Squalene synthase as a chemotherapeutic target in Trypanosoma cruzi and Leishmania mexicana

Molecular and Biochemical Parasitology

Volumn 125, Issue 1-2, 2002, Pages 35-45

  Urbina, Julio A ^a   Concepcion, Juan Luis ^a   Rangel, Salomé ^a   Visbal, Gonzalo ^b   Lira, Renee ^a  

^a INSTITUTO VENEZOLANO DE INVESTIGACIONES CIENTÍFICAS   (Venezuela)

^b FACULTAD DE CIENCIAS   (Venezuela)

Author keywords

5 Dihydroepisterol; Chemotherapy; Enzyme kinetics; Episterol; Ergosterol; Parasitic protozoa; Squalene synthase; Sterol biosynthesis inhibitors

Indexed keywords

3 (BIPHENYL 4 YL) 3 HYDROXYQUINUCLIDINE; SQUALENE SYNTHASE; SQUALENE SYNTHASE INHIBITOR; UNCLASSIFIED DRUG;

AMASTIGOTE; ANIMAL CELL; ARTICLE; CELL CULTURE; CELL FRACTIONATION; CONTROLLED STUDY; CYTOLYSIS; DOSE RESPONSE; DRUG EFFECT; DRUG POTENCY; DRUG PURIFICATION; DRUG SYNTHESIS; ENZYME INHIBITION; ENZYME KINETICS; GROWTH INHIBITION; LEISHMANIA MEXICANA; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; PRIORITY JOURNAL; STEROL ANALYSIS; TRYPANOSOMA CRUZI; VERO CELL;

LEISHMANIA MEXICANA; MAMMALIA; PROTOZOA; TRYPANOSOMA; TRYPANOSOMA CRUZI;

EID: 0036860240     PISSN: 01666851     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0166-6851(02)00206-2     Document Type: Article

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