The inhibitory effect of microRNA-146a expression on bone destruction in collagen-induced arthritis

Arthritis and Rheumatism

Volumn 63, Issue 6, 2011, Pages 1582-1590

  Nakasa, Tomoyuki ^a   Shibuya, Hayatoshi ^a   Nagata, Yoshihiko ^a   Niimoto, Takuya ^a   Ochi, Mitsuo ^a  

^a HIROSHIMA UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ACID PHOSPHATASE TARTRATE RESISTANT ISOENZYME; COLLAGEN; DOUBLE STRANDED RNA; INTERLEUKIN 1BETA; INTERLEUKIN 6; MICRORNA; PROTEIN C JUN; PROTEIN NFATC1; SMALL INTERFERING RNA; TRANSCRIPTION FACTOR NFAT; TRANSCRIPTION FACTOR PU 1; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; BONE DESTRUCTION; BONE RADIOGRAPHY; CONTROLLED STUDY; DOWN REGULATION; GENE EXPRESSION; HISTOLOGY; HUMAN; HUMAN CELL; INFLAMMATION; JOINT DESTRUCTION; MALE; MOUSE; MULTINUCLEAR CELL; NONHUMAN; OSTEOCLASTOGENESIS; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; QUANTITATIVE ANALYSIS; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RHEUMATOID ARTHRITIS; SYNOVIUM; TREATMENT OUTCOME;

ACID PHOSPHATASE; ANIMALS; ARTHRITIS, EXPERIMENTAL; BONE RESORPTION; CELLS, CULTURED; COCULTURE TECHNIQUES; HUMANS; ISOENZYMES; JNK MITOGEN-ACTIVATED PROTEIN KINASES; LEUKOCYTES, MONONUCLEAR; MACROPHAGE COLONY-STIMULATING FACTOR; MALE; MICE; MICRORNAS; NFATC TRANSCRIPTION FACTORS; OSTEOCLASTS; PROTO-ONCOGENE PROTEINS; RANK LIGAND; RNA, DOUBLE-STRANDED; TRANS-ACTIVATORS; TRANSFECTION; TUMOR NECROSIS FACTOR-ALPHA;

EID: 79958053053     PISSN: 00043591     EISSN: 15290131     Source Type: Journal    
DOI: 10.1002/art.30321     Document Type: Article

References (32)

1. Goldring SR, Gravallese EM,. Pathogenesis of bone lesions in rheumatoid arthritis. Curr Rheumatol Rep 2000; 4: 226-31.
2. Gardner DL,. Rheumatoid arthritis: cell and tissue pathology. In: Pathological basis of the connective tissue diseases. London; 1992. p. 444-526.
3. Arend WP, Dayer JM,. Inhibition of the production and effects of interleukin-1 and tumor necrosis factor α in rheumatoid arthritis [review]. Arthritis Rheum 1995; 38: 151-60.
4. Romas E, Gillespie MT, Martin TJ,. Involvement of receptor activator of NFκB ligand and tumor necrosis factor-α in bone destruction in rheumatoid arthritis. Bone 2002; 30: 340-6. (Pubitemid 34154863)
5. Cohen SB, Dore RK, Lane NE, Ory PA, Peterfy CG, Sharp JT, et al on behalf of the Denosumab Rheumatoid Arthritis Study Group. Denosumab treatment effects on structural damage, bone mineral density, and bone turnover in rheumatoid arthritis: a twelve-month, multicenter, randomized, double-blind, placebo-controlled, phase II clinical trial. Arthritis Rheum 2008; 58: 1299-309. (Pubitemid 351705919)
6. Ambros V,. The functions of animal microRNAs. Nature 2004; 431: 350-5. (Pubitemid 39265675)
7. Chendrimada TP, Gregory RI, Kumaraswamy E, Norman J, Cooch N, Nishikura K, et al. TRBP recruits the Dicer complex to Ago2 for microRNA processing and gene silencing. Nature 2005; 436: 740-4. (Pubitemid 41117280)
8. Gregory RI, Yan KP, Amuthan G, Chendrimada T, Doratotaj B, Cooch N, et al. The Microprocessor complex mediates the genesis of microRNAs. Nature 2004; 432: 235-40. (Pubitemid 39545855)
9. Lee Y, Ahn C, Han J, Choi H, Kim J, Yim J, et al. The nuclear RNase III Drosha initiates microRNA processing. Nature 2003; 425: 415-9. (Pubitemid 37187272)
10. Calin GA, Dumitru CD, Shimizu M, Bichi R, Zupo S, Noch E, et al. Frequent deletions and down-regulation of micro-RNA genes miR15 and miR16 at 13q14 in chronic lymphocytic leukemia. Proc Natl Acad Sci U S A 2002; 99: 15524-9. (Pubitemid 35403967)
11. Calin GA, Sevignani C, Dumitru CD, Hyslop T, Noch E, Yendamuri S, et al. Human microRNA genes are frequently located at fragile sites and genomic regions involved in cancers. Proc Natl Acad Sci U S A 2004; 101: 2999-3004. (Pubitemid 38327724)
12. Lecellier CH, Dunoyer P, Arar K, Lehmann-Che J, Eyquem S, Himber C, et al. A cellular microRNA mediates antiviral defense in human cells. Science 2005; 308: 557-60. (Pubitemid 40570587)
13. Stanczyk J, Pedrioli DM, Brentano F, Sanchez-Pernaute O, Kolling C, Gay RE, et al. Altered expression of microRNA in synovial fibroblasts and synovial tissue in rheumatoid arthritis. Arthritis Rheum 2008; 58: 1001-9. (Pubitemid 351564001)
14. Nakasa T, Miyaki S, Okubo A, Hashimoto M, Nishida K, Ochi M, et al. Expression of microRNA-146 in rheumatoid arthritis synovial tissue. Arthritis Rheum 2008; 58: 1284-92. (Pubitemid 351705917)
15. Pauley KM, Satoh M, Chan AL, Bubb MR, Reeves WH, Chan EK,. Upregulated miR-146a expression in peripheral blood mononuclear cells from rheumatoid arthritis patients. Arthritis Res Ther 2008; 10: R101.
16. Taganov KD, Boldin MP, Chang KJ, Baltimore D,. NF-κB-dependent induction of microRNA miR-146, an inhibitor targeted to signaling proteins of innate immune responses. Proc Natl Acad Sci U S A 2006; 103: 12481-6. (Pubitemid 44267285)
17. Franzoso G, Carlson L, Xing L, Poljak L, Shores EW, Brown KD, et al. Requirement for NF-κB in osteoclast and B-cell development. Genes Dev 1997; 11: 3482-96. (Pubitemid 28023969)
18. Clohisy JC, Roy BC, Biondo C, Frazier E, Willis D, Teitelbaum SL, et al. Direct inhibition of NF-kB blocks bone erosion associated with inflammatory arthritis. J Immunol 2003; 171: 5547-53. (Pubitemid 37432845)
19. Jimi E, Aoki K, Saito H, D'Acquisto F, May JJ, Nakamura I, et al. Selective inhibition of NF-kB blocks osteoclastogenesis and prevents inflammatory bone destruction in vivo. Nat Med 2004; 10: 617-24. (Pubitemid 38796853)
20. Terato K, Hasty KA, Reife RA, Cremer MA, Kang AH, Stuart JM,. Induction of arthritis with monoclonal antibodies to collagen. J Immunol 1992; 148: 2103-8.
21. Sancho D, Gomez M, Viedma F, Esplugues E, Gordon-Alonso M, Garcia-Lopez MA, et al. CD69 downregulates autoimmune reactivity through active transforming growth factor-β production in collagen-induced arthritis. J Clin Invest 2003; 112: 872-82. (Pubitemid 38063745)
22. Tazawa H, Tsuchiya N, Izumiya M, Nakagama H,. Tumor-suppressive miR-34a induces senescence-like growth arrest through modulation of the E2F pathway in human colon cancer cells. Proc Natl Acad Sci U S A 2007; 104: 15472-7. (Pubitemid 47502941)
23. Nakasa T, Ishikawa M, Shi M, Shibuya H, Adachi N, Ochi M,. Acceleration of muscle regeneration by local injection of muscle-specific microRNAs in rat skeletal muscle injury model. J Cell Mol Med 2010; 14: 2495-505.
24. Nagata Y, Nakasa T, Mochizuki Y, Ishikawa M, Miyaki S, Shibuya H, et al. Induction of apoptosis in the synovium of mice with autoantibody-mediated arthritis by the intraarticular injection of double-stranded microRNA-15a. Arthritis Rheum 2009; 60: 2677-83.
25. Lipsky PE, van der Heijde DM, St Clair EW, Furst DE, Breedveld FC, Kalden JR, et al for the Anti-Tumor Necrosis Factor Trial in Rheumatoid Arthritis with Concomitant Therapy Study Group. Infliximab and methotrexate in the treatment of rheumatoid arthritis. N Engl J Med 2000; 343: 1594-602. (Pubitemid 32162982)
26. Hounoki H, Sugiyama E, Mohamed SG, Shinoda K, Taki H, Abdel-Aziz HO, et al. Activation of peroxisome proliferator-activated receptor γ inhibits TNF-α-mediated osteoclast differentiation in human peripheral monocytes in part via suppression of monocyte chemoattractant protein-1 expression. Bone 2008; 42: 765-74.
27. Bhaumik D, Scott GK, Schokrpur S, Patil CK, Campisi J, Benz CC,. Expression of microRNA-146 suppresses NF-κB activity with reduction of metastatic potential in breast cancer cells. Oncogene 2008; 27: 5643-7.
28. Lomaga MA, Yeh WC, Sarosi I, Duncan GS, Furlonger C, Ho A, et al. TRAF6 deficiency results in osteopetrosis and defective interleukin-1, CD40, and LPS signaling. Genes Dev 1999; 13: 1015-24. (Pubitemid 29200984)
29. Ye H, Arron JR, Lamothe B, Cirilli M, Kobayashi T, Shevde NK, et al. Distinct molecular mechanism for initiating TRAF6 signalling. Nature 2002; 418: 443-7. (Pubitemid 34826847)
30. Poblenz AT, Jacoby JJ, Singh S, Darnay BG,. Inhibition of RANKL-mediated osteoclast differentiation by selective TRAF6 decoy peptides. Biochem Biophys Res Commun 2007; 359: 510-5. (Pubitemid 46898981)
31. Krek A, Grun D, Poy MN, Wolf R, Rosenberg L, Epstein EJ, et al. Combinatorial microRNA target predictions. Nat Genet 2005; 37: 495-500. (Pubitemid 40617277)
32. Khoury M, Escriou V, Courties G, Galy A, Yao R, Largeau C, et al. Efficient suppression of murine arthritis by combined anticytokine small interfering RNA lipoplexes. Arthritis Rheum 2008; 58: 2356-67.