A class of sterol 14-demethylase inhibitors as anti-Trypanosoma cruzi agents

Proceedings of the National Academy of Sciences of the United States of America

Volumn 100, Issue 25, 2003, Pages 15149-15153

  Buckner, Frederick ^a   Yokoyama, Kohei ^a   Lockman, Jeffrey ^c   Aikenhead, Kendra ^a   Ohkanda, Junko ^c   Sadilek, Martin ^a   Sebti, Saïd ^d   Van Voorhis, Wesley ^a   Hamilton, Andrew ^c   Gelb, Michael H ^a,b  

^a UNIVERSITY OF WASHINGTON   (United States)

^b UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

^c YALE UNIVERSITY   (United States)

^d H LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTITRYPANOSOMAL AGENT; CYTOCHROME P450; FARNESYL TRANS TRANSFERASE; FTI 2220; IMIDAZOLE DERIVATIVE; STEROL 14 DEMETHYLASE INHIBITOR; STEROL 14ALPHA DEMETHYLASE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CHAGAS DISEASE; CONTROLLED STUDY; DRUG ABSORPTION; DRUG BLOOD LEVEL; DRUG IDENTIFICATION; DRUG POTENCY; DRUG TARGETING; DRUG TOLERABILITY; FEMALE; GAS CHROMATOGRAPHY; MASS SPECTROMETRY; MOUSE; NONHUMAN; PRIORITY JOURNAL; SCREENING; SOUTH AND CENTRAL AMERICA; STEROL SYNTHESIS; SURVIVAL; TREATMENT OUTCOME; TRYPANOSOMA CRUZI; TRYPANOSOMIASIS;

ANIMALS; CELL DIVISION; CHAGAS DISEASE; CYTOCHROME P-450 ENZYME SYSTEM; DISEASE MODELS, ANIMAL; ENZYME INHIBITORS; GAS CHROMATOGRAPHY-MASS SPECTROMETRY; IMIDAZOLES; MICE; MICE, INBRED BALB C; MODELS, CHEMICAL; OXIDOREDUCTASES; PEPTIDES; SPECTROPHOTOMETRY; STEROLS; TIME FACTORS; TRYPANOCIDAL AGENTS; TRYPANOSOMA CRUZI;

ANIMALIA; PROTOZOA; TRYPANOSOMA; TRYPANOSOMA CRUZI;

EID: 10744230525     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.2535442100     Document Type: Article

References (23)

1. World Health Organization (2002) Control of Chagas Disease: Second Report of the Expert Committee (W.H.O., Geneva), W.H.O. Technical Report Series 905.
2. Buckner, F. S., Eastman, R., Speelmon, E., Nepomuceno-Silva, J. L., Myler P., Van Voorhis, W. C. & Yokoyama, K. (2002) Mol. Biochem. Parasitol. 122, 181-188.
3. Buckner, F. S., Yokoyama, K., Nguyen, L. N., Grewal, A., Erdjument-Bromage, H., Tempst, P., Strickland, C. L., Xiao, L., Van Voorhis, W. C. & Gelb, M. H. (2000) J. Biol. Chem. 29, 21870-21876.
4. Haluska, P., Dy, G. K. & Adjei, A. A. (2002) Eur. J. Cancer 38, 1685-1700.
5. Gelb, M. H., Buckner, F. S., Yokoyama, K., Ohkanda, J., Hamilton, A., Hguyen, L., Rossi-Bergmann, B., Sebti, S. M. & Van Voorhis, W. C. (2000) in Farnesyltransferase and Geranylgeranyltransferase-I: Targets for Cancer and Cardiovascular Therapy, ed. Sebti, S. M. (Humana, Totowa, NJ), pp. 221-232.
6. Karp, J. E., Kaufmann, S. H., Adjei, A. A., Lancet, J. E., Wright, J. J. & End, D. W. (2001) Curr. Opin. Oncol. 13, 470-476.
7. Ohkanda, J., Lockman, J. W., Yokoyama, K., Gelb, M. H., Croft, S. L., Kendrick, H., Harrell, M. I., Feagin, J. E., Blaskovich, M. A., Sebti, S. M., et al. (2001) Bioorg. Med. Chem. Lett. 11, 761-764.
8. Van Voorhis, W. C. & Eisen, H. (1989) J. Exp. Med. 169, 641-652.
9. Buckner, F. S., Verlinde, C. L. M. J., La Flamme, A. C. & Van Voorhis, W. C. (1996) Antimicrob. Agents Chemother. 40, 2592-2597.
10. Yokoyama, K., Trobridge, P., Buckner, F. S., Van Voorhis, W. C., Stuart, K. D. & Gelb, M. H. (1998) J. Biol. Chem. 273, 26497-26505.
11. Pompliano, D. L., Schaber, M. D., Mosser, S. D., Omer, C. A., Shafer, J. A. & Gibbs, J. B. (1993) Biochem. 32, 8341-8347.
12. McGeady, P., Kuroda, S., Shimizu, K., Takai, Y. & Gelb, M. H. (1995). J. Biol. Chem. 270, 26347-26351.
13. Haughan, P. A., Chance, M. L. & Goad, L. J. (1992) Biochem. Pharmacol. 44, 2199-2206.
14. White, T. C. (1997) Antimicrob. Agents Chemother. 41, 1488-1494.
15. Urbina, J. A., Vivas, J., Visbal, G. & Contreras, L. M. (1995) Mol. Biochem. Parasitol. 73, 199-210.
16. Buckner, F. S., Joubert, B. M., Boyle, S. M., Eastman, R. T., Verlinde, C. L. & Matsuda, S. P. T. (2003) Mol. Biochem. Parasitol. 132, 75-81.
17. Goad, L. J., Berens, R. L., Marr, J. J., Beach, D. H. & Holz, G. G. (1989) Mol. Biochem. Parasitol. 32, 179-190.
18. Podust, L. M., Poulos, T. L. & Waterman, M. R. (2001) Proc. Natl. Acad. Sci. USA 98, 3068-3073.
19. Sun, J., Blaskovich, M. A., Knowles, D., Qian, Y., Ohkanda, J., Bailey, R. D., Hamilton, A. D. & Sebti, S. M. (1999) Cancer Res. 59, 4919-4926.
20. McCabe, R. E., Remmington, J. S. & Araujo, F. G. (1986) Am. J. Trop. Med. Hyg. 35, 280-284.
21. Urbina, J. A., Payares, G., Contreras, L. M., Liendo, A., Sanoja, C., Molina, J., Piras, M., Piras, R., Perez, N., Wincker, P., et al. (1998) Antimicrob. Agents Chemother. 42, 1771-1777.
22. Urbina, J. A., Payares, G., Sanoja, C., Lira, R. & Romanha, A. J. (2003) Int. J. Antimicrob. Agents 21, 27-38.
23. Ohkanda, J., Buckner, F. S., Lockman, J. L., Yokoyama, K., Carrico, D., Eastman, R., Luca-Fradley, K., Davies, W., Croft, S., Van Voorhis, W. C., et al. (2004) J. Med. Chem., in press.