Interleukin-21 induces T-cell activation and proinflammatory cytokine secretion in rheumatoid arthritis

Scandinavian Journal of Immunology

Volumn 64, Issue 5, 2006, Pages 515-522

  Li, J ^a,b   Shen, W ^b   Kong, K ^b   Liu, Z ^a  

^a ZHENGZHOU UNIVERSITY   (China)

^b SHANTOU UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE; GAMMA INTERFERON; INTERLEUKIN 21; INTERLEUKIN 21 RECEPTOR; MONOCLONAL ANTIBODY CD3; TUMOR NECROSIS FACTOR ALPHA;

ADOLESCENT; ADULT; ARTICLE; B LYMPHOCYTE; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CLINICAL ARTICLE; COMPARATIVE STUDY; CONTROLLED STUDY; CYTOKINE RELEASE; FEMALE; FLOW CYTOMETRY; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; IMMUNOPATHOGENESIS; INFLAMMATION; LYMPHOCYTE PROLIFERATION; MALE; NATURAL KILLER CELL; OSTEOARTHRITIS; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; RHEUMATOID ARTHRITIS; SIGNAL TRANSDUCTION; SYNOVIAL FLUID; SYNOVITIS; SYNOVIUM; T LYMPHOCYTE; T LYMPHOCYTE ACTIVATION;

ADOLESCENT; ADULT; ARTHRITIS, RHEUMATOID; CASE-CONTROL STUDIES; CELL PROLIFERATION; CYTOKINES; FEMALE; FLOW CYTOMETRY; HUMANS; IN SITU HYBRIDIZATION; INTERFERON TYPE II; INTERFERON-GAMMA; INTERLEUKINS; LYMPHOCYTE ACTIVATION; MALE; MIDDLE AGED; RECEPTORS, INTERLEUKIN-21; SYNOVIAL FLUID; SYNOVIAL MEMBRANE; SYNOVITIS; T-LYMPHOCYTES; TUMOR NECROSIS FACTOR-ALPHA;

EID: 33749552196     PISSN: 03009475     EISSN: 13653083     Source Type: Journal    
DOI: 10.1111/j.1365-3083.2006.01795.x     Document Type: Article

References (28)

1. Firestein GS. Evolving concepts of rheumatoid arthritis. Nature 2003;423:356-61.
2. Corrigall VM, Panayi GS. Autoantigens and immune pathways in rheumatoid arthritis. Crit Rev Immunol 2002;22:281-93.
3. Weyand CM, Cornorzy JJ. Ectopic germinal center formation in rheumatoid arthritis. Annu NY Acad Sci 2003;987:140-9.
4. Liew FY. The role of innate cytokines in inflammatory response. Immunol Lett 2003;22:131-4.
5. Keffer J, Probert L, Cazlaris H et al. Transgenic mice expressing human tumour necrosis factor: a predictive genetic model of arthritis. EMBO J 1991;10:4025-31.
6. Taylor GA, Carballo E, Lee DM et al. A pathogenetic role for TNF alpha in the syndrome of cachexia, arthritis, and autoimmunity resulting from tristetraprolin (TTP) deficiency. Immunity 1996;4:445-54.
7. Wahid S, Blades MC, De Lord D et al. Tumor necrosis factor-a (TNF-α) enhances lymphocyte migration into rheumatoid synovial tissue transplanted into severe combined immunodeficient (SCID) mice. Clin Exp Immunol 2000;122:133-42.
8. Oppenheimer-Marks N, Brezinschek RI, Mohamadzadeh M, Vita R, Lipsky PE. Interleukin 15 is produced by endothelial cells and increases the transendothelial migration of T cells in vitro and in the SCID mouse-human rheumatoid arthritis model in vivo. J Clin Invest 1998;101:1261-72.
9. Goldblatt F, Isenberg DA. New therapies for rheumatoid arthritis. Clin Exp Immunol 2005;140:195-204.
10. Wei XQ, Orchardson M, Gracie JA et al. The Sushi domain of soluble IL-15 receptor alpha is essential for binding IL-15 and inhibiting inflammatory and allogenic responses in vitro and in vivo. J Immunol 2001;167:277-82.
11. Ferrai-Lacraz S, Zanelli E, Neuberg M et al. Targeting IL-15 receptor-bearing cells with an antagonist mutant IL-15/Fc protein prevents disease development and progression in murine collagen-induced arthritis. J Immunol 2004;173:5818-26.
12. Parrish-Novak J, Dillon SR, Nelson A et al. Interleukin 21 and its receptor are involved in NK cell expansion and regulation of lymphocyte function. Nature 2000;408:57-63.
13. Ozaki K, Spolski R, Feng CG et al. A critical role for IL-21 in regulating immunoglobulin production. Science 2002;298:1630-4.
14. Sivakumar LV, Foster DC, Clegg CH. Interleukin-21 is a T-helper cytokine that regulates humoral immunity and cell-mediated anti-tumor responses. Immunology 2004;112:177-82.
15. Strengell M, Sareneva T, Foster D, Julkunen I, Matikainen S. IL-21 up-regulates the expression of genes associated with innate immunity and Th1 response. J Immunol 2002;169:3600-5.
16. Suto A, Nakajima H, Hirose K et al. Interleukin-21 prevents antigen-induced IgE production by inhibiting germline Cs transcription of IL-4-stimulated B cells. Blood 2002;100:4565-73.
17. Monteleone G, Monteleone I, Fina D et al. Interleukin-21 enhances T-helper cell type I signaling and interferon-c production in Crohn's disease. Gastroenterology 2005;128:687-94.
18. Distler JH, Jungle A, Kowal-Bielecka O et al. Expression of interleukin-21 receptor in epidermis from patients with systemic sclerosis. Arthritis Rheum 2005;2:856-64.
19. Jungel A, Distler JHW, Kurowska-Stolarska M et al. Expression of interleukin-21 receptor, but not interleukin-21, in synovial fibroblasts and synovial macrophages of patients with rheumatoid arthritis. Arthritis Rheum 2004;50:1468-76.
20. Liu Z, Geboes K, Colpaert S, D'Haens GR, Rutgeerts P, Ceuppens JL. IL-15 is highly expressed in inflammatory bowel disease and regulates local T cell-dependent cytokine production. J Immunol 2000;164:3608-15.
21. Liu Z, Lefrancois L. Intestinal epithelial antigen induces mucosal CD8 T cell tolerance, activation and inflammatory response. J Immunol 2004;173:3240-8.
22. Ruth JH, Rottman JB, Katschke KJ Jr et al. Selective lymphocyte chemokine receptor expression in the rheumatoid joint. Arthritis Rheum 2001;44:2750-60.
23. Vollmer TL, Liu R, Price M, Rhodes S, La Cava A, Shi FD. Differential effects of IL-21 during initiation and progression of autoimmunity against neuroantigen. J Immunol 2005;174:2696-701.
24. Wurster AL, Rodgers VL, Satoskar AR et al. Interleukin 21 is a T helper (Th) cell 2 cytokine that specially inhibits the differentiation of naive Th cells into interferon gamma-producing Th1 cells. J Exp Med 2002;196:969-77.
25. Steiner G, Smolen J. Autoantibodies in rheumatoid arthritis and their clinical significance. Arthritis Res 2002;4:S1-5.
26. De Vita S, Zaja F, Sacco S, De Candia A, Fanin R, Ferraccioli G. Efficacy of selective B cell blockade in the treatment of rheumatoid arthritis: evidence for a pathogenic role of B cells. Arthritis Rheum 2002;46:2029-33.
27. Pene J, Gauchat JF, Lecart S et al. Cutting edge: IL-21 is a switch factor for the production of IgG1 and IgG3 by human B cells. J Immunol 2004;172:5154-7.
28. Feldmann M, Maini RN. Anti-TNFα therapy of rheumatoid arthritis: what we have learned. Annu Rev Immunol 2001;19:163-6.