Inhibition of squalene synthase of rat liver by novel 3′ substituted quinuclidines

Biochemical Pharmacology

Volumn 51, Issue 11, 1996, Pages 1477-1487

  McTaggart, Fergus ^a   Brown, George R ^a   Davidson, Robert G ^a   Freeman, Susan ^a   Holdgate, Geoffrey A ^a   Mallion, Keith B ^a   Mirrlees, Donald J ^a   Smith, Graham J ^a   Ward, Walter H J ^a  

^a ASTRAZENECA   (United Kingdom)

Author keywords

Anticholesteremic agents; Dolichol; Enzyme inhibitors; Farnesol; Farnesyl pyrophosphate; Squalene synthase; Ubiquinone

Indexed keywords

DOLICHOL; GERANYLTRANSFERASE; HYPOCHOLESTEROLEMIC AGENT; QUINUCLIDINE DERIVATIVE; SQUALENE SYNTHASE; UBIQUINONE;

AMINO ACID METABOLISM; AMINO ACID SUBSTITUTION; ANIMAL TISSUE; ARTICLE; CELL FUNCTION; CHOLESTEROL METABOLISM; DRUG INHIBITION; ENZYME INHIBITION; ENZYME MECHANISM; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; LIVER MICROSOME; NONHUMAN; PRENYLATION; PRIORITY JOURNAL; RADIOACTIVITY; RAT; TARGET CELL;

ANIMALS; ENZYME INHIBITORS; FARNESYL-DIPHOSPHATE FARNESYLTRANSFERASE; FEMALE; KINETICS; LIVER; MEVALONIC ACID; QUINUCLIDINES; RATS; RATS, INBRED STRAINS; SENSITIVITY AND SPECIFICITY; TRITIUM;

EID: 0030047147     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/0006-2952(96)00089-5     Document Type: Article

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