Amiodarone has intrinsic anti-Trypanosoma cruzi activity and acts synergistically with posaconazole

Journal of Medicinal Chemistry

Volumn 49, Issue 3, 2006, Pages 892-899

  Benaim, Gustavo ^b,c   Sanders, John M ^f   Garcia Marchán, Yael ^c   Colina, Claudia ^a   Lira, Renee ^a   Caldera, Aura R ^a   Payares, Gilberto ^c   Sanoja, Cristina ^c   Burgos, Juan Miguel ^d   Leon Rossell, Annette ^f   Concepcion, Juan Luis ^g   Schijman, Alejandro G ^d   Levin, Mariano ^d,e   Oldfield, Eric ^f   Urbina, Julio A ^a  

^a INSTITUTO VENEZOLANO DE INVESTIGACIONES CIENTÍFICAS   (Venezuela)

^b Instituto Internacional de Estudios Avanzados IDEA   (Venezuela)

^c FACULTAD DE CIENCIAS   (Venezuela)

^d INSTITUTO DE INVESTIGACIONES EN INGENIERÍA GENÉTICA Y BIOLOGÍA MOLECULAR   (Argentina)

^e INSTITUT COCHIN   (France)

^f UNIVERSITY OF ILLINOIS AT URBANA CHAMPAIGN   (United States)

^g UNIVERSIDAD DE LOS ANDES   (Venezuela)

Author keywords

[No Author keywords available]

Indexed keywords

AMIODARONE; ANTITRYPANOSOMAL AGENT; CALCIUM ION; ERGOSTEROL; NIFURTIMOX; POSACONAZOLE; SQUALENE SYNTHASE;

AMASTIGOTE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIPROTOZOAL ACTIVITY; ARTICLE; CALCIUM CELL LEVEL; CALCIUM HOMEOSTASIS; CHAGAS DISEASE; CONTROLLED STUDY; DRUG POTENTIATION; EPIMASTIGOTE; FEMALE; IN VITRO STUDY; IN VIVO STUDY; MOUSE; NONHUMAN; STEROL SYNTHESIS; TRYPANOSOMA CRUZI; TRYPOMASTIGOTE; VERO CELL;

ACUTE DISEASE; AMIODARONE; ANIMALS; CALCIUM; CERCOPITHECUS AETHIOPS; CHAGAS DISEASE; CRYSTALLOGRAPHY, X-RAY; DRUG SYNERGISM; ERGOSTEROL; INTRAMOLECULAR TRANSFERASES; MICE; MODELS, MOLECULAR; MOLECULAR STRUCTURE; TRIAZOLES; TRYPANOCIDAL AGENTS; TRYPANOSOMA CRUZI; VERO CELLS;

EID: 32344435160     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm050691f     Document Type: Article

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