Kinetic characterization of squalene synthase from Trypanosoma cruzi: Selective inhibition by quinuclidine derivatives

Antimicrobial Agents and Chemotherapy

Volumn 51, Issue 6, 2007, Pages 2123-2129

  Sealey Cardona, Marco ^a   Cammerer, Simon ^b   Jones, Simon ^b   Ruiz Pérez, Luis M ^a   Brun, Reto ^c   Gilbert, Ian H ^b   Urbina, Julio A ^d   González Pacanowska, Dolores ^a  

^a INSTITUTO DE PARASITOLOGÍA Y BIOMEDICINA LÓPEZ NEYRA   (Spain)

^b CARDIFF UNIVERSITY   (United Kingdom)

^c SWISS TROPICAL AND PUBLIC HEALTH INSTITUTE   (Switzerland)

^d INSTITUTO VENEZOLANO DE INVESTIGACIONES CIENTÍFICAS   (Venezuela)

Author keywords

[No Author keywords available]

Indexed keywords

FARNESYL DIPHOSPHATE; NICOTINAMIDE ADENINE DINUCLEOTIDE; QUINUCLIDINE DERIVATIVE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; SQUALENE SYNTHASE;

AMINO ACID SEQUENCE; AMINO TERMINAL SEQUENCE; ANIMAL CELL; ANTIPROTOZOAL ACTIVITY; ARTICLE; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; DRUG MECHANISM; ENZYME ACTIVITY; ENZYME ANALYSIS; ENZYME INHIBITION; ENZYME KINETICS; ENZYME PURIFICATION; ESCHERICHIA COLI; GENE DELETION; MICHAELIS CONSTANT; MICHAELIS MENTEN KINETICS; NONHUMAN; PRIORITY JOURNAL; RAT; SOLUBILITY; TRYPANOSOMA CRUZI;

AMINO ACID SEQUENCE; ANIMALS; ANTIPROTOZOAL AGENTS; FARNESYL-DIPHOSPHATE FARNESYLTRANSFERASE; KINETICS; MOLECULAR SEQUENCE DATA; PARASITIC SENSITIVITY TESTS; QUINUCLIDINES; TRYPANOSOMA CRUZI;

EID: 34250162861     PISSN: 00664804     EISSN: None     Source Type: Journal    
DOI: 10.1128/AAC.01454-06     Document Type: Article

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