메뉴 건너뛰기




Volumn 43, Issue 2, 2013, Pages 158-170

Th17 cells and IL-17 A-Focus on immunopathogenesis and immunotherapeutics

Author keywords

Brodalumab; Interleukin 17; Ixekizumab; Secukinumab; Th17 cells

Indexed keywords

BRIAKINUMAB; BRODALUMAB; ETANERCEPT; INTERLEUKIN 12; INTERLEUKIN 15; INTERLEUKIN 17; INTERLEUKIN 17 RECEPTOR; INTERLEUKIN 22; INTERLEUKIN 7; IXEKIZUMAB; PLACEBO; SECUKINUMAB; TUMOR NECROSIS FACTOR ALPHA; USTEKINUMAB;

EID: 84886067284     PISSN: 00490172     EISSN: 1532866X     Source Type: Journal    
DOI: 10.1016/j.semarthrit.2013.04.006     Document Type: Article
Times cited : (123)

References (157)
  • 1
    • 77952570639 scopus 로고    scopus 로고
    • The dual nature of TH17 cells: shifting the focus to function
    • O'Connor W. Jr, Zenewicz L.A., Flavell R.A. The dual nature of TH17 cells: shifting the focus to function. Nat Immunol 2010;11:471-476.
    • (2010) Nat Immunol , vol.11 , pp. 471-476
    • O'Connor Jr., W.1    Zenewicz, L.A.2    Flavell, R.A.3
  • 2
    • 55849095891 scopus 로고    scopus 로고
    • Evidence that cytokines play a role in rheumatoid arthritis
    • Brennan F.M., McInnes I.B. Evidence that cytokines play a role in rheumatoid arthritis. J Clin Invest 2008, 118:3537-3545.
    • (2008) J Clin Invest , vol.118 , pp. 3537-3545
    • Brennan, F.M.1    McInnes, I.B.2
  • 3
    • 69349093225 scopus 로고    scopus 로고
    • Interleukin-17 and type 17 helper T cells
    • Miossec P., Korn T., Kuchroo V.K. Interleukin-17 and type 17 helper T cells. N Engl J Med 2009, 361:888-898.
    • (2009) N Engl J Med , vol.361 , pp. 888-898
    • Miossec, P.1    Korn, T.2    Kuchroo, V.K.3
  • 4
    • 84860238945 scopus 로고    scopus 로고
    • IL-17/IL-17 receptor system in autoimmune disease: mechanisms and therapeutics
    • Zhu S., Qian Y. IL-17/IL-17 receptor system in autoimmune disease: mechanisms and therapeutics. Clin Sci 2012, 122:487-511.
    • (2012) Clin Sci , vol.122 , pp. 487-511
    • Zhu, S.1    Qian, Y.2
  • 5
    • 59549083038 scopus 로고    scopus 로고
    • Interleukin-17 as a drug target in human disease
    • Ivanov S., Lindén A. Interleukin-17 as a drug target in human disease. Trends Pharmacol Sci 2009, 30:95-103.
    • (2009) Trends Pharmacol Sci , vol.30 , pp. 95-103
    • Ivanov, S.1    Lindén, A.2
  • 6
    • 0022640843 scopus 로고
    • Two types of murine helper T cell clone: I. Definition according to profiles of lymphokine activities and secreted proteins
    • Mosmann T.R., Cherwinski H., Bond M.W., Giedlin M.A., Coffman R.L. Two types of murine helper T cell clone: I. Definition according to profiles of lymphokine activities and secreted proteins. J Immunol 1986, 136:2348-2357.
    • (1986) J Immunol , vol.136 , pp. 2348-2357
    • Mosmann, T.R.1    Cherwinski, H.2    Bond, M.W.3    Giedlin, M.A.4    Coffman, R.L.5
  • 9
    • 27544465354 scopus 로고    scopus 로고
    • A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17
    • Park H., Li Z., Yang X.O., Chang S.H., Nurieva R., Wang Y.H., et al. A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17. Nat Immunol 2005, 6:1133-1141.
    • (2005) Nat Immunol , vol.6 , pp. 1133-1141
    • Park, H.1    Li, Z.2    Yang, X.O.3    Chang, S.H.4    Nurieva, R.5    Wang, Y.H.6
  • 11
    • 82755165048 scopus 로고    scopus 로고
    • Type I IFN promotes IL-10 production from T cells to suppress Th17 cells and Th17-associated autoimmune inflammation
    • Zhang L., Yuan S., Cheng G., Guo B. Type I IFN promotes IL-10 production from T cells to suppress Th17 cells and Th17-associated autoimmune inflammation. PLoS ONE 2011, 6:e28432.
    • (2011) PLoS ONE , vol.6
    • Zhang, L.1    Yuan, S.2    Cheng, G.3    Guo, B.4
  • 14
    • 47749124186 scopus 로고    scopus 로고
    • Foxp3 inhibits RORγt-mediated IL-17A mRNA transcription through direct interaction with RORγt
    • Ichiyama K., Yoshida H., Wakabayashi Y., Chinen T., Saeki K., Nakaya M., et al. Foxp3 inhibits RORγt-mediated IL-17A mRNA transcription through direct interaction with RORγt. J Biol Chem 2008, 283:17003-17008.
    • (2008) J Biol Chem , vol.283 , pp. 17003-17008
    • Ichiyama, K.1    Yoshida, H.2    Wakabayashi, Y.3    Chinen, T.4    Saeki, K.5    Nakaya, M.6
  • 16
    • 2942625911 scopus 로고    scopus 로고
    • Interactions between commensal intestinal bacteria and the immune system
    • Macpherson A.J., Harris N.L. Interactions between commensal intestinal bacteria and the immune system. Nat Rev Immunol 2004, 4:478-485.
    • (2004) Nat Rev Immunol , vol.4 , pp. 478-485
    • Macpherson, A.J.1    Harris, N.L.2
  • 17
    • 82355191456 scopus 로고    scopus 로고
    • Regulation of Th17 cell differentiation by intestinal commensal bacteria
    • Atarashi K., Tanoue T., Umesaki Y., Honda K. Regulation of Th17 cell differentiation by intestinal commensal bacteria. Benef Microbes 2010, 1:327-334.
    • (2010) Benef Microbes , vol.1 , pp. 327-334
    • Atarashi, K.1    Tanoue, T.2    Umesaki, Y.3    Honda, K.4
  • 18
    • 70350343544 scopus 로고    scopus 로고
    • Induction of intestinal Th17 cells by segmented filamentous bacteria
    • Ivanov I.I., Atarashi K., Manel N., Brodie E.L., Shima T., Karaoz U., et al. Induction of intestinal Th17 cells by segmented filamentous bacteria. Cell 2009, 139:485-498.
    • (2009) Cell , vol.139 , pp. 485-498
    • Ivanov, I.I.1    Atarashi, K.2    Manel, N.3    Brodie, E.L.4    Shima, T.5    Karaoz, U.6
  • 20
    • 83655180137 scopus 로고    scopus 로고
    • The starting lineup: key microbial players in intestinal immunity and homeostasis
    • Reading N.C., Kasper D.L. The starting lineup: key microbial players in intestinal immunity and homeostasis. Front Microbiol 2011, 2:148.
    • (2011) Front Microbiol , vol.2 , pp. 148
    • Reading, N.C.1    Kasper, D.L.2
  • 21
    • 77951480203 scopus 로고    scopus 로고
    • Segmented filamentous bacteria take the stage
    • Ivanov I.I., Littman D.R. Segmented filamentous bacteria take the stage. Mucosal Immunol 2010, 3:209-212.
    • (2010) Mucosal Immunol , vol.3 , pp. 209-212
    • Ivanov, I.I.1    Littman, D.R.2
  • 23
    • 77953913586 scopus 로고    scopus 로고
    • Gut-residing segmented filamentous bacteria drive autoimmune arthritis via T helper 17 cells
    • Wu H.J., Ivanov I.I., Darce J., Hattori K., Shima T., Umesaki Y., et al. Gut-residing segmented filamentous bacteria drive autoimmune arthritis via T helper 17 cells. Immunity 2010, 32:815-827.
    • (2010) Immunity , vol.32 , pp. 815-827
    • Wu, H.J.1    Ivanov, I.I.2    Darce, J.3    Hattori, K.4    Shima, T.5    Umesaki, Y.6
  • 24
    • 34848840994 scopus 로고    scopus 로고
    • Inhibition of toll-like receptor 4 breaks the inflammatory loop in autoimmune destructive arthritis
    • Abdollahi-Roodsaz S., Joosten L.A., Roelofs M.F., Radstake T.R., Matera G., Popa C., et al. Inhibition of toll-like receptor 4 breaks the inflammatory loop in autoimmune destructive arthritis. Arthritis Rheum 2007, 56:2957-2967.
    • (2007) Arthritis Rheum , vol.56 , pp. 2957-2967
    • Abdollahi-Roodsaz, S.1    Joosten, L.A.2    Roelofs, M.F.3    Radstake, T.R.4    Matera, G.5    Popa, C.6
  • 25
    • 84886005941 scopus 로고    scopus 로고
    • Innate IL-17-producin cells: the sentinels of the immune system
    • Cua D.J., Tato C.M. Innate IL-17-producin cells: the sentinels of the immune system. Nat Rev Immunol 2010, 10:49-89.
    • (2010) Nat Rev Immunol , vol.10 , pp. 49-89
    • Cua, D.J.1    Tato, C.M.2
  • 26
    • 0027215897 scopus 로고
    • CTLA-8, cloned from an activated T cell, bearing AU-rich messenger RNA instability sequences, and homologous to a herpesvirus saimiri gene
    • Rouvier E., Luciani M.F., Mattéi M.G., Denizot F., Golstein P. CTLA-8, cloned from an activated T cell, bearing AU-rich messenger RNA instability sequences, and homologous to a herpesvirus saimiri gene. J Immunol 1993, 150:5445-5456.
    • (1993) J Immunol , vol.150 , pp. 5445-5456
    • Rouvier, E.1    Luciani, M.F.2    Mattéi, M.G.3    Denizot, F.4    Golstein, P.5
  • 28
    • 68849084891 scopus 로고    scopus 로고
    • Structure and signaling in the IL-17 receptor family
    • Gaffen S.L. Structure and signaling in the IL-17 receptor family. Nat Rev Immunol 2009, 9:556-567.
    • (2009) Nat Rev Immunol , vol.9 , pp. 556-567
    • Gaffen, S.L.1
  • 30
    • 34248574863 scopus 로고    scopus 로고
    • A novel heterodimeric cytokine consisting of IL-17 and IL-17F regulates inflammatory responses
    • Chang S.H., Dong C. A novel heterodimeric cytokine consisting of IL-17 and IL-17F regulates inflammatory responses. Cell Res 2007, 17:435-440.
    • (2007) Cell Res , vol.17 , pp. 435-440
    • Chang, S.H.1    Dong, C.2
  • 32
    • 30744437656 scopus 로고    scopus 로고
    • Evidence for ligand-independent multimerization of the IL-17 receptor
    • Kramer J.M., Yi L., Shen F., Maitra A., Jiao X., Jin T., et al. Evidence for ligand-independent multimerization of the IL-17 receptor. J Immunol 2006, 176:711-715.
    • (2006) J Immunol , vol.176 , pp. 711-715
    • Kramer, J.M.1    Yi, L.2    Shen, F.3    Maitra, A.4    Jiao, X.5    Jin, T.6
  • 33
    • 77955489738 scopus 로고    scopus 로고
    • IL-17RC is required for immune signaling via an extended SEF/IL-17R signaling domain in the cytoplasmic tail
    • Ho A.W., Shen F., Conti H.R., Patel N., Childs E.E., Peterson A.C., et al. IL-17RC is required for immune signaling via an extended SEF/IL-17R signaling domain in the cytoplasmic tail. J Immunol 2010, 185:1063-1070.
    • (2010) J Immunol , vol.185 , pp. 1063-1070
    • Ho, A.W.1    Shen, F.2    Conti, H.R.3    Patel, N.4    Childs, E.E.5    Peterson, A.C.6
  • 34
    • 33846022750 scopus 로고    scopus 로고
    • Act1 adaptor protein is an intermediate and essential signaling component of interleukin-17 receptor
    • Chang S.H., Park H., Dong C. Act1 adaptor protein is an intermediate and essential signaling component of interleukin-17 receptor. J Biol Chem 2006, 281:35603-35607.
    • (2006) J Biol Chem , vol.281 , pp. 35603-35607
    • Chang, S.H.1    Park, H.2    Dong, C.3
  • 35
    • 34247873196 scopus 로고    scopus 로고
    • The adaptor Act1 is required for interleukin 17-dependent signaling associated with autoimmune and inflammatory disease
    • Qian Y., Liu C., Hartupee J., Altuntas C.Z., Gulen M.F., Jane-Wit D., et al. The adaptor Act1 is required for interleukin 17-dependent signaling associated with autoimmune and inflammatory disease. Nat Immunol 2007, 8:247-256.
    • (2007) Nat Immunol , vol.8 , pp. 247-256
    • Qian, Y.1    Liu, C.2    Hartupee, J.3    Altuntas, C.Z.4    Gulen, M.F.5    Jane-Wit, D.6
  • 36
    • 35748973565 scopus 로고    scopus 로고
    • IL-17 enhances chemokine gene expression through mRNA stabilization
    • Hartupee J., Liu C., Novotny M., Li X., Hamilton T. IL-17 enhances chemokine gene expression through mRNA stabilization. J Immunol 2007, 179:4135-4141.
    • (2007) J Immunol , vol.179 , pp. 4135-4141
    • Hartupee, J.1    Liu, C.2    Novotny, M.3    Li, X.4    Hamilton, T.5
  • 37
    • 1642576088 scopus 로고    scopus 로고
    • Functional cooperation between interleukin-17 and tumor necrosis factor-α is mediated by CCAAT/enhancer-binding protein family members
    • Ruddy M.J., Wong G.C., Liu X.K., Yamamoto H., Kasayama S., Kirkwood K.L., et al. Functional cooperation between interleukin-17 and tumor necrosis factor-α is mediated by CCAAT/enhancer-binding protein family members. J Biol Chem 2004, 279:2559-2567.
    • (2004) J Biol Chem , vol.279 , pp. 2559-2567
    • Ruddy, M.J.1    Wong, G.C.2    Liu, X.K.3    Yamamoto, H.4    Kasayama, S.5    Kirkwood, K.L.6
  • 38
    • 33747662347 scopus 로고    scopus 로고
    • Identification of common transcriptional regulatory elements in interleukin-17 target genes
    • Shen F., Hu Z., Goswami J., Gaffen S.L. Identification of common transcriptional regulatory elements in interleukin-17 target genes. J Biol Chem 2006, 281:24138-24148.
    • (2006) J Biol Chem , vol.281 , pp. 24138-24148
    • Shen, F.1    Hu, Z.2    Goswami, J.3    Gaffen, S.L.4
  • 39
    • 66149138031 scopus 로고    scopus 로고
    • IL-17 receptor signaling inhibits C/EBPβ by sequential phosphorylation of the regulatory 2 domain
    • Shen F., Li N., Gade P., Kalvakolanu D.V., Weibley T., Doble B., et al. IL-17 receptor signaling inhibits C/EBPβ by sequential phosphorylation of the regulatory 2 domain. Sci Signal 2009, 2(59):ra8.
    • (2009) Sci Signal , vol.2 , Issue.59
    • Shen, F.1    Li, N.2    Gade, P.3    Kalvakolanu, D.V.4    Weibley, T.5    Doble, B.6
  • 40
    • 34250667109 scopus 로고    scopus 로고
    • Distinct functional motifs within the IL-17 receptor regulate signal transduction and target gene expression
    • Maitra A., Shen F., Hanel W., Mossman K., Tocker J., Swart D., et al. Distinct functional motifs within the IL-17 receptor regulate signal transduction and target gene expression. Proc Natl Acad Sci USA 2007, 104:7506-7511.
    • (2007) Proc Natl Acad Sci USA , vol.104 , pp. 7506-7511
    • Maitra, A.1    Shen, F.2    Hanel, W.3    Mossman, K.4    Tocker, J.5    Swart, D.6
  • 42
    • 78751705672 scopus 로고    scopus 로고
    • IL-17A- versus IL-17F-induced intracellular signal transduction pathways and modulation by IL-17RA and IL-17RC RNA interference in rheumatoid synoviocytes
    • Hot A., Zrioual S., Toh M.L., Lenief V., Miossec P. IL-17A- versus IL-17F-induced intracellular signal transduction pathways and modulation by IL-17RA and IL-17RC RNA interference in rheumatoid synoviocytes. Ann Rheum Dis 2011, 70:341-348.
    • (2011) Ann Rheum Dis , vol.70 , pp. 341-348
    • Hot, A.1    Zrioual, S.2    Toh, M.L.3    Lenief, V.4    Miossec, P.5
  • 43
    • 55149113836 scopus 로고    scopus 로고
    • The roles of IL-17A in inflammatory immune responses and host defense against pathogens
    • Iwakura Y., Nakae S., Saijo S., Ishigame H. The roles of IL-17A in inflammatory immune responses and host defense against pathogens. Immunol Rev 2008, 226:57-79.
    • (2008) Immunol Rev , vol.226 , pp. 57-79
    • Iwakura, Y.1    Nakae, S.2    Saijo, S.3    Ishigame, H.4
  • 44
    • 75949102667 scopus 로고    scopus 로고
    • Interleukin-17 and its target genes: mechanisms of interleukin-17 function in disease
    • Onishi R.M., Gaffen S.L. Interleukin-17 and its target genes: mechanisms of interleukin-17 function in disease. Immunology 2010, 129:311-321.
    • (2010) Immunology , vol.129 , pp. 311-321
    • Onishi, R.M.1    Gaffen, S.L.2
  • 45
    • 58149231532 scopus 로고    scopus 로고
    • Differential roles of interleukin-17A and -17F in host defense against mucoepithelial bacterial infection and allergic responses
    • Ishigame H., Kakuta S., Nagai T., Kadoki M., Nambu A., Komiyama Y., et al. Differential roles of interleukin-17A and -17F in host defense against mucoepithelial bacterial infection and allergic responses. Immunity 2009, 30:108-119.
    • (2009) Immunity , vol.30 , pp. 108-119
    • Ishigame, H.1    Kakuta, S.2    Nagai, T.3    Kadoki, M.4    Nambu, A.5    Komiyama, Y.6
  • 46
    • 0034660183 scopus 로고    scopus 로고
    • Up-regulation of macrophage inflammatory protein-3α/CCL-20 and CC chemokine receptor 6 in psoriasis
    • Homey B., Dieu-Nosjean M.C., Wiesenborn A., Massacrier C., Pin J.J., Oldham E., et al. Up-regulation of macrophage inflammatory protein-3α/CCL-20 and CC chemokine receptor 6 in psoriasis. J Immunol 2000, 164:6621-6632.
    • (2000) J Immunol , vol.164 , pp. 6621-6632
    • Homey, B.1    Dieu-Nosjean, M.C.2    Wiesenborn, A.3    Massacrier, C.4    Pin, J.J.5    Oldham, E.6
  • 48
    • 70349753261 scopus 로고    scopus 로고
    • Th17 cytokines stimulate CCL20 expression in keratinocytes in vitro and in vivo: implications for psoriasis pathogenesis
    • Harper E.G., Guo C., Rizzo H., Lillis J.V., Kurtz S.E., Skorcheva I., et al. Th17 cytokines stimulate CCL20 expression in keratinocytes in vitro and in vivo: implications for psoriasis pathogenesis. J Invest Dermatol 2009, 129:2175-2183.
    • (2009) J Invest Dermatol , vol.129 , pp. 2175-2183
    • Harper, E.G.1    Guo, C.2    Rizzo, H.3    Lillis, J.V.4    Kurtz, S.E.5    Skorcheva, I.6
  • 49
    • 33749318470 scopus 로고    scopus 로고
    • Interleukin (IL)-22 and IL-17 are coexpressed by Th17 cells and cooperatively enhance expression of antimicrobial peptides
    • Liang S.C., Tan X.Y., Luxenberg D.P., Karim R., Dunussi-Joannopoulos K., Collins M., et al. Interleukin (IL)-22 and IL-17 are coexpressed by Th17 cells and cooperatively enhance expression of antimicrobial peptides. J Exp Med 2006, 203:2271-2279.
    • (2006) J Exp Med , vol.203 , pp. 2271-2279
    • Liang, S.C.1    Tan, X.Y.2    Luxenberg, D.P.3    Karim, R.4    Dunussi-Joannopoulos, K.5    Collins, M.6
  • 50
    • 84855695526 scopus 로고    scopus 로고
    • IL-17 downregulates filaggrin and affects keratinocyte expression of genes associated with cellular adhesion
    • Gutowska-Owsiak D., Schaupp A.L., Salimi M., Selvakumar T.A., McPherson T., Taylor S., et al. IL-17 downregulates filaggrin and affects keratinocyte expression of genes associated with cellular adhesion. Exp Dermatol 2012, 21:104-110.
    • (2012) Exp Dermatol , vol.21 , pp. 104-110
    • Gutowska-Owsiak, D.1    Schaupp, A.L.2    Salimi, M.3    Selvakumar, T.A.4    McPherson, T.5    Taylor, S.6
  • 51
    • 80855148155 scopus 로고    scopus 로고
    • IL-17A upregulates keratin 17 expression in keratinocytes through STAT1- and STAT3-dependent mechanisms
    • Shi X., Jin L., Dang E., Chang T., Feng Z., Liu Y., et al. IL-17A upregulates keratin 17 expression in keratinocytes through STAT1- and STAT3-dependent mechanisms. J Invest Dermatol 2011, 131:2401-2408.
    • (2011) J Invest Dermatol , vol.131 , pp. 2401-2408
    • Shi, X.1    Jin, L.2    Dang, E.3    Chang, T.4    Feng, Z.5    Liu, Y.6
  • 52
    • 48249149426 scopus 로고    scopus 로고
    • TPA induction leads to a Th17-like response in transgenic K14/VEGF mice: a novel in vivo screening model of psoriasis
    • Hvid H., Teige I., Kvist P.H., Svensson L., Kemp K. TPA induction leads to a Th17-like response in transgenic K14/VEGF mice: a novel in vivo screening model of psoriasis. Int Immunol 2008, 20:1097-1106.
    • (2008) Int Immunol , vol.20 , pp. 1097-1106
    • Hvid, H.1    Teige, I.2    Kvist, P.H.3    Svensson, L.4    Kemp, K.5
  • 53
    • 66949162673 scopus 로고    scopus 로고
    • Imiquimod-induced psoriasis-like skin inflammation in mice is mediated via the IL-23/IL-17 axis
    • van der Fits L., Mourits S., Voerman J.S.A., Kant M., Boon L., Laman J.D., et al. Imiquimod-induced psoriasis-like skin inflammation in mice is mediated via the IL-23/IL-17 axis. J Immunol 2009, 182:5836-5845.
    • (2009) J Immunol , vol.182 , pp. 5836-5845
    • van der Fits, L.1    Mourits, S.2    Voerman, J.S.A.3    Kant, M.4    Boon, L.5    Laman, J.D.6
  • 55
    • 38849187386 scopus 로고    scopus 로고
    • IL-22 is required for Th17 cell-mediated pathology in a mouse model of psoriasis-like skin inflammation
    • Ma H.L., Liang S., Li J., Napierata L., Brown T., Benoit S., et al. IL-22 is required for Th17 cell-mediated pathology in a mouse model of psoriasis-like skin inflammation. J Clin Invest 2008, 118:597-607.
    • (2008) J Clin Invest , vol.118 , pp. 597-607
    • Ma, H.L.1    Liang, S.2    Li, J.3    Napierata, L.4    Brown, T.5    Benoit, S.6
  • 56
    • 79959584686 scopus 로고    scopus 로고
    • Mast cells and neutrophils release IL-17 through extracellular trap formation in psoriasis
    • Lin A.M., Rubin C.J., Khandpur R., Wang J.Y., Riblett M., Yalavarthi S., et al. Mast cells and neutrophils release IL-17 through extracellular trap formation in psoriasis. J Immunol 2011, 187:490-500.
    • (2011) J Immunol , vol.187 , pp. 490-500
    • Lin, A.M.1    Rubin, C.J.2    Khandpur, R.3    Wang, J.Y.4    Riblett, M.5    Yalavarthi, S.6
  • 58
    • 0034161692 scopus 로고    scopus 로고
    • High levels of IL-17 in rheumatoid arthritis patients: IL-15 triggers in vitro IL-17 production via cyclosporine A-sensitive mechanism
    • Ziolkowska M., Koc A., Luszczykiewicz G., Ksiezopolska-Pietrzak K., Klimczak E., Chwalinska-Sadowska H., et al. High levels of IL-17 in rheumatoid arthritis patients: IL-15 triggers in vitro IL-17 production via cyclosporine A-sensitive mechanism. J Immunol 2000, 164:2832-2838.
    • (2000) J Immunol , vol.164 , pp. 2832-2838
    • Ziolkowska, M.1    Koc, A.2    Luszczykiewicz, G.3    Ksiezopolska-Pietrzak, K.4    Klimczak, E.5    Chwalinska-Sadowska, H.6
  • 59
    • 80052611560 scopus 로고    scopus 로고
    • Serum and synovial fluid levels of interleukin-17 in correlation with disease activity in patients with RA
    • Metawi S.A., Abbas D., Kamal M.M., Ibrahim M.K. Serum and synovial fluid levels of interleukin-17 in correlation with disease activity in patients with RA. Clin Rheumatol 2011, 30:1201-1207.
    • (2011) Clin Rheumatol , vol.30 , pp. 1201-1207
    • Metawi, S.A.1    Abbas, D.2    Kamal, M.M.3    Ibrahim, M.K.4
  • 60
    • 80053172579 scopus 로고    scopus 로고
    • Mast cells are the main interleukin 17-positive cells in anticitrullinated protein antibody-positive and -negative rheumatoid arthritis and osteoarthritis synovium
    • Suurmond J., Dorjée A.L., Boon M.R., Knol E.F., Huizinga T.W.J., Toes R.E.M., et al. Mast cells are the main interleukin 17-positive cells in anticitrullinated protein antibody-positive and -negative rheumatoid arthritis and osteoarthritis synovium. Arthritis Res Ther 2011, 13:R150.
    • (2011) Arthritis Res Ther , vol.13
    • Suurmond, J.1    Dorjée, A.L.2    Boon, M.R.3    Knol, E.F.4    Huizinga, T.W.J.5    Toes, R.E.M.6
  • 61
    • 0032939156 scopus 로고    scopus 로고
    • Human interleukin-17: a T cell-derived proinflammatory cytokine produced by the rheumatoid synovium
    • Chabaud M., Durand J.M., Buchs N., Fossiez F., Page G., Frappart L., et al. Human interleukin-17: a T cell-derived proinflammatory cytokine produced by the rheumatoid synovium. Arthritis Rheum 1999, 42:963-970.
    • (1999) Arthritis Rheum , vol.42 , pp. 963-970
    • Chabaud, M.1    Durand, J.M.2    Buchs, N.3    Fossiez, F.4    Page, G.5    Frappart, L.6
  • 62
    • 5644289875 scopus 로고    scopus 로고
    • IL-17 induces production of IL-6 and IL-8 in rheumatoid arthritis synovial fibroblasts via NF-κB- and PI3-kinase/Akt-dependent pathways
    • Hwang S.Y., Kim J.Y., Kim K.W., Park M.K., Moon Y., Kim W.U., et al. IL-17 induces production of IL-6 and IL-8 in rheumatoid arthritis synovial fibroblasts via NF-κB- and PI3-kinase/Akt-dependent pathways. Arthritis Res Ther 2004, 6:R120-R128.
    • (2004) Arthritis Res Ther , vol.6
    • Hwang, S.Y.1    Kim, J.Y.2    Kim, K.W.3    Park, M.K.4    Moon, Y.5    Kim, W.U.6
  • 63
    • 65449167961 scopus 로고    scopus 로고
    • IL-17 induces monocyte migration in rheumatoid arthritis
    • Shahrara S., Pickens S.R., Dorfleutner A., Pope R.M. IL-17 induces monocyte migration in rheumatoid arthritis. J Immunol 2009, 182:3884-3891.
    • (2009) J Immunol , vol.182 , pp. 3884-3891
    • Shahrara, S.1    Pickens, S.R.2    Dorfleutner, A.3    Pope, R.M.4
  • 64
    • 77952772125 scopus 로고    scopus 로고
    • IL-17-mediated monocyte migration occurs partially through CC chemokine ligand 2/monocyte chemoattractant protein-1 induction
    • Shahrara S., Pickens S.R., Mandelin A.M., Karpus W.J., Huang Q., Kolls J.K., et al. IL-17-mediated monocyte migration occurs partially through CC chemokine ligand 2/monocyte chemoattractant protein-1 induction. J Immunol 2010, 184:4479-4487.
    • (2010) J Immunol , vol.184 , pp. 4479-4487
    • Shahrara, S.1    Pickens, S.R.2    Mandelin, A.M.3    Karpus, W.J.4    Huang, Q.5    Kolls, J.K.6
  • 65
    • 0033926254 scopus 로고    scopus 로고
    • Contribution of interleukin 17 to synovium matrix destruction in rheumatoid arthritis
    • Chabaud M., Garnero P., Dayer J.M., Guerne P.A., Fossiez F., Miossec P. Contribution of interleukin 17 to synovium matrix destruction in rheumatoid arthritis. Cytokine 2000, 12:1092-1099.
    • (2000) Cytokine , vol.12 , pp. 1092-1099
    • Chabaud, M.1    Garnero, P.2    Dayer, J.M.3    Guerne, P.A.4    Fossiez, F.5    Miossec, P.6
  • 66
    • 0036785194 scopus 로고    scopus 로고
    • Interleukin 17 synergises with tumour necrosis factor α to induce cartilage destruction in vitro
    • van Bezooijen R.L., van der Wee-Pals L., Papapoulos S.E., Löwik C.W.G.M. Interleukin 17 synergises with tumour necrosis factor α to induce cartilage destruction in vitro. Ann Rheum Dis 2002, 61:870-876.
    • (2002) Ann Rheum Dis , vol.61 , pp. 870-876
    • van Bezooijen, R.L.1    van der Wee-Pals, L.2    Papapoulos, S.E.3    Löwik, C.W.G.M.4
  • 67
    • 33750351338 scopus 로고    scopus 로고
    • Potential new targets in arthritis therapy: interleukin (IL)-17 and its relation to tumour necrosis factor and IL-1 in experimental arthritis
    • Koenders M.I., Joosten L.A.B., van den Berg W.B. Potential new targets in arthritis therapy: interleukin (IL)-17 and its relation to tumour necrosis factor and IL-1 in experimental arthritis. Ann Rheum Dis 2006, 65(SUPPL. 3):iii29-iii33.
    • (2006) Ann Rheum Dis , vol.65 , Issue.SUPPL. 3 , pp. 329-333
    • Koenders, M.I.1    Joosten, L.A.B.2    Van Den Berg, W.B.3
  • 68
    • 33751521013 scopus 로고    scopus 로고
    • Th17 functions as an osteoclastogenic helper T cell subset that links T cell activation and bone destruction
    • Sato K., Suematsu A., Okamoto K., Yamaguchi A., Morishita Y., Kadono Y., et al. Th17 functions as an osteoclastogenic helper T cell subset that links T cell activation and bone destruction. J Exp Med 2006, 203:2673-2682.
    • (2006) J Exp Med , vol.203 , pp. 2673-2682
    • Sato, K.1    Suematsu, A.2    Okamoto, K.3    Yamaguchi, A.4    Morishita, Y.5    Kadono, Y.6
  • 70
    • 0035879192 scopus 로고    scopus 로고
    • IL-1-independent role of IL-17 in synovial inflammation and joint destruction during collagen-induced arthritis
    • Lubberts E., Joosten L., Oppers B., van den Bersselaar L., Coenen-de Roo C., Kolls J., et al. IL-1-independent role of IL-17 in synovial inflammation and joint destruction during collagen-induced arthritis. J Immunol 2001, 167:1004-1013.
    • (2001) J Immunol , vol.167 , pp. 1004-1013
    • Lubberts, E.1    Joosten, L.2    Oppers, B.3    Van Den Bersselaar, L.4    Coenen-de Roo, C.5    Kolls, J.6
  • 71
    • 79961122266 scopus 로고    scopus 로고
    • Tumor necrosis factor-interleukin-17 interplay induces S100A8, interleukin-1β, and matrix metalloproteinases, and drives irreversible cartilage destruction in murine arthritis: rationale for combination treatment during arthritis
    • Koenders M.I., Marijnissen R.J., Devesa I., Lubberts E., Joosten L.A.B., Roth J., et al. Tumor necrosis factor-interleukin-17 interplay induces S100A8, interleukin-1β, and matrix metalloproteinases, and drives irreversible cartilage destruction in murine arthritis: rationale for combination treatment during arthritis. Arthritis Rheum 2011, 63:2329-2339.
    • (2011) Arthritis Rheum , vol.63 , pp. 2329-2339
    • Koenders, M.I.1    Marijnissen, R.J.2    Devesa, I.3    Lubberts, E.4    Joosten, L.A.B.5    Roth, J.6
  • 72
    • 21244482587 scopus 로고    scopus 로고
    • Blocking of interleukin-17 during reactivation of experimental arthritis prevents joint inflammation and bone erosion by decreasing RANKL and interleukin-1
    • Koenders M.I., Lubberts E., Oppers-Walgreen B., van den Bersselaar L., Helsen M.M., Di Padova F.E., et al. Blocking of interleukin-17 during reactivation of experimental arthritis prevents joint inflammation and bone erosion by decreasing RANKL and interleukin-1. Am J Pathol 2005, 167:141-149.
    • (2005) Am J Pathol , vol.167 , pp. 141-149
    • Koenders, M.I.1    Lubberts, E.2    Oppers-Walgreen, B.3    Van Den Bersselaar, L.4    Helsen, M.M.5    Di Padova, F.E.6
  • 73
    • 57349165831 scopus 로고    scopus 로고
    • Shift from toll-like receptor 2 (TLR-2) toward TLR-4 dependency in the erosive stage of chronic streptococcal cell wall arthritis coincident with TLR-4-mediated interleukin-17 production
    • Abdollahi-Roodsaz S., Joosten L.A., Helsen M.M., Walgreen B., van Lent P.L., van den Bersselaar L.A., et al. Shift from toll-like receptor 2 (TLR-2) toward TLR-4 dependency in the erosive stage of chronic streptococcal cell wall arthritis coincident with TLR-4-mediated interleukin-17 production. Arthritis Rheum 2008, 58:3753-3764.
    • (2008) Arthritis Rheum , vol.58 , pp. 3753-3764
    • Abdollahi-Roodsaz, S.1    Joosten, L.A.2    Helsen, M.M.3    Walgreen, B.4    van Lent, P.L.5    Van Den Bersselaar, L.A.6
  • 74
    • 84861799713 scopus 로고    scopus 로고
    • T cell lessons from the rheumatoid arthritis synovium SCID mouse model: CD3-rich synovium lacks response to CTLA-4Ig but is successfully treated by interleukin-17 neutralization
    • Koenders M.I., Marijnissen R.J., Joosten L.A., Abdollahi-Roodsaz S., Di Padova F.E., van de Loo F.A., et al. T cell lessons from the rheumatoid arthritis synovium SCID mouse model: CD3-rich synovium lacks response to CTLA-4Ig but is successfully treated by interleukin-17 neutralization. Arthritis Rheum 2012, 64:1762-1770.
    • (2012) Arthritis Rheum , vol.64 , pp. 1762-1770
    • Koenders, M.I.1    Marijnissen, R.J.2    Joosten, L.A.3    Abdollahi-Roodsaz, S.4    Di Padova, F.E.5    van de Loo, F.A.6
  • 75
    • 84858703918 scopus 로고    scopus 로고
    • Novel regulatory mechanisms in inflammatory arthritis: a role for microRNA
    • Baxter D., McInnes I.B., Kurowska-Stolarska M. Novel regulatory mechanisms in inflammatory arthritis: a role for microRNA. Immunol Cell Biol 2012, 90:288-292.
    • (2012) Immunol Cell Biol , vol.90 , pp. 288-292
    • Baxter, D.1    McInnes, I.B.2    Kurowska-Stolarska, M.3
  • 76
    • 42449156220 scopus 로고    scopus 로고
    • Altered expression of microRNA in synovial fibroblasts and synovial tissue in rheumatoid arthritis
    • Stanczyk J., Pedrioli D.M., Brentano F., Sanchez-Pernaute O., Kolling C., Gay R.E., et al. Altered expression of microRNA in synovial fibroblasts and synovial tissue in rheumatoid arthritis. Arthritis Rheum 2008, 58:1001-1009.
    • (2008) Arthritis Rheum , vol.58 , pp. 1001-1009
    • Stanczyk, J.1    Pedrioli, D.M.2    Brentano, F.3    Sanchez-Pernaute, O.4    Kolling, C.5    Gay, R.E.6
  • 77
    • 79551655444 scopus 로고    scopus 로고
    • Altered expression of microRNA-203 in rheumatoid arthritis synovial fibroblasts and its role in fibroblast activation
    • Stanczyk J., Ospelt C., Karouzakis E., Filer A., Raza K., Kolling C., et al. Altered expression of microRNA-203 in rheumatoid arthritis synovial fibroblasts and its role in fibroblast activation. Arthritis Rheum 2011, 63:373-381.
    • (2011) Arthritis Rheum , vol.63 , pp. 373-381
    • Stanczyk, J.1    Ospelt, C.2    Karouzakis, E.3    Filer, A.4    Raza, K.5    Kolling, C.6
  • 79
    • 79955561084 scopus 로고    scopus 로고
    • Essential role of microRNA-155 in the pathogenesis of autoimmune arthritis in mice
    • Blüml S., Bonelli M., Niederreiter B., Puchner A., Mayr G., Hayer S., et al. Essential role of microRNA-155 in the pathogenesis of autoimmune arthritis in mice. Arthritis Rheum 2011, 63:1281-1288.
    • (2011) Arthritis Rheum , vol.63 , pp. 1281-1288
    • Blüml, S.1    Bonelli, M.2    Niederreiter, B.3    Puchner, A.4    Mayr, G.5    Hayer, S.6
  • 80
    • 84863686039 scopus 로고    scopus 로고
    • The microRNA miR-23b suppresses IL-17-associated autoimmune inflammation by targeting Table2, Table3 and IKK-α
    • Zhu S., Pan W., Song X., Liu Y., Shao X., Tang Y., et al. The microRNA miR-23b suppresses IL-17-associated autoimmune inflammation by targeting Table2, Table3 and IKK-α. Nat Med 2012, 18:1077-1086.
    • (2012) Nat Med , vol.18 , pp. 1077-1086
    • Zhu, S.1    Pan, W.2    Song, X.3    Liu, Y.4    Shao, X.5    Tang, Y.6
  • 81
    • 77956511013 scopus 로고    scopus 로고
    • MicroRNA-146a expresses in interleukin-17 producing T cells in rheumatoid arthritis patients
    • Niimoto T., Nakasa T., Ishikawa M., Okuhara A., Izumi B., Deie M., et al. MicroRNA-146a expresses in interleukin-17 producing T cells in rheumatoid arthritis patients. BMC Musculoskelet Disord 2010, 11:209.
    • (2010) BMC Musculoskelet Disord , vol.11 , pp. 209
    • Niimoto, T.1    Nakasa, T.2    Ishikawa, M.3    Okuhara, A.4    Izumi, B.5    Deie, M.6
  • 82
    • 79958053053 scopus 로고    scopus 로고
    • The inhibitory effect of microRNA-146a expression on bone destruction in collagen-induced arthritis
    • Nakasa T., Shibuya H., Nagata Y., Niimoto T., Ochi M. The inhibitory effect of microRNA-146a expression on bone destruction in collagen-induced arthritis. Arthritis Rheum 2011, 63:1582-1590.
    • (2011) Arthritis Rheum , vol.63 , pp. 1582-1590
    • Nakasa, T.1    Shibuya, H.2    Nagata, Y.3    Niimoto, T.4    Ochi, M.5
  • 83
    • 84879502221 scopus 로고    scopus 로고
    • Role of IL-17 in psoriasis and psoriatic arthritis
    • [Epub ahead of print, accessed 24 Feb 2012]
    • Raychaudhuri S.P. Role of IL-17 in psoriasis and psoriatic arthritis. Clin Rev Allergy Immunol 2012, [Epub ahead of print, accessed 24 Feb 2012].
    • (2012) Clin Rev Allergy Immunol
    • Raychaudhuri, S.P.1
  • 84
    • 79955636935 scopus 로고    scopus 로고
    • IL-17 receptor signaling and T helper 17-mediated autoimmune demyelinating disease
    • Zepp J., Wu L., Li X. IL-17 receptor signaling and T helper 17-mediated autoimmune demyelinating disease. Trends Immunol 2011, 32:232-239.
    • (2011) Trends Immunol , vol.32 , pp. 232-239
    • Zepp, J.1    Wu, L.2    Li, X.3
  • 85
    • 81055125976 scopus 로고    scopus 로고
    • The potential role of interleukin-17 in severe asthma
    • Wang Y.H., Wills-Karp M. The potential role of interleukin-17 in severe asthma. Curr Allergy Asthma Rep 2011, 11:388-394.
    • (2011) Curr Allergy Asthma Rep , vol.11 , pp. 388-394
    • Wang, Y.H.1    Wills-Karp, M.2
  • 87
    • 79959207913 scopus 로고    scopus 로고
    • + cells in facet joints of patients with spondyloarthritis suggests that the innate immune pathway might be of greater relevance than the Th17-mediated adaptive immune response
    • + cells in facet joints of patients with spondyloarthritis suggests that the innate immune pathway might be of greater relevance than the Th17-mediated adaptive immune response. Arthritis Res Ther 2011, 13:R95.
    • (2011) Arthritis Res Ther , vol.13
    • Appel, H.1    Maier, R.2    Wu, P.3    Scheer, R.4    Hempfing, A.5    Kayser, R.6
  • 88
    • 68949158362 scopus 로고    scopus 로고
    • Human rheumatoid arthritis tissue production of IL-17A drives matrix and cartilage degradation: synergy with tumour necrosis factor-α, Oncostatin M and response to biological therapies
    • Moran E.M., Mullan R., McCormick J., Connolly M., Sullivan O., FitzGerald O., et al. Human rheumatoid arthritis tissue production of IL-17A drives matrix and cartilage degradation: synergy with tumour necrosis factor-α, Oncostatin M and response to biological therapies. Arthritis Res Ther 2009, 11:R113.
    • (2009) Arthritis Res Ther , vol.11
    • Moran, E.M.1    Mullan, R.2    McCormick, J.3    Connolly, M.4    Sullivan, O.5    FitzGerald, O.6
  • 89
    • 79951512605 scopus 로고    scopus 로고
    • Integrative responses to IL-17 and TNF-α in human keratinocytes account for key inflammatory pathogenic circuits in psoriasis
    • Chiricozzi A., Guttman-Yassky E., Suárez-Fariñas M., Nograles K.E., Tian S., Cardinale I., et al. Integrative responses to IL-17 and TNF-α in human keratinocytes account for key inflammatory pathogenic circuits in psoriasis. J Invest Dermatol 2011, 131:677-687.
    • (2011) J Invest Dermatol , vol.131 , pp. 677-687
    • Chiricozzi, A.1    Guttman-Yassky, E.2    Suárez-Fariñas, M.3    Nograles, K.E.4    Tian, S.5    Cardinale, I.6
  • 90
    • 2442621078 scopus 로고    scopus 로고
    • Combination of the pro-inflammatory cytokines IL-1, TNF-α, and IL-17 leads to enhanced expression and additional recruitment of AP-1 family members, Egr-1, and NF-κB in osteoblast-like cells
    • Granet C., Miossec P. Combination of the pro-inflammatory cytokines IL-1, TNF-α, and IL-17 leads to enhanced expression and additional recruitment of AP-1 family members, Egr-1, and NF-κB in osteoblast-like cells. Cytokine 2004, 26:169-177.
    • (2004) Cytokine , vol.26 , pp. 169-177
    • Granet, C.1    Miossec, P.2
  • 91
    • 0033638507 scopus 로고    scopus 로고
    • Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12
    • Oppmann B., Lesley R., Blom B., Timans J.C., Xu Y., Hunte B., et al. Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12. Immunity 2000, 13:715-725.
    • (2000) Immunity , vol.13 , pp. 715-725
    • Oppmann, B.1    Lesley, R.2    Blom, B.3    Timans, J.C.4    Xu, Y.5    Hunte, B.6
  • 92
    • 0030445948 scopus 로고    scopus 로고
    • A functional interleukin 12 complex is composed of two β-type cytokine receptor subunits
    • Presky D.H., Yang H., Minetti L.J., Chua A.O., Nabavi N., Wu C.Y., et al. A functional interleukin 12 complex is composed of two β-type cytokine receptor subunits. Proc Natl Acad Sci USA 1996, 93:14002-14007.
    • (1996) Proc Natl Acad Sci USA , vol.93 , pp. 14002-14007
    • Presky, D.H.1    Yang, H.2    Minetti, L.J.3    Chua, A.O.4    Nabavi, N.5    Wu, C.Y.6
  • 93
    • 0036604306 scopus 로고    scopus 로고
    • A receptor for the heterodimeric cytokine IL-23 is composed of IL-12Rβ1 and a novel cytokine receptor subunit, IL-23R
    • Parham C., Chirica M., Timans J., Vaisberg E., Travis M., Cheung J., et al. A receptor for the heterodimeric cytokine IL-23 is composed of IL-12Rβ1 and a novel cytokine receptor subunit, IL-23R. J Immunol 2002, 168:5699-5708.
    • (2002) J Immunol , vol.168 , pp. 5699-5708
    • Parham, C.1    Chirica, M.2    Timans, J.3    Vaisberg, E.4    Travis, M.5    Cheung, J.6
  • 94
    • 42249084849 scopus 로고    scopus 로고
    • Either a Th17 or a Th1 effector response can drive autoimmunity: conditions of disease induction affect dominant effector category
    • Luger D., Silver P.B., Tang J., Cua D., Chen Z., Iwakura Y., et al. Either a Th17 or a Th1 effector response can drive autoimmunity: conditions of disease induction affect dominant effector category. J Exp Med 2008, 205:799-810.
    • (2008) J Exp Med , vol.205 , pp. 799-810
    • Luger, D.1    Silver, P.B.2    Tang, J.3    Cua, D.4    Chen, Z.5    Iwakura, Y.6
  • 95
    • 75749097320 scopus 로고    scopus 로고
    • Th1 and Th17 cells: adversaries and collaborators
    • Damsker J.M., Hansen A.M., Caspi R.R. Th1 and Th17 cells: adversaries and collaborators. Ann N Y Acad Sci 2010, 1183:211-221.
    • (2010) Ann N Y Acad Sci , vol.1183 , pp. 211-221
    • Damsker, J.M.1    Hansen, A.M.2    Caspi, R.R.3
  • 96
    • 0029034038 scopus 로고
    • Administration of interleukin 12 in combination with type II collagen induces severe arthritis in DBA/1 mice
    • Germann T., Szeliga J., Hess H., Störkel S., Podlaski F.J., Gately M.K., et al. Administration of interleukin 12 in combination with type II collagen induces severe arthritis in DBA/1 mice. Proc Natl Acad Sci USA 1995, 92:4823-4827.
    • (1995) Proc Natl Acad Sci USA , vol.92 , pp. 4823-4827
    • Germann, T.1    Szeliga, J.2    Hess, H.3    Störkel, S.4    Podlaski, F.J.5    Gately, M.K.6
  • 97
    • 0346962972 scopus 로고    scopus 로고
    • Divergent pro- and antiinflammatory roles for IL-23 and IL-12 in joint autoimmune inflammation
    • Murphy C.A., Langrish C.L., Chen Y., Blumenschein W., McClanahan T., Kastelein R.A., et al. Divergent pro- and antiinflammatory roles for IL-23 and IL-12 in joint autoimmune inflammation. J Exp Med 2003, 198:1951-1957.
    • (2003) J Exp Med , vol.198 , pp. 1951-1957
    • Murphy, C.A.1    Langrish, C.L.2    Chen, Y.3    Blumenschein, W.4    McClanahan, T.5    Kastelein, R.A.6
  • 98
    • 0031691282 scopus 로고    scopus 로고
    • Interleukin-17 and interferon-γ synergize in the enhancement of proinflammatory cytokine production by human keratinocytes
    • Teunissen M.B., Koomen C.W., de Waal Malefyt R., Wierenga E.A., Bos J.D. Interleukin-17 and interferon-γ synergize in the enhancement of proinflammatory cytokine production by human keratinocytes. J Invest Dermatol 1998, 111:645-649.
    • (1998) J Invest Dermatol , vol.111 , pp. 645-649
    • Teunissen, M.B.1    Koomen, C.W.2    de Waal Malefyt, R.3    Wierenga, E.A.4    Bos, J.D.5
  • 99
    • 33749552196 scopus 로고    scopus 로고
    • Interleukin-21 induces T-cell activation and proinflammatory cytokine secretion in rheumatoid arthritis
    • Li J., Shen W., Kong K., Liu Z. Interleukin-21 induces T-cell activation and proinflammatory cytokine secretion in rheumatoid arthritis. Scand J Immunol 2006, 64:515-522.
    • (2006) Scand J Immunol , vol.64 , pp. 515-522
    • Li, J.1    Shen, W.2    Kong, K.3    Liu, Z.4
  • 100
    • 44849114296 scopus 로고    scopus 로고
    • Neutralizing IL-21 and IL-15 inhibits pro-inflammatory cytokine production in rheumatoid arthritis
    • Andersson A.K., Feldmann M., Brennan F.M. Neutralizing IL-21 and IL-15 inhibits pro-inflammatory cytokine production in rheumatoid arthritis. Scand J Immunol 2008, 68:103-111.
    • (2008) Scand J Immunol , vol.68 , pp. 103-111
    • Andersson, A.K.1    Feldmann, M.2    Brennan, F.M.3
  • 101
    • 34247257447 scopus 로고    scopus 로고
    • Blockade of the interleukin-21/interleukin-21 receptor pathway ameliorates disease in animal models of rheumatoid arthritis
    • Young D.A., Hegen M., Ma H.L.M., Whitters M.J., Albert L.M., Lowe L., et al. Blockade of the interleukin-21/interleukin-21 receptor pathway ameliorates disease in animal models of rheumatoid arthritis. Arthritis Rheum 2007, 56:1152-1163.
    • (2007) Arthritis Rheum , vol.56 , pp. 1152-1163
    • Young, D.A.1    Hegen, M.2    Ma, H.L.M.3    Whitters, M.J.4    Albert, L.M.5    Lowe, L.6
  • 102
    • 65249180981 scopus 로고    scopus 로고
    • - T cell expansion is essential for the development of arthritis in autoimmune K/BxN mice
    • - T cell expansion is essential for the development of arthritis in autoimmune K/BxN mice. J Immunol 2009, 182:4649-4656.
    • (2009) J Immunol , vol.182 , pp. 4649-4656
    • Jang, E.1    Cho, S.H.2    Park, H.3    Paik, D.J.4    Kim, J.M.5    Youn, J.6
  • 103
    • 78649757427 scopus 로고    scopus 로고
    • Interleukin-22: a cytokine produced by T, NK and NKT cell subsets, with importance in the innate immune defense and tissue protection
    • Witte E., Witte K., Warszawska K., Sabat R., Wolk K. Interleukin-22: a cytokine produced by T, NK and NKT cell subsets, with importance in the innate immune defense and tissue protection. Cytokine Growth Factor Rev 2010, 21:365-379.
    • (2010) Cytokine Growth Factor Rev , vol.21 , pp. 365-379
    • Witte, E.1    Witte, K.2    Warszawska, K.3    Sabat, R.4    Wolk, K.5
  • 104
    • 80053510122 scopus 로고    scopus 로고
    • Increased expression of interleukin-22 by synovial Th17 cells during late stages of murine experimental arthritis is controlled by interleukin-1 and enhances bone degradation
    • Marijnissen R.J., Koenders M.I., Smeets R.L., Stappers M.H., Nickerson-Nutter C., Joosten L.A.B., et al. Increased expression of interleukin-22 by synovial Th17 cells during late stages of murine experimental arthritis is controlled by interleukin-1 and enhances bone degradation. Arthritis Rheum 2011, 63:2939-2948.
    • (2011) Arthritis Rheum , vol.63 , pp. 2939-2948
    • Marijnissen, R.J.1    Koenders, M.I.2    Smeets, R.L.3    Stappers, M.H.4    Nickerson-Nutter, C.5    Joosten, L.A.B.6
  • 105
    • 59649086053 scopus 로고    scopus 로고
    • Proinflammatory role of the Th17 cytokine interleukin-22 in collagen-induced arthritis in C57BL/6 mice
    • Geboes L., Dumoutier L., Keichtermans H., Schurgers E., Mitera T., Renauld J.C., et al. Proinflammatory role of the Th17 cytokine interleukin-22 in collagen-induced arthritis in C57BL/6 mice. Arthritis Rheum 2009, 60:390-395.
    • (2009) Arthritis Rheum , vol.60 , pp. 390-395
    • Geboes, L.1    Dumoutier, L.2    Keichtermans, H.3    Schurgers, E.4    Mitera, T.5    Renauld, J.C.6
  • 106
    • 84875710026 scopus 로고    scopus 로고
    • IL-22 reduces the severity of collagen arthritis in association with increased levels of IL-10
    • Sarkar S., Zhou X., Justa S., Bommireddy S.R. IL-22 reduces the severity of collagen arthritis in association with increased levels of IL-10. Arthritis Rheum 2013, 10.1002/art.37849.
    • (2013) Arthritis Rheum
    • Sarkar, S.1    Zhou, X.2    Justa, S.3    Bommireddy, S.R.4
  • 107
    • 84866173091 scopus 로고    scopus 로고
    • Interleukin-22 promotes osteoclastogenesis in rheumatoid arthritis through induction of RANKL in human synovial fibroblasts
    • Kim K.W., Kim H.R., Park J.Y., Park J.S., Oh H.J., Woo Y.J., et al. Interleukin-22 promotes osteoclastogenesis in rheumatoid arthritis through induction of RANKL in human synovial fibroblasts. Arthritis Rheum 2012, 64:1015-1023.
    • (2012) Arthritis Rheum , vol.64 , pp. 1015-1023
    • Kim, K.W.1    Kim, H.R.2    Park, J.Y.3    Park, J.S.4    Oh, H.J.5    Woo, Y.J.6
  • 108
    • 79959811817 scopus 로고    scopus 로고
    • Interleukin 22 serum levels are associated with radiographic progression in rheumatoid arthritis
    • Leipe J., Schramm M.A., Grunke M., Baeuerle M., Dechant C., Nigg A.P., et al. Interleukin 22 serum levels are associated with radiographic progression in rheumatoid arthritis. Ann Rheum Dis 2011, 70:1453-1457.
    • (2011) Ann Rheum Dis , vol.70 , pp. 1453-1457
    • Leipe, J.1    Schramm, M.A.2    Grunke, M.3    Baeuerle, M.4    Dechant, C.5    Nigg, A.P.6
  • 110
    • 77953495368 scopus 로고    scopus 로고
    • Pathological versus protective functions of IL-22 in airway inflammation are regulated by IL-17A
    • Sonnenberg G.F., Nair M.G., Kirn T.J., Zaph C., Fouser L.A., Artis D. Pathological versus protective functions of IL-22 in airway inflammation are regulated by IL-17A. J Exp Med 2010, 207:1293-1305.
    • (2010) J Exp Med , vol.207 , pp. 1293-1305
    • Sonnenberg, G.F.1    Nair, M.G.2    Kirn, T.J.3    Zaph, C.4    Fouser, L.A.5    Artis, D.6
  • 111
    • 0037310778 scopus 로고    scopus 로고
    • Interleukin 7 stimulates tumour necrosis factor α and Th1 cytokine production in joints of patients with rheumatoid arthritis
    • van Roon J.A.G., Glaudemans K.A.F.M., Bijlsma J.W.J., Lafeber F.P.J.G. Interleukin 7 stimulates tumour necrosis factor α and Th1 cytokine production in joints of patients with rheumatoid arthritis. Ann Rheum Dis 2003, 62:113-119.
    • (2003) Ann Rheum Dis , vol.62 , pp. 113-119
    • van Roon, J.A.G.1    Glaudemans, K.A.F.M.2    Bijlsma, J.W.J.3    Lafeber, F.P.J.G.4
  • 114
    • 77956380527 scopus 로고    scopus 로고
    • Blockade of the interleukin-7 receptor inhibits collagen-induced arthritis and is associated with reduction of T cell activity and proinflammatory mediators
    • Hartgring S.A.Y., Willis C.R., Alcorn D., Nelson L.J., Bijlsma J.W.J., Lafeber F.P.J.G., et al. Blockade of the interleukin-7 receptor inhibits collagen-induced arthritis and is associated with reduction of T cell activity and proinflammatory mediators. Arthritis Rheum 2010, 62:2716-2725.
    • (2010) Arthritis Rheum , vol.62 , pp. 2716-2725
    • Hartgring, S.A.Y.1    Willis, C.R.2    Alcorn, D.3    Nelson, L.J.4    Bijlsma, J.W.J.5    Lafeber, F.P.J.G.6
  • 115
    • 3342897676 scopus 로고    scopus 로고
    • Interleukin-15: a new cytokine target for the treatment of inflammatory diseases
    • McInnes I.B., Gracie J.A. Interleukin-15: a new cytokine target for the treatment of inflammatory diseases. Curr Opin Pharmacol 2004, 4:392-397.
    • (2004) Curr Opin Pharmacol , vol.4 , pp. 392-397
    • McInnes, I.B.1    Gracie, J.A.2
  • 116
    • 0030022275 scopus 로고    scopus 로고
    • The role of interleukin-15 in T-cell migration and activation in rheumatoid arthritis
    • McInnes I.B., al-Mughales J., Field M., Leung B.P., Huang F.P., Dixon R., et al. The role of interleukin-15 in T-cell migration and activation in rheumatoid arthritis. Nat Med 1996, 2:175-182.
    • (1996) Nat Med , vol.2 , pp. 175-182
    • McInnes, I.B.1    al-Mughales, J.2    Field, M.3    Leung, B.P.4    Huang, F.P.5    Dixon, R.6
  • 117
    • 0031042456 scopus 로고    scopus 로고
    • Interleukin-15 mediates T cell-dependent regulation of tumor necrosis factor-α production in rheumatoid arthritis
    • McInnes I.B., Leung B.P., Sturrock R.D., Field M., Liew F.Y. Interleukin-15 mediates T cell-dependent regulation of tumor necrosis factor-α production in rheumatoid arthritis. Nat Med 1997, 3:189-195.
    • (1997) Nat Med , vol.3 , pp. 189-195
    • McInnes, I.B.1    Leung, B.P.2    Sturrock, R.D.3    Field, M.4    Liew, F.Y.5
  • 119
    • 79551672737 scopus 로고    scopus 로고
    • Interleukin-15 induces interleukin-17 production by synovial T cell lines from patients with rheumatoid arthritis
    • Halvorsen E.H., Strønen E., Hammer H.B., Goll G.L., Sollid L.M., Molberg Ø. Interleukin-15 induces interleukin-17 production by synovial T cell lines from patients with rheumatoid arthritis. Scand J Immunol 2011, 73:243-249.
    • (2011) Scand J Immunol , vol.73 , pp. 243-249
    • Halvorsen, E.H.1    Strønen, E.2    Hammer, H.B.3    Goll, G.L.4    Sollid, L.M.5    Molberg, Ø.6
  • 121
    • 6344269986 scopus 로고    scopus 로고
    • Targeting IL-15 receptor-bearing cells with an antagonist mutant IL-15/Fc protein prevents disease development and progression in murine collagen-induced arthritis
    • Ferrari-Lacraz S., Zanelli E., Neuberg M., Donskoy E., Kim Y.S., Zheng X.X., et al. Targeting IL-15 receptor-bearing cells with an antagonist mutant IL-15/Fc protein prevents disease development and progression in murine collagen-induced arthritis. J Immunol 2004, 173:5818-5826.
    • (2004) J Immunol , vol.173 , pp. 5818-5826
    • Ferrari-Lacraz, S.1    Zanelli, E.2    Neuberg, M.3    Donskoy, E.4    Kim, Y.S.5    Zheng, X.X.6
  • 122
    • 0036754255 scopus 로고    scopus 로고
    • Antigen-specific T cell sensitization is impaired in IL-17-deficient mice, causing suppression of allergic cellular and humoral responses
    • Nakae S., Komiyama Y., Nambu A., Sudo K., Iwase M., Homma I., et al. Antigen-specific T cell sensitization is impaired in IL-17-deficient mice, causing suppression of allergic cellular and humoral responses. Immunity 2002, 17:375-387.
    • (2002) Immunity , vol.17 , pp. 375-387
    • Nakae, S.1    Komiyama, Y.2    Nambu, A.3    Sudo, K.4    Iwase, M.5    Homma, I.6
  • 123
    • 0344585384 scopus 로고    scopus 로고
    • Suppression of immune induction of collagen-induced arthritis in IL-17-deficient mice
    • Nakae S., Nambu A., Sudo K., Iwakura Y. Suppression of immune induction of collagen-induced arthritis in IL-17-deficient mice. J Immunol 2003, 171:6173-6177.
    • (2003) J Immunol , vol.171 , pp. 6173-6177
    • Nakae, S.1    Nambu, A.2    Sudo, K.3    Iwakura, Y.4
  • 125
    • 0036188478 scopus 로고    scopus 로고
    • Reduction of joint inflammation and bone erosion in rat adjuvant arthritis by treatment with interleukin-17 receptor IgG1 Fc fusion protein
    • Bush K.A., Farmer K.M., Walker J.S., Kirkham B.W. Reduction of joint inflammation and bone erosion in rat adjuvant arthritis by treatment with interleukin-17 receptor IgG1 Fc fusion protein. Arthritis Rheum 2002, 46:802-805.
    • (2002) Arthritis Rheum , vol.46 , pp. 802-805
    • Bush, K.A.1    Farmer, K.M.2    Walker, J.S.3    Kirkham, B.W.4
  • 126
    • 1042267236 scopus 로고    scopus 로고
    • Treatment with a neutralizing anti-murine interleukin-17 antibody after the onset of collagen-induced arthritis reduces joint inflammation, cartilage destruction, and bone erosion
    • Lubberts E., Koenders M.I., Oppers-Walgreen B., van den Bersselaar L., Coenen-de Roo C.J.J., Joosten L.A.B., et al. Treatment with a neutralizing anti-murine interleukin-17 antibody after the onset of collagen-induced arthritis reduces joint inflammation, cartilage destruction, and bone erosion. Arthritis Rheum 2004, 50:650-659.
    • (2004) Arthritis Rheum , vol.50 , pp. 650-659
    • Lubberts, E.1    Koenders, M.I.2    Oppers-Walgreen, B.3    Van Den Bersselaar, L.4    Coenen-de Roo, C.J.J.5    Joosten, L.A.B.6
  • 127
    • 79953073305 scopus 로고    scopus 로고
    • Anti-IL-17A therapy protects against bone erosion in experimental models of rheumatoid arthritis
    • Chao C.C., Chen S.J., Adamopoulos I.E., Davis N., Hong K., Vu A., et al. Anti-IL-17A therapy protects against bone erosion in experimental models of rheumatoid arthritis. Autoimmunity 2011, 44:243-252.
    • (2011) Autoimmunity , vol.44 , pp. 243-252
    • Chao, C.C.1    Chen, S.J.2    Adamopoulos, I.E.3    Davis, N.4    Hong, K.5    Vu, A.6
  • 128
    • 79551676198 scopus 로고    scopus 로고
    • Therapeutic potential of anti-interleukin-17A aptamer; suppression of interleukin-17A signaling and attenuation of autoimmunity in two mouse models
    • Ishiguro A., Akiyama T., Adachi H., Inoue J., Nakamura Y. Therapeutic potential of anti-interleukin-17A aptamer; suppression of interleukin-17A signaling and attenuation of autoimmunity in two mouse models. Arthritis Rheum 2011, 63:455-466.
    • (2011) Arthritis Rheum , vol.63 , pp. 455-466
    • Ishiguro, A.1    Akiyama, T.2    Adachi, H.3    Inoue, J.4    Nakamura, Y.5
  • 131
    • 79955045064 scopus 로고    scopus 로고
    • Distinct roles of IL-23 and IL-17 in the development of psoriasis-like lesions in a mouse model
    • Nakajima K., Kanda T., Takaishi M., Shiga T., Miyoshi K., Nakajima H., et al. Distinct roles of IL-23 and IL-17 in the development of psoriasis-like lesions in a mouse model. J Immunol 2011, 186:4481-4489.
    • (2011) J Immunol , vol.186 , pp. 4481-4489
    • Nakajima, K.1    Kanda, T.2    Takaishi, M.3    Shiga, T.4    Miyoshi, K.5    Nakajima, H.6
  • 133
    • 80755180843 scopus 로고    scopus 로고
    • Pivotal role of dermal IL-17-producing γδ T cells in skin inflammation
    • Cai Y., Shen X., Ding C., Qi C., Li K., Li X., et al. Pivotal role of dermal IL-17-producing γδ T cells in skin inflammation. Immunity 2011, 35:596-610.
    • (2011) Immunity , vol.35 , pp. 596-610
    • Cai, Y.1    Shen, X.2    Ding, C.3    Qi, C.4    Li, K.5    Li, X.6
  • 134
    • 60749107176 scopus 로고    scopus 로고
    • The interleukin 23 receptor is essential for the terminal differentiation of interleukin 17-producing effector T helper cells in vivo
    • McGeachy MJ, Chen Y, Tato CM, Laurence A, Joyce-Shaikh B, Blumenschein WM, et al. The interleukin 23 receptor is essential for the terminal differentiation of interleukin 17-producing effector T helper cells in vivo. Nat Immunol 2009;10:314-324.
    • (2009) Nat Immunol , vol.10 , pp. 314-324
    • McGeachy, M.J.1    Chen, Y.2    Tato, C.M.3    Laurence, A.4    Joyce-Shaikh, B.5    Blumenschein, W.M.6
  • 136
    • 36448931232 scopus 로고    scopus 로고
    • IL-23 induces human osteoclastogenesis via IL-17 in vitro, and anti-IL-23 antibody attenuates collagen-induced arthritis in rats
    • Yago T., Nanke Y., Kawamoto M., Furuya T., Kobashigawa T., Kamatani N., et al. IL-23 induces human osteoclastogenesis via IL-17 in vitro, and anti-IL-23 antibody attenuates collagen-induced arthritis in rats. Arthritis Rheum 2007, 9:R96.
    • (2007) Arthritis Rheum , vol.9
    • Yago, T.1    Nanke, Y.2    Kawamoto, M.3    Furuya, T.4    Kobashigawa, T.5    Kamatani, N.6
  • 137
    • 77958072084 scopus 로고    scopus 로고
    • Effects of AIN457, a fully human antibody to interleukin-17A, on psoriasis, rheumatoid arthritis, and uveitis
    • Hueber W., Patel D.D., Dryja T., Wright A.M., Koroleva I., Bruin G., et al. Effects of AIN457, a fully human antibody to interleukin-17A, on psoriasis, rheumatoid arthritis, and uveitis. Sci Transl Med 2010, 2:52ra72.
    • (2010) Sci Transl Med , vol.2
    • Hueber, W.1    Patel, D.D.2    Dryja, T.3    Wright, A.M.4    Koroleva, I.5    Bruin, G.6
  • 138
    • 77950535421 scopus 로고    scopus 로고
    • LY2439821, a humanized anti-interleukin-17 monoclonal antibody, in the treatment of patients with rheumatoid arthritis: a phase I randomized, double-blind, placebo-controlled, proof-of-concept study
    • Genovese M.C., Van den Bosch F., Roberson S.A., Bojin S., Biagini I.M., Ryan P., et al. LY2439821, a humanized anti-interleukin-17 monoclonal antibody, in the treatment of patients with rheumatoid arthritis: a phase I randomized, double-blind, placebo-controlled, proof-of-concept study. Arthritis Rheum 2010, 62:929-939.
    • (2010) Arthritis Rheum , vol.62 , pp. 929-939
    • Genovese, M.C.1    Van Den Bosch, F.2    Roberson, S.A.3    Bojin, S.4    Biagini, I.M.5    Ryan, P.6
  • 140
    • 84873124241 scopus 로고    scopus 로고
    • Efficacy and safety of secukinumab in the treatment of moderate to severe plaque psoriasis: a randomised, double-blind, placebo-controlled phase II dose-ranging study
    • Papp K.A., Langley R.G., Sigurgeirsson B., Abe M., Baker D.R., Konno P., et al. Efficacy and safety of secukinumab in the treatment of moderate to severe plaque psoriasis: a randomised, double-blind, placebo-controlled phase II dose-ranging study. Br J Dermatol 2013, 168(2):412-421.
    • (2013) Br J Dermatol , vol.168 , Issue.2 , pp. 412-421
    • Papp, K.A.1    Langley, R.G.2    Sigurgeirsson, B.3    Abe, M.4    Baker, D.R.5    Konno, P.6
  • 141
    • 84873168729 scopus 로고    scopus 로고
    • Secukinumab induction and maintenance therapy in moderate-to-severe plaque psoriasis: a randomised, double-blind, placebo-controlled, phase II regimen-finding study
    • Rich P., Sigurgeirsson B., Thaci D.P., Ortonne J.P., Paul C., Schopf R.E., et al. Secukinumab induction and maintenance therapy in moderate-to-severe plaque psoriasis: a randomised, double-blind, placebo-controlled, phase II regimen-finding study. Br J Dermatol 2013, 168(2):402-411.
    • (2013) Br J Dermatol , vol.168 , Issue.2 , pp. 402-411
    • Rich, P.1    Sigurgeirsson, B.2    Thaci, D.P.3    Ortonne, J.P.4    Paul, C.5    Schopf, R.E.6
  • 143
    • 84877603562 scopus 로고    scopus 로고
    • Efficacy and safety of secukinumab in patients with rheumatoid arthritis: a phase II, dose-finding, double-blind, randomised, placebo controlled study
    • Genovese M.C., Durez P., Richards H.B., Supronik J., Dokoupilova E., Mazurov V., et al. Efficacy and safety of secukinumab in patients with rheumatoid arthritis: a phase II, dose-finding, double-blind, randomised, placebo controlled study. Ann Rheum Dis 2012, 10.1136/annrheumdis-2012-201601.
    • (2012) Ann Rheum Dis
    • Genovese, M.C.1    Durez, P.2    Richards, H.B.3    Supronik, J.4    Dokoupilova, E.5    Mazurov, V.6
  • 144
    • 84876280630 scopus 로고    scopus 로고
    • Secukinumab treatment improves ACR50, HAQ-DI and EULAR remission rates in patients with rheumatoid arthritis
    • [abstract]
    • Genovese M., Kellner H., Durez P., Codding C., Logozio G., Richards H., et al. Secukinumab treatment improves ACR50, HAQ-DI and EULAR remission rates in patients with rheumatoid arthritis. Ann Rheum Dis 2012, 71(SUPPL. 3):191. [abstract].
    • (2012) Ann Rheum Dis , vol.71 , Issue.SUPPL. 3 , pp. 191
    • Genovese, M.1    Kellner, H.2    Durez, P.3    Codding, C.4    Logozio, G.5    Richards, H.6
  • 145
    • 84857769677 scopus 로고    scopus 로고
    • A phase 2 study of multiple subcutaneous doses of LY2439821, an anti-IL-17 monoclonal antibody, in patients with rheumatoid arthritis in two populations: naïve to biologic therapy or inadequate responders to tumor necrosis factor alpha inhibitors
    • [abstract]
    • Genovese M.C., Greenwald M.W., Cho C.S., Berman A., Jin L., Cameron G., et al. A phase 2 study of multiple subcutaneous doses of LY2439821, an anti-IL-17 monoclonal antibody, in patients with rheumatoid arthritis in two populations: naïve to biologic therapy or inadequate responders to tumor necrosis factor alpha inhibitors. Arthritis Rheum 2011, 63(SUPPL. 10):S1017. [abstract].
    • (2011) Arthritis Rheum , vol.63 , Issue.SUPPL. 10
    • Genovese, M.C.1    Greenwald, M.W.2    Cho, C.S.3    Berman, A.4    Jin, L.5    Cameron, G.6
  • 146
    • 84891742677 scopus 로고    scopus 로고
    • Efficacy and safety of secukinumab, a fully human anti-interleukin-17A monoclonal antibody, in patients with moderate-to-severe psoriatic arthritis: a 24-week, randomized, double-blind, placebo-controlled, phase 2 proof-of-concept trial
    • [Epub ahead of print]
    • McInnes I., Sieper J., Braun J., et al. Efficacy and safety of secukinumab, a fully human anti-interleukin-17A monoclonal antibody, in patients with moderate-to-severe psoriatic arthritis: a 24-week, randomized, double-blind, placebo-controlled, phase 2 proof-of-concept trial. Ann Rheum Dis 2013, [Epub ahead of print].
    • (2013) Ann Rheum Dis
    • McInnes, I.1    Sieper, J.2    Braun, J.3
  • 147
    • 84857715883 scopus 로고    scopus 로고
    • Interleukin-17A blockade with secukinumab reduces spinal inflammation in patients with ankylosing spondylitis as early as week 6, as detected by magnetic resonance imaging
    • [abstract]
    • Baraliakos X., Braun J., Laurent D.D., Baeten D., van der Heijde D., Sieper J., et al. Interleukin-17A blockade with secukinumab reduces spinal inflammation in patients with ankylosing spondylitis as early as week 6, as detected by magnetic resonance imaging. Arthritis Rheum 2011, 63(SUPPL. 10):S972. [abstract].
    • (2011) Arthritis Rheum , vol.63 , Issue.SUPPL. 10
    • Baraliakos, X.1    Braun, J.2    Laurent, D.D.3    Baeten, D.4    van der Heijde, D.5    Sieper, J.6
  • 148
    • 43449111187 scopus 로고    scopus 로고
    • Efficacy and safety of ustekinumab, a human interleukin-12/23 monoclonal antibody, in patients with psoriasis: 76-week results from a randomized, double-blind, placebo-controlled trial (PHOENIX 1)
    • Leonardi C.L., Kimball A.B., Papp K.A., Yeilding N., Guzzo C., Wang Y., et al. Efficacy and safety of ustekinumab, a human interleukin-12/23 monoclonal antibody, in patients with psoriasis: 76-week results from a randomized, double-blind, placebo-controlled trial (PHOENIX 1). Lancet 2008, 371:1665-1674.
    • (2008) Lancet , vol.371 , pp. 1665-1674
    • Leonardi, C.L.1    Kimball, A.B.2    Papp, K.A.3    Yeilding, N.4    Guzzo, C.5    Wang, Y.6
  • 149
    • 43449139402 scopus 로고    scopus 로고
    • Efficacy and safety of ustekinumab, a human interleukin-12/23 monoclonal antibody, in patients with psoriasis: 52-week results from a randomized, double-blind, placebo-controlled trial (PHOENIX 2)
    • Papp K.A., Langley R.G., Lebowl M., Krueger G.G., Szapary P., Yeilding N., et al. Efficacy and safety of ustekinumab, a human interleukin-12/23 monoclonal antibody, in patients with psoriasis: 52-week results from a randomized, double-blind, placebo-controlled trial (PHOENIX 2). Lancet 2008, 371:1675-1684.
    • (2008) Lancet , vol.371 , pp. 1675-1684
    • Papp, K.A.1    Langley, R.G.2    Lebowl, M.3    Krueger, G.G.4    Szapary, P.5    Yeilding, N.6
  • 151
    • 80051726086 scopus 로고    scopus 로고
    • Efficacy and safety results from a phase III, randomized controlled trial comparing the safety and efficacy of briakinumab with etanercept and placebo in patients with moderate to severe chronic plaque psoriasis
    • Strober B.E., Crowley J.J., Yamauchi P.S., Olds M., Williams D.A. Efficacy and safety results from a phase III, randomized controlled trial comparing the safety and efficacy of briakinumab with etanercept and placebo in patients with moderate to severe chronic plaque psoriasis. Br J Dermatol 2011, 165:661-668.
    • (2011) Br J Dermatol , vol.165 , pp. 661-668
    • Strober, B.E.1    Crowley, J.J.2    Yamauchi, P.S.3    Olds, M.4    Williams, D.A.5
  • 152
    • 84855938590 scopus 로고    scopus 로고
    • A phase III, randomized, controlled trial of the fully human IL-12/23 mAb briakinumab in moderate-to-severe psoriasis
    • Gordon K.B., Langley R.G., Gottlieb A.B., Papp K.A., Kreuger G.G., Strober B.E., et al. A phase III, randomized, controlled trial of the fully human IL-12/23 mAb briakinumab in moderate-to-severe psoriasis. J Invest Dermatol 2012, 132:304-314.
    • (2012) J Invest Dermatol , vol.132 , pp. 304-314
    • Gordon, K.B.1    Langley, R.G.2    Gottlieb, A.B.3    Papp, K.A.4    Kreuger, G.G.5    Strober, B.E.6
  • 153
    • 80054949734 scopus 로고    scopus 로고
    • A 52-week trial comparing briakinumab with methotrexate in patients with psoriasis
    • Reich K., Langley R.G., Papp K.A., Ortonne J.P., Unnebrink K., Kaul M., et al. A 52-week trial comparing briakinumab with methotrexate in patients with psoriasis. N Engl J Med 2011, 365:1586-1596.
    • (2011) N Engl J Med , vol.365 , pp. 1586-1596
    • Reich, K.1    Langley, R.G.2    Papp, K.A.3    Ortonne, J.P.4    Unnebrink, K.5    Kaul, M.6
  • 154
    • 60249084148 scopus 로고    scopus 로고
    • Ustekinumab, a human interleukin 12/23 monoclonal antibody, for psoriatic arthritis: randomised, double-blind, placebo-controlled, crossover trial
    • Gottlieb A., Menter A., Mendelsohn A., Shen Y.K., Li S., Guzzo C., et al. Ustekinumab, a human interleukin 12/23 monoclonal antibody, for psoriatic arthritis: randomised, double-blind, placebo-controlled, crossover trial. Lancet 2009, 373:633-640.
    • (2009) Lancet , vol.373 , pp. 633-640
    • Gottlieb, A.1    Menter, A.2    Mendelsohn, A.3    Shen, Y.K.4    Li, S.5    Guzzo, C.6
  • 155
    • 84877047834 scopus 로고    scopus 로고
    • Ustekinumab in patients with active psoriatic arthritis: results of the phase 3, multicenter, double-blind, placebo-controlled Psummit I study
    • [abstract]
    • Kavanaugh A., McInnes I.B., Gottlieb A.B., Puig L., Rahman P., Ritchlin C.T., et al. Ustekinumab in patients with active psoriatic arthritis: results of the phase 3, multicenter, double-blind, placebo-controlled Psummit I study. Arthritis Rheum 2012, 64(SUPPL. 10):S1083-S1084. [abstract].
    • (2012) Arthritis Rheum , vol.64 , Issue.SUPPL. 10
    • Kavanaugh, A.1    McInnes, I.B.2    Gottlieb, A.B.3    Puig, L.4    Rahman, P.5    Ritchlin, C.T.6
  • 156
    • 84873581440 scopus 로고    scopus 로고
    • Ustekinumab in active psoriatic arthritis including patients previously treated with anti-TNF agents: results of a phase 3, multicenter, double-blind, placebo-controlled study
    • [abstract]
    • Ritchlin C.T., Gottlieb A.B., McInnes I.B., Puig L., Rahman P., Li S., et al. Ustekinumab in active psoriatic arthritis including patients previously treated with anti-TNF agents: results of a phase 3, multicenter, double-blind, placebo-controlled study. Arthritis Rheum 2012, 64(SUPPL. 10):S1080-S1081. [abstract].
    • (2012) Arthritis Rheum , vol.64 , Issue.SUPPL. 10
    • Ritchlin, C.T.1    Gottlieb, A.B.2    McInnes, I.B.3    Puig, L.4    Rahman, P.5    Li, S.6
  • 157
    • 79953284685 scopus 로고    scopus 로고
    • Chronic mucocutaneous candidiasis in humans with inborn errors of interleukin-17 immunity
    • Puel A., Cypowyj S., Bustamante J., Wright J.F., Liu L., Lim H.K., et al. Chronic mucocutaneous candidiasis in humans with inborn errors of interleukin-17 immunity. Science 2011, 332:65-68.
    • (2011) Science , vol.332 , pp. 65-68
    • Puel, A.1    Cypowyj, S.2    Bustamante, J.3    Wright, J.F.4    Liu, L.5    Lim, H.K.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.