • Chen, C.K.1    Leung, S.S.2    Guilbert, C.3    Jacobson, M.P.4    McKerrow, J.H.5    Podust, L.M.6
  • 88
    • 84862909219 scopus 로고    scopus 로고
    • Structural complex of sterol 14alpha-demethylase (CYP51) with 14alpha-methylenecyclopropyl-{delta}7-24,25-dihydrolanosterol
    • Hargrove, T.Y.,Wawrzak, Z., Liu, J., Waterman, M.R., Nes, W.D., and Lepesheva, G.I. (2012) Structural complex of sterol 14alpha-demethylase (CYP51) with 14alpha-methylenecyclopropyl-{delta}7-24,25-dihydrolanosterol. J. Lipid. Res., 52, 311-320.
    • (2012) J. Lipid. Res. , vol.52 , pp. 311-320
    • Hargrove, T.Y.1    Wawrzak, Z.2    Liu, J.3    Waterman, M.R.4    Nes, W.D.5    Lepesheva, G.I.6
  • 89
    • 0036234361 scopus 로고    scopus 로고
    • Chemotherapy of Chagas disease
    • Urbina, J.A. (2002) Chemotherapy of Chagas disease. Curr. Pharm. Design, 8, 287-295.
    • (2002) Curr. Pharm. Design , vol.8 , pp. 287-295
    • Urbina, J.A.1
  • 90
    • 0033003357 scopus 로고    scopus 로고
    • Chemotherapy of Chagas' disease: the how and the why
    • Urbina, J.A. (1999) Chemotherapy of Chagas' disease: the how and the why. J. Mol. Med., 77, 332-338.
    • (1999) J. Mol. Med. , vol.77 , pp. 332-338
    • Urbina, J.A.1
  • 92
    • 33646765351 scopus 로고    scopus 로고
    • Cytoskeleton reassembly in cardiomyocytes infected by Trypanosoma cruzi is triggered by treatment with ergosterol biosynthesis inhibitors
    • Silva, D.T., de Meirelles Mde, N., Almeida, D., Urbina, J.A., and Pereira, M. C. (2006) Cytoskeleton reassembly in cardiomyocytes infected by Trypanosoma cruzi is triggered by treatment with ergosterol biosynthesis inhibitors. Int. J. Antimicrob. Agents, 27, 530-537.
    • (2006) Int. J. ntimicrob. Agents , vol.27 , pp. 530-537
    • Silva, D.T.1    de Meirelles Mde, N.2    Almeida, D.3    Urbina, J.A.4    Pereira, M.C.5
  • 93
    • 34247144012 scopus 로고    scopus 로고
    • The anti-Trypanosoma cruzi activity of posaconazole in a murine model of acute Chagas' disease is less dependent on gamma interferon than that of benznidazole
    • Ferraz, M.L., Gazzinelli, R.T., Alves, R.O., Urbina, J.A., and Romanha, A.J. (2007) The anti-Trypanosoma cruzi activity of posaconazole in a murine model of acute Chagas' disease is less dependent on gamma interferon than that of benznidazole. Antimicrob. Agents Chemother., 51, 1359-1364.
    • (2007) Antimicrob. Agents Chemother. , vol.51 , pp. 1359-1364
    • Ferraz, M.L.1    Gazzinelli, R.T.2    Alves, R.O.3    Urbina, J.A.4    Romanha, A.J.5
  • 94
    • 59749103737 scopus 로고    scopus 로고
    • + T lymphocytes, or B lymphocytes has different effects on the efficacy of posaconazole and benznidazole in treatment of experimental acute Trypanosoma cruzi infection
    • + T lymphocytes, or B lymphocytes has different effects on the efficacy of posaconazole and benznidazole in treatment of experimental acute Trypanosoma cruzi infection. Antimicrob. Agents Chemother., 53, 174-179.
    • (2009) Antimicrob. Agents Chemother. , vol.53 , pp. 174-179
    • Ferraz, M.L.1    Gazzinelli, R.T.2    Alves, R.O.3    Urbina, J.A.4    Romanha, A.J.5
  • 95
    • 77953021818 scopus 로고    scopus 로고
    • A comparative study of posaconazole and benznidazole in the prevention of heart damage and promotion of trypanocidal immune response in a murine model of Chagas disease
    • Olivieri, B.P., Molina, J.T., de Castro, S.L., Pereira, M.C., Calvet, C.M., Urbina, J.A., and Araujo-Jorge, T.C. (2010) A comparative study of posaconazole and benznidazole in the prevention of heart damage and promotion of trypanocidal immune response in a murine model of Chagas disease. Int. J. Antimicrob. Agents, 36, 79-83.
    • (2010) Int. J. Antimicrob. Agents , vol.36 , pp. 79-83
    • Olivieri, B.P.1    Molina, J.T.2    de Castro, S.L.3    Pereira, M.C.4    Calvet, C.M.5    Urbina, J.A.6    Araujo-Jorge, T.C.7
  • 96
    • 77950961025 scopus 로고    scopus 로고
    • Successful treatment with posaconazole of a patient with chronic Chagas disease and systemic lupus erythematosus
    • Pinazo, M.J., Espinosa, G., Gallego, M., Lopez-Chejade, P.L., Urbina, J.A., and Gascon, J. (2010) Successful treatment with posaconazole of a patient with chronic Chagas disease and systemic lupus erythematosus. Am. J. Trop. Med. Hyg., 82, 583-587.
    • (2010) Am. J. Trop. Med. Hyg. , vol.82 , pp. 583-587
    • Pinazo, M.J.1    Espinosa, G.2    Gallego, M.3    Lopez-Chejade, P.L.4    Urbina, J.A.5    Gascon, J.6
  • 97
    • 79951644930 scopus 로고    scopus 로고
    • Posaconazole: a pharmacoeconomic review of its use in the prophylaxis of invasive fungal disease in immunocompromised hosts
    • Lyseng-Williamson, K.A. (2011) Posaconazole: a pharmacoeconomic review of its use in the prophylaxis of invasive fungal disease in immunocompromised hosts. Pharmacoeconomics, 29, 251-268.
    • (2011) Pharmacoeconomics , vol.29 , pp. 251-268
    • Lyseng-Williamson, K.A.1
  • 98
    • 60549085066 scopus 로고    scopus 로고
    • Posaconazole: a new oral antifungal agent with an expanded spectrum of activity
    • Morris, M.I. (2009) Posaconazole: a new oral antifungal agent with an expanded spectrum of activity. Am. J. Health Syst. Pharm., 66, 225-236.
    • (2009) Am. J. Health Syst. Pharm. , vol.66 , pp. 225-236
    • Morris, M.I.1
  • 99
    • 34548607781 scopus 로고    scopus 로고
    • At what price?
    • Danzon, P.M. (2007) At what price? Nature, 449, 176-179.
    • (2007) Nature , vol.449 , pp. 176-179
    • Danzon, P.M.1
  • 100
    • 16244418371 scopus 로고    scopus 로고
    • Comparative efficacies of TAK-187, a longlasting ergosterol biosynthesis inhibitor, and benznidazole in preventing cardiac damage in a murine model of Chagas' disease
    • Corrales, M., Cardozo, R., Segura, M.A., Urbina, J.A., and Basombrio, M.A. (2005) Comparative efficacies of TAK-187, a longlasting ergosterol biosynthesis inhibitor, and benznidazole in preventing cardiac damage in a murine model of Chagas' disease. Antimicrob. Agents Chemother., 49, 1556-1560.
    • (2005) Antimicrob. Agents Chemother. , vol.49 , pp. 1556-1560
    • Corrales, M.1    Cardozo, R.2    Segura, M.A.3    Urbina, J.A.4    Basombrio, M.A.5
  • 101
    • 0037220818 scopus 로고    scopus 로고
    • Parasitological cure of acute and chronic experimental Chagas disease using the long-acting experimental triazole TAK-187. Activity against drug-resistant Trypanosoma cruzi strains
    • Urbina, J.A., Payares, G., Sanoja, C., Molina, J., Lira, R., Brener, Z., and Romanha, A.J. (2003) Parasitological cure of acute and chronic experimental Chagas disease using the long-acting experimental triazole TAK-187. Activity against drug-resistant Trypanosoma cruzi strains. Int. J. Antimicrob. Agents, 21, 39-48.
    • (2003) Int. J. Antimicrob. Agents , vol.21 , pp. 39-48
    • Urbina, J.A.1    Payares, G.2    Sanoja, C.3    Molina, J.4    Lira, R.5    Brener, Z.6    Romanha, A.J.7
  • 102
    • 0033844976 scopus 로고    scopus 로고
    • In Vitro Antiproliferative Effects and Mechanism of Action of the New Triazole Derivative UR-9825 Against the Protozoan Parasite Trypanosoma (Schizotrypanum) cruzi
    • Urbina, J.A., Lira, R., Visbal, G., and Bartrolí, J. (2000) In Vitro Antiproliferative Effects and Mechanism of Action of the New Triazole Derivative UR-9825 Against the Protozoan Parasite Trypanosoma (Schizotrypanum) cruzi. Antimicrob. Agents Chemother., 44, 2498-2502.
    • (2000) Antimicrob. Agents Chemother. , vol.44 , pp. 2498-2502
    • Urbina, J.A.1    Lira, R.2    Visbal, G.3    Bartrolí, J.4
  • 104
    • 0037220817 scopus 로고    scopus 로고
    • In vitro and in vivo activities of ravuconazole on Trypanosoma cruzi, the causative agent of Chagas disease
    • Urbina, J.A., Payares, G., Sanoja, C., Lira, R., and Romanha, A.J. (2003) In vitro and in vivo activities of ravuconazole on Trypanosoma cruzi, the causative agent of Chagas disease. Intern. J. Antimicrob. Agents, 21, 27-38.
    • (2003) Intern. J. Antimicrob. Agents , vol.21 , pp. 27-38
    • Urbina, J.A.1    Payares, G.2    Sanoja, C.3    Lira, R.4    Romanha, A.J.5
  • 105
    • 77953742894 scopus 로고    scopus 로고
    • Effects of ravuconazole treatment on parasite load and immune response in dogs experimentally infected with Trypanosoma cruzi
    • Diniz Lde, F., Caldas, I.S., Guedes, P.M., Crepalde, G., de Lana, M., Carneiro, C.M., Talvani, A. et al. (2010) Effects of ravuconazole treatment on parasite load and immune response in dogs experimentally infected with Trypanosoma cruzi. Antimicrob. Agents Chemother., 54, 2979-2986.
    • (2010) Antimicrob. Agents Chemother. , vol.54 , pp. 2979-2986
    • Diniz Lde, F.1    Caldas, I.S.2    Guedes, P.M.3    Crepalde, G.4    de Lana, M.5    Carneiro, C.M.6    Talvani, A.7
  • 106
    • 0037378773 scopus 로고    scopus 로고
    • In vivo pharmacodynamics of a new triazole, ravuconazole, in a murine candidiasis model
    • Andes, D., Marchillo, K., Stamstad, T., and Conklin, R. (2003) In vivo pharmacodynamics of a new triazole, ravuconazole, in a murine candidiasis model. Antimicrob. Agents Chemother., 47, 1193-1199.
    • (2003) Antimicrob. Agents Chemother. , vol.47 , pp. 1193-1199
    • Andes, D.1    Marchillo, K.2    Stamstad, T.3    Conklin, R.4
  • 108
    • 41949128129 scopus 로고    scopus 로고
    • New and emerging treatments for fungal infections
    • Pasqualotto, A.C. and Denning, D.W. (2008) New and emerging treatments for fungal infections. J. Antimicrob. Chemother., 61 (Suppl. 1), 19-30.
    • (2008) J. Antimicrob. Chemother. , vol.61 , Issue.SUPPL. 1 , pp. 19-30
    • Pasqualotto, A.C.1    Denning, D.W.2
  • 110
    • 23944466866 scopus 로고    scopus 로고
    • The protein farnesyltransferase inhibitor tipifarnib as a new lead for the development of drugs against Chagas disease
    • Hucke, O., Gelb, M.H., Verlinde, C.L., and Buckner, F.S. (2005) The protein farnesyltransferase inhibitor tipifarnib as a new lead for the development of drugs against Chagas disease. J. Med. Chem., 48, 5415-5418.
    • (2005) J. Med. Chem. , vol.48 , pp. 5415-5418
    • Hucke, O.1    Gelb, M.H.2    Verlinde, C.L.3    Buckner, F.S.4
  • 112
    • 77952732116 scopus 로고    scopus 로고
    • Second generation analogues of the cancer drug clinical candidate tipifarnib for anti-Chagas disease drug discovery
    • Kraus, J.M., Tatipaka, H.B., McGuffin, S. A., Chennamaneni, N.K., Karimi, M., Arif, J., Verlinde, C.L. et al. (2010) Second generation analogues of the cancer drug clinical candidate tipifarnib for anti-Chagas disease drug discovery. J. Med. Chem., 53, 3887-3898.
    • (2010) J. Med. Chem. , vol.53 , pp. 3887-3898
    • Kraus, J.M.1    Tatipaka, H.B.2    McGuffin, S.A.3    Chennamaneni, N.K.4    Karimi, M.5    Arif, J.6    Verlinde, C.L.7
  • 114
    • 36049032778 scopus 로고    scopus 로고
    • Sterol 14alphademethylase as a potential target for antitrypanosomal therapy: enzyme inhibition and parasite cell growth
    • Lepesheva, G.I., Ott, R.D., Hargrove, T.Y., Kleshchenko, Y.Y., Schuster, I., Nes, W.D., Hill, G.C. et al. (2007) Sterol 14alphademethylase as a potential target for antitrypanosomal therapy: enzyme inhibition and parasite cell growth. Chem. Biol., 14, 1283-1293.
    • (2007) Chem. Biol. , vol.14 , pp. 1283-1293
    • Lepesheva, G.I.1    Ott, R.D.2    Hargrove, T.Y.3    Kleshchenko, Y.Y.4    Schuster, I.5    Nes, W.D.6    Hill, G.C.7
  • 115
    • 76249100348 scopus 로고    scopus 로고
    • Crystal structures of Trypanosoma brucei sterol 14alpha-demethylase and implications for selective treatment of human infections
    • Lepesheva, G.I., Park, H.W., Hargrove, T. Y., Vanhollebeke, B., Wawrzak, Z., Harp, J.M., Sundaramoorthy, M. et al. (2010) Crystal structures of Trypanosoma brucei sterol 14alpha-demethylase and implications for selective treatment of human infections. J. Biol. Chem., 285, 1773-1780.
    • (2010) J. Biol. Chem. , vol.285 , pp. 1773-1780
    • Lepesheva, G.I.1    Park, H.W.2    Hargrove, T.Y.3    Vanhollebeke, B.4    Wawrzak, Z.5    Harp, J.M.6    Sundaramoorthy, M.7
  • 120
    • 0033727547 scopus 로고    scopus 로고
    • Cloning and expression of the Trypanosoma brucei lanosterol synthase gene
    • Buckner, F.S., Nguyen, L.N., Joubert, B. M., and Matsuda, S.P. (2000) Cloning and expression of the Trypanosoma brucei lanosterol synthase gene. Mol. Biochem. Parasitol., 110, 399-403.
    • (2000) Mol. Biochem. Parasitol. , vol.110 , pp. 399-403
    • Buckner, F.S.1    Nguyen, L.N.2    Joubert, B.M.3    Matsuda, S.P.4
  • 121
    • 0035859360 scopus 로고    scopus 로고
    • Trypanosome and animal lanosterol synthases use different catalytic motifs
    • Joubert, B.M., Buckner, F.S., and Matsuda, S.P. (2001) Trypanosome and animal lanosterol synthases use different catalytic motifs. Org. Lett., 14, 1957-1960.
    • (2001) Org. Lett. , vol.14 , pp. 1957-1960
    • Joubert, B.M.1    Buckner, F.S.2    Matsuda, S.P.3
  • 123
    • 0038446640 scopus 로고    scopus 로고
    • New chemotherapeutic approaches for the treatment of Chagas disease (American Trypanosomiasis)
    • Urbina, J.A. (2003) New chemotherapeutic approaches for the treatment of Chagas disease (American Trypanosomiasis). Expert Opin. Ther. Pat, 13, 661-669.
    • (2003) Expert Opin. Ther. Pat , vol.13 , pp. 661-669
    • Urbina, J.A.1
  • 125
    • 32344435160 scopus 로고    scopus 로고
    • Amiodarone has intrinsic anti-Trypanosoma cruzi activity and acts synergistically with posaconazole
    • Benaim, G., Sanders, J.M., Garcia-Marchan, Y., Colina, C., Lira, R., Caldera, A.R., Payares, G. et al. (2006) Amiodarone has intrinsic anti-Trypanosoma cruzi activity and acts synergistically with posaconazole. J. Med. Chem., 49, 892-899.
    • (2006) J. Med. Chem. , vol.49 , pp. 892-899
    • Benaim, G.1    Sanders, J.M.2    Garcia-Marchan, Y.3    Colina, C.4    Lira, R.5    Caldera, A.R.6    Payares, G.7
  • 126
    • 78650636036 scopus 로고    scopus 로고
    • Amiodarone inhibits Trypanosoma cruzi infection and promotes cardiac cell recovery with gap junction and cytoskeleton reassembly in vitro
    • Adesse, D., Azzam, E.M., Meirelles Mde, N., Urbina, J.A., and Garzoni, L.R. (2011) Amiodarone inhibits Trypanosoma cruzi infection and promotes cardiac cell recovery with gap junction and cytoskeleton reassembly in vitro. Antimicrob. Agents Chemother., 55, 203-210.
    • (2011) Antimicrob. Agents Chemother. , vol.55 , pp. 203-210
    • Adesse, D.1    Azzam, E.M.2    Meirelles Mde, N.3    Urbina, J.A.4    Garzoni, L.R.5
  • 127
    • 65649117884 scopus 로고    scopus 로고
    • Amiodarone and itraconazole: a rational therapeutic approach for the treatment of chronic Chagas' disease
    • Paniz-Mondolfi, A.E., Perez-Alvarez, A. M., Lanza, G., Marquez, E., and Concepcion, J.L. (2009) Amiodarone and itraconazole: a rational therapeutic approach for the treatment of chronic Chagas' disease. Chemotherapy, 55, 228-233.
    • (2009) Chemotherapy , vol.55 , pp. 228-233
    • Paniz-Mondolfi, A.E.1    Perez-Alvarez, A.M.2    Lanza, G.3    Marquez, E.4    Concepcion, J.L.5
  • 129
    • 71249161926 scopus 로고    scopus 로고
    • Amiodarone and miltefosine act synergistically against Leishmania mexicana and can induce parasitological cure in a murine model of cutaneous leishmaniasis
    • Serrano-Martin, X., Payares, G., De Lucca, M., Martinez, J.C., Mendoza-Leon, A., and Benaim, G. (2009) Amiodarone and miltefosine act synergistically against Leishmania mexicana and can induce parasitological cure in a murine model of cutaneous leishmaniasis. Antimicrob. Agents Chemother., 53, 5108-5113.
    • (2009) Antimicrob. Agents Chemother. , vol.53 , pp. 5108-5113
    • Serrano-Martin, X.1    Payares, G.2    De Lucca, M.3    Martinez, J.C.4    Mendoza-Leon, A.5    Benaim, G.6
  • 133
    • 33846241795 scopus 로고    scopus 로고
    • Squalene synthase inhibitors: clinical pharmacology and cholesterollowering potential
    • Charlton-Menys, V. and Durrington, P.N. (2007) Squalene synthase inhibitors: clinical pharmacology and cholesterollowering potential. Drugs, 67, 11-16.
    • (2007) Drugs , vol.67 , pp. 11-16
    • Charlton-Menys, V.1    Durrington, P.N.2
  • 134
    • 37849187005 scopus 로고    scopus 로고
    • The return of two old targets?
    • Suckling, K.E. (2006) The return of two old targets? Expert Opin. Ther. Targets, 10, 785-788.
    • (2006) Expert Opin. Ther. Targets , vol.10 , pp. 785-788
    • Suckling, K.E.1
  • 135
    • 0036860240 scopus 로고    scopus 로고
    • Squalene synthase as a chemotherapeutic target in Trypanosoma cruzi and Leishmania mexicana
    • Urbina, J.A., Concepcion, J.L., Rangel, S., Visbal, G., and Lira, R. (2002) Squalene synthase as a chemotherapeutic target in Trypanosoma cruzi and Leishmania mexicana. Mol. Biochem. Parasitol., 125, 35-45.
    • (2002) Mol. Biochem. Parasitol. , vol.125 , pp. 35-45
    • Urbina, J.A.1    Concepcion, J.L.2    Rangel, S.3    Visbal, G.4    Lira, R.5
  • 136
    • 3042570789 scopus 로고    scopus 로고
    • In vitro and in vivo activities of E5700 and ER-119884, two novel orally active squalene synthase inhibitors, against Trypanosoma cruzi
    • Urbina, J.A., Concepcion, J.L., Caldera, A., Payares, G., Sanoja, C., Otomo, T., and Hiyoshi, H. (2004) In vitro and in vivo activities of E5700 and ER-119884, two novel orally active squalene synthase inhibitors, against Trypanosoma cruzi. Antimicrob. Agents Chemother., 48, 2379-2387.
    • (2004) Antimicrob. Agents Chemother. , vol.48 , pp. 2379-2387
    • Urbina, J.A.1    Concepcion, J.L.2    Caldera, A.3    Payares, G.4    Sanoja, C.5    Otomo, T.6    Hiyoshi, H.7
  • 139
  • 140
    • 16644386172 scopus 로고    scopus 로고
    • Synthesis and biological evaluation of quinuclidine derivatives incorporating phenothiazine moieties as squalene synthase inhibitors
    • Ishihara, T., Kakuta, H., Moritani, H., Ugawa, T., and Yanagisawa, I. (2004) Synthesis and biological evaluation of quinuclidine derivatives incorporating phenothiazine moieties as squalene synthase inhibitors. Chem. Pharm. Bull. (Tokyo), 52, 1204-1209.
    • (2004) Chem. Pharm. Bull. (Tokyo) , vol.52 , pp. 1204-1209
    • Ishihara, T.1    Kakuta, H.2    Moritani, H.3    Ugawa, T.4    Yanagisawa, I.5
  • 141
    • 0035906980 scopus 로고    scopus 로고
    • The cholesterol quartet
    • Goldstein, J.L. and Brown, M.S. (2001) The cholesterol quartet. Science, 292, 1310-1312.
    • (2001) Science , vol.292 , pp. 1310-1312
    • Goldstein, J.L.1    Brown, M.S.2
  • 144
    • 0037194642 scopus 로고    scopus 로고
    • Design, synthesis, and biological evaluation of aryloxyethyl thiocyanate derivatives against Trypanosoma cruzi
    • Elhalem, E., Bailey, B.N., Docampo, R., Ujvary, I., Szajnman, S.H., and Rodriguez, J.B. (2002) Design, synthesis, and biological evaluation of aryloxyethyl thiocyanate derivatives against Trypanosoma cruzi. J. Med. Chem., 45, 3984-3999.
    • (2002) J. Med. Chem. , vol.45 , pp. 3984-3999
    • Elhalem, E.1    Bailey, B.N.2    Docampo, R.3    Ujvary, I.4    Szajnman, S.H.5    Rodriguez, J.B.6
  • 145
    • 0034030531 scopus 로고    scopus 로고
    • Design and synthesis of aryloxyethyl thiocyanate derivatives as potent inhibitors of Trypanosoma cruzi proliferation
    • Szajnman, S.H., Yan, W., Bailey, B.N., Docampo, R., Elhalem, E., and Rodriguez, J.B. (2000) Design and synthesis of aryloxyethyl thiocyanate derivatives as potent inhibitors of Trypanosoma cruzi proliferation. J. Med. Chem., 43, 1826-1840.
    • (2000) J. Med. Chem. , vol.43 , pp. 1826-1840
    • Szajnman, S.H.1    Yan, W.2    Bailey, B.N.3    Docampo, R.4    Elhalem, E.5    Rodriguez, J.B.6
  • 146
    • 0038778632 scopus 로고    scopus 로고
    • Mechanism of action of 4-phenoxyphenoxyethyl thiocyanate (WC-9) against Trypanosoma cruzi, the causative agent of Chagas' disease
    • Urbina, J.A., Concepcion, J.L., Montalvetti, A., Rodriguez, J.B., and Docampo, R. (2003) Mechanism of action of 4-phenoxyphenoxyethyl thiocyanate (WC-9) against Trypanosoma cruzi, the causative agent of Chagas' disease. Antimicrob. Agents Chemother., 47, 2047-2050.
    • (2003) Antimicrob. Agents Chemother. , vol.47 , pp. 2047-2050
    • Urbina, J.A.1    Concepcion, J.L.2    Montalvetti, A.3    Rodriguez, J.B.4    Docampo, R.5
  • 147
  • 148
    • 0343527887 scopus 로고    scopus 로고
    • A combination of benznidazole and ketoconazole enhances efficacy of chemotherapy of experimental Chagas' disease
    • Araujo, M.S.,Martins-Filho, O.A., Pereira, M.E., and Brener, Z. (2000) A combination of benznidazole and ketoconazole enhances efficacy of chemotherapy of experimental Chagas' disease. J. Antimicrob. Chemother., 45, 819-824.
    • (2000) J. Antimicrob. Chemother. , vol.45 , pp. 819-824
    • Araujo, M.S.1    Martins-Filho, O.A.2    Pereira, M.E.3    Brener, Z.4
  • 149
    • 0023681312 scopus 로고
    • Antiproliferative synergism of the allylamine SF 86-327 and ketoconazole on epimastigotes and amastigotes of Trypanosoma (Schizotrypanum) cruzi
    • Urbina, J.A., Lazardi, K., Aguirre, T., Piras, M.M., and Piras, R. (1988) Antiproliferative synergism of the allylamine SF 86-327 and ketoconazole on epimastigotes and amastigotes of Trypanosoma (Schizotrypanum) cruzi. Antimicrob. Agents Chemother., 32, 1237-1242.
    • (1988) Antimicrob. Agents Chemother. , vol.32 , pp. 1237-1242
    • Urbina, J.A.1    Lazardi, K.2    Aguirre, T.3    Piras, M.M.4    Piras, R.5
  • 150
    • 0027413385 scopus 로고
    • Mevinolin (lovastatin) potentiates the antiproliferative effects of ketoconazole and terbinafine against Trypanosoma (Schizotrypanum) cruzi: in vitro and in vivo studies
    • Urbina, J.A., Lazardi, K., Marchan, E., Visbal, G., Aguirre, T., Piras, M.M., Piras, R. et al. (1993) Mevinolin (lovastatin) potentiates the antiproliferative effects of ketoconazole and terbinafine against Trypanosoma (Schizotrypanum) cruzi: in vitro and in vivo studies. Antimicrob. Agents Chemother., 37, 580-591.
    • (1993) Antimicrob. Agents Chemother. , vol.37 , pp. 580-591
    • Urbina, J.A.1    Lazardi, K.2    Marchan, E.3    Visbal, G.4    Aguirre, T.5    Piras, M.M.6    Piras, R.7
  • 151
    • 0029975328 scopus 로고    scopus 로고
    • Antiproliferative effects of delta 24(25) sterol methyl transferase inhibitors on Trypanosoma (Schizotrypanum) cruzi: in vitro and in vivo studies
    • Urbina, J.A., Vivas, J., Lazardi, K., Molina, J., Payares, G., Piras, M.M., and Piras, R. (1996) Antiproliferative effects of delta 24(25) sterol methyl transferase inhibitors on Trypanosoma (Schizotrypanum) cruzi: in vitro and in vivo studies. Chemotherapy, 42, 294-307.
    • (1996) Chemotherapy , vol.42 , pp. 294-307
    • Urbina, J.A.1    Vivas, J.2    Lazardi, K.3    Molina, J.4    Payares, G.5    Piras, M.M.6    Piras, R.7
  • 152
    • 18844381913 scopus 로고    scopus 로고
    • Anti-proliferative synergy of lysophospholipid analogues and ketoconazole against Trypanosoma cruzi (Kinetoplastida: Trypanosomatidae): cellular and ultrastructural analysis
    • Santa-Rita, R.M., Lira, R., Barbosa, H.S., Urbina, J.A., and de Castro, S.L. (2005) Anti-proliferative synergy of lysophospholipid analogues and ketoconazole against Trypanosoma cruzi (Kinetoplastida: Trypanosomatidae): cellular and ultrastructural analysis. J. Antimicrob. Chemother., 55, 780-784.
    • (2005) J. Antimicrob. Chemother. , vol.55 , pp. 780-784
    • Santa-Rita, R.M.1    Lira, R.2    Barbosa, H.S.3    Urbina, J.A.4    de Castro, S.L.5
  • 153
    • 33846146354 scopus 로고    scopus 로고
    • Squalene synthase inhibition: a novel target for the management of dyslipidemia
    • Davidson, M.H. (2007) Squalene synthase inhibition: a novel target for the management of dyslipidemia. Curr. Atheroscler. Rep., 9, 78-80.
    • (2007) Curr. Atheroscler. Rep. , vol.9 , pp. 78-80
    • Davidson, M.H.1
  • 154
    • 33748646581 scopus 로고    scopus 로고
    • Drug evaluation: TAK-475-an oral inhibitor of squalene synthase for hyperlipidemia
    • Burnett, J.R. (2006) Drug evaluation: TAK-475-an oral inhibitor of squalene synthase for hyperlipidemia. Curr. Opin. Investig. Drugs, 7, 850-856.
    • (2006) Curr. Opin. Investig. Drugs , vol.7 , pp. 850-856
    • Burnett, J.R.1
  • 155
    • 84886502532 scopus 로고    scopus 로고
    • Evaluation of combined therapies for the treatment of Chagas disease (in portuguese) presented at 27th Reuniao Anual de Pesquisa Aplicada de DoenSca de Chagas Uberaba Minas Gerais.
    • Bahia, M.T. (2011) Evaluation of combined therapies for the treatment of Chagas disease (in portuguese), presented at 27th Reuniao Anual de Pesquisa Aplicada de DoenSca de Chagas, Uberaba, Minas Gerais.
    • (2011)
    • Bahia, M.T.1
  • 156
    • 72849122497 scopus 로고    scopus 로고
    • Changes in Trypanosoma cruzi-specific immune responses after treatment: surrogate markers of treatment efficacy
    • Laucella, S.A., Mazliah, D.P., Bertocchi, G., Alvarez, M.G., Cooley, G., Viotti, R., Albareda, M.C. et al. (2009) Changes in Trypanosoma cruzi-specific immune responses after treatment: surrogate markers of treatment efficacy. Clin. Infect. Dis., 49, 1675-1684.
    • (2009) Clin. Infect. Dis. , vol.49 , pp. 1675-1684
    • Laucella, S.A.1    Mazliah, D.P.2    Bertocchi, G.3    Alvarez, M.G.4    Cooley, G.5    Viotti, R.6    Albareda, M.C.7
  • 157
    • 56149088543 scopus 로고    scopus 로고
    • High throughput selection of effective serodiagnostics for Trypanosoma cruzi infection. PLoS Negl. Trop. Dis.
    • Cooley, G., Etheridge, R.D., Boehlke, C., Bundy, B.,Weatherly, D.B., Minning, T., Haney, M. et al. (2008) High throughput selection of effective serodiagnostics for Trypanosoma cruzi infection. PLoS Negl. Trop. Dis., 2, e316.
    • (2008) , vol.2
    • Cooley, G.1    Etheridge, R.D.2    Boehlke, C.3    Bundy, B.4    Weatherly, D.B.5    Minning, T.6    Haney, M.7
  • 158
    • 72849128723 scopus 로고    scopus 로고
    • New advances in the management of a long-neglected disease
    • Urbina, J.A. (2009) New advances in the management of a long-neglected disease. Clin. Infect. Dis., 49, 1685-1687.
    • (2009) Clin. Infect. Dis. , vol.49 , pp. 1685-1687
    • Urbina, J.A.1


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