IL-23 induces spondyloarthropathy by acting on ROR-γt+ CD3+ CD4- CD8- entheseal resident T cells

Nature Medicine

Volumn 18, Issue 7, 2012, Pages 1069-1076

  Sherlock, Jonathan P ^a,b,c   Joyce Shaikh, Barbara ^a   Turner, Scott P ^a   Chao, Cheng Chi ^a   Sathe, Manjiri ^a   Grein, Jeff ^a   Gorman, Daniel M ^a   Bowman, Edward P ^a   McClanahan, Terrill K ^a   Yearley, Jennifer H ^a   Eberl, Gérard ^d   Buckley, Christopher D ^c   Kastelein, Robert A ^a   Pierce, Robert H ^a   Laface, Drake M ^a   Cua, Daniel J ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

^b TRINITY COLLEGE   (United Kingdom)

^c UNIVERSITY OF BIRMINGHAM   (United Kingdom)

^d INSTITUT PASTEUR   (France)

Author keywords

[No Author keywords available]

Indexed keywords

CD3 ANTIGEN; CD4 ANTIGEN; CD8 ANTIGEN; CXCL1 CHEMOKINE; INTERLEUKIN 17; INTERLEUKIN 22; INTERLEUKIN 23; INTERLEUKIN 6; RAR RELATED ORPHAN RECEPTOR GAMMAT; RECEPTOR; STAT3 PROTEIN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ENTHESITIS; IN VIVO STUDY; MOUSE; NONHUMAN; OSSIFICATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; SPONDYLOARTHROPATHY; SYNOVITIS; T LYMPHOCYTE;

ANIMALS; ANTIGENS, CD; ANTIGENS, CD3; ANTIGENS, CD4; ANTIGENS, CD8; AORTA; ARTHRITIS, EXPERIMENTAL; BONE REMODELING; DISEASE MODELS, ANIMAL; EXTREMITIES; FLOW CYTOMETRY; HUMANS; IMMUNIZATION, PASSIVE; INFLAMMATION; INTERLEUKIN-17; INTERLEUKIN-23; INTERLEUKINS; MICE; NUCLEAR RECEPTOR SUBFAMILY 1, GROUP F, MEMBER 3; OSTEOGENESIS; PERIOSTEUM; RECEPTORS, INTERLEUKIN; SPONDYLARTHROPATHIES; T-LYMPHOCYTES; TENDONS; TH17 CELLS;

EID: 84863697312     PISSN: 10788956     EISSN: 1546170X     Source Type: Journal    
DOI: 10.1038/nm.2817     Document Type: Article

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