Antiproliferative effects of 24(25) sterol methyl transferase inhibitors on trypanosoma (Schizotrypanum) cruzi: In vitro and in vivo studies

Chemotherapy

Volumn 42, Issue 4, 1996, Pages 294-307

  Urbin, Julio A ^a,b   Vivas, Julio ^a,b   Lazardi, Keyla ^a   Molina, Judith ^c   Payares, Gilberto ^c   Piras, Marta M ^d   Pirns, Romano ^d  

^a INSTITUTO VENEZOLANO DE INVESTIGACIONES CIENTÍFICAS   (Venezuela)

^b Departamento de Biología Celular   (Venezuela)

^c UNIVERSIDAD CENTRAL DE VENEZUELA   (Venezuela)

^d Centra Medico Docente La Trinidad Caracas   (Venezuela)

Author keywords

Antimycotic azoles; Chagas disease; Sterol 14 demethylase; Sterol biosynthesis inhibitors; Sterol methyl transferase; Synergic effects; Trypanosoma cruzi

Indexed keywords

22,26 AZASTEROL; 24,25 EPIMINOLANOSTEROL; ALPHA (4 CHLOROPHENYL) ALPHA (1 CYCLOPROPYL 1 METHYLETHYL) 1H 1,2,4 TRIAZOLE 1 ETHANOL; KETOCONAZOLE; STEROL DERIVATIVE; UNCLASSIFIED DRUG;

AMASTIGOTE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CAPILLARY GAS CHROMATOGRAPHY; CHAGAS DISEASE; CONTROLLED STUDY; CYTOLYSIS; DOSE RESPONSE; EPIMASTIGOTE; EXPERIMENTAL INFECTION; FEMALE; GROWTH INHIBITION; GROWTH RATE; MASS SPECTROMETRY; MOUSE; NONHUMAN; ORAL DRUG ADMINISTRATION; PARASITEMIA; PRIORITY JOURNAL; THIN LAYER CHROMATOGRAPHY; TRYPANOSOMA CRUZI; TRYPANOSOMIASIS;

ANIMALS; CHAGAS DISEASE; CHOLESTANOL; DRUG SYNERGISM; ENZYME INHIBITORS; FEMALE; KETOCONAZOLE; LANOSTEROL; LIPIDS; METHYLTRANSFERASES; MICE; TRYPANOCIDAL AGENTS; TRYPANOSOMA CRUZI;

EID: 0029975328     PISSN: 00093157     EISSN: 14219794     Source Type: Journal    
DOI: 10.1159/000239458     Document Type: Article

References (48)

1. Bloch K: Slcrol structure and membrane function. CRC Crit Rev Bio-chcm 1983:14:47-92.
2. McCabe RE, Remington JS, Araujo FG: In vitro and in vivo effects of itraconazole against Trypanosoma cruzi. Am J Trop Med Hyg 1986:35: 280-284.
3. McCabe RE, Remington JS, Araujo FJ: Ketoconazolc promotes parasitological cure of mice infected with Trypanosoma cruzi. Trans R Soc IropMed Hyg 1987:81:613-615.
4. Beach DH, Goad U, Holz GG Jr: Effects of ketoconazole on sterol biosynthesis by Trypanosoma cruzi. Biochem Biophys Res Commun 1986;135:851-856.
5. Goad U, Berens RL, Marr JJ, Beach DH, Holz GG Jr: The activity of ketoconazolc and other azolcs against Trypanosoma cruzi: Biochemistry and chemotherapeutic action in vitro. Mol Biochem Parasitol 1989:32:179-190.
6. Urbina JA, Lazardi K, Aguirre T, Piras MM. Piras R: Antiproliferative synergism of the allylamine SF-86327 and ketoconazolc on cpimas-tigotcs and amastigotes of Trypanosoma (Schizotrypanum) cruzi. Anti-microb Agents C'hemothcr 1988:32: 1237-1242.
7. Urbina JA, Lazardi K, Marchan E, Visbal G, Aguirre T, Piras MM, Piras R, Maldonado RA, Payarcs G, DeSouza W: Mevinolin (lovastatin) potentiates the antiproliferative effects of ketoconazole and terbina-fine against Trypanosoma (Schizotrypanum) cruzi: In vivo and in vitro studies. Antimicrob Agents Che-mother 1993;37:580-591.
8. Maldonado RA, Molina J, Payarcs G, Urbina JA: Experimental chemotherapy with combinations of crgo-sterol biosynthesis inhibitors in murine models of Chagas disease. Antimicrob Agents Chemother 1993: 37:1353-1359.
9. Vanden Bossche H: Chemotherapy of human fungal infections: in Lyr H (cd): Modern Selective Fungicides. Properties. Applications, Mechanism of Action. Stuttgart. Fisher. 1995, pp 431-484.
10. Vanden Bossche H, Marichal P: Azole antifungals: Mode of action; in Yamaguchi H, Kobayashi GS, Takahashi H (eds): Recent Progress in Antifungal Chemotherapy. New York. Dekker, 1992, pp 25-40.
11. Ryder NS, Micth H: Allylamine antifungal drugs. CurrTop Med Mycol 1992;4:158-188.
12. McCabe RE: failure of ketoconazole to cure chronic murine Chagas disease. J Infect Dis 1988:158:1408-1409.
13. Moreira AAB, DcSouza HBWT, Amalo Neto V, Malsubara L, Pinto PI.S, Tolezano JE. Nunes EV, Oku-mura M: Avaliacao da atividade terapéutica do itraconazol nas infec-foes crónicas, experimental e humana, pelo Trypanosoma cruzi. Rev Inst Med Trop Sao Paulo 1992:34: 177-180.
14. Brener Z, Campado JR, Galváo LM, da Luz ZMP, Filardi LdS, Pereira MES, Santos LMT. Candado CB: An experimental and clinical assay with ketoconazole in the treatment of Chagas disease. Mem Inst Oswal-doCruz 1993;88:149-153.
15. Ochlschlagcr AC, Czyzewska E: Rationally designed inhibitors of sterol biosynthesis; in Sutcliffe J, Georgo-papadakou NH (eds): Emerging Targets in Antibacterial and Antifungal Chemotherapy. New York, Chapman &Hall, 1992, pp 437-475.
16. Mercer El: Inhibitors of sterol biosynthesis and their applications. Prog Lipid Res 1993;32:357-416.
17. Rahicr A, Taton M, Benvenistc P: Inhibition of sterol biosynthesis in higher plants by analogues of high energy carbocationic intermediates: in Kuhn PJ, Trinci APJ. Jung MJ. Goosey MW. Copping LG (eds): Biochemistry of Cell Walls and Membranes in Fungi. Berlin, Springer, 1990, pp 205-221.
18. Boyle FT: Drug discovery: A chemist approach; in Ryley JF (ed): Chemotherapy of Fungal Infections. Berlin, Springer, 1990. pp 3-30.
19. Barrett-Bee K, Ryder NS: Biochemical aspects of ergostcrol biosynthesis inhibition; in Sutcliffe J. Georgopa-padakou NH (eds): Emerging Targets in Antibacterial and Antifungal Chemotherapy. New York, Chapman & Hall. 1992. pp 410-436.
20. 24 methyl transferase. J Med Chem 1992:35:100-106.
21. Nes WD, Hanncrs PK, Parish EJ: Control of fungal sterol C-24 trans-alkylation: Importance to developmental regulation. Biochcm Bio-phys Res Commun 1986:139:410-415.
22. Nes WD, Janssen GG, Norton RA, Kalinowska M, Crumley FG, Tal B, Bergcnstrahle A, Johnsson L: Regulation of sterol biosynthesis in sunflower by 24(7?, S).25-epiminolanos-terol. a novel C-24 methyl transferase inhibitor. Biochcm Biophys Res Commun 1991;177:566-574
23. Rahman MD, Pascal RA: Inhibitors of crgosterol biosynthesis and growth of the trypanosomatid protozoan Crithidia fasciculata. J Biol Chem 1990:265:4989-4996.
24. Hudson L, Grover F, Gutteridge WE, Klein RA, Peters W, Neal RA, Miles MA, Scott MT, Nourish R, Ager BP: Suggested guidelines for work with live Trypanosoma cruzi. Trans R Soc Trop Med Hyg 1983; 77:416-419.
25. De Maio A, Urbina JA: Trypanosoma (Schizotrypanum) cruzi: Terminal oxidases in two growth phases in vitro. Acta Cient Vcnez 1984:35: 136-141.
26. Urbina JA, Lazardi K, Aguirre T, Piras MM, Piras R: Antiproliferative effects and mechanism of action of ICI 195.739. a novel bis-triazole derivative, on epimastigotes and amastigotes of Trypanosoma (Schizotrypanum) cruzi. Antimicrob Agents Chemother 1991:35:730-735.
27. 5-sterol methyl transferase inhibitors and their combinations with ketoconazole. Mol Bio-chem Parasitol 1995;73:199-210.
28. Hallander HO, Dombush K, Geze-lius I., Jacobson K, Karlsson I: Synergism between aminoglycosides and cephalosporin with antipseudo-monal activity: Interaction index and killing curve method. Antimicrob Agents Chemother 1982:22: 743-752.
29. Prichard MN, Prichard LE, Shipman C Jr: Strategic design and three-dimensional analysis of antiviral drug combinations. Antimicrob Agents Chemother 1995:37:540-545.
30. McCabe RE, Remington JS, Araujo FG: Ketoconazole inhibition of intracellular multiplication of Trypanosoma cruzi and protection against a lethal infection with the organism. J Infect Dis 1984:150:594-601.
31. Conover WJ: Practical Nonpara-metric Statistics. New York. Wiley &Sons. 1980, pp 344-393.
32. Parish EJ, Nes WD: Synthesis of new epiminoisopentcnoids. Synth Commun 1988:18:221-226.
33. Vanden Bossche H: Mode of action of pyridine, pyrimidine and azoic antifungals: in Berg D, Plcmpcl M (eds): Sterol Biosynthesis Inhibitors: Pharmaceutical and Agrochemical Aspects. Chichester. VCH Press. Ellis Harwood, 1988. pp 79-119.
34. Vanden Bossche H, Marichal P, Gorrens J, Gecrts H, Janssen PJ: Mode of action studies: Basis for the search of new antifungal drugs. Ann NY Acad Sei 1988:544:191-207.
35. Schaude M, Petrany G, Ackerbauer H, Meingassner JG, Micth H: Pre-clinical antimycotic activity of SDZ 89,485: A new orally and topically effective triazole. J Med Vet Mycol 1990:28:445-454.
36. Larraldc G, Vivas J, Urbina JA: Concentration and time dependence of the effects of ketoconazole on growth and sterol biosynthesis in Trypanosoma (Schizotrypanum) cruzi epimastigotes. Acta Cient Vcnez 1988:39:140-146.
37. Lazardi K, Urbina JA, DeSouza W: Ultrastructural alterations induced by ICI 195.739. a bis triazole with strong antiproliferative action against Trypanosoma (Schizotrypanum) cruzi. Antimicrob Agents Chemother 1991;35:736-740.
38. Vanden Bossche H: Importance and role of sterols in fungal membranes: in Kuhn PJ. Trinci APJ. Jung MJ, Goosey MW, Copping LG (eds): Biochemistry of Cell Walls and Membranes. Berlin, Springer, 1990, pp 135-157.
39. Parks LW, Lorenz RT, Casey WM: Functions of sterols in yeast mem-branccs; in Sutcliffe J. Georgopa-padakou NH (eds): Emerging Targets in Antibacterial and Antifungal Chemotherapy. New York, Chapman &Hall. 1992, pp 393-409.
40. Nés WR, Sekula BC, Nes WD, Adler JH: The functional importance of structural features of ergosterol in yeast. J Biol Chem 1978:253:6218-6225.
41. Rodriguez RJ, Taylor FR, Parks LW: A requirement for ergosterol to permit growth of yeast sterol auxo-trophson cholcstanol. Biochem Bio-phys Res Commun 1982:106:435-441.
42. Dahl JS, Dahl CE: Stimulation of cell proliferation and phosphoinosi-tidc metabolism in Saccharomyces cerevisiae GL7 by ergosterol. Biochem Biophys Res Commun 1985: 133:844-850.
43. Rodriguez RJ, Low C, Bottema CDK, Parks LW: Multiple functions for sterols in Saccharomyces cerevisiae. Biochim Biophys Acta 1985: 837:336-343.
44. Guyer W, Block K: The sterol requirement of Teirahymena setosa HZ-1. J Protozool 1983:30:625-629.
45. Whitaker BD, Nelson DL: Growth support and metabolism of phytosterols in Paramecium aurelia. Lipids 1987:22:386-396.
46. Nes WD, Hcupel RC: Physiological requirement for biosynthesis of multiple b-methyl sterols in Gibberella fujikuroi. Arch Biochem Biophys 1986;244:211-217.
47. McCammon MT, Hartmann M-A, Bottema CDK, Parks LW: Sterol methylation in Saccliaromyces cerevisiae. J Bactcriol 1984; 157:475-483.
48. Gaber RF, Copple DM, Kennedy BK, Vidal M, Bard M: The yeast gene erg6 is required for normal membrane function but is not essential for biosynthesis of the ccll-cyclc sparking sterol. Mol Cell Biol 1989; 9:3447-3456.