Anti-proliferative synergy of lysophospholipid analogues and ketoconazole against Trypanosoma cruzi (Kinetoplastida: Trypanosomatidae): Cellular and ultrastructural analysis

Journal of Antimicrobial Chemotherapy

Volumn 55, Issue 5, 2005, Pages 780-784

  Santa Rita, Ricardo M ^a   Lira, Renee ^b   Barbosa, Helene Santos ^a   Urbina, Julio A ^b   de Castro, Solange L ^a  

^a INSTITUTO OSWALDO CRUZ   (Brazil)

^b INSTITUTO VENEZOLANO DE INVESTIGACIONES CIENTÍFICAS   (Venezuela)

Author keywords

Chemotherapy; Edelfosine; Ilmofosine; Miltefosine; Synergy; T. cruzi

Indexed keywords

EDELFOSINE; ERGOSTEROL; ILMOFOSINE; KETOCONAZOLE; LIPID; LYSOPHOSPHOLIPID; MILTEFOSINE;

AMASTIGOTE; ARTICLE; AUTOPHAGY; CELL DAMAGE; CELL MEMBRANE; CELL STRUCTURE; CELL ULTRASTRUCTURE; CONTROLLED STUDY; DRUG POTENTIATION; DRUG TARGETING; EPIMASTIGOTE; FLAGELLATE; IC 50; LIPID METABOLISM; MITOCHONDRION; MULTINUCLEAR CELL; NONHUMAN; PHARMACOLOGICAL PARAMETERS; SCANNING ELECTRON MICROSCOPY; STEROL SYNTHESIS; TRANSMISSION ELECTRON MICROSCOPY; TRYPANOSOMA; TRYPANOSOMA CRUZI;

ANIMALS; CERCOPITHECUS AETHIOPS; DRUG SYNERGISM; DRUG THERAPY, COMBINATION; ERGOSTEROL; KETOCONAZOLE; LYSOPHOSPHOLIPIDS; MICROSCOPY, ELECTRON; MICROSCOPY, ELECTRON, SCANNING; PARASITIC SENSITIVITY TESTS; PHOSPHOLIPID ETHERS; PHOSPHORYLCHOLINE; TRYPANOCIDAL AGENTS; TRYPANOSOMA CRUZI; VERO CELLS;

EID: 18844381913     PISSN: 03057453     EISSN: None     Source Type: Journal    
DOI: 10.1093/jac/dki087     Document Type: Article

References (15)

1. De Castro, S. L., Santa-Rita, R. M., Urbina, J. A. et al. (2004). Antiprotozoal lysophospholipid analogues: a comparison of their activity against trypanosomatid parasites and tumour cells. Mini-Reviews in Medicinal Chemistry 4, 139-48.
2. Coura, J. R. & De Castro, S. L. (2002). A critical review on Chagas' disease chemotherapy. Memórias do Instituto Oswaldo Cruz 97, 3-24.
3. Croft, S. L., Snowdon, D. & Yardley, V. (1996). The activities of four anticancer alkyllysophospholipids against Leishmania donovani, Trypanosoma cruzi and Trypanosoma brucei. Journal of Antimicrobial Chemotherapy 38, 1041-7.
4. Santa-Rita, R. M., Barbosa, H. S., Meirelles, M. N. L. et al. (2000). Effect of alkyllysophospholipids on the proliferation and differentiation of Trypanosoma cruzi. Acta Tropica 75, 219-28.
5. Lira, R., Contreras, L. M., Santa-Rita, R. M. et al. (2001). Mechanism of action of anti-proliferative lysophospholipid analogues against the protozoan parasite Trypanosoma cruzi: potentiation of in vitro activity by the sterol biosynthesis inhibitor ketoconazole. Journal of Antimicrobial Chemotherapy 47, 537-46.
6. Urbina, J. A., Concepcion, J. L., Caldera, A. et al. (2004). In vitro and in vivo activities of E5700 and ER-119884, two novel orally active squalene synthase inhibitors, against Trypanosoma cruzi. Antimicrobial Agents and Chemotherapy 48, 2379-87.
7. Hallander, H. O., Dornbush, K., Gezelius, L. et al. (1982). Synergism between aminoglycosides and cephalosporins with antipseudomonal activity: interaction index and killing curve method. Antimicrobial Agents and Chemotherapy 22, 743-52.
8. Soares, M. J. (1999). The reservosome of Trypanosoma cruzi epimastigotes: an organelle of the endocytic pathway with a role on metacyclogenesis. Memórias do Instituto Oswaldo Cruz 94, Suppl. 1, 139-41.
9. Cunha-e-Silva, N. L., Atella, G. C., Porto-Carreiro, I. A. et al. (2002). Isolation and characterization of a reservosome fraction from Trypanosoma cruzi. FEMS Microbiology Letters 214, 7-12.
10. Lazardi, K., Urbina, J. A. & De Souza, W. (1990). Ultrastructural alterations induced by two ergosterol biosynthesis inhibitors, ketoconazole and terbinafine, on epimastigotes and amastigotes of Trypanosoma (Schizotrypanum) cruzi. Antimicrobial Agents and Chemotherapy 34, 2097-105.
11. Lazardi, K., Urbina, J. A. & De Souza, W. (1991). Ultrastructural alterations induced by ICI 195,739, a bis-triazole derivative with strong antiproliferative action against Trypanosoma (Schizotrypanum) cruzi. Antimicrobial Agents and Chemotherapy 35, 736-40.
12. 24(25)-sterol methyltransferase inhibitors and their combinations with ketoconazole. International Journal of Antimicrobial Chemotherapy 7, 235-40.
13. Braga, M. V., Urbina, J. A. & DeSouza, W. (2004). Effects of squalene synthase inhibitors on the growth and ultrastructure of Trypanosoma cruzi. International Journal of Antimicrobial Agents 24, 72-8.
14. 3, is mediated by inhibition of cytokinesis. Cancer Chemotherapy and Pharmacology 51, 209-15.
15. Maldonado, R. A., Molina, J., Payares, G. et al. (1993). Experimental chemotherapy with combinations of ergosterol biosynthesis inhibitors in murine models of Chagas' disease. Antimicrobial Agents and Chemotherapy 37, 1353-9.