Trypanosome and animal lanosterol synthases use different catalytic motifs

Organic Letters

Volumn 3, Issue 12, 2001, Pages 1957-1959

  Joubert, Bridget M ^a   Buckner, Frederick S ^b   Matsuda, Seiichi P T ^a  

^a RICE UNIVERSITY   (United States)

^b UNIVERSITY OF WASHINGTON   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

LANOSTEROL SYNTHASE; MUTASE;

AMINO ACID SEQUENCE; ANIMAL; ARTICLE; ENZYME ACTIVE SITE; ENZYMOLOGY; HUMAN; METABOLISM; MOLECULAR GENETICS; PROTEIN MOTIF; SEQUENCE HOMOLOGY; TRYPANOSOMA CRUZI;

AMINO ACID MOTIFS; AMINO ACID SEQUENCE; ANIMALS; CATALYTIC DOMAIN; HUMANS; INTRAMOLECULAR TRANSFERASES; MOLECULAR SEQUENCE DATA; SEQUENCE HOMOLOGY, AMINO ACID; TRYPANOSOMA CRUZI;

EID: 0035859360     PISSN: 15237060     EISSN: None     Source Type: Journal    
DOI: 10.1021/ol0160506     Document Type: Article

References (48)

1. World Development Report, Investing in Health; World Bank: 1993.
2. Mercer, E. I. Lipids 1991, 26, 584-597.
3. (a) Gebre-Hiwot, A.; Frommel, D. J. Antimicrob. Chemother. 1993, 32, 837-842.
4. (b) Urbina, J. A. Parasitology 1997, 114, S91-S99.
5. (c) Urbina, J. A. J. Mol. Med. 1999, 77, 332-338.
6. (a) Matsuda, S. P. T. In Biochemical Principles and Mechanisms of Biosynthesis and Biodegradation of Polymers; Steinbüchel, A., Ed.; Wiley-VCH: Weinheim, 1998; pp 300-307.
7. (b) Wendt, K. U.; Schulz, G. E.; Corey, E. J.; Liu, D. R. Angew. Chem., Int. Ed. 2000, 39, 2812-2833.
8. (a) Abe, I.; Tomesch, J. C.; Wattanasin, S.; Prestwich, G. D. Nat. Prod. Rep. 1994, 11, 279-302.
9. (b) Morand, O. H.; Aebi, J. D.; Dehmlow, H.; Ji, Y. H.; Gains, N.; Lengsfeld, H.; Himber, J. J. Lipid Res. 1997, 38, 373-390.
10. (c) Brown, G. R.; Hollinshead, D. M.; Stokes, E. S.; Clarke, D. S.; Eakin, M. A.; Foubister, A. J.; Glossop, S. C.; Griffiths, D.; Johnson, M. C.; McTaggart, F.; Mirrlees, D. J.; Smith, G. J.; Wood, R. J. Med. Chem. 1999, 42, 1306-1311.
11. Buckner, F. S.; Griffin, J. H.; Wilson, A. J.; Van Voorhis, W. C. Antimicrob. Agents Chemother. 2001, 45, 1210-1215.
12. Agüero, F.; Verdún, R. E.; Carlos, A.; Frasch, C.; Sánchez, D. O. Genome Res. 2000, 10, 1996-2005.
13. Van Voorhis, W. C.; Eisen, H. J. Exp. Med. 1989, 169, 641-652.
14. Ausubel, F. M.; Brent, R.; Kingston, R. E.; Moore, D. D.; Seidman, J. G.; Smith, J. A.; Struhl, K. Current Protocols in Molecular Biology; Wiley-Interscience: New York, 1999.
15. Corey, E. J.; Matsuda, S. P. T.; Baker, C. H.; Ting, A. Y.; Cheng, H. Biochem. Biophys. Res. Commun. 1996, 219, 327-331.
16. Hart, E. A.; Hua, L.; Darr, L. B.; Wilson, W. K.; Pang, J.; Matsuda, S. P. T. J. Am. Chem. Soc. 1999, 121, 9887-9888.
17. Corey, E. J.; Matsuda, S. P. T.; Bartel, B. Proc. Natl. Acad. Sci. U.S.A. 1994, 91, 2211-2215.
18. Buckner, F. S.; Ngyuen, L. N.; Joubert, B. M.; Matsuda, S. P. T. Mol. Biochem. Parasitol. 2000, 110, 399-403.
19. Nadeau, R. G.; Hanzlik, R. P. Methods Enzymol. 1968, 15, 346-351.
20. Emmons, G. T.; Wilson. W. K.; Schroepfer, G. J. Jr. Magn. Reson. Chem. 1989, 27, 1012-1024.
21. Raederstorff, D.; Rohmer, R. FEMS Microbiol. Lett. 1986, 34, 269-272.
22. Raederstorff, D.; Rohmer, M. Biochem. J. 1985, 231, 609-615.
23. (a) Nes, W. D.; Norton, R. A.; Crumley, F. G.; Madigan, S. J.; Katz, E. R. Proc. Natl. Acad. Sci. U.S.A. 1990, 87, 7565-7569.
24. (b) Godzina, S. M.; Lovato, M. A.; Meyer, M. M.; Foster, K. A.; Wilson, W. K.; Gu, W.; de Hostos, E. L.; Matsuda, S. P. T. Lipids 2000, 36, 249-255.
25. Raederstorff, D.; Rohmer, M. Eur. J. Biochem. 1987, 164, 427-434.
26. Anding, C.; Brandt, R. D.; Ourisson, G. Eur. J. Biochem. 1971, 24, 259-263.
27. Rohmer, M.; Brandt, R. D. Eur. J. Biochem. 1973, 36, 446-454.
28. (a) Buntel, C. J.; Griffin, J. H. J. Am. Chem. Soc. 1992, 114, 9711-9713.
29. (b) Roessner, C. A.; Min, C.; Hardin, S. H.; Harris-Haller, L. W.; McCollum, J. C.; Scott, A. I. Gene 1993, 127, 149-150.
30. (c) Shi, Z.; Buntel, C. J.; Griffin, J. H. Proc. Natl. Acad. Sci. U.S.A. 1994, 91, 7370-7374.
31. (d) Kusano, M.; Shibuya, M.; Sankawa, U.; Ebizuka, Y. Biol. Pharm. Bull. 1995, 18, 195-197.
32. (e) Abe, I.; Prestwich, G. D. Proc. Natl. Acad. Sci. U.S.A. 1995, 92, 9274-9278.
33. (f) Baker, C. H.; Matsuda, S. P. T.; Liu, D. R.; Corey, E. J. Biochem. Biophys. Res. Commun. 1995, 213, 154-160.
34. (g) Sung, C.-K.; Shibuya, M.; Sankawa, U.; Ebizuka, Y. Biol. Pharm. Bull. 1995, 18, 1459-1461.
35. (a) Corey, E. J.; Matsuda, S. P. T.; Bartel, B. Proc. Natl. Acad. Sci. U.S.A. 1993, 90, 11628-11632.
36. (b) Morita, M.; Shibuya, M.; Lee, M.-S.; Sankawa, U.; Ebizuka, Y. Biol. Pharm. Bull. 1997, 20, 770-775.
37. (c) Kushiro, T.; Shibuya, M.; Ebizuka, Y. Eur. J. Biochem. 1998, 256, 238-244.
38. (d) Hayashi, H.; Hiraoka, N.; Ikeshiro, Y.; Yazaki, K.; Tanaka, S.; Kushiro, T.; Shibuya, M.; Ebizuka, Y. Plant Physiol. 1999, 121, 1384.
39. (e) Hayashi, H.; Hiraoka, N.; Ikeshiro, Y.; Kushiro, T.; Morita, M.; Shibuya, M.; Ebizuka, Y. Biol. Pharm. Bull. 2000, 23, 231-234.
40. Meyer, M. M.; Segura, M. J. R.; Wilson, W. K.; Matsuda, S. P. T. Angew. Chem. 2000, 112, 4256-4258, Angew. Chem., Int. Ed. 2000, 39, 4090-4092.
41. Meyer, M. M.; Segura, M. J. R.; Wilson, W. K.; Matsuda, S. P. T. Angew. Chem. 2000, 112, 4256-4258, Angew. Chem., Int. Ed. 2000, 39, 4090-4092.
42. Herrera, J. B. R.; Wilson, W. K.; Matsuda, S. P. T. J. Am. Chem. Soc. 2000, 122, 6765-6766.
43. (a) Corey, E. J.; Cheng, H.; Baker, C. H.; Matsuda, S. P. T.; Li, D.; Song, X. J. Am. Chem. Soc. 1997, 119, 1289-1296.
44. (b) Joubert, B. M.; Hua, L.; Matsuda, S. P. T. Org. Lett. 2000, 2, 339-341.
45. (c) Matsuda, S. P. T.; Darr, L. B.; Hart, E. A.; Herrera, J. B. R.; McCann, K. E.; Meyer, M. M.; Pang, J.; Schepmann, H. G. Org. Lett. 2000, 2, 2261-2263.
46. Ochs, D.; Kaletta, C.; Entian, K.-D.; Beck-Sickinger, A.; Poralla, K. J. Bacteriol. 1992, 174, 298-302.
47. (a) Wendt, K. U.; Poralla, K.; Schulz, G. E. Science 1997, 277, 1811-1815.
48. (b) Wendt, K. U.; Lenhart, A.; Schulz, G. E. J. Mol. Biol. 1999, 286, 175-187.