Oxidosqualene cyclase inhibitors as antimicrobial agents

Journal of Medicinal Chemistry

Volumn 46, Issue 20, 2003, Pages 4240-4243

  Hinshaw, Jerald C ^a   Suh, Dae Yeon ^a   Garnier, Philippe ^a   Buckner, Frederick S ^b   Eastman, Richard T ^b   Matsuda, Seiichi P T ^c   Joubert, Bridget M ^c   Coppens, Isabelle ^d   Joiner, Keith A ^d   Merali, Salim ^e   Nash, Theodore E ^f   Prestwich, Glenn D ^a  

^a UNIVERSITY OF UTAH   (United States)

^b UNIVERSITY OF WASHINGTON   (United States)

^c RICE UNIVERSITY   (United States)

^d YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^e NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

^f NATIONAL INSTITUTES OF HEALTH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHOLESTEROL; ENZYME INHIBITOR; LANOSTEROL; OXIDOSQUALENE CYCLASE INHIBITOR; UNCLASSIFIED DRUG;

ANTIMICROBIAL ACTIVITY; ARTICLE; COMBINATORIAL CHEMISTRY; CYCLIZATION; ENZYME INHIBITION; LEISHMANIA MEXICANA; MOLECULAR CLONING; NONHUMAN; PNEUMOCYSTIS CARINII; TRYPANOSOMA CRUZI;

3T3 CELLS; AMINES; ANIMALS; ANTI-INFECTIVE AGENTS; ANTIFUNGAL AGENTS; ANTIPROTOZOAL AGENTS; CHO CELLS; COMBINATORIAL CHEMISTRY TECHNIQUES; CRICETINAE; ENZYME INHIBITORS; HUMANS; INHIBITORY CONCENTRATION 50; INTRAMOLECULAR TRANSFERASES; LEISHMANIA MEXICANA; MICE; MICROBIAL SENSITIVITY TESTS; PHENOLS; PNEUMOCYSTIS; RATS; TOXOPLASMA; TRYPANOSOMA BRUCEI GAMBIENSE; TRYPANOSOMA CRUZI;

EID: 0141457812     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm034126t     Document Type: Article

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