Parasitological cure of acute and chronic experimental Chagas disease using the long-acting experimental triazole TAK-187. Activity against drug-resistant Trypanosoma cruzi strains

International Journal of Antimicrobial Agents

Volumn 21, Issue 1, 2003, Pages 39-48

  Urbina, Julio A ^a   Payares, Gilberto ^b   Sanoja, Cristina ^b   Molina, Judith ^c   Lira, Renee ^a   Brener, Zigman ^c   Romanha, Alvaro J ^c  

^a INSTITUTO VENEZOLANO DE INVESTIGACIONES CIENTÍFICAS   (Venezuela)

^b FACULTAD DE CIENCIAS   (Venezuela)

^c INSTITUTO OSWALDO CRUZ   (Brazil)

Author keywords

Chemotherapy; Parasitic protozoa; Pharmacokinetics; Sterol biosynthesis inhibitors; TAK 187; Trypanosoma cruzi

Indexed keywords

2 [2 (2,4 DIFLUOROPHENYL) 2 HYDROXY 1 METHYL 3 (1H 1,2,4 TRIAZOL 1 YL)PROPYL] 4 [4 (2,2,3,3 TETRAFLUOROPROPOXY)PHENYL] 1,2,4 TRIAZOL 3(2H) ONE; ANTIFUNGAL AGENT; ANTIPARASITIC AGENT; BENZNIDAZOLE; NIFURTIMOX; NITROFURAN DERIVATIVE; NITROIMIDAZOLE DERIVATIVE; PLACEBO; TRIAZOLE DERIVATIVE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIFUNGAL ACTIVITY; ARTICLE; CHAGAS DISEASE; CONTROLLED STUDY; DRUG ACTIVITY; DRUG SENSITIVITY; EPIMASTIGOTE; MINIMUM INHIBITORY CONCENTRATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; TRYPANOSOMA CRUZI;

ACUTE DISEASE; ANIMALS; CHAGAS DISEASE; CHRONIC DISEASE; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG RESISTANCE; FEMALE; MICE; TRIAZOLES; TRYPANOCIDAL AGENTS;

EID: 0037220818     PISSN: 09248579     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0924-8579(02)00274-1     Document Type: Article

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