IL-23 induces human osteoclastogenesis via IL-17 in vitro, and anti-IL-23 antibody attenuates collagen-induced arthritis in rats

Arthritis Research and Therapy

Volumn 9, Issue 5, 2007, Pages

  Yago, Toru ^a   Nanke, Yuki ^a   Kawamoto, Manabu ^a   Furuya, Takefumi ^a   Kobashigawa, Tsuyoshi ^a   Kamatani, Naoyuki ^a   Kotake, Shigeru ^a  

^a TOKYO WOMEN'S MEDICAL UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBODY; COLLAGEN; ETANERCEPT; GAMMA INTERFERON; INTERLEUKIN 17; INTERLEUKIN 17 ANTIBODY; INTERLEUKIN 23; INTERLEUKIN 23 ANTIBODY; OSTEOCLAST DIFFERENTIATION FACTOR; OSTEOPROTEGERIN; PROTEIN ANTIBODY; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTHRITIS; ARTICLE; BONE DESTRUCTION; CELL DIFFERENTIATION; CELL STIMULATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; DOSE RESPONSE; DRUG DOSE COMPARISON; DRUG MEGADOSE; FEMALE; HISTOPATHOLOGY; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; LOW DRUG DOSE; NONHUMAN; OSSIFICATION; OSTEOBLAST; OSTEOCLAST; PAW EDEMA; PERIPHERAL BLOOD MONONUCLEAR CELL; PROTEIN FUNCTION; RAT; T LYMPHOCYTE ACTIVATION; ANIMAL; BIOSYNTHESIS; CELL CULTURE; COMPARATIVE STUDY; CYTOLOGY; DRUG ANTAGONISM; GENETICS; METABOLISM; PATHOLOGY;

ANIMALS; ANTIBODIES; ARTHRITIS, EXPERIMENTAL; CELLS, CULTURED; FEMALE; HUMANS; INTERLEUKIN-17; INTERLEUKIN-23; OSTEOCLASTS; RATS;

EID: 36448931232     PISSN: 14786354     EISSN: 14786362     Source Type: Journal    
DOI: 10.1186/ar2297     Document Type: Article

References (37)

1. Wilder RL Rheumatoid arthritis. Epidemiology, pathology, and pathogenesis Origins of Primer on the Rheumatic Diseases Atlanta: The Arthritis Foundation Shumacher HR Jr 10 1993:86-89.
2. Kotake S Sato K Kim KJ Takahashi N Udagawa N Nakamura I Yamaguchi A Kishimoto T Suda T Kashiwazaki S Interleukin-6 and soluble interleukin-6 receptors in the synovial fluids from rheumatoid arthritis patients are responsible for osteoclast-like cell formation J Bone Miner Res 1996, 11:88-95. 8770701
3. Gravallese EM Harada Y Wang JT Gorn AH Thornhill TS Goldring SR Identification of cell types responsible for bone resorption in rheumatoid arthritis and juvenile rheumatoid arthritis Am J Pathol 1998, 152:943-951. 1858257 9546355
4. Steiner G Tohidast-Akrad M Witzmann G Vesely M Studnicka-Benke A Gal A Kunaver M Zenz P Smolen JS Cytokine production by synovial T cells in rheumatoid arthritis Rheumatology (Oxford) 1999, 38:202-213. 10.1093/ rheumatology/38.3.202 10325658
5. al-Janadi N al-Dalaan A al-Balla S Raziuddin S CD4+ T cell inducible immunoregulatory cytokine response in rheumatoid arthritis J Rheumatol 1996, 23:809-814. 8724289
6. Pacifici R Brown C Puscheck E Friedrich E Slatopolsky E Maggio D McCracken R Avioli LV Effect of surgical menopause and estrogen replacement on cytokine release from human blood mononuclear cells Proc Natl Acad Sci USA 1991, 88:5134-5138. 51826 2052592 10.1073/ pnas.88.12.5134
7. Assuma R Oates T Cochran D Amar S Graves DT IL-1 and TNF antagonists inhibit the inflammatory response and bone loss in experimental periodontitis J Immunol 1998, 160:403-409. 9551997
8. Oppmann B Lesley R Blom B Timans JC Xu Y Hunte B Vega F Yu N Wang J Singh K Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12 Immunity 2000, 13:715-725. 10.1016/S1074-7613(00)00070-4 11114383
9. Parham C Chirica M Timans J Vaisberg E Travis M Cheung J Pflanz S Zhang R Singh KP Vega F A receptor for the heterodimeric cytokine IL-23 is composed of IL-12Rβ1 and a novel cytokine receptor subunit, IL-23R J Immunol 2002, 168:5699-5708. 12023369
10. Aggarwal S Ghilardi N Xie MH de Sauvage FJ Gurney AL Interleukin-23 promotes a distinct CD4 T cell activation state characterized by the production of interleukin-17 J Biol Chem 2003, 278:1910-1914. 10.1074/ jbc.M207577200 12417590
11. Vanden Eijnden S Goriely S De Wit D Willems F Goldman M IL-23 up-regulates IL-10 and induces IL-17 synthesis by polyclonally activated naive T cells in human Eur J Immunol 2005, 35:469-475. 10.1002/ eji.200425677 15682457
12. Brombacher F Kastelein RA Alber G Novel IL-12 family members shed light on the orchestration of Th1 responses Trends Immunol 2003, 24:207-212. 10.1016/S1471-4906(03)00067-X 12697453
13. Lankford CS Frucht DM A unique role for IL-23 in promoting cellular immunity J Leukoc Biol 2003, 73:49-56. 10.1189/jlb.0602326 12525561
14. Trinchieri G Interleukin-12 and the regulation of innate resistance and adaptive immunity Nat Rev Immunol 2003, 3:133-146. 10.1038/nri1001 12563297
15. Cua DJ Sherlock J Chen Y Murphy CA Joyce B Seymour B Lucian L To W Kwan S Churakova T Interleukin-23 rather than interleukin-12 is the critical cytokine for autoimmune inflammation of the brain Nature 2003, 421:744-748. 10.1038/nature01355 12610626
16. Murphy CA Langrish CL Chen Y Blumenschein W McClanahan T Kastelein RA Sedgwick JD Cua DJ Divergent pro- and antiinflammatory roles for IL-23 and IL-12 in joint autoimmune inflammation J Exp Med 2003, 198:1951-1957. 10.1084/jem.20030896 14662908
17. Wiekowski MT Leach MW Evans EW Sullivan L Chen SC Vassileva G Bazan JF Gorman DM Kastelein RA Narula S Ubiquitous transgenic expression of the IL-23 subunit p19 induces multiorgan inflammation, runting, infertility, and premature death J Immunol 2001, 166:7563-7570. 11390512
18. Langrish CL Chen Y Blumenschein WM Mattson J Basham B Sedgwick JD McClanahan T Kastelein RA Cua DJ IL-23 drives a pathogenic T cell population that induces autoimmune inflammation J Exp Med 2005, 201:233-240. 10.1084/jem.20041257 15657292
19. Broxmeyer HE Is interleukin 17, an inducible cytokine that stimulates production of other cytokines, merely a redundant player in a sea of other biomolecules? J Exp Med 1996, 183:2411-2415. 10.1084/ jem.183.6.2411 8676060
20. Ferretti S Bonneau O Dubois GR Jones CE Trifilieff A IL-17, produced by lymphocytes and neutrophils, is necessary for lipopolysaccharide-induced airway neutrophilia: IL-15 as a possible trigger J Immunol 2003, 170:2106-2112. 12574382
21. Kotake S Udagawa N Takahashi N Matsuzaki K Itoh K Ishiyama S Saito S Inoue K Kamatani N Gillespie MT IL-17 in synovial fluids from patients with rheumatoid arthritis is a potent stimulator of osteoclastogenesis J Clin Invest 1999, 103:1345-1352. 408356 10225978
22. Yago T Nanke Y Furuya T Kobashigawa T Kamatani N Kotake S Infliximab potently inhibits osteoclastogenesis from human monocytes alone induced by IL-17 in the absence of osteoblasts [abstract] Arthritis Rheum 2004, 50:s289.
23. Kotake S Kamatani N The role of IL-17 in joint destruction Drug News Perspect 2002, 15:17-23. 10.1358/dnp.2002.15.1.660504 12677240
24. Miossec P Interleukin-17 in rheumatoid arthritis: If T cells were to contribute to inflammation and destruction through synergy Arthritis Rheum 2003, 48:594-601. 10.1002/art.10816 12632409
25. Lubberts E Koenders MI van den Berg WB The role of T cell interleukin-17 in conducting destructive arthritis: Lessons from animal models Arthritis Res Ther 2005, 7:29-37. 1064899 15642151 10.1186/ar1478
26. Kotake S Nanke Y Mogi M Kawamoto M Furuya T Yago T Kobashigawa T Togari A Kamatani N IFN-gamma-producing human T cells directly induce osteoclastogenesis from human monocytes via the expression of RANKL Eur J Immunol 2005, 35:3353-3363. 10.1002/eji.200526141 16220542
27. Bendele AM Chlipala ES Scherrer J Frazier J Sennello G Rich WJ Edwards CK Combination benefit of treatment with the cytokine inhibitors interleukin-1 receptor antagonist and PEGylated soluble tumor necrosis factor receptor type I in animal models of rheumatoid arthritis Arthritis Rheum 2000, 43:2648-2659. 10.1002/ 1529-0131(200012)43:12<2648::AID-ANR4>3.0.CO;2-M 11145022
28. Takayanagi H Ogasawara K Hida S Chiba T Murata S Sato K Takaoka A Yokochi T Oda H Tanaka K T-cell-mediated regulation of osteoclastogenesis by signalling cross-talk between RANKL and IFN-γ Nature 2000, 408:600-605. 10.1038/35046102 11117749
29. Happel KI Zheng M Young E Quinton LJ Lockhart E Ramsay AJ Shellito JE Schurr JR Bagby GJ Nelson S Cutting edge: Roles of Toll-like receptor 4 and IL-23 in IL-17 expression in response to Klebsiella pneumoniae infection J Immunol 2003, 170:4432-4436. 12707317
30. Ghilardi N Kljavin N Chen Q Lucas S Gurney AL De Sauvage FJ Compromised humoral and delayed-type hypersensitivity responses in IL-23-deficient mice J Immunol 2004, 172:2827-2833. 14978083
31. Ferber IA Brocke S Taylor-Edwards C Ridgway W Dinisco C Steinman L Dalton D Fathman CG Mice with a disrupted IFN-γ gene are susceptible to the induction of experimental autoimmune encephalomyelitis (EAE) J Immunol 1996, 156:5-7. 8598493
32. Willenborg DO Fordham S Bernard CC Cowden WB Ramshaw IA IFN-γ plays a critical down-regulatory role in the induction and effector phase of myelin oligodendrocyte glycoprotein-induced autoimmune encephalomyelitis J Immunol 1996, 157:3223-3227. 8871615
33. Park H Li Z Yang XO Chang SH Nurieva R Wang YH Wang Y Hood L Zhu Z Tian Q A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17 Nat Immunol 2005, 6:1133-1141. 1618871 16200068 10.1038/ni1261
34. Kotake S Schumacher HR Jr Yarboro CH Arayssi TK Pando JA Kanik KS Gourley MF Klippel JH Wilder RL In vivo gene expression of type 1 and type 2 cytokines in synovial tissues from patients in early stages of rheumatoid, reactive, and undifferentiated arthritis Proc Assoc Am Physicians 1997, 109:286-301. 9154645
35. Saxne T Palladino MA Jr Heinegard D Talal N Wollheim FA Detection of tumor necrosis factor alpha but not tumor necrosis factor beta in rheumatoid arthritis synovial fluid and serum Arthritis Rheum 1988, 31:1041-1045. 10.1002/art.1780310816 3136775
36. Kong YY Yoshida H Sarosi I Tan HL Timms E Capparelli C Morony S Oliveira-dos-Santos AJ Van G Itie A OPGL is a key regulator of osteoclastogenesis, lymphocyte development and lymph-node organogenesis Nature 1999, 397:315-323. 10.1038/16852 9950424
37. Kotake S Udagawa N Hakoda M Mogi M Yano K Tsuda E Takahashi K Furuya T Ishiyama S Kim KJ Activated human T cells directly induce osteoclastogenesis from human monocytes: Possible role of T cells in bone destruction in rheumatoid arthritis patients Arthritis Rheum 2001, 44:1003-1012. 10.1002/ 1529-0131(200105)44:5<1003::AID-ANR179>3.0.CO;2-# 11352231