-
1
-
-
0000921923
-
Novo entidade morbida do homen. Resumo greal dos estudos etiologicos e clínicos
-
Chagas, C. Novo entidade morbida do homen. Resumo greal dos estudos etiologicos e clínicos. Mem Inst Oswaldo Cruz 1911, 3: 219-75.
-
(1911)
Mem Inst Oswaldo Cruz
, vol.3
, pp. 219-275
-
-
Chagas, C.1
-
2
-
-
10744233073
-
A 9,000-year record of Chagas' disease
-
Aufderheide, A.C., Sato, W., Madden, M. et al. A 9,000-year record of Chagas' disease. Proc Natl Acad Sci U S A 2004, 101(7): 2034-9.
-
(2004)
Proc Natl Acad Sci U S A
, vol.101
, Issue.7
, pp. 2034-2039
-
-
Aufderheide, A.C.1
Sato, W.2
Madden, M.3
-
3
-
-
56249089380
-
The neglected tropical diseases of Latin America and the Caribbean: A review of disease burden and distribution and a roadmap for control and elimination
-
Hotez, P.J., Bottazzi, M.E., Franco-Paredes, C., Ault, S.K., Periago, M.R. The neglected tropical diseases of Latin America and the Caribbean: A review of disease burden and distribution and a roadmap for control and elimination. PLoS Negl Trop Dis 2008, 2(9): e300.
-
(2008)
PLoS Negl Trop Dis
, vol.2
, Issue.9
-
-
Hotez, P.J.1
Bottazzi, M.E.2
Franco-Paredes, C.3
Ault, S.K.4
Periago, M.R.5
-
4
-
-
33751234970
-
The future of Chagas disease control
-
Schofield, C.J., Jannin, J., Salvatella, R. The future of Chagas disease control. Trends Parasitol 2006, 22(12): 583-8.
-
(2006)
Trends Parasitol
, vol.22
, Issue.12
, pp. 583-588
-
-
Schofield, C.J.1
Jannin, J.2
Salvatella, R.3
-
5
-
-
38049079910
-
The challenges of Chagas Disease - Grim outlook or glimmer of hope
-
Tarleton, R.L., Reithinger, R., Urbina, J.A., Kitron, U. Gurtler, R.E. The challenges of Chagas Disease - Grim outlook or glimmer of hope. PLoS Med 2007, 4(12): e332.
-
(2007)
PLoS Med
, vol.4
, Issue.12
-
-
Tarleton, R.L.1
Reithinger, R.2
Urbina, J.A.3
Kitron, U.4
Gurtler, R.E.5
-
6
-
-
48349098874
-
Commentary: Chagas disease: 100 years since discovery and lessons for the future
-
Gurtler, R.E., Diotaiuti, L., Kitron, U. Commentary: Chagas disease: 100 years since discovery and lessons for the future. Int J Epidemiol 2008, 37(4): 698-701.
-
(2008)
Int J Epidemiol
, vol.37
, Issue.4
, pp. 698-701
-
-
Gurtler, R.E.1
Diotaiuti, L.2
Kitron, U.3
-
7
-
-
0037789142
-
Epidemiologia
-
2 Ed. Z. Brener, Z. Andrade, C. Barral-Netto (Eds.). Guanabara Koogan: Rio de Janeiro
-
Pinto Dias, J.C. Epidemiologia. In: Trypanosoma Cruzi e Doença de Chagas, 2 Ed. Z. Brener, Z. Andrade, C. Barral-Netto (Eds.). Guanabara Koogan: Rio de Janeiro, 1999, 48-74.
-
(1999)
Trypanosoma Cruzi e Doença de Chagas
, pp. 48-74
-
-
Pinto Dias, J.C.1
-
8
-
-
36148997207
-
Evaluation and treatment of Chagas disease in the United States: A systematic review
-
Bern, C., Montgomery, S.P., Herwaldt, B.L. et al. Evaluation and treatment of Chagas disease in the United States: A systematic review. JAMA 2007, 298(18): 2171-81.
-
(2007)
JAMA
, vol.298
, Issue.18
, pp. 2171-2181
-
-
Bern, C.1
Montgomery, S.P.2
Herwaldt, B.L.3
-
9
-
-
34249650285
-
Chagas disease in the United States: A cause for concern in Louisiana?
-
5-9
-
Diaz, J.H. Chagas disease in the United States: A cause for concern in Louisiana? J La State Med Soc 2007, 159(1): 21-3, 5-9.
-
(2007)
J la State Med Soc
, vol.159
, Issue.1
, pp. 21-23
-
-
Diaz, J.H.1
-
10
-
-
50849110476
-
Seroprevalence of Trypanosoma cruzi infection in at-risk blood donors in Catalonia (Spain)
-
Piron, M., Verges, M., Munoz, J. et al. Seroprevalence of Trypanosoma cruzi infection in at-risk blood donors in Catalonia (Spain). Transfusion 2008, 48(9): 1862-8.
-
(2008)
Transfusion
, vol.48
, Issue.9
, pp. 1862-1868
-
-
Piron, M.1
Verges, M.2
Munoz, J.3
-
11
-
-
34247855091
-
Diagnosis, management and treatment of chronic Chagas' heart disease in areas where Trypanosoma cruzi infection is not endemic
-
Gascon, J., Albajar, P., Canas, E. et al. [Diagnosis, management and treatment of chronic Chagas' heart disease in areas where Trypanosoma cruzi infection is not endemic]. Rev Esp Cardiol 2007, 60(3): 285-93.
-
(2007)
Rev Esp Cardiol
, vol.60
, Issue.3
, pp. 285-293
-
-
Gascon, J.1
Albajar, P.2
Canas, E.3
-
12
-
-
67649111331
-
Eliminating Chagas disease: Challenges and a roadmap
-
Reithinger, R., Tarleton, R.L., Urbina, J.A., Kitron, U., Gurtler, R.E. Eliminating Chagas disease: Challenges and a roadmap. BMJ 2009, 338: 1044-6.
-
(2009)
BMJ
, vol.338
, pp. 1044-1046
-
-
Reithinger, R.1
Tarleton, R.L.2
Urbina, J.A.3
Kitron, U.4
Gurtler, R.E.5
-
13
-
-
0036637084
-
The impact of Chagas disease control in Latin America: A review
-
Dias, J.C., Silveira, A.C., Schofield, C.J. The impact of Chagas disease control in Latin America: A review. Mem Inst Oswaldo Cruz 2002, 97(5): 603-12.
-
(2002)
Mem Inst Oswaldo Cruz
, vol.97
, Issue.5
, pp. 603-612
-
-
Dias, J.C.1
Silveira, A.C.2
Schofield, C.J.3
-
14
-
-
70449591251
-
The unfinished public health agenda of Chagas disease in the era of globalization
-
Franco-Paredes, C., Bottazzi, M.E., Hotez, P.J. The unfinished public health agenda of Chagas disease in the era of globalization. PLoS Negl Trop Dis 2009, 3(7): e470.
-
(2009)
PLoS Negl Trop Dis
, vol.3
, Issue.7
-
-
Franco-Paredes, C.1
Bottazzi, M.E.2
Hotez, P.J.3
-
15
-
-
77950946226
-
Large urban outbreak of orally acquired acute Chagas disease at a school in Caracas, Venezuela
-
Alarcon de Noya, B., Diaz-Bello, Z. Cotmenares, C. et al. Large urban outbreak of orally acquired acute Chagas disease at a school in Caracas, Venezuela. J Infect Dis 2010, 201(9): 1308-15.
-
(2010)
J Infect Dis
, vol.201
, Issue.9
, pp. 1308-1315
-
-
De Alarcon Noya, B.1
Diaz-Bello, Z.2
Cotmenares, C.3
-
16
-
-
63849239548
-
Urban outbreak of acute Chagas disease in Amazon region of Brazil: Four-year follow-up after treatment with benznidazole
-
Pinto, A.Y., Ferreira, A.G. Jr., Valente, V.D., Harada, G.S., Valente, S.A. Urban outbreak of acute Chagas disease in Amazon region of Brazil: Four-year follow-up after treatment with benznidazole. Rev Panam Salud Publica 2009, 25(1): 77-83.
-
(2009)
Rev Panam Salud Publica
, vol.25
, Issue.1
, pp. 77-83
-
-
Pinto, A.Y.1
Ferreira Jr., A.G.2
Valente, V.D.3
Harada, G.S.4
Valente, S.A.5
-
17
-
-
77955435200
-
Trends on acute Chagas' disease transmitted by oral route in Brazil: Steady increase in new cases and a concealed residual fluctuation
-
Epub ahead of print
-
Benchimol-Barbosa, P.R. Trends on acute Chagas' disease transmitted by oral route in Brazil: Steady increase in new cases and a concealed residual fluctuation. Int J Cardiol 2009, Epub ahead of print.
-
(2009)
Int J Cardiol
-
-
Benchimol-Barbosa, P.R.1
-
18
-
-
59649124719
-
Identification of novel vaccine candidates for Chagas' disease by immunization with sequential fractions of a trypomastigote cDNA expression library
-
Tekiel, V., Alba-Soto, C.D., Gonzalez Cappa, S.M., Postan, M., Sanchez, D.O. Identification of novel vaccine candidates for Chagas' disease by immunization with sequential fractions of a trypomastigote cDNA expression library. Vaccine 2009, 27(9): 1323-32.
-
(2009)
Vaccine
, vol.27
, Issue.9
, pp. 1323-1332
-
-
Tekiel, V.1
Alba-Soto, C.D.2
Gonzalez Cappa, S.M.3
Postan, M.4
Sanchez, D.O.5
-
19
-
-
72849128723
-
New advances in the management of a long-neglected disease
-
Urbina, J.A. New advances in the management of a long-neglected disease. Clin Infect Dis 2009, 49(11): 1685-7.
-
(2009)
Clin Infect Dis
, vol.49
, Issue.11
, pp. 1685-1687
-
-
Urbina, J.A.1
-
20
-
-
70449562088
-
New, improved treatments for chagas disease: From the r&d pipeline to the patients
-
Ribeiro, I., Sevcsik, A.M., Alves, F. et al. New, improved treatments for chagas disease: From the r&d pipeline to the patients. PLoS Negl Trap Dis 2009, 3(7): e484.
-
(2009)
PLoS Negl Trap Dis
, vol.3
, Issue.7
-
-
Ribeiro, I.1
Sevcsik, A.M.2
Alves, F.3
-
21
-
-
70349967303
-
The role of parasite persistence in pathogenesis of Chagas heart disease
-
Gutierrez, F.R., Guedes, P.M., Gazzinelli, R.T., Silva, J.S. The role of parasite persistence in pathogenesis of Chagas heart disease. Parasite Immunol 2009, 31(11): 673-85.
-
(2009)
Parasite Immunol
, vol.31
, Issue.11
, pp. 673-685
-
-
Gutierrez, F.R.1
Guedes, P.M.2
Gazzinelli, R.T.3
Silva, J.S.4
-
22
-
-
0030870893
-
Immunological control of Trypanosoma cruzi infection and pathogenesis of Chagas' disease
-
Brener, Z., Gazzinelli, R.T. Immunological control of Trypanosoma cruzi infection and pathogenesis of Chagas' disease. Int Arch Allergy Immunol 1997, 114(2): 103-10.
-
(1997)
Int Arch Allergy Immunol
, vol.114
, Issue.2
, pp. 103-110
-
-
Brener, Z.1
Gazzinelli, R.T.2
-
23
-
-
68149179567
-
CD8+ T cells in Trypanosoma cruzi infection
-
Padilla, A.M., Bustamante, J.M., Tarleton, R.L. CD8+ T cells in Trypanosoma cruzi infection. Curr Opin Immunol 2009, 21(4): 385-90.
-
(2009)
Curr Opin Immunol
, vol.21
, Issue.4
, pp. 385-390
-
-
Padilla, A.M.1
Bustamante, J.M.2
Tarleton, R.L.3
-
24
-
-
33947597320
-
Pathogenesis of chronic Chagas heart disease
-
Marin-Neto, J.A., Cunha-Neto, E., Maciel, B.C., Simoes, M.V. Pathogenesis of chronic Chagas heart disease. Circulation 2007, 115(9): 1109-23.
-
(2007)
Circulation
, vol.115
, Issue.9
, pp. 1109-1123
-
-
Marin-Neto, J.A.1
Cunha-Neto, E.2
Maciel, B.C.3
Simoes, M.V.4
-
25
-
-
33644698263
-
Trypanosoma cruzi modulates the profile of memory CD8+ T cells in chronic Chagas' disease patients
-
Albareda, M.C., Laucella, S.A., Alvarez, M.G., Armenti, A.H., Bertochi, G., Tarleton, R.L., Postan, M. Trypanosoma cruzi modulates the profile of memory CD8+ T cells in chronic Chagas' disease patients. Int Immunol 2006, 18(3): 465-71.
-
(2006)
Int Immunol
, vol.18
, Issue.3
, pp. 465-471
-
-
Albareda, M.C.1
Laucella, S.A.2
Alvarez, M.G.3
Armenti, A.H.4
Bertochi, G.5
Tarleton, R.L.6
Postan, M.7
-
26
-
-
64749110340
-
Challenges and opportunities for primary, secondary, and tertiary prevention of Chagas disease
-
Rassi, A., Jr., Dias, J.C., Marin-Neto, J.A., Rassi, A. Challenges and opportunities for primary, secondary, and tertiary prevention of Chagas disease. Heart 2009, 95: 524-34.
-
(2009)
Heart
, vol.95
, pp. 524-534
-
-
Rassi Jr., A.1
Dias, J.C.2
Marin-Neto, J.A.3
Rassi, A.4
-
27
-
-
0033668986
-
Chagas' heart disease
-
Rassi, A., Jr., Rassi, A., Little, W.C. Chagas' heart disease. Clin Cardiol 2000, 23(12): 883-9.
-
(2000)
Clin Cardiol
, vol.23
, Issue.12
, pp. 883-889
-
-
Rassi Jr., A.1
Rassi, A.2
Little, W.C.3
-
28
-
-
17544400692
-
Long term evaluation of etiological treatment of Chagas disease with benznidazole
-
Cançado, J.R. Long term evaluation of etiological treatment of Chagas disease with benznidazole. Rev Inst Med Trap Sao Paulo 2002, 44(1): 29-37.
-
(2002)
Rev Inst Med Trap Sao Paulo
, vol.44
, Issue.1
, pp. 29-37
-
-
Cançado, J.R.1
-
29
-
-
0033253710
-
Criteria of Chagas disease cure
-
Cançado, J.R. Criteria of Chagas disease cure. Mem Inst Oswaldo Cruz 1999, 94 (Suppl. 1): 331-6.
-
(1999)
Mem Inst Oswaldo Cruz
, vol.94
, Issue.SUPPL. 1
, pp. 331-336
-
-
Cançado, J.R.1
-
30
-
-
64749110340
-
Challenges and opportunities for primary, secondary, and tertiary prevention of Chagas' disease
-
Rassi, A., Jr., Dias, J.C., Marin-Neto, J.A., Rassi, A. Challenges and opportunities for primary, secondary, and tertiary prevention of Chagas' disease. Heart 2009, 95(7): 524-34.
-
(2009)
Heart
, vol.95
, Issue.7
, pp. 524-534
-
-
Rassi Jr., A.1
Dias, J.C.2
Marin-Neto, J.A.3
Rassi, A.4
-
31
-
-
0006911591
-
Chagas' disease (American trypanosomiasis): A Tropical disease now emerging in the United States
-
3rd Ed. W.M. Scheid, W.A. Craig, J.M. Hughes (Eds.). ASM Press Washington, D.C.
-
Kirchhoff, L.V. Chagas' disease (American trypanosomiasis): A Tropical disease now emerging in the United States. In: Emerging Infections, 3rd Ed. W.M. Scheid, W.A. Craig, J.M. Hughes (Eds.). ASM Press Washington, D.C., 1999, 111-34.
-
(1999)
Emerging Infections
, pp. 111-134
-
-
Kirchhoff, L.V.1
-
32
-
-
0023609713
-
Susceptibility and natural resistance of Trypanosoma cruzi strains to drugs used clinically in Chagas disease
-
Filardi, L.S., Brener, Z. Susceptibility and natural resistance of Trypanosoma cruzi strains to drugs used clinically in Chagas disease. Trans R Soc Trop Med Hyg 1987, 81(5): 755-9.
-
(1987)
Trans R Soc Trop Med Hyg
, vol.81
, Issue.5
, pp. 755-759
-
-
Filardi, L.S.1
Brener, Z.2
-
33
-
-
17344379918
-
Molecular characterization of susceptible and naturally resistant strains of Trypanosoma cruzi to benznidazole and nifurtimox
-
Murta, S.M., Gazzinelli, R.T., Brener, Z., Romanha, A.J. Molecular characterization of susceptible and naturally resistant strains of Trypanosoma cruzi to benznidazole and nifurtimox. Mol Biochem Parasitol 1998, 93(2): 203-14.
-
(1998)
Mol Biochem Parasitol
, vol.93
, Issue.2
, pp. 203-214
-
-
Murta, S.M.1
Gazzinelli, R.T.2
Brener, Z.3
Romanha, A.J.4
-
34
-
-
0037105691
-
Experimental chemotherapy against Trypanosoma cruzi infection: Essential role of endogenous interferon-gamma in mediating parasitologic cure
-
Romanha, A.J., Alves, R.O., Murta, S.M., Silva, J.S., Ropert, C., Gazzinelli, R.T. Experimental chemotherapy against Trypanosoma cruzi infection: Essential role of endogenous interferon-gamma in mediating parasitologic cure. J Infect Dis 2002, 186(6): 823-8.
-
(2002)
J Infect Dis
, vol.186
, Issue.6
, pp. 823-828
-
-
Romanha, A.J.1
Alves, R.O.2
Murta, S.M.3
Silva, J.S.4
Ropert, C.5
Gazzinelli, R.T.6
-
35
-
-
0033836587
-
Immunological and clinical evaluation of chagasic patients subjected to chemotherapy during the acute phase of Trypanosoma cruzi infection 14-30 years ago
-
Bahia-Oliveira, L.M., Gomes, J.A., Cancado, J.R. et al. Immunological and clinical evaluation of chagasic patients subjected to chemotherapy during the acute phase of Trypanosoma cruzi infection 14-30 years ago. J Infect Dis 2000, 182(2): 634-8.
-
(2000)
J Infect Dis
, vol.182
, Issue.2
, pp. 634-638
-
-
Bahia-Oliveira, L.M.1
Gomes, J.A.2
Cancado, J.R.3
-
36
-
-
10044268612
-
Short report: Benznidazole efficacy among Trypanosoma cruzi-infected adolescents after a six-year follow-up
-
Andrade, A.L., Martelli, C.M., Oliveira, R.M. et al. Short report: Benznidazole efficacy among Trypanosoma cruzi-infected adolescents after a six-year follow-up. Am J Trop Med Hyg 2004, 71(5): 594-7.
-
(2004)
Am J Trop Med Hyg
, vol.71
, Issue.5
, pp. 594-597
-
-
Andrade, A.L.1
Martelli, C.M.2
Oliveira, R.M.3
-
37
-
-
10544244169
-
Randomised trial of efficacy of benznidazole in treatment of early Trypanosoma cruzi infection
-
de Andrade, A.L., Zicker, F., de Oliveira, R.M. et al. Randomised trial of efficacy of benznidazole in treatment of early Trypanosoma cruzi infection. Lancet 1996, 348(9039): 1407-13.
-
(1996)
Lancet
, vol.348
, Issue.9039
, pp. 1407-1413
-
-
De Andrade, A.L.1
Zicker, F.2
De Oliveira, R.M.3
-
38
-
-
33750503607
-
Etiological treatment in patients infected by Trypanosoma cruzi: Experiences in Argentina
-
Sosa-Estani, S., Segura, E.L. Etiological treatment in patients infected by Trypanosoma cruzi: Experiences in Argentina. Curr Opin Infect Dis 2006, 19(6): 583-7.
-
(2006)
Curr Opin Infect Dis
, vol.19
, Issue.6
, pp. 583-587
-
-
Sosa-Estani, S.1
Segura, E.L.2
-
39
-
-
0034153419
-
Evaluation of an specific treatment for Trypanosoma cruzi in children, in the evolution of the indeterminate phase
-
Silveira, C.A., Castillo, E., Castro, C. [Evaluation of an specific treatment for Trypanosoma cruzi in children, in the evolution of the indeterminate phase]. Rev Soc Bras Med Trap 2000, 33(2): 191-6.
-
(2000)
Rev Soc Bras Med Trap
, vol.33
, Issue.2
, pp. 191-196
-
-
Silveira, C.A.1
Castillo, E.2
Castro, C.3
-
40
-
-
0034757465
-
Treatment of Trypanosoma cruzi-infected children with nifurtimox: A 3 year follow-up by PCR
-
Solari, A., Ortiz, S., Soto, A. et al. Treatment of Trypanosoma cruzi-infected children with nifurtimox: A 3 year follow-up by PCR. J Antimicrob Chemother 2001, 48(4): 515-9.
-
(2001)
J Antimicrob Chemother
, vol.48
, Issue.4
, pp. 515-519
-
-
Solari, A.1
Ortiz, S.2
Soto, A.3
-
41
-
-
70449566766
-
Feasibility, drug safety, and effectiveness of etiological treatment programs for Chagas disease in Honduras, Guatemala, and Bolivia: 10-year experience of Medecins sans Frontieres
-
Yun, O., Lima, M.A., Ellman, T. et al. Feasibility, drug safety, and effectiveness of etiological treatment programs for Chagas disease in Honduras, Guatemala, and Bolivia: 10-year experience of Medecins sans Frontieres. PLoS Negl Trop Dis 2009, 3(7): e488.
-
(2009)
PLoS Negl Trop Dis
, vol.3
, Issue.7
-
-
Yun, O.1
Lima, M.A.2
Ellman, T.3
-
42
-
-
44449142382
-
Persistence of PCR-positive tissue in benznidazole-treated mice with negative blood parasitological and serological tests in dual infections with Trypanosoma cruzi stocks from different genotypes
-
Martins, H.R., Figueiredo, L.M., Valamiel-Silva, J.C. et al. Persistence of PCR-positive tissue in benznidazole-treated mice with negative blood parasitological and serological tests in dual infections with Trypanosoma cruzi stocks from different genotypes. J Antimicrob Chemother 2008, 61(6): 1319-27.
-
(2008)
J Antimicrob Chemother
, vol.61
, Issue.6
, pp. 1319-1327
-
-
Martins, H.R.1
Figueiredo, L.M.2
Valamiel-Silva, J.C.3
-
43
-
-
0344655613
-
Myocardial parasite persistence in chronic chagasic patients
-
Anez, N., Carrasco, H., Parada, H. et al. Myocardial parasite persistence in chronic chagasic patients. Am J Trap Med Hyg 1999, 60(5): 726-32.
-
(1999)
Am J Trap Med Hyg
, vol.60
, Issue.5
, pp. 726-732
-
-
Anez, N.1
Carrasco, H.2
Parada, H.3
-
44
-
-
0035434832
-
Parasite persistence in treated chagasic patients revealed by xenodiagnosis and polymerase chain reaction
-
Britto, C., Silveira, C., Cardoso, M.A., Marques, P., Luquetti, A., Macedo, V., Fernandes, O. Parasite persistence in treated chagasic patients revealed by xenodiagnosis and polymerase chain reaction. Mem Inst Oswaldo Cruz 2001, 96(6): 823-6.
-
(2001)
Mem Inst Oswaldo Cruz
, vol.96
, Issue.6
, pp. 823-826
-
-
Britto, C.1
Silveira, C.2
Cardoso, M.A.3
Marques, P.4
Luquetti, A.5
Macedo, V.6
Fernandes, O.7
-
45
-
-
0034467499
-
Persistent infections in chronic Chagas' disease patients treated with anti-Trypanosoma cruzi nitroderivatives
-
Braga, M.S., Lauria-Pires, L., Arganaraz, E.R., Nascimento, R.J., Teixeira, A.R. Persistent infections in chronic Chagas' disease patients treated with anti-Trypanosoma cruzi nitroderivatives. Rev Inst Med Trop Sao Paulo 2000, 42(3): 157-61.
-
(2000)
Rev Inst Med Trop Sao Paulo
, vol.42
, Issue.3
, pp. 157-161
-
-
Braga, M.S.1
Lauria-Pires, L.2
Arganaraz, E.R.3
Nascimento, R.J.4
Teixeira, A.R.5
-
46
-
-
0034443066
-
Progressive chronic Chagas heart disease ten years after treatment with anti-Trypanosoma cruzi nitroderivatives
-
Lauria-Pires, L., Braga, M.S., Vexenat, A.C., Nitz, N., Simoes-Barbosa, A., Tinoco, D.L., Teixeira, A.R. Progressive chronic Chagas heart disease ten years after treatment with anti-Trypanosoma cruzi nitroderivatives. Am J Trop Med Hyg 2000, 63(3-4): 111-8.
-
(2000)
Am J Trop Med Hyg
, vol.63
, Issue.3-4
, pp. 111-118
-
-
Lauria-Pires, L.1
Braga, M.S.2
Vexenat, A.C.3
Nitz, N.4
Simoes-Barbosa, A.5
Tinoco, D.L.6
Teixeira, A.R.7
-
47
-
-
16244419348
-
Treatment with benznidazole during the chronic phase of experimental Chagas' disease decreases cardiac alterations
-
Garcia, S., Ramos, C.O., Senra, J.F. et al. Treatment with benznidazole during the chronic phase of experimental Chagas' disease decreases cardiac alterations. Antimicrob Agents Chemother 2005, 49(4): 1521-8.
-
(2005)
Antimicrob Agents Chemother
, vol.49
, Issue.4
, pp. 1521-1528
-
-
Garcia, S.1
Ramos, C.O.2
Senra, J.F.3
-
48
-
-
62549113879
-
Efficacy of benznidazol treatment for asymptomatic chagasic patients from state of Rio Grande do SuI evaluated during a three years follow-up
-
Fernandes, C.D., Tiecher, F.M., Balbinot, M.M., Liarte, D.B., Scholl, D., Steindel, M., Romanha, A. Efficacy of benznidazol treatment for asymptomatic chagasic patients from state of Rio Grande do SuI evaluated during a three years follow-up. Mem Inst Oswaldo Cruz 2009, 104(1): 27-32.
-
(2009)
Mem Inst Oswaldo Cruz
, vol.104
, Issue.1
, pp. 27-32
-
-
Fernandes, C.D.1
Tiecher, F.M.2
Balbinot, M.M.3
Liarte, D.B.4
Scholl, D.5
Steindel, M.6
Romanha, A.7
-
49
-
-
0033963255
-
The targets of the lytic antibody response against Trypanosoma cruzi
-
Krautz, G.M., Kissinger, J.C., Krettli, A.U. The targets of the lytic antibody response against Trypanosoma cruzi. Parasitol Today 2000, 16(1): 31-4.
-
(2000)
Parasitol Today
, vol.16
, Issue.1
, pp. 31-34
-
-
Krautz, G.M.1
Kissinger, J.C.2
Krettli, A.U.3
-
50
-
-
0029047960
-
Use of a 24-kilodalton Trypanosoma cruzi recombinant protein to monitor cure of human Chagas' disease
-
Krautz, G.M., Galvao, L.M., Cancado, J.R., Guevara-Espinoza, A., Ouaissi, A., Krettli, A.U. Use of a 24-kilodalton Trypanosoma cruzi recombinant protein to monitor cure of human Chagas' disease. J Clin Microbiol 1995, 33(8): 2086-90.
-
(1995)
J Clin Microbiol
, vol.33
, Issue.8
, pp. 2086-2090
-
-
Krautz, G.M.1
Galvao, L.M.2
Cancado, J.R.3
Guevara-Espinoza, A.4
Ouaissi, A.5
Krettli, A.U.6
-
51
-
-
0141675203
-
Enzyme-linked immunoassay using recombinant transsialidase of Trypanosoma cruzi can be employed for monitoring of patients with Chagas' disease after drug treatment
-
Pereira-Chioccola, V.L., Fragata-Filho, A.A., Levy, A.M., Rodrigues, M.M., Schenkman, S. Enzyme-linked immunoassay using recombinant transsialidase of Trypanosoma cruzi can be employed for monitoring of patients with Chagas' disease after drug treatment. Clin Diagn Lab Immunol 2003, 10(5): 826-30.
-
(2003)
Clin Diagn Lab Immunol
, vol.10
, Issue.5
, pp. 826-830
-
-
Pereira-Chioccola, V.L.1
Fragata-Filho, A.A.2
Levy, A.M.3
Rodrigues, M.M.4
Schenkman, S.5
-
52
-
-
0142227145
-
Specific chemotherapy of Chagas disease: Controversies and advances
-
Urbina, J.A., Docampo, R. Specific chemotherapy of Chagas disease: Controversies and advances. Trends Parasitol 2003, 19(11): 495-501.
-
(2003)
Trends Parasitol
, vol.19
, Issue.11
, pp. 495-501
-
-
Urbina, J.A.1
Docampo, R.2
-
53
-
-
84934440537
-
Sterol 14-demethylase inhibitors for Trypanosoma cruzi infections
-
Buckner, F.S. Sterol 14-demethylase inhibitors for Trypanosoma cruzi infections. Adv Exp Med Biol 2008, 625: 61-80.
-
(2008)
Adv Exp Med Biol
, vol.625
, pp. 61-80
-
-
Buckner, F.S.1
-
54
-
-
34547905013
-
Etiological treatment of chronic Chagas disease: Neglected 'evidence' by evidence-based medicine
-
Viotti, R., Vigliano, C. Etiological treatment of chronic Chagas disease: Neglected 'evidence' by evidence-based medicine. Expert Rev Anti Infect Ther 2007, 5(4): 717-26.
-
(2007)
Expert Rev Anti Infect Ther
, vol.5
, Issue.4
, pp. 717-726
-
-
Viotti, R.1
Vigliano, C.2
-
55
-
-
33646847271
-
Long-term cardiac outcomes of treating chronic Chagas disease with benznidazole versus no treatment: A nonrandomized trial
-
Viotti, R., Vigtiano, C., Lococo, B. et al. Long-term cardiac outcomes of treating chronic Chagas disease with benznidazole versus no treatment: A nonrandomized trial. Ann Intern Med 2006, 144(10): 724-34.
-
(2006)
Ann Intern Med
, vol.144
, Issue.10
, pp. 724-734
-
-
Viotti, R.1
Vigtiano, C.2
Lococo, B.3
-
56
-
-
77953082627
-
Specific chemotherapy of Chagas disease: Relevance, current limitations and new approaches
-
Urbina, J.A. Specific chemotherapy of Chagas disease: Relevance, current limitations and new approaches. Acta Trop 2009, 115(1-2): 55-68.
-
(2009)
Acta Trop
, vol.115
, Issue.1-2
, pp. 55-68
-
-
Urbina, J.A.1
-
57
-
-
0025166484
-
Sensitivity of parasites to free radical damage by antiparasitic drugs
-
Docampo, R. Sensitivity of parasites to free radical damage by antiparasitic drugs. Chem Biol Interact 1990, 73(1): 1-27.
-
(1990)
Chem Biol Interact
, vol.73
, Issue.1
, pp. 1-27
-
-
Docampo, R.1
-
58
-
-
0030271981
-
Autoimmunity in Chagas disease cardiomyopathy: Fullfilling the criteria at last?
-
Kalil, J., Cunha-Neto, E. Autoimmunity in Chagas disease cardiomyopathy: Fullfilling the criteria at last? ParasitolToday 1996, 12: 396-9.
-
(1996)
ParasitolToday
, vol.12
, pp. 396-399
-
-
Kalil, J.1
Cunha-Neto, E.2
-
59
-
-
0028939403
-
Autoinmunity in Chagas disease cardiopathy: Biological relevance of a cardiac myosin-specific epitope crossreactive to an inmunodominant Trypanosoma cruzi antigen
-
Cunha-Neto, E., Duranti, M., Gruber, A. et al. Autoinmunity in Chagas disease cardiopathy: Biological relevance of a cardiac myosin-specific epitope crossreactive to an inmunodominant Trypanosoma cruzi antigen. Proc Natl Acad Sci U S A 1995, 92(8): 3541-5.
-
(1995)
Proc Natl Acad Sci U S A
, vol.92
, Issue.8
, pp. 3541-3545
-
-
Cunha-Neto, E.1
Duranti, M.2
Gruber, A.3
-
60
-
-
0033256630
-
Parasitological cure of Chagas disease: Is it possible? Is it Relevant?
-
Urbina, J.A. Parasitological cure of Chagas disease: Is it possible? Is it Relevant? Mem Inst Oswaldo Cruz 1999, 94(Suppl. 1): 349-55.
-
(1999)
Mem Inst Oswaldo Cruz
, vol.94
, Issue.SUPPL. 1
, pp. 349-355
-
-
Urbina, J.A.1
-
61
-
-
26844461073
-
Chemotherapy of trypanosomiases and leishmaniasis
-
Croft, S.L., Barrett, M.P., Urbina, J.A. Chemotherapy of trypanosomiases and leishmaniasis. Trends Parasitol 2005, 21(11): 508-12.
-
(2005)
Trends Parasitol
, vol.21
, Issue.11
, pp. 508-512
-
-
Croft, S.L.1
Barrett, M.P.2
Urbina, J.A.3
-
62
-
-
0035340666
-
Parasite persistence in the aetiology of Chagas disease
-
Tarleton, R.L. Parasite persistence in the aetiology of Chagas disease. Int J Parasitol 2001, 31(5-6): 550-4.
-
(2001)
Int J Parasitol
, vol.31
, Issue.5-6
, pp. 550-554
-
-
Tarleton, R.L.1
-
63
-
-
53849119912
-
Tratamiento antiparasitario de la enfremedad de Chagas
-
Apt, W., Heitmann, I., Jercic, L. et al. [Tratamiento antiparasitario de la enfremedad de Chagas]. Rev Chil Infect 2008, 25(5): 384-9.
-
(2008)
Rev Chil Infect
, vol.25
, Issue.5
, pp. 384-389
-
-
Apt, W.1
Heitmann, I.2
Jercic, L.3
-
64
-
-
45549100534
-
Rationale and design of a randomized placebo-controlled trial assessing the effects of etiologic treatment in Chagas' cardiomyopathy: The BENznidazole Evaluation for Interrupting Trypanosomiasis (BENEFIT)
-
Marin-Neto, J.A., Rassi, A. Jr., Morillo, C.A. et al. Rationale and design of a randomized placebo-controlled trial assessing the effects of etiologic treatment in Chagas' cardiomyopathy: The BENznidazole Evaluation For Interrupting Trypanosomiasis (BENEFIT). Am Heart J 2008, 156(1): 37-43.
-
(2008)
Am Heart J
, vol.156
, Issue.1
, pp. 37-43
-
-
Marin-Neto, J.A.1
Rassi Jr., A.2
Morillo, C.A.3
-
65
-
-
33646833207
-
The treatment of Chagas disease (South American trypanosomiasis)
-
Pinto Dias, J.C. The treatment of Chagas disease (South American trypanosomiasis). Ann Intern Med 2006, 144(10): 772-4.
-
(2006)
Ann Intern Med
, vol.144
, Issue.10
, pp. 772-774
-
-
Pinto Dias, J.C.1
-
66
-
-
68949220490
-
Diagnosis of Chagas disease: What has been achieved? What remains to be done with regard to diagnosis and follow up studies?
-
Gomes, Y.M., Lorena, V.M., Luquetti, A.O. Diagnosis of Chagas disease: What has been achieved? What remains to be done with regard to diagnosis and follow up studies? Mem Inst Oswaldo Cruz 2009, 104(4): 115-21.
-
(2009)
Mem Inst Oswaldo Cruz
, vol.104
, Issue.4
, pp. 115-121
-
-
Gomes, Y.M.1
Lorena, V.M.2
Luquetti, A.O.3
-
67
-
-
0033254195
-
Polymerase chain reaction detection: New insights into the diagnosis of chronic Chagas disease
-
Britto, C., Cardoso, M.A., Marques, P., Fernandes, O., Morel, C.M. Polymerase chain reaction detection: New insights into the diagnosis of chronic Chagas disease. Mem Inst Oswaldo Cruz 1999, 94(Suppl. 1): 305-6.
-
(1999)
Mem Inst Oswaldo Cruz
, vol.94
, Issue.SUPPL. 1
, pp. 305-306
-
-
Britto, C.1
Cardoso, M.A.2
Marques, P.3
Fernandes, O.4
Morel, C.M.5
-
68
-
-
0028926829
-
Polymerase chain reaction detection of Trypanosoma cruzi in human blood samples as a tool for diagnosis and treatment evaluation
-
Britto, C., Cardoso, M.A., Vanni, C.M. et al. Polymerase chain reaction detection of Trypanosoma cruzi in human blood samples as a tool for diagnosis and treatment evaluation. Parasitology 1995, 110(Pt. 3): 241-7.
-
(1995)
Parasitology
, vol.110
, Issue.PART 3
, pp. 241-247
-
-
Britto, C.1
Cardoso, M.A.2
Vanni, C.M.3
-
69
-
-
51649086111
-
Chronic American trypanosomiasis: Parasite persistence in endomyocardial biopsies is associated with high-grade myocarditis
-
Benvenuti, L.A., Roggerio, A., Freitas, H.F., Mansur, A.J., Fiorelli, A., Higuchi, M.L.. Chronic American trypanosomiasis: Parasite persistence in endomyocardial biopsies is associated with high-grade myocarditis. Ann Trap Med Parasitot 2008, 102(6): 481-7.
-
(2008)
Ann Trap Med Parasitot
, vol.102
, Issue.6
, pp. 481-487
-
-
Benvenuti, L.A.1
Roggerio, A.2
Freitas, H.F.3
Mansur, A.J.4
Fiorelli, A.5
Higuchi, M.L.6
-
70
-
-
33746255331
-
Comparison of Trypanosoma cruzi detection by PCR in blood and dejections of Triatoma infestans fed on patients with chronic Chagas disease
-
Coronado, X., Zulntay, I., Reyes, E. et al. Comparison of Trypanosoma cruzi detection by PCR in blood and dejections of Triatoma infestans fed on patients with chronic Chagas disease. Acta Trap 2006, 98(3): 314-7.
-
(2006)
Acta Trap
, vol.98
, Issue.3
, pp. 314-317
-
-
Coronado, X.1
Zulntay, I.2
Reyes, E.3
-
71
-
-
0036038280
-
Blood culture and polymerase chain reaction for the diagnosis of the chronic phase of human infection with Trypanosoma cruzi
-
Castro, A.M., Luquetti, A.O., Rassi, A., Rassi, G.G., Chiari, E., Galvao, L.M. Blood culture and polymerase chain reaction for the diagnosis of the chronic phase of human infection with Trypanosoma cruzi. Parasitol Res 2002, 88(10): 894-900.
-
(2002)
Parasitol Res
, vol.88
, Issue.10
, pp. 894-900
-
-
Castro, A.M.1
Luquetti, A.O.2
Rassi, A.3
Rassi, G.G.4
Chiari, E.5
Galvao, L.M.6
-
72
-
-
43249116465
-
Drug-induced cure drives conversion to a stable and protective CD8+ T central memory response in chronic Chagas disease
-
Bustamante, J.M., Bixby, L.M., Tarleton, R.L. Drug-induced cure drives conversion to a stable and protective CD8+ T central memory response in chronic Chagas disease. Nat Med 2008, 14(5): 542-50.
-
(2008)
Nat Med
, vol.14
, Issue.5
, pp. 542-550
-
-
Bustamante, J.M.1
Bixby, L.M.2
Tarleton, R.L.3
-
73
-
-
72849122497
-
Changes in Trypanosoma cruzi-specific immune responses after treatment: Surrogate markers of treatment efficacy
-
Laucella, S.A., Mazliah, D.P., Bertocchi, G. et al. Changes in Trypanosoma cruzi-specific immune responses after treatment: Surrogate markers of treatment efficacy. Clin Infect Dis 2009, 49(11): 1675-84.
-
(2009)
Clin Infect Dis
, vol.49
, Issue.11
, pp. 1675-1684
-
-
Laucella, S.A.1
Mazliah, D.P.2
Bertocchi, G.3
-
74
-
-
56149088543
-
High throughput selection of effective serodiagnostics for Trypanosoma cruzi infection
-
Cooley, G., Etheridge, R.D., Boehlke, C. et al. High throughput selection of effective serodiagnostics for Trypanosoma cruzi infection. PLoS Negl Trop Dis 2008, 2(10): e316.
-
(2008)
PLoS Negl Trop Dis
, vol.2
, Issue.10
-
-
Cooley, G.1
Etheridge, R.D.2
Boehlke, C.3
-
75
-
-
61449562202
-
Trypanosoma cruzi targets for new chemotherapeutic approaches
-
Soeiro, M.N., de Castro, S.L. Trypanosoma cruzi targets for new chemotherapeutic approaches. Expert Opin Ther Targets 2009, 13(1): 105-21.
-
(2009)
Expert Opin Ther Targets
, vol.13
, Issue.1
, pp. 105-121
-
-
Soeiro, M.N.1
De Castro, S.L.2
-
76
-
-
69049116505
-
Ergosterol biosynthesis and drug development for Chagas disease
-
Urbina, J.A. Ergosterol biosynthesis and drug development for Chagas disease. Mem Inst Oswaldo Cruz 2009, 104(Suppl. 1): 311-8.
-
(2009)
Mem Inst Oswaldo Cruz
, vol.104
, Issue.SUPPL. 1
, pp. 311-318
-
-
Urbina, J.A.1
-
77
-
-
65549095093
-
Tolerability and safety profile of posaconazole: Evaluation of 18 controlled studies in healthy volunteers
-
Moton, A., Krishna, G., Wang, Z. Tolerability and safety profile of posaconazole: Evaluation of 18 controlled studies in healthy volunteers. J Clin Pharm Ther 2009, 34(3): 301-11.
-
(2009)
J Clin Pharm Ther
, vol.34
, Issue.3
, pp. 301-311
-
-
Moton, A.1
Krishna, G.2
Wang, Z.3
-
78
-
-
34250731402
-
Safety and efficacy of posaconazole in the long-term treatment of azole-refractory oropharyngeal and esophageal candidiasis in patients with HIV infection
-
Vazquez, J.A., Skiest, D.J., Tissot-Dupont, H., Lennox, J.L., Boparai, N., Isaacs, R. Safety and efficacy of posaconazole in the long-term treatment of azole-refractory oropharyngeal and esophageal candidiasis in patients with HIV infection. HIV Clin Trials 2007, 8(2): 86-97.
-
(2007)
HIV Clin Trials
, vol.8
, Issue.2
, pp. 86-97
-
-
Vazquez, J.A.1
Skiest, D.J.2
Tissot-Dupont, H.3
Lennox, J.L.4
Boparai, N.5
Isaacs, R.6
-
79
-
-
31944443967
-
Pharmacokinetics, safety, and efficacy of posaconazole in patients with persistent febrile neutropenia or refractory invasive fungal infection
-
Ullmann, A.J., Comely, O.A., Burchardt, A. et al. Pharmacokinetics, safety, and efficacy of posaconazole in patients with persistent febrile neutropenia or refractory invasive fungal infection. Antimicrob Agents Chemother 2006, 50(2): 658-66.
-
(2006)
Antimicrob Agents Chemother
, vol.50
, Issue.2
, pp. 658-666
-
-
Ullmann, A.J.1
Comely, O.A.2
Burchardt, A.3
-
80
-
-
33646765351
-
Cytoskeleton reassembly in cardiomyocytes infected by Trypanosoma cruzi is triggered by treatment with ergosterol biosynthesis inhibitors
-
Silva, D.T., de Meirelles Mde, N., Almeida, D., Urbina, J.A., Pereira, M.C. Cytoskeleton reassembly in cardiomyocytes infected by Trypanosoma cruzi is triggered by treatment with ergosterol biosynthesis inhibitors. Int J Antimicrob Agents 2006, 27(6): 530-7.
-
(2006)
Int J Antimicrob Agents
, vol.27
, Issue.6
, pp. 530-537
-
-
Silva, D.T.1
De Meirelles Mde, N.2
Almeida, D.3
Urbina, J.A.4
Pereira, M.C.5
-
81
-
-
59749103737
-
Absence of CD4+ T lymphocytes, CD8+ T lymphocytes, or B lymphocytes has different effects on the efficacy of posaconazole and benznidazole in treatment of experimental acute Trypanosoma cruzi infection
-
Ferraz, M.L., Gazzinelli, R.T., Alves, R.O., Urbina, J.A., Romanha, A.J. Absence of CD4+ T lymphocytes, CD8+ T lymphocytes, or B lymphocytes has different effects on the efficacy of posaconazole and benznidazole in treatment of experimental acute Trypanosoma cruzi infection. Antimicrob Agents Chemother 2009, 53(1): 174-9.
-
(2009)
Antimicrob Agents Chemother
, vol.53
, Issue.1
, pp. 174-179
-
-
Ferraz, M.L.1
Gazzinelli, R.T.2
Alves, R.O.3
Urbina, J.A.4
Romanha, A.J.5
-
82
-
-
34247144012
-
The anti-Trypanosoma cruzi activity of posaconazole in a murine model of acute Chagas' disease is less dependent on gamma interferon than that of benznidazole
-
Ferraz, M.L., Gazzinelli, R.T., Alves, R.O., Urbina, J.A., Romanha, A.J. The anti-Trypanosoma cruzi activity of posaconazole in a murine model of acute Chagas' disease is less dependent on gamma interferon than that of benznidazole. Antimicrob Agents Chemother 2007, 51(4): 1359-64.
-
(2007)
Antimicrob Agents Chemother
, vol.51
, Issue.4
, pp. 1359-1364
-
-
Ferraz, M.L.1
Gazzinelli, R.T.2
Alves, R.O.3
Urbina, J.A.4
Romanha, A.J.5
-
83
-
-
77953021818
-
A comparative study of posaconazole and benznidazole in the prevention of heart damage and promotion of trypanocidal immune response in a murine model of Chagas disease
-
Olivieri, B.P., Molina, J., de Castro, S.L., Pereira, M., Calvet, C.M., Urbina, J.A., Araujo-Jorge, T.C. A comparative study of posaconazole and benznidazole in the prevention of heart damage and promotion of trypanocidal immune response in a murine model of Chagas disease. Int J Anticrob Agents 2010, 36(1): 79-83.
-
(2010)
Int J Anticrob Agents
, vol.36
, Issue.1
, pp. 79-83
-
-
Olivieri, B.P.1
Molina, J.2
De Castro, S.L.3
Pereira, M.4
Calvet, C.M.5
Urbina, J.A.6
Araujo-Jorge, T.C.7
-
84
-
-
77950961025
-
Successful treatment with posaconazole of patient with chronic Chagas disease and systemic lupus erythematosus
-
Pinazo, M.J., Espinosa, G., Gallego, M., Lopez-Chejade, P., Urbina, J.A., Gascon, J. Successful treatment with posaconazole of patient with chronic Chagas disease and systemic lupus erythematosus. Am J Trop Med Hyg 2010, 82(4): 583-7.
-
(2010)
Am J Trop Med Hyg
, vol.82
, Issue.4
, pp. 583-587
-
-
Pinazo, M.J.1
Espinosa, G.2
Gallego, M.3
Lopez-Chejade, P.4
Urbina, J.A.5
Gascon, J.6
-
85
-
-
0037220817
-
In vitro and in vivo activities of ravuconazole on Trypanosoma cruzi, the causative agent of Chagas disease
-
Urbina, J.A., Payares, G., Sanoja, C., Lira, R., Romanha, A.J. In vitro and in vivo activities of ravuconazole on Trypanosoma cruzi, the causative agent of Chagas disease. Int J Antimicrob Agents 2003, 21(1): 27-38.
-
(2003)
Int J Antimicrob Agents
, vol.21
, Issue.1
, pp. 27-38
-
-
Urbina, J.A.1
Payares, G.2
Sanoja, C.3
Lira, R.4
Romanha, A.J.5
-
86
-
-
77953742894
-
Effects of ravuconazole treatment on parasite load and immune response in dogs experimentally infected with Trypanosoma cruzi
-
Epub ahead of print
-
Diniz, L.F., Caldas, I.S., Guedes, P.M. et al. Effects of ravuconazole treatment on parasite load and immune response in dogs experimentally infected with Trypanosoma cruzi. Antimicrob Agents Chemother 2010, Epub ahead of print.
-
(2010)
Antimicrob Agents Chemother
-
-
Diniz, L.F.1
Caldas, I.S.2
Guedes, P.M.3
-
87
-
-
41949128129
-
New and emerging treatments for fungal infections
-
Pasqualotto, A.C., Denning, D.W. New and emerging treatments for fungal infections. J Antimicrob Chemother 2008, 61(Suppl. 1): i19-30.
-
(2008)
J Antimicrob Chemother
, vol.61
, Issue.SUPPL. 1
-
-
Pasqualotto, A.C.1
Denning, D.W.2
-
88
-
-
0037220818
-
Parasitological cure of acute and chronic experimental Chagas disease using the long-acting experimental triazole TAK-187. Activity against drug-resistant Trypanosoma cruzi strains
-
Urbina, J.A., Payares, G., Sanoja, C., Molina, J., Lira, R., Brener, Z., Romanha, A.J. Parasitological cure of acute and chronic experimental Chagas disease using the long-acting experimental triazole TAK-187. Activity against drug-resistant Trypanosoma cruzi strains. Int J Antimicrob Agents 2003, 21(1): 39-48.
-
(2003)
Int J Antimicrob Agents
, vol.21
, Issue.1
, pp. 39-48
-
-
Urbina, J.A.1
Payares, G.2
Sanoja, C.3
Molina, J.4
Lira, R.5
Brener, Z.6
Romanha, A.J.7
-
89
-
-
16244418371
-
Comparative efficacies of TAK-187, a long-lasting ergosterol biosynthesis inhibitor, and benznidazole in preventing cardiac damage in a murine model of Chagas' disease
-
Corrales, M., Cardozo, R., Segura, M.A., Urbina, J.A., Basombrio, M.A. Comparative efficacies of TAK-187, a long-lasting ergosterol biosynthesis inhibitor, and benznidazole in preventing cardiac damage in a murine model of Chagas' disease. Antimicrob Agents Chemother 2005, 49(4): 1556-60.
-
(2005)
Antimicrob Agents Chemother
, vol.49
, Issue.4
, pp. 1556-1560
-
-
Corrales, M.1
Cardozo, R.2
Segura, M.A.3
Urbina, J.A.4
Basombrio, M.A.5
-
90
-
-
23944466866
-
The protein farnesyl-transferase inhibitor Tipifarnib as a new lead for the development of drugs against Chagas disease
-
Hucke, O., Gelb, M.H., Verlinde, C.L., Buckner, F.S. The protein farnesyl-transferase inhibitor Tipifarnib as a new lead for the development of drugs against Chagas disease. J Med Chem 2005, 48(17): 5415-8.
-
(2005)
J Med Chem
, vol.48
, Issue.17
, pp. 5415-5418
-
-
Hucke, O.1
Gelb, M.H.2
Verlinde, C.L.3
Buckner, F.S.4
-
91
-
-
10744230525
-
A class of sterol 14-demethylase inhibitors as anti-Trypanosoma cruzi agents
-
Buckner, F., Yokoyama, K., Lockman, J. et al. A class of sterol 14-demethylase inhibitors as anti-Trypanosoma cruzi agents. Proc Natl Acad Sci U S A 2003, 100(25): 15149-53.
-
(2003)
Proc Natl Acad Sci U S A
, vol.100
, Issue.25
, pp. 15149-15153
-
-
Buckner, F.1
Yokoyama, K.2
Lockman, J.3
-
92
-
-
64349102737
-
Rational modification of a candidate cancer drug for use against Chagas disease
-
Kraus, J.M., Verlinde, C.L., Karimi, M. Lepesheva, G.I., Gelb, M.H., Buckner, F.S. Rational modification of a candidate cancer drug for use against Chagas disease. J Med Chem 2009, 52(6): 1639-47.
-
(2009)
J Med Chem
, vol.52
, Issue.6
, pp. 1639-1647
-
-
Kraus, J.M.1
Verlinde, C.L.2
Karimi, M.3
Lepesheva, G.I.4
Gelb, M.H.5
Buckner, F.S.6
-
93
-
-
67549086262
-
Structurally simple inhibitors of lanosterol 14alpha-demethylase are efficacious in a rodent model of acute Chagas disease
-
Suryadevara, P.K., Olepu, S., Lockman, J.W. et al. Structurally simple inhibitors of lanosterol 14alpha-demethylase are efficacious in a rodent model of acute Chagas disease. J Med Chem 2009, 52(12): 3703-15.
-
(2009)
J Med Chem
, vol.52
, Issue.12
, pp. 3703-3715
-
-
Suryadevara, P.K.1
Olepu, S.2
Lockman, J.W.3
-
94
-
-
65549090030
-
Trypanosoma cruzi CYP51 inhibitor Derived from a Mycobacterium tuberculosis screen hit
-
Chen, C.K., Doyle, P.S., Yermalitskaya, L.V., Mackey, Z.B., Ang, K.K., McKerrow, J.H., Podust, L.M. Trypanosoma cruzi CYP51 inhibitor Derived from a Mycobacterium tuberculosis screen hit. PLoS Negl Trap Dis 2009, 3(2): e372.
-
(2009)
PLoS Negl Trap Dis
, vol.3
, Issue.2
-
-
Chen, C.K.1
Doyle, P.S.2
Yermalitskaya, L.V.3
Mackey, Z.B.4
Ang, K.K.5
McKerrow, J.H.6
Podust, L.M.7
-
95
-
-
77952622536
-
A nonazole CYP51 inhibitor cures Chagas disease in a mouse model of acute infection
-
Doyle, P.S., Chen, C.K., Johnston, J.B. et al. A nonazole CYP51 inhibitor cures Chagas disease in a mouse model of acute infection. Antimicrob Agents Chemother 2010, 54(6): 2480-8.
-
(2010)
Antimicrob Agents Chemother
, vol.54
, Issue.6
, pp. 2480-2488
-
-
Doyle, P.S.1
Chen, C.K.2
Johnston, J.B.3
-
96
-
-
76249100348
-
Crystal structures of Trypanosoma brucei sterol 14alpha-demethylase and implications for selective treatment of human infections
-
Lepesheva, G.I., Park, H.W., Hargrove, T.Y. et al. Crystal structures of Trypanosoma brucei sterol 14alpha-demethylase and implications for selective treatment of human infections. J Biol Chem 2010, 285(3): 1773-80.
-
J Biol Chem 2010
, vol.285
, Issue.3
, pp. 1773-1780
-
-
Lepesheva, G.I.1
Park, H.W.2
Hargrove, T.Y.3
-
97
-
-
0020610230
-
Ten years of experience with amiodarone
-
Rosenbaum, M.B., Chiale, P.A., Haedo, A., Lazzari, J.O., Elizari, M.V. Ten years of experience with amiodarone. Am Heart J 1983, 106(4 Pt. 2): 957-64.
-
(1983)
Am Heart J
, vol.106
, Issue.4 PART 2
, pp. 957-964
-
-
Rosenbaum, M.B.1
Chiale, P.A.2
Haedo, A.3
Lazzari, J.O.4
Elizari, M.V.5
-
98
-
-
32344435160
-
Amiodarone has intrinsic anti-Trypanosoma cruzi activity and acts synergistically with posaconazole
-
Benaim, G., Sanders, J.M., Garcia-Marchan, Y. et al. Amiodarone has intrinsic anti-Trypanosoma cruzi activity and acts synergistically with posaconazole. J Med Chem 2006, 49(3): 892-9.
-
(2006)
J Med Chem
, vol.49
, Issue.3
, pp. 892-899
-
-
Benaim, G.1
Sanders, J.M.2
Garcia-Marchan, Y.3
-
99
-
-
65649117884
-
Amiodarone and itraconazole: A rational therapeutic approach for the treatment of chronic Chagas' disease
-
Paniz-Mondolfi, A.E., Perez-Alvarez, A.M., Lanza, G., Marquez, E., Concepcion, J.L. Amiodarone and itraconazole: A rational therapeutic approach for the treatment of chronic Chagas' disease. Chemotherapy 2009, 55(4): 228-33.
-
(2009)
Chemotherapy
, vol.55
, Issue.4
, pp. 228-233
-
-
Paniz-Mondolfi, A.E.1
Perez-Alvarez, A.M.2
Lanza, G.3
Marquez, E.4
Concepcion, J.L.5
-
100
-
-
71249161926
-
Amiodarone and miltefosine act synergistically against Leishmania mexicana and can induce parasitological cure in a murine model of cutaneous leishmaniasis
-
Serrano-Martin, X., Payares, G., De Lucca, M., Martinez, J.C., Mendoza-Leon, A., Benaim, G. Amiodarone and miltefosine act synergistically against Leishmania mexicana and can induce parasitological cure in a murine model of cutaneous leishmaniasis. Antimicrob Agents Chemother 2009, 53(12): 5108-13.
-
(2009)
Antimicrob Agents Chemother
, vol.53
, Issue.12
, pp. 5108-5113
-
-
Serrano-Martin, X.1
Payares, G.2
De Lucca, M.3
Martinez, J.C.4
Mendoza-Leon, A.5
Benaim, G.6
-
101
-
-
65649143532
-
Amiodarone destabilizes intracellular Ca2+ homeostasis and biosynthesis of sterols in Leishmania mexicana
-
Serrano-Martin, X., Garcia-Marchan, Y., Fernandez, A., Rodriguez, N., Rojas, H., Visbal, G., Benaim, G. Amiodarone destabilizes intracellular Ca2+ homeostasis and biosynthesis of sterols in Leishmania mexicana. Antimicrob Agents Chemother 2009, 53(4): 1403-10.
-
(2009)
Antimicrob Agents Chemother
, vol.53
, Issue.4
, pp. 1403-1410
-
-
Serrano-Martin, X.1
Garcia-Marchan, Y.2
Fernandez, A.3
Rodriguez, N.4
Rojas, H.5
Visbal, G.6
Benaim, G.7
-
102
-
-
47849091390
-
Concurrent Chagas' disease and borderline disseminated cutaneous leishmaniasis: The role of amiodarone as an antitrypanosomatidae drug
-
Paniz-Mondolfi, A.E., Perez-Alvarez, A.M., Reyes-Jaimes, O., Socorro, G., Zerpa, O., Slova, D., Concepcion, J.L. Concurrent Chagas' disease and borderline disseminated cutaneous leishmaniasis: The role of amiodarone as an antitrypanosomatidae drug. Ther Clin Risk Manag 2008, 4(3): 659-63.
-
(2008)
Ther Clin Risk Manag
, vol.4
, Issue.3
, pp. 659-663
-
-
Paniz-Mondolfi, A.E.1
Perez-Alvarez, A.M.2
Reyes-Jaimes, O.3
Socorro, G.4
Zerpa, O.5
Slova, D.6
Concepcion, J.L.7
-
103
-
-
0036835142
-
Proteinases of Trypanosoma cruzi: Potential targets for the chemotherapy of Changas desease
-
Cazzulo, J.J. Proteinases of Trypanosoma cruzi: Potential targets for the chemotherapy of Changas desease. Curr Top Med Chem 2002, 2(11): 1261-71.
-
(2002)
Curr Top Med Chem
, vol.2
, Issue.11
, pp. 1261-1271
-
-
Cazzulo, J.J.1
-
104
-
-
0032541311
-
Cysteine protease inhibitors cure experimental Trypanosma cruzi infection
-
Engel, J.C., Doyle, P.S., Hsieh, I., McKerrow, J.H. Cysteine protease inhibitors cure experimental Trypanosma cruzi infection. J Exp Med 1998, 188: 725-34.
-
(1998)
J Exp Med
, vol.188
, pp. 725-734
-
-
Engel, J.C.1
Doyle, P.S.2
Hsieh, I.3
McKerrow, J.H.4
-
105
-
-
28844509592
-
A cysteine protease inhibitor protects dogs from cardiac damage during infection by Trypanosoma cruzi
-
Barr, S.C., Warner, K.L., Kornreic, B.G., Piscitelli, J., Wolfe, A., Benet, L., McKerrow, J.H. A cysteine protease inhibitor protects dogs from cardiac damage during infection by Trypanosoma cruzi. Antimicrob Agents Chemother 2005, 49(12): 5160-1.
-
(2005)
Antimicrob Agents Chemother
, vol.49
, Issue.12
, pp. 5160-5161
-
-
Barr, S.C.1
Warner, K.L.2
Kornreic, B.G.3
Piscitelli, J.4
Wolfe, A.5
Benet, L.6
McKerrow, J.H.7
-
106
-
-
35848971033
-
A cysteine protease inhibitor cures Chagas' disease in an immunodeficient-mouse model of infection
-
Doyle, P.S., Zhou, Y.M., Engel, J.C., McKerrow, J.H. A cysteine protease inhibitor cures Chagas' disease in an immunodeficient-mouse model of infection. Antimicrob Agents Chemother 2007, 51(11): 3932-9.
-
(2007)
Antimicrob Agents Chemother
, vol.51
, Issue.11
, pp. 3932-3939
-
-
Doyle, P.S.1
Zhou, Y.M.2
Engel, J.C.3
McKerrow, J.H.4
-
107
-
-
68949200543
-
Two approaches to discovering and developing new drugs for Chagas disease
-
McKerrow, J.H., Doyle, P.S., Engel, J.C. et al. Two approaches to discovering and developing new drugs for Chagas disease. Mem Inst Oswaldo Cruz 2009, 104(Suppl. 1): 263-9.
-
(2009)
Mem Inst Oswaldo Cruz
, vol.104
, Issue.SUPPL. 1
, pp. 263-269
-
-
McKerrow, J.H.1
Doyle, P.S.2
Engel, J.C.3
-
108
-
-
43949095150
-
Identification of a new class of nonpeptidic inhibitors of cruzain
-
Brak, K., Doyle, P.S., McKerrow, J.H., Ellman, J.A. Identification of a new class of nonpeptidic inhibitors of cruzain. J Am Chem Soc 2008, 130(20): 6404-10.
-
(2008)
J Am Chem Soc
, vol.130
, Issue.20
, pp. 6404-6410
-
-
Brak, K.1
Doyle, P.S.2
McKerrow, J.H.3
Ellman, J.A.4
-
109
-
-
0036199463
-
Screening of acyl hydrazide proteinase inhibitors for antiparasitic activity against Trypanosoma brucei
-
Caffrey, C.R., Schanz, M., Nkemgu-Njinkeng, J. et al. Screening of acyl hydrazide proteinase inhibitors for antiparasitic activity against Trypanosoma brucei. Int J Antimicrob Agents 2002, 19(3): 227-31.
-
(2002)
Int J Antimicrob Agents
, vol.19
, Issue.3
, pp. 227-231
-
-
Caffrey, C.R.1
Schanz, M.2
Nkemgu-Njinkeng, J.3
-
110
-
-
0037142343
-
Synthesis and structure-activity relationship study of potent trypanocidal thiosemicarbazone inhibitors of the trypanosomal cysteine protease cruzain
-
Du, X., Guo, C., Hansell, E. et al. Synthesis and structure-activity relationship study of potent trypanocidal thiosemicarbazone inhibitors of the trypanosomal cysteine protease cruzain. J Med Chem 2002, 45(13): 2695-707.
-
(2002)
J Med Chem
, vol.45
, Issue.13
, pp. 2695-2707
-
-
Du, X.1
Guo, C.2
Hansell, E.3
-
111
-
-
77649200180
-
Nonpeptidic tetrafluorophenoxymethyl ketone cruzain inhibitors as promising new leads for Chagas disease chemotherapy
-
Brak, K., Kerr, I.D., Barrett, K.T. et al. Nonpeptidic tetrafluorophenoxymethyl ketone cruzain inhibitors as promising new leads for Chagas disease chemotherapy. J Med Chem 2010, 53(4): 1763-73.
-
(2010)
J Med Chem
, vol.53
, Issue.4
, pp. 1763-1773
-
-
Brak, K.1
Kerr, I.D.2
Barrett, K.T.3
-
112
-
-
55549085194
-
Synthesis of macrocyclic trypanosomal cysteine protease inhibitors
-
Chen, Y.T., Lira, R., Hansell, E., McKerrow, J.H., Roush, W.R. Synthesis of macrocyclic trypanosomal cysteine protease inhibitors. Bioorg Med Chem Lett 2008, 18(22): 5860-3.
-
(2008)
Bioorg Med Chem Lett
, vol.18
, Issue.22
, pp. 5860-5863
-
-
Chen, Y.T.1
Lira, R.2
Hansell, E.3
McKerrow, J.H.4
Roush, W.R.5
-
113
-
-
56449128034
-
Structure-activity relationships for a class of selective inhibitors of the major cysteine protease from Trypanosoma cruzi
-
Guido, R.V., Trossini, G.H., Castilho, M.S., Oliva, G., Ferreira, E.I., Andricopulo, A.D. Structure-activity relationships for a class of selective inhibitors of the major cysteine protease from Trypanosoma cruzi. J Enzyme Inhib Med Chem 2008, 23(6): 964-73.
-
(2008)
J Enzyme Inhib Med Chem
, vol.23
, Issue.6
, pp. 964-973
-
-
Guido, R.V.1
Trossini, G.H.2
Castilho, M.S.3
Oliva, G.4
Ferreira, E.I.5
Andricopulo, A.D.6
-
114
-
-
0033003357
-
Chemotherapy of Chagas' disease: The how and the why
-
Urbina, J.A. Chemotherapy of Chagas' disease: The how and the why. J Mol Med 1999, 77(3): 332-8.
-
(1999)
J Mol Med
, vol.77
, Issue.3
, pp. 332-338
-
-
Urbina, J.A.1
-
115
-
-
0025114817
-
Ultrastructural alterations induced by two ergosterol biosynthesis inhibitors, ketoconazole and terbinafme, on epimastigotes and amastigotes of Trypanosoma (Schizotrypanum) cruzi
-
Lazardi, K., Urbina, J.A., de Souza, W. Ultrastructural alterations induced by two ergosterol biosynthesis inhibitors, ketoconazole and terbinafme, on epimastigotes and amastigotes of Trypanosoma (Schizotrypanum) cruzi. Antimicrob Agents Chemother 1990, 34(11): 2097-105.
-
(1990)
Antimicrob Agents Chemother
, vol.34
, Issue.11
, pp. 2097-2105
-
-
Lazardi, K.1
Urbina, J.A.2
De Souza, W.3
-
116
-
-
0023681312
-
Antiproliferative synergism of the allylamine SF 86-327 and ketoconazole on epimastigotes and amastigotes of Trypanosoma (Schizotrypanum) cruzi
-
Urbina, J.A., Lazardi, K., Aguirre, T., Piras, M.M., Piras, R. Antiproliferative synergism of the allylamine SF 86-327 and ketoconazole on epimastigotes and amastigotes of Trypanosoma (Schizotrypanum) cruzi. Antimicrob Agents Chemother 1988, 32(8): 1237-42.
-
(1988)
Antimicrob Agents Chemother
, vol.32
, Issue.8
, pp. 1237-1242
-
-
Urbina, J.A.1
Lazardi, K.2
Aguirre, T.3
Piras, M.M.4
Piras, R.5
-
117
-
-
0027413385
-
Mevinolin (lovastatin) potentiates the antiproliferative effects of ketoconazole and terbinafine against Trypanosoma (Schizotrypanum) cruzi: In vitro and in vivo studies
-
Urbina, J.A., Lazardi, K., Marchan, E. et al. Mevinolin (lovastatin) potentiates the antiproliferative effects of ketoconazole and terbinafine against Trypanosoma (Schizotrypanum) cruzi: in vitro and in vivo studies. Antimicrob Agents Chemother 1993, 37(3): 580-91.
-
(1993)
Antimicrob Agents Chemother
, vol.37
, Issue.3
, pp. 580-591
-
-
Urbina, J.A.1
Lazardi, K.2
Marchan, E.3
-
118
-
-
0029975328
-
Antiproliferative effects of delta 24(25) sterol methyl transferase inhibitors on Trypanosoma (Schizotrypanum) cruzi: In vitro and in vivo studies
-
Urbina, J.A., Vivas, J., Lazardi, K., Molina, J., Payares, G., Piras, M.M., Piras, R. Antiproliferative effects of delta 24(25) sterol methyl transferase inhibitors on Trypanosoma (Schizotrypanum) cruzi: In vitro and in vivo studies. Chemotherapy 1996, 42(4): 294-307.
-
(1996)
Chemotherapy
, vol.42
, Issue.4
, pp. 294-307
-
-
Urbina, J.A.1
Vivas, J.2
Lazardi, K.3
Molina, J.4
Payares, G.5
Piras, M.M.6
Piras, R.7
-
119
-
-
0343527887
-
A combination of benznidazole and ketoconazole enhances efficacy of chemotherapy of experimental Chagas' disease
-
Araujo, M.S., Martins-Filho, O.A., Pereira, M.E., Brener, Z. A combination of benznidazole and ketoconazole enhances efficacy of chemotherapy of experimental Chagas' disease. J Antimicrob Chemother 2000, 45(6): 819-24.
-
(2000)
J Antimicrob Chemother
, vol.45
, Issue.6
, pp. 819-824
-
-
Araujo, M.S.1
Martins-Filho, O.A.2
Pereira, M.E.3
Brener, Z.4
-
120
-
-
33846241795
-
Squalene synthase inhibitors: Clinical pharmacology and cholesterol-lowering potential
-
Charlton-Menys, V., Durrington, P.N. Squalene synthase inhibitors: Clinical pharmacology and cholesterol-lowering potential. Drugs 2007, 67(1): 11-6.
-
(2007)
Drugs
, vol.67
, Issue.1
, pp. 11-16
-
-
Charlton-Menys, V.1
Durrington, P.N.2
-
121
-
-
33846146354
-
Squalene synthase inhibition: A novel target for the management of dyslipidemia
-
Davidson, M.H. Squalene synthase inhibition: A novel target for the management of dyslipidemia. Curr Atheroscler Rep 2007, 9(1): 78-80.
-
(2007)
Curr Atheroscler Rep
, vol.9
, Issue.1
, pp. 78-80
-
-
Davidson, M.H.1
-
122
-
-
33748646581
-
Drug evaluation: TAK-475 - An oral inhibitor of squalene synthase for hyperlipidemia
-
Burnett, J.R. Drug evaluation: TAK-475 - An oral inhibitor of squalene synthase for hyperlipidemia. Curr Opin Investig Drugs 2006, 7(9): 850-6.
-
(2006)
Curr Opin Investig Drugs
, vol.7
, Issue.9
, pp. 850-856
-
-
Burnett, J.R.1
-
123
-
-
3042570789
-
In vitro and in vivo activities of E5700 and ER-119884, two novel orally active squalene synthase inhibitors, against Trypanosoma cruzi
-
Urbina, J.A., Concepcion, J.L., Caldera, A., Payares, G., Sanoja, C., Otomo, T., Hiyoshi, H. In vitro and in vivo activities of E5700 and ER-119884, two novel orally active squalene synthase inhibitors, against Trypanosoma cruzi. Antimicrob Agents Chemother 2004, 48(7): 2379-87.
-
(2004)
Antimicrob Agents Chemother
, vol.48
, Issue.7
, pp. 2379-2387
-
-
Urbina, J.A.1
Concepcion, J.L.2
Caldera, A.3
Payares, G.4
Sanoja, C.5
Otomo, T.6
Hiyoshi, H.7
-
124
-
-
80054878894
-
Combination of benznidazole and nifurtimox plus posaconazole enhances the activity against Trypanosoma cruzi in experimental Chagas disease
-
Abst 747
-
Bahia, M.T., Talvani, A., Chang, S., Ribeiro, I. Combination of benznidazole and nifurtimox plus posaconazole enhances the activity against Trypanosoma cruzi in experimental Chagas disease. Am J Trop Med Hyg [58th Annu Med Am Soc Trop Med Hyg (Nov 18-22, Washington) 2009] 2009, Abst 747.
-
(2009)
Am J Trop Med Hyg [58th Annu Med Am Soc Trop Med Hyg (Nov 18-22, Washington) 2009]
-
-
Bahia, M.T.1
Talvani, A.2
Chang, S.3
Ribeiro, I.4
-
125
-
-
34548607781
-
At what price?
-
Danzon, P.M. At what price? Nature 2007, 449(159): 176-9.
-
(2007)
Nature
, vol.449
, Issue.159
, pp. 176-179
-
-
Danzon, P.M.1
|