-
1
-
-
0026468180
-
A nuclear factor induced by hypoxia via de novo protein synthesis binds to the human eryth-ropoietin gene enhancer at a site required for transcriptional activation
-
Semenza, G. L. & Wang, G. L. A nuclear factor induced by hypoxia via de novo protein synthesis binds to the human eryth-ropoietin gene enhancer at a site required for transcriptional activation. Mol Cell Biol 12, 5447-54 (1992).
-
(1992)
Mol Cell Biol
, vol.12
, pp. 5447-5454
-
-
Semenza, G.L.1
Wang, G.L.2
-
2
-
-
0028816847
-
Purification and characterization of hypoxia-inducible factor 1
-
Wang, G. L. & Semenza, G. L. Purification and characterization of hypoxia-inducible factor 1. J Biol Chem 270, 1230-7 (1995).
-
(1995)
J Biol Chem
, vol.270
, pp. 1230-1237
-
-
Wang, G.L.1
Semenza, G.L.2
-
3
-
-
8044253996
-
Structural and functional analysis of hypoxia-inducible factor 1
-
Semenza, G. L. et al. Structural and functional analysis of hypoxia-inducible factor 1. Kidney Int 51, 553-5 (1997).
-
(1997)
Kidney Int
, vol.51
, pp. 553-555
-
-
Semenza, G.L.1
-
4
-
-
0029051439
-
Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension
-
Wang, G. L., Jiang, B. H., Rue, E. A. & Semenza, G. L. Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension. Proc Natl Acad Sci USA 92, 5510-4 (1995).
-
(1995)
Proc Natl Acad Sci USA
, vol.92
, pp. 5510-5514
-
-
Wang, G.L.1
Jiang, B.H.2
Rue, E.A.3
Semenza, G.L.4
-
5
-
-
0024378079
-
Interactions between heterologous helix-loop-helix proteins generate complexes that bind specifically to a common DNA sequence
-
Murre, C. et al. Interactions between heterologous helix-loop-helix proteins generate complexes that bind specifically to a common DNA sequence. Cell 58, 537-44 (1989).
-
(1989)
Cell
, vol.58
, pp. 537-544
-
-
Murre, C.1
-
6
-
-
0026072341
-
Cell-type-specific and hypoxia-inducible expression of the human erythropoietin gene in transgenic mice
-
Semenza, G. L., Koury, S. T., Nejfelt, M. K., Gearhart, J. D. & Antonarakis, S. E. Cell-type-specific and hypoxia-inducible expression of the human erythropoietin gene in transgenic mice. Proc Natl Acad Sci USA 88, 8725-9 (1991).
-
(1991)
Proc Natl Acad Sci USA
, vol.88
, pp. 8725-8729
-
-
Semenza, G.L.1
Koury, S.T.2
Nejfelt, M.K.3
Gearhart, J.D.4
Antonarakis, S.E.5
-
7
-
-
0035834409
-
A conserved family of prolyl-4-hydroxylases that modify HIF
-
Bruick, R. K. & McKnight, S. L. A conserved family of prolyl-4-hydroxylases that modify HIF. Science 294, 1337-40 (2001).
-
(2001)
Science
, vol.294
, pp. 1337-1340
-
-
Bruick, R.K.1
McKnight, S.L.2
-
8
-
-
17944375360
-
C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydrox-ylation
-
Epstein, A. C. et al. C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydrox-ylation. Cell 107, 43-54 (2001).
-
(2001)
Cell
, vol.107
, pp. 43-54
-
-
Epstein, A.C.1
-
9
-
-
0035917313
-
HIFalpha targeted for VHL-mediated destruction by proline hydroxylation: Implications for O2 sensing
-
Ivan, M. et al. HIFalpha targeted for VHL-mediated destruction by proline hydroxylation: implications for O2 sensing. Science 292, 464-8 (2001).
-
(2001)
Science
, vol.292
, pp. 464-468
-
-
Ivan, M.1
-
10
-
-
0035917808
-
Targeting of HIF-alpha to the von hippel-lindau ubiquitylation complex by O2-regulated prolyl hydroxylation
-
Jaakkola, P. et al. Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation. Science 292, 468-72 (2001).
-
(2001)
Science
, vol.292
, pp. 468-472
-
-
Jaakkola, P.1
-
11
-
-
14044257943
-
Role of CBP in regulating HIF-1-mediated activation of transcription
-
Ruas, J. L., Poellinger, L. & Pereira, T. Role of CBP in regulating HIF-1-mediated activation of transcription. J Cell Sci 118, 301-11 (2005).
-
(2005)
J Cell Sci
, vol.118
, pp. 301-311
-
-
Ruas, J.L.1
Poellinger, L.2
Pereira, T.3
-
12
-
-
0042368882
-
The hypoxia-inducible factors: Key transcriptional regulators of hypoxic responses
-
Bracken, C. P., Whitelaw, M. L. & Peet, D. J. The hypoxia-inducible factors: key transcriptional regulators of hypoxic responses. Cell Mol Life Sci 60, 1376-93 (2003).
-
(2003)
Cell Mol Life Sci
, vol.60
, pp. 1376-1393
-
-
Bracken, C.P.1
Whitelaw, M.L.2
Peet, D.J.3
-
13
-
-
0038037735
-
Regulation of angiogenesis by hypoxia: Role of the HIF system
-
Pugh, C. W. & Ratcliffe, P. J. Regulation of angiogenesis by hypoxia: role of the HIF system. Nat Med 9, 677-84 (2003).
-
(2003)
Nat Med
, vol.9
, pp. 677-684
-
-
Pugh, C.W.1
Ratcliffe, P.J.2
-
14
-
-
33745138232
-
Regulation of angiogenesis by hypoxia-inducible factor 1
-
Hirota, K. & Semenza, G. L. Regulation of angiogenesis by hypoxia-inducible factor 1. Crit Rev Oncol Hematol 59, 15-26 (2006).
-
(2006)
Crit Rev Oncol Hematol
, vol.59
, pp. 15-26
-
-
Hirota, K.1
Semenza, G.L.2
-
15
-
-
20544465985
-
Regulation of transcription and translation by hypoxia
-
Liu, L. & Simon, M. C. Regulation of transcription and translation by hypoxia. Cancer Biol Ther 3, 492-7 (2004).
-
(2004)
Cancer Biol Ther
, vol.3
, pp. 492-497
-
-
Liu, L.1
Simon, M.C.2
-
16
-
-
2342611976
-
Radiation activates HIF-1 to regulate vascular radiosensitivity in tumors: Role of reoxygenation, free radicals, and stress granules
-
Moeller, B. J., Cao, Y., Li, C. Y. & Dewhirst, M. W. Radiation activates HIF-1 to regulate vascular radiosensitivity in tumors: role of reoxygenation, free radicals, and stress granules. Cancer Cell 5, 429-41 (2004).
-
(2004)
Cancer Cell
, vol.5
, pp. 429-441
-
-
Moeller, B.J.1
Cao, Y.2
Li, C.Y.3
Dewhirst, M.W.4
-
17
-
-
0037008770
-
Insulin stimulates hypoxia-inducible factor 1 through a phosphatidylinositol 3-kinase/target of rapamy-cin-dependent signaling pathway
-
Treins, C., Giorgetti-Peraldi, S., Murdaca, J., Semenza, G. L. & Van Obberghen, E. Insulin stimulates hypoxia-inducible factor 1 through a phosphatidylinositol 3-kinase/target of rapamy-cin-dependent signaling pathway. J Biol Chem 277, 27975-81 (2002).
-
(2002)
J Biol Chem
, vol.277
, pp. 27975-27981
-
-
Treins, C.1
Giorgetti-Peraldi, S.2
Murdaca, J.3
Semenza, G.L.4
Van Obberghen, E.5
-
18
-
-
0038308573
-
Tumor necrosis factor-alpha causes accumulation of a ubiquitinated form of hypoxia induc-ible factor-1alpha through a nuclear factor-kappaB-dependent pathway
-
Zhou, J., Schmid, T. & Brune, B. Tumor necrosis factor-alpha causes accumulation of a ubiquitinated form of hypoxia induc-ible factor-1alpha through a nuclear factor-kappaB-dependent pathway. Mol Biol Cell 14, 2216-25 (2003).
-
(2003)
Mol Biol Cell
, vol.14
, pp. 2216-2225
-
-
Zhou, J.1
Schmid, T.2
Brune, B.3
-
19
-
-
0035937715
-
Regulation of glut1 mRNA by hypoxia-inducible factor-1. Interaction between H-ras and hypoxia
-
Chen, C., Pore, N., Behrooz, A., Ismail-Beigi, F. & Maity, A. Regulation of glut1 mRNA by hypoxia-inducible factor-1. Interaction between H-ras and hypoxia. J Biol Chem 276, 9519-25 (2001).
-
(2001)
J Biol Chem
, vol.276
, pp. 9519-9525
-
-
Chen, C.1
Pore, N.2
Behrooz, A.3
Ismail-Beigi, F.4
Maity, A.5
-
20
-
-
0030659531
-
V-SRC induces expression of hypoxia-inducible factor 1 (HIF-1) and transcription of genes encoding vascular endothelial growth factor and enolase 1: Involvement of HIF-1 in tumor progression
-
Jiang, B. H., Agani, F., Passaniti, A. & Semenza, G. L. V-SRC induces expression of hypoxia-inducible factor 1 (HIF-1) and transcription of genes encoding vascular endothelial growth factor and enolase 1: involvement of HIF-1 in tumor progression. Cancer Res 57, 5328-35 (1997).
-
(1997)
Cancer Res
, vol.57
, pp. 5328-5335
-
-
Jiang, B.H.1
Agani, F.2
Passaniti, A.3
Semenza, G.L.4
-
21
-
-
0035012605
-
HER2 (neu) signaling increases the rate of hypoxia-induc-ible factor 1alpha (HIF-1alpha) synthesis: Novel mechanism for HIF-1-mediated vascular endothelial growth factor expression
-
Laughner, E., Taghavi, P., Chiles, K., Mahon, P. C. & Semenza, G. L. HER2 (neu) signaling increases the rate of hypoxia-induc-ible factor 1alpha (HIF-1alpha) synthesis: novel mechanism for HIF-1-mediated vascular endothelial growth factor expression. Mol Cell Biol 21, 3995-4004 (2001).
-
(2001)
Mol Cell Biol
, vol.21
, pp. 3995-4004
-
-
Laughner, E.1
Taghavi, P.2
Chiles, K.3
Mahon, P.C.4
Semenza, G.L.5
-
22
-
-
0034671256
-
Relationship of hypoxia-inducible factor (HIF)-1alpha and HIF-2alpha expression to vascular endothelial growth factor induction and hypoxia survival in human breast cancer cell lines
-
Blancher, C., Moore, J. W., Talks, K. L., Houlbrook, S. & Harris, A. L. Relationship of hypoxia-inducible factor (HIF)-1alpha and HIF-2alpha expression to vascular endothelial growth factor induction and hypoxia survival in human breast cancer cell lines. Cancer Res 60, 7106-13 (2000).
-
(2000)
Cancer Res
, vol.60
, pp. 7106-7113
-
-
Blancher, C.1
Moore, J.W.2
Talks, K.L.3
Houlbrook, S.4
Harris, A.L.5
-
23
-
-
4043181214
-
Cancer genes and the pathways they control
-
Vogelstein, B. & Kinzler, K. W. Cancer genes and the pathways they control. Nat Med 10, 789-99 (2004).
-
(2004)
Nat Med
, vol.10
, pp. 789-799
-
-
Vogelstein, B.1
Kinzler, K.W.2
-
24
-
-
0035370253
-
Activation of the HIF pathway in cancer
-
Maxwell, P. H., Pugh, C. W. & Ratcliffe, P. J. Activation of the HIF pathway in cancer. Curr Opin Genet Dev 11, 293-9 (2001).
-
(2001)
Curr Opin Genet Dev
, vol.11
, pp. 293-299
-
-
Maxwell, P.H.1
Pugh, C.W.2
Ratcliffe, P.J.3
-
25
-
-
0142166332
-
Targeting HIF-1 for cancer therapy
-
Semenza, G. L. Targeting HIF-1 for cancer therapy. Nat Rev Cancer 3, 721-32 (2003).
-
(2003)
Nat Rev Cancer
, vol.3
, pp. 721-732
-
-
Semenza, G.L.1
-
26
-
-
0345491599
-
Differential roles of hypoxia-inducible factor 1alpha (HIF-1alpha) and HIF-2alpha in hypoxic gene regulation
-
Hu, C. J., Wang, L. Y., Chodosh, L. A., Keith, B. & Simon, M. C. Differential roles of hypoxia-inducible factor 1alpha (HIF-1alpha) and HIF-2alpha in hypoxic gene regulation. Mol Cell Biol 23, 9361-74 (2003).
-
(2003)
Mol Cell Biol
, vol.23
, pp. 9361-9374
-
-
Hu, C.J.1
Wang, L.Y.2
Chodosh, L.A.3
Keith, B.4
Simon, M.C.5
-
27
-
-
20744445650
-
Contrasting properties of hypoxia-inducible factor 1 (HIF-1) and HIF-2 in von hippel-lindau-associated renal cell carcinoma
-
Raval, R. R. et al. Contrasting properties of hypoxia-inducible factor 1 (HIF-1) and HIF-2 in von Hippel-Lindau-associated renal cell carcinoma. Mol Cell Biol 25, 5675-86 (2005).
-
(2005)
Mol Cell Biol
, vol.25
, pp. 5675-5686
-
-
Raval, R.R.1
-
28
-
-
0036527785
-
The contribution of VHL substrate binding and HIF1-alpha to the phenotype of VHL loss in renal cell carcinoma
-
Maranchie, J. K. et al. The contribution of VHL substrate binding and HIF1-alpha to the phenotype of VHL loss in renal cell carcinoma. Cancer Cell 1, 247-55 (2002).
-
(2002)
Cancer Cell
, vol.1
, pp. 247-255
-
-
Maranchie, J.K.1
-
29
-
-
0037031808
-
Inhibitory PAS domain protein (IPAS) is a hypoxia-inducible splicing variant of the hypoxia-inducible factor-3alpha locus
-
Makino, Y., Kanopka, A., Wilson, W. J., Tanaka, H. & Poellinger, L. Inhibitory PAS domain protein (IPAS) is a hypoxia-inducible splicing variant of the hypoxia-inducible factor-3alpha locus. J Biol Chem 277, 32405-8 (2002).
-
(2002)
J Biol Chem
, vol.277
, pp. 32405-32408
-
-
Makino, Y.1
Kanopka, A.2
Wilson, W.J.3
Tanaka, H.4
Poellinger, L.5
-
30
-
-
0036718539
-
Molecular basis of the VHL hereditary cancer syndrome
-
Kaelin, W. G., Jr. Molecular basis of the VHL hereditary cancer syndrome. Nat Rev Cancer 2, 673-82 (2002).
-
(2002)
Nat Rev Cancer
, vol.2
, pp. 673-682
-
-
Kaelin Jr., W.G.1
-
31
-
-
0034649507
-
Identification of novel hypoxia dependent and independent target genes of the von hippel-lindau (VHL) tumour suppressor by mRNA differential expression profiling
-
Wykoff, C. C., Pugh, C. W., Maxwell, P. H., Harris, A. L. & Ratcliffe, P. J. Identification of novel hypoxia dependent and independent target genes of the von Hippel-Lindau (VHL) tumour suppressor by mRNA differential expression profiling. Oncogene 19, 6297-305 (2000).
-
(2000)
Oncogene
, vol.19
, pp. 6297-6305
-
-
Wykoff, C.C.1
Pugh, C.W.2
Maxwell, P.H.3
Harris, A.L.4
Ratcliffe, P.J.5
-
32
-
-
0028080215
-
Cytokine networks in solid human tumors: Regulation of angiogenesis
-
Leek, R. D., Harris, A. L. & Lewis, C. E. Cytokine networks in solid human tumors: regulation of angiogenesis. J Leukoc Biol 56, 423-35 (1994).
-
(1994)
J Leukoc Biol
, vol.56
, pp. 423-435
-
-
Leek, R.D.1
Harris, A.L.2
Lewis, C.E.3
-
34
-
-
4944244259
-
Mechanisms regulating the recruitment of macrophages into hypoxic areas of tumors and other ischemic tissues
-
Murdoch, C., Giannoudis, A. & Lewis, C. E. Mechanisms regulating the recruitment of macrophages into hypoxic areas of tumors and other ischemic tissues. Blood 104, 2224-34 (2004).
-
(2004)
Blood
, vol.104
, pp. 2224-2234
-
-
Murdoch, C.1
Giannoudis, A.2
Lewis, C.E.3
-
35
-
-
0029867554
-
Migration of human monocytes in response to vascular endothelial growth factor (VEGF) is mediated via the VEGF receptor flt-1
-
Barleon, B. et al. Migration of human monocytes in response to vascular endothelial growth factor (VEGF) is mediated via the VEGF receptor flt-1. Blood 87, 3336-43 (1996).
-
(1996)
Blood
, vol.87
, pp. 3336-3343
-
-
Barleon, B.1
-
36
-
-
0033780453
-
Expression of vascular endothelial growth factor by macrophages is up-regulated in poorly vascularized areas of breast carcinomas
-
Lewis, J. S., Landers, R. J., Underwood, J. C., Harris, A. L. & Lewis, C. E. Expression of vascular endothelial growth factor by macrophages is up-regulated in poorly vascularized areas of breast carcinomas. J Pathol 192, 150-8 (2000).
-
(2000)
J Pathol
, vol.192
, pp. 150-158
-
-
Lewis, J.S.1
Landers, R.J.2
Underwood, J.C.3
Harris, A.L.4
Lewis, C.E.5
-
37
-
-
0141425768
-
Hypoxia-induced gene expression in human macrophages: Implications for ischemic tissues and hypoxia-regulated gene therapy
-
Burke, B. et al. Hypoxia-induced gene expression in human macrophages: implications for ischemic tissues and hypoxia-regulated gene therapy. Am J Pathol 163, 1233-43 (2003).
-
(2003)
Am J Pathol
, vol.163
, pp. 1233-1243
-
-
Burke, B.1
-
38
-
-
33645991795
-
Tumour-associated macrophages are a distinct M2 polarised population promoting tumour progression: Potential targets of anti-cancer therapy
-
Sica, A., Schioppa, T., Mantovani, A. & Allavena, P. Tumour-associated macrophages are a distinct M2 polarised population promoting tumour progression: potential targets of anti-cancer therapy. Eur J Cancer 42, 717-27 (2006).
-
(2006)
Eur J Cancer
, vol.42
, pp. 717-727
-
-
Sica, A.1
Schioppa, T.2
Mantovani, A.3
Allavena, P.4
-
39
-
-
0003090004
-
-
(ed. Bicknell R, L. C.) Oxford University Press
-
Leek, R. D., Lewis, C. E. & Harris, A. L. The role of macrophages in tumour angiogenesis (ed. Bicknell R, L. C.) (Oxford University Press, 1997).
-
(1997)
The Role of Macrophages in Tumour Angiogenesis
-
-
Leek, R.D.1
Lewis, C.E.2
Harris, A.L.3
-
40
-
-
0033870281
-
The expression and distribution of the hypoxia-inducible factors HIF-1alpha and HIF-2alpha in normal human tissues, cancers, and tumor-associated macrophages
-
Talks, K. L. et al. The expression and distribution of the hypoxia-inducible factors HIF-1alpha and HIF-2alpha in normal human tissues, cancers, and tumor-associated macrophages. Am J Pathol 157, 411-21 (2000).
-
(2000)
Am J Pathol
, vol.157
, pp. 411-421
-
-
Talks, K.L.1
-
41
-
-
0034676331
-
Up-regulation of hypoxia-inducible factors HIF-1alpha and HIF-2alpha under normoxic conditions in renal carcinoma cells by von hippel-lindau tumor suppressor gene loss of function
-
Krieg, M. et al. Up-regulation of hypoxia-inducible factors HIF-1alpha and HIF-2alpha under normoxic conditions in renal carcinoma cells by von Hippel-Lindau tumor suppressor gene loss of function. Oncogene 19, 5435-43 (2000).
-
(2000)
Oncogene
, vol.19
, pp. 5435-5443
-
-
Krieg, M.1
-
42
-
-
0034671307
-
Hypoxia-inducible expression of tumor-associated carbonic anhydrases
-
Wykoff, C. C. et al. Hypoxia-inducible expression of tumor-associated carbonic anhydrases. Cancer Res 60, 7075-83 (2000).
-
(2000)
Cancer Res
, vol.60
, pp. 7075-7083
-
-
Wykoff, C.C.1
-
43
-
-
0033587146
-
The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis
-
Maxwell, P. H. et al. The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis. Nature 399, 271-5 (1999).
-
(1999)
Nature
, vol.399
, pp. 271-275
-
-
Maxwell, P.H.1
-
44
-
-
0033954247
-
Regulation of tumor angiogenesis by p53-induced degradation of hypoxia-inducible factor 1alpha
-
Ravi, R. et al. Regulation of tumor angiogenesis by p53-induced degradation of hypoxia-inducible factor 1alpha. Genes Dev 14, 34-44 (2000).
-
(2000)
Genes Dev
, vol.14
, pp. 34-44
-
-
Ravi, R.1
-
45
-
-
0034050050
-
Loss of PTEN facilitates HIF-1-mediated gene expression
-
Zundel, W. et al. Loss of PTEN facilitates HIF-1-mediated gene expression. Genes Dev 14, 391-6 (2000).
-
(2000)
Genes Dev
, vol.14
, pp. 391-396
-
-
Zundel, W.1
-
46
-
-
0041382820
-
The hypoxic response of tumors is dependent on their microenvironment
-
Blouw, B. et al. The hypoxic response of tumors is dependent on their microenvironment. Cancer Cell 4, 133-46 (2003).
-
(2003)
Cancer Cell
, vol.4
, pp. 133-146
-
-
Blouw, B.1
-
47
-
-
10444223878
-
The hypoxia-inducible factor and tumor progression along the angiogenic pathway
-
Brahimi-Horn, M. C. & Pouyssegur, J. The hypoxia-inducible factor and tumor progression along the angiogenic pathway. Int Rev Cytol 242, 157-213 (2005).
-
(2005)
Int Rev Cytol
, vol.242
, pp. 157-213
-
-
Brahimi-Horn, M.C.1
Pouyssegur, J.2
-
48
-
-
0036216692
-
HIF-1 and tumor progression: Pathophysiology and therapeutics
-
Semenza, G. L. HIF-1 and tumor progression: pathophysiology and therapeutics. Trends Mol Med 8, S62-7 (2002).
-
(2002)
Trends Mol Med
, vol.8
-
-
Semenza, G.L.1
-
49
-
-
1542314896
-
Expression of HIF-2alpha/EPAS1 in hepatocellular carcinoma
-
Bangoura, G., Yang, L. Y., Huang, G. W. & Wang, W. Expression of HIF-2alpha/EPAS1 in hepatocellular carcinoma. World J Gastroenterol 10, 525-30 (2004).
-
(2004)
World J Gastroenterol
, vol.10
, pp. 525-530
-
-
Bangoura, G.1
Yang, L.Y.2
Huang, G.W.3
Wang, W.4
-
50
-
-
17044452288
-
HIF activation identifies early lesions in VHL kidneys: Evidence for site-specific tumor suppressor function in the nephron
-
Mandriota, S. J. et al. HIF activation identifies early lesions in VHL kidneys: evidence for site-specific tumor suppressor function in the nephron. Cancer Cell 1, 459-68 (2002).
-
(2002)
Cancer Cell
, vol.1
, pp. 459-468
-
-
Mandriota, S.J.1
-
51
-
-
0034529914
-
Suppression of tumor growth through disruption of hypoxia-inducible transcription
-
Kung, A. L., Wang, S., Klco, J. M., Kaelin, W. G. & Livingston, D. M. Suppression of tumor growth through disruption of hypoxia-inducible transcription. Nat Med 6, 1335-40 (2000).
-
(2000)
Nat Med
, vol.6
, pp. 1335-1340
-
-
Kung, A.L.1
Wang, S.2
Klco, J.M.3
Kaelin, W.G.4
Livingston, D.M.5
-
52
-
-
0030816109
-
Hypoxia-inducible factor-1 modulates gene expression in solid tumors and influences both angiogenesis and tumor growth
-
Maxwell, P. H. et al. Hypoxia-inducible factor-1 modulates gene expression in solid tumors and influences both angiogenesis and tumor growth. Proc Natl Acad Sci USA 94, 8104-9 (1997).
-
(1997)
Proc Natl Acad Sci USA
, vol.94
, pp. 8104-8109
-
-
Maxwell, P.H.1
-
53
-
-
2942707871
-
Hypoxia-inducible factor 1alpha/vascu-lar endothelial growth factor axis in astrocytomas. Associations with microvessel morphometry, proliferation and prognosis
-
Korkolopoulou, P. et al. Hypoxia-inducible factor 1alpha/vascu-lar endothelial growth factor axis in astrocytomas. Associations with microvessel morphometry, proliferation and prognosis. Neuropathol Appl Neurobiol 30, 267-78 (2004).
-
(2004)
Neuropathol Appl Neurobiol
, vol.30
, pp. 267-278
-
-
Korkolopoulou, P.1
-
54
-
-
0036278899
-
Overexpression of hypoxia-inducible factor 1alpha is associated with an unfavorable prognosis in lymph node-positive breast cancer
-
Schindl, M. et al. Overexpression of hypoxia-inducible factor 1alpha is associated with an unfavorable prognosis in lymph node-positive breast cancer. Clin Cancer Res 8, 1831-7 (2002).
-
(2002)
Clin Cancer Res
, vol.8
, pp. 1831-1837
-
-
Schindl, M.1
-
55
-
-
3142534607
-
Hypoxia-inducible factor 1 alpha expression correlates with angiogenesis and unfavorable prognosis in bladder cancer
-
Theodoropoulos, V. E. et al. Hypoxia-inducible factor 1 alpha expression correlates with angiogenesis and unfavorable prognosis in bladder cancer. Eur Urol 46, 200-8 (2004).
-
(2004)
Eur Urol
, vol.46
, pp. 200-208
-
-
Theodoropoulos, V.E.1
-
56
-
-
0034896068
-
Expression of hypoxia-inducible factor 1alpha in epithelial ovarian tumors: Its impact on prognosis and on response to chemotherapy
-
Birner, P., Schindl, M., Obermair, A., Breitenecker, G. & Oberhuber, G. Expression of hypoxia-inducible factor 1alpha in epithelial ovarian tumors: its impact on prognosis and on response to chemotherapy. Clin Cancer Res 7, 1661-8 (2001).
-
(2001)
Clin Cancer Res
, vol.7
, pp. 1661-1668
-
-
Birner, P.1
Schindl, M.2
Obermair, A.3
Breitenecker, G.4
Oberhuber, G.5
-
57
-
-
0034282518
-
Overexpression of hypoxia-inducible factor 1alpha is a marker for an unfavorable prognosis in early-stage invasive cervical cancer
-
Birner, P. et al. Overexpression of hypoxia-inducible factor 1alpha is a marker for an unfavorable prognosis in early-stage invasive cervical cancer. Cancer Res 60, 4693-6 (2000).
-
(2000)
Cancer Res
, vol.60
, pp. 4693-4696
-
-
Birner, P.1
-
58
-
-
12944266844
-
The expression of hypoxia-inducible factor 1alpha is a favorable independent prognostic factor in renal cell carcinoma
-
Lidgren, A. et al. The expression of hypoxia-inducible factor 1alpha is a favorable independent prognostic factor in renal cell carcinoma. Clin Cancer Res 11, 1129-35 (2005).
-
(2005)
Clin Cancer Res
, vol.11
, pp. 1129-1135
-
-
Lidgren, A.1
-
59
-
-
0037531790
-
DEC1 (STRA13) protein expression relates to hypoxia-inducible factor 1-alpha and carbonic anhy-drase-9 overexpression in non-small cell lung cancer
-
Giatromanolaki, A. et al. DEC1 (STRA13) protein expression relates to hypoxia-inducible factor 1-alpha and carbonic anhy-drase-9 overexpression in non-small cell lung cancer. J Pathol 200, 222-8 (2003).
-
(2003)
J Pathol
, vol.200
, pp. 222-228
-
-
Giatromanolaki, A.1
-
60
-
-
0035860147
-
Relation of hypoxia inducible factor 1 alpha and 2 alpha in operable non-small cell lung cancer to angiogenic/molecular profile of tumours and survival
-
Giatromanolaki, A. et al. Relation of hypoxia inducible factor 1 alpha and 2 alpha in operable non-small cell lung cancer to angiogenic/molecular profile of tumours and survival. Br J Cancer 85, 881-90 (2001).
-
(2001)
Br J Cancer
, vol.85
, pp. 881-890
-
-
Giatromanolaki, A.1
-
61
-
-
23744479831
-
Expression of HIF-1alpha, CA IX, VEGF, and MMP-9 in surgically resected non-small cell lung cancer
-
Kim, S. J. et al. Expression of HIF-1alpha, CA IX, VEGF, and MMP-9 in surgically resected non-small cell lung cancer. Lung Cancer 49, 325-35 (2005).
-
(2005)
Lung Cancer
, vol.49
, pp. 325-335
-
-
Kim, S.J.1
-
62
-
-
0342433777
-
Hypoxia-inducible factor (HIF-1) and its relationship to apoptosis and proliferation in lung cancer
-
Volm, M. & Koomagi, R. Hypoxia-inducible factor (HIF-1) and its relationship to apoptosis and proliferation in lung cancer. Anticancer Res 20, 1527-33 (2000).
-
(2000)
Anticancer Res
, vol.20
, pp. 1527-1533
-
-
Volm, M.1
Koomagi, R.2
-
63
-
-
0036680153
-
Hypoxia-inducible factor (HIF1A and HIF2A), angiogenesis, and chemoradiotherapy outcome of squa-mous cell head-and-neck cancer
-
Koukourakis, M. I. et al. Hypoxia-inducible factor (HIF1A and HIF2A), angiogenesis, and chemoradiotherapy outcome of squa-mous cell head-and-neck cancer. Int J Radiat Oncol Biol Phys 53, 1192-202 (2002).
-
(2002)
Int J Radiat Oncol Biol Phys
, vol.53
, pp. 1192-1202
-
-
Koukourakis, M.I.1
-
64
-
-
33748037026
-
Hypoxia-inducible factor-1alpha expression predicts a poor response to primary chemoendocrine therapy and disease-free survival in primary human breast cancer
-
Generali, D. et al. Hypoxia-inducible factor-1alpha expression predicts a poor response to primary chemoendocrine therapy and disease-free survival in primary human breast cancer. Clin Cancer Res 12, 4562-8 (2006).
-
(2006)
Clin Cancer Res
, vol.12
, pp. 4562-4568
-
-
Generali, D.1
-
65
-
-
33644849887
-
Endogenous markers of two separate hypoxia response pathways (hypoxia inducible factor 2 alpha and carbonic anhydrase 9) are associated with radiotherapy failure in head and neck cancer patients recruited in the CHART randomized trial
-
Koukourakis, M. I. et al. Endogenous markers of two separate hypoxia response pathways (hypoxia inducible factor 2 alpha and carbonic anhydrase 9) are associated with radiotherapy failure in head and neck cancer patients recruited in the CHART randomized trial. J Clin Oncol 24, 727-35 (2006).
-
(2006)
J Clin Oncol
, vol.24
, pp. 727-735
-
-
Koukourakis, M.I.1
-
66
-
-
0035266307
-
Hypoxia inducible factor (HIF-1a and HIF-2a) expression in early esophageal cancer and response to photodynamic therapy and radiotherapy
-
Koukourakis, M. I. et al. Hypoxia inducible factor (HIF-1a and HIF-2a) expression in early esophageal cancer and response to photodynamic therapy and radiotherapy. Cancer Res 61, 1830-2 (2001).
-
(2001)
Cancer Res
, vol.61
, pp. 1830-1832
-
-
Koukourakis, M.I.1
-
67
-
-
27644561755
-
Hypoxia requires notch signaling to maintain the undifferentiated cell state
-
Gustafsson, M. V. et al. Hypoxia requires notch signaling to maintain the undifferentiated cell state. Dev Cell 9, 617-28 (2005).
-
(2005)
Dev Cell
, vol.9
, pp. 617-628
-
-
Gustafsson, M.V.1
-
68
-
-
3142631736
-
HIF-1alpha induces cell cycle arrest by functionally counteracting myc
-
Koshiji, M. et al. HIF-1alpha induces cell cycle arrest by functionally counteracting Myc. Embo J 23, 1949-56 (2004).
-
(2004)
Embo J
, vol.23
, pp. 1949-1956
-
-
Koshiji, M.1
-
69
-
-
33751192872
-
Regulation of angiogenesis by hypoxia and hypoxia-inducible factors
-
Hickey, M. M. & Simon, M. C. Regulation of angiogenesis by hypoxia and hypoxia-inducible factors. Curr Top Dev Biol 76, 217-57 (2006).
-
(2006)
Curr Top Dev Biol
, vol.76
, pp. 217-257
-
-
Hickey, M.M.1
Simon, M.C.2
-
70
-
-
0032953340
-
What guides early embryonic blood vessel formation?
-
Weinstein, B. M. What guides early embryonic blood vessel formation? Dev Dyn 215, 2-11 (1999).
-
(1999)
Dev Dyn
, vol.215
, pp. 2-11
-
-
Weinstein, B.M.1
-
71
-
-
0029103274
-
Hypoxia regulates vascular endothelial growth factor gene expression in endo-thelial cells. Identification of a 5' enhancer
-
Liu, Y., Cox, S. R., Morita, T. & Kourembanas, S. Hypoxia regulates vascular endothelial growth factor gene expression in endo-thelial cells. Identification of a 5' enhancer. Circ Res 77, 638-43 (1995).
-
(1995)
Circ Res
, vol.77
, pp. 638-643
-
-
Liu, Y.1
Cox, S.R.2
Morita, T.3
Kourembanas, S.4
-
72
-
-
0029761644
-
Activation of vascular endothelial growth factor gene transcription by hypoxia-inducible factor 1
-
Forsythe, J. A. et al. Activation of vascular endothelial growth factor gene transcription by hypoxia-inducible factor 1. Mol Cell Biol 16, 4604-13 (1996).
-
(1996)
Mol Cell Biol
, vol.16
, pp. 4604-4613
-
-
Forsythe, J.A.1
-
73
-
-
0030751493
-
Differential transcriptional regulation of the two vascular endothelial growth factor receptor genes. Flt-1, but not flk-1/KDR, is up-regulated by hypoxia
-
Gerber, H. P., Condorelli, F., Park, J. & Ferrara, N. Differential transcriptional regulation of the two vascular endothelial growth factor receptor genes. Flt-1, but not Flk-1/KDR, is up-regulated by hypoxia. J Biol Chem 272, 23659-67 (1997).
-
(1997)
J Biol Chem
, vol.272
, pp. 23659-23667
-
-
Gerber, H.P.1
Condorelli, F.2
Park, J.3
Ferrara, N.4
-
74
-
-
0032513043
-
Hypoxic stabilization of vascular endothelial growth factor mRNA by the RNA-binding protein HuR
-
Levy, N. S., Chung, S., Furneaux, H. & Levy, A. P. Hypoxic stabilization of vascular endothelial growth factor mRNA by the RNA-binding protein HuR. J Biol Chem 273, 6417-23 (1998).
-
(1998)
J Biol Chem
, vol.273
, pp. 6417-6423
-
-
Levy, N.S.1
Chung, S.2
Furneaux, H.3
Levy, A.P.4
-
75
-
-
0031869662
-
Translation of vascular endothelial growth factor mRNA by internal ribosome entry: Implications for translation under hypoxia
-
Stein, I. et al. Translation of vascular endothelial growth factor mRNA by internal ribosome entry: implications for translation under hypoxia. Mol Cell Biol 18, 3112-9 (1998).
-
(1998)
Mol Cell Biol
, vol.18
, pp. 3112-3119
-
-
Stein, I.1
-
76
-
-
30644461078
-
Adrenomedullin and tumour angiogenesis
-
Nikitenko, L. L., Fox, S. B., Kehoe, S., Rees, M. C. & Bicknell, R. Adrenomedullin and tumour angiogenesis. Br J Cancer 94, 1-7 (2006).
-
(2006)
Br J Cancer
, vol.94
, pp. 1-7
-
-
Nikitenko, L.L.1
Fox, S.B.2
Kehoe, S.3
Rees, M.C.4
Bicknell, R.5
-
77
-
-
17744366566
-
Hypoxia-inducible factor-1 (HIF-1) up-regu-lates adrenomedullin expression in human tumor cell lines during oxygen deprivation: A possible promotion mechanism of carcinogenesis
-
Garayoa, M. et al. Hypoxia-inducible factor-1 (HIF-1) up-regu-lates adrenomedullin expression in human tumor cell lines during oxygen deprivation: a possible promotion mechanism of carcinogenesis. Mol Endocrinol 14, 848-62 (2000).
-
(2000)
Mol Endocrinol
, vol.14
, pp. 848-862
-
-
Garayoa, M.1
-
78
-
-
8644229386
-
Hypoxic induction of ctgf is directly mediated by hif-1
-
Higgins, D. F. et al. Hypoxic induction of Ctgf is directly mediated by Hif-1. Am J Physiol Renal Physiol 287, F1223-32 (2004).
-
(2004)
Am J Physiol Renal Physiol
, vol.287
-
-
Higgins, D.F.1
-
79
-
-
0032576971
-
Hypoxia regulates expression of the endothelin-1 gene through a proximal hypoxia-inducible factor-1 binding site on the antisense strand
-
Hu, J., Discher, D. J., Bishopric, N. H. & Webster, K. A. Hypoxia regulates expression of the endothelin-1 gene through a proximal hypoxia-inducible factor-1 binding site on the antisense strand. Biochem Biophys Res Commun 245, 894-9 (1998).
-
(1998)
Biochem Biophys Res Commun
, vol.245
, pp. 894-899
-
-
Hu, J.1
Discher, D.J.2
Bishopric, N.H.3
Webster, K.A.4
-
80
-
-
0038380366
-
Endothelin-2 is a hypoxia-induced autocrine survival factor for breast tumor cells
-
Grimshaw, M. J., Naylor, S. & Balkwill, F. R. Endothelin-2 is a hypoxia-induced autocrine survival factor for breast tumor cells. Mol Cancer Ther 1, 1273-81 (2002).
-
(2002)
Mol Cancer Ther
, vol.1
, pp. 1273-1281
-
-
Grimshaw, M.J.1
Naylor, S.2
Balkwill, F.R.3
-
81
-
-
0037467569
-
Endothelin-1: A multifunctional molecule in cancer
-
Grant, K., Loizidou, M. & Taylor, I. Endothelin-1: a multifunctional molecule in cancer. Br J Cancer 88, 163-6 (2003).
-
(2003)
Br J Cancer
, vol.88
, pp. 163-166
-
-
Grant, K.1
Loizidou, M.2
Taylor, I.3
-
82
-
-
1942538390
-
A role for endothelin-2 and its receptors in breast tumor cell invasion
-
Grimshaw, M. J. et al. A role for endothelin-2 and its receptors in breast tumor cell invasion. Cancer Res 64, 2461-8 (2004).
-
(2004)
Cancer Res
, vol.64
, pp. 2461-2468
-
-
Grimshaw, M.J.1
-
83
-
-
14944348618
-
Role of NF-kappaB signaling in hepatocyte growth factor/scatter factor-mediated cell protection
-
Fan, S. et al. Role of NF-kappaB signaling in hepatocyte growth factor/scatter factor-mediated cell protection. Oncogene 24, 1749-66 (2005).
-
(2005)
Oncogene
, vol.24
, pp. 1749-1766
-
-
Fan, S.1
-
84
-
-
8844286064
-
Hepatocyte growth factor-activated NF-kappaB regulates HIF-1 activity and ODC expression, implicated in survival, differently in different carcinoma cell lines
-
Tacchini, L., De Ponti, C., Matteucci, E., Follis, R. & Desiderio, M. A. Hepatocyte growth factor-activated NF-kappaB regulates HIF-1 activity and ODC expression, implicated in survival, differently in different carcinoma cell lines. Carcinogenesis 25, 2089-100 (2004).
-
(2004)
Carcinogenesis
, vol.25
, pp. 2089-2100
-
-
Tacchini, L.1
De Ponti, C.2
Matteucci, E.3
Follis, R.4
Desiderio, M.A.5
-
85
-
-
33847276194
-
HGF induces CXCR4 and CXCL12-mediated tumor invasion through ets1 and NF-{kappa}B
-
Maroni, P., Bendinelli, P., Matteucci, E. & Desiderio, M. A. HGF induces CXCR4 and CXCL12-mediated tumor invasion through Ets1 and NF-{kappa}B. Carcinogenesis 28, 267-79 (2007).
-
(2007)
Carcinogenesis
, vol.28
, pp. 267-279
-
-
Maroni, P.1
Bendinelli, P.2
Matteucci, E.3
Desiderio, M.A.4
-
86
-
-
0037478437
-
Hypoxia promotes invasive growth by transcriptional activation of the met protooncogene
-
Pennacchietti, S. et al. Hypoxia promotes invasive growth by transcriptional activation of the met protooncogene. Cancer Cell 3, 347-61 (2003).
-
(2003)
Cancer Cell
, vol.3
, pp. 347-361
-
-
Pennacchietti, S.1
-
87
-
-
33745354482
-
Hypoxia enhances c-met/HGF receptor expression and signaling by activating HIF-1alpha in human salivary gland cancer cells
-
Hara, S. et al. Hypoxia enhances c-Met/HGF receptor expression and signaling by activating HIF-1alpha in human salivary gland cancer cells. Oral Oncol 42, 593-8 (2006).
-
(2006)
Oral Oncol
, vol.42
, pp. 593-598
-
-
Hara, S.1
-
88
-
-
0037816586
-
Nuclear factor-kappaB mediates angiogen-esis and metastasis of human bladder cancer through the regulation of interleukin-8
-
Karashima, T. et al. Nuclear factor-kappaB mediates angiogen-esis and metastasis of human bladder cancer through the regulation of interleukin-8. Clin Cancer Res 9, 2786-97 (2003).
-
(2003)
Clin Cancer Res
, vol.9
, pp. 2786-2797
-
-
Karashima, T.1
-
89
-
-
33750802140
-
A novel role of hypoxia-inducible factor in cobalt chloride-and hypoxia-mediated expression of IL-8 chemokine in human endothelial cells
-
Kim, K. S., Rajagopal, V., Gonsalves, C., Johnson, C. & Kalra, V. K. A novel role of hypoxia-inducible factor in cobalt chloride-and hypoxia-mediated expression of IL-8 chemokine in human endothelial cells. J Immunol 177, 7211-24 (2006).
-
(2006)
J Immunol
, vol.177
, pp. 7211-7224
-
-
Kim, K.S.1
Rajagopal, V.2
Gonsalves, C.3
Johnson, C.4
Kalra, V.K.5
-
90
-
-
33646471404
-
Hypoxia-regulated differentiation: Let's step it up a notch
-
Sainson, R. C. & Harris, A. L. Hypoxia-regulated differentiation: let's step it up a Notch. Trends Mol Med 12, 141-3 (2006).
-
(2006)
Trends Mol Med
, vol.12
, pp. 141-143
-
-
Sainson, R.C.1
Harris, A.L.2
-
91
-
-
33748155240
-
Notch signaling in breast cancer and tumor angiogenesis: Cross-talk and therapeutic potentials
-
Shi, W. & Harris, A. L. Notch signaling in breast cancer and tumor angiogenesis: cross-talk and therapeutic potentials. J Mammary Gland Biol Neoplasia 11, 41-52 (2006).
-
(2006)
J Mammary Gland Biol Neoplasia
, vol.11
, pp. 41-52
-
-
Shi, W.1
Harris, A.L.2
-
92
-
-
2942511574
-
Role of osteopontin in tumour progression
-
Rittling, S. R. & Chambers, A. F. Role of osteopontin in tumour progression. Br J Cancer 90, 1877-81 (2004).
-
(2004)
Br J Cancer
, vol.90
, pp. 1877-1881
-
-
Rittling, S.R.1
Chambers, A.F.2
-
93
-
-
26944478634
-
Hypoxia upregulates osteopontin expression in NIH-3T3 cells via a ras-activated enhancer
-
Zhu, Y. et al. Hypoxia upregulates osteopontin expression in NIH-3T3 cells via a Ras-activated enhancer. Oncogene 24, 6555-63 (2005).
-
(2005)
Oncogene
, vol.24
, pp. 6555-6563
-
-
Zhu, Y.1
-
94
-
-
12244267969
-
Identification of osteopontin as a prognostic plasma marker for head and neck squamous cell carcinomas
-
Le, Q. T. et al. Identification of osteopontin as a prognostic plasma marker for head and neck squamous cell carcinomas. Clin Cancer Res 9, 59-67 (2003).
-
(2003)
Clin Cancer Res
, vol.9
, pp. 59-67
-
-
Le, Q.T.1
-
95
-
-
10744219598
-
Regulation of the chemokine receptor CXCR4 by hypoxia
-
Schioppa, T. et al. Regulation of the chemokine receptor CXCR4 by hypoxia. J Exp Med 198, 1391-402 (2003).
-
(2003)
J Exp Med
, vol.198
, pp. 1391-1402
-
-
Schioppa, T.1
-
96
-
-
4043184065
-
Progenitor cell trafficking is regulated by hypoxic gradients through HIF-1 induction of SDF-1
-
Ceradini, D. J. et al. Progenitor cell trafficking is regulated by hypoxic gradients through HIF-1 induction of SDF-1. Nat Med 10, 858-64 (2004).
-
(2004)
Nat Med
, vol.10
, pp. 858-864
-
-
Ceradini, D.J.1
-
97
-
-
6344282203
-
Characterization of stanniocalcin 2, a novel target of the mammalian unfolded protein response with cytoprotective properties
-
Ito, D. et al. Characterization of stanniocalcin 2, a novel target of the mammalian unfolded protein response with cytoprotective properties. Mol Cell Biol 24, 9456-69 (2004).
-
(2004)
Mol Cell Biol
, vol.24
, pp. 9456-9469
-
-
Ito, D.1
-
98
-
-
26844510900
-
Hypoxia-inducible factor-1-mediated activation of stanniocalcin-1 in human cancer cells
-
Yeung, H. Y. et al. Hypoxia-inducible factor-1-mediated activation of stanniocalcin-1 in human cancer cells. Endocrinology 146, 4951-60 (2005).
-
(2005)
Endocrinology
, vol.146
, pp. 4951-4960
-
-
Yeung, H.Y.1
-
99
-
-
0035812284
-
Transcriptional response to hypoxia in human tumors
-
Lal, A. et al. Transcriptional response to hypoxia in human tumors. J Natl Cancer Inst 93, 1337-43 (2001).
-
(2001)
J Natl Cancer Inst
, vol.93
, pp. 1337-1343
-
-
Lal, A.1
-
100
-
-
0346500512
-
A cross-talk between hypoxia and TGF-beta orchestrates erythropoietin gene regulation through SP1 and smads
-
Sanchez-Elsner, T. et al. A cross-talk between hypoxia and TGF-beta orchestrates erythropoietin gene regulation through SP1 and Smads. J Mol Biol 336, 9-24 (2004).
-
(2004)
J Mol Biol
, vol.336
, pp. 9-24
-
-
Sanchez-Elsner, T.1
-
101
-
-
0142243186
-
Oxygen-regulated expression of TGF-beta 3, a growth factor involved in trophoblast differentiation
-
Schaffer, L. et al. Oxygen-regulated expression of TGF-beta 3, a growth factor involved in trophoblast differentiation. Placenta 24, 941-50 (2003).
-
(2003)
Placenta
, vol.24
, pp. 941-950
-
-
Schaffer, L.1
-
102
-
-
0035318510
-
Tie receptors: New modulators of angiogenic and lymphangiogenic responses
-
Jones, N., Iljin, K., Dumont, D. J. & Alitalo, K. Tie receptors: new modulators of angiogenic and lymphangiogenic responses. Nat Rev Mol Cell Biol 2, 257-67 (2001).
-
(2001)
Nat Rev Mol Cell Biol
, vol.2
, pp. 257-267
-
-
Jones, N.1
Iljin, K.2
Dumont, D.J.3
Alitalo, K.4
-
103
-
-
0141640863
-
Hypoxia-inducible factor-1 mediates activation of cultured vascular endothelial cells by inducing multiple angiogenic factors
-
Yamakawa, M. et al. Hypoxia-inducible factor-1 mediates activation of cultured vascular endothelial cells by inducing multiple angiogenic factors. Circ Res 93, 664-73 (2003).
-
(2003)
Circ Res
, vol.93
, pp. 664-673
-
-
Yamakawa, M.1
-
104
-
-
33749452709
-
Tenascin-C induced signaling in cancer
-
Orend, G. & Chiquet-Ehrismann, R. Tenascin-C induced signaling in cancer. Cancer Lett 244, 143-63 (2006).
-
(2006)
Cancer Lett
, vol.244
, pp. 143-163
-
-
Orend, G.1
Chiquet-Ehrismann, R.2
-
105
-
-
0000655498
-
Identification of a hypoxia response element in the transferrin receptor gene
-
Lok, C. N. & Ponka, P. Identification of a hypoxia response element in the transferrin receptor gene. J Biol Chem 274, 24147-52 (1999).
-
(1999)
J Biol Chem
, vol.274
, pp. 24147-24152
-
-
Lok, C.N.1
Ponka, P.2
-
106
-
-
33645066360
-
Effects of transferrin receptor blockade on cancer cell proliferation and hypoxia-inducible factor function and their differential regulation by ascorbate
-
Jones, D. T., Trowbridge, I. S. & Harris, A. L. Effects of transferrin receptor blockade on cancer cell proliferation and hypoxia-inducible factor function and their differential regulation by ascorbate. Cancer Res 66, 2749-56 (2006).
-
(2006)
Cancer Res
, vol.66
, pp. 2749-2756
-
-
Jones, D.T.1
Trowbridge, I.S.2
Harris, A.L.3
-
107
-
-
33644770260
-
Adenosine receptors as therapeutic targets
-
Jacobson, K. A. & Gao, Z. G. Adenosine receptors as therapeutic targets. Nat Rev Drug Discov 5, 247-64 (2006).
-
(2006)
Nat Rev Drug Discov
, vol.5
, pp. 247-264
-
-
Jacobson, K.A.1
Gao, Z.G.2
-
108
-
-
33845604971
-
HIF-dependent induction of adenosine A2B receptor in hypoxia
-
Kong, T., Westerman, K. A., Faigle, M., Eltzschig, H. K. & Colgan, S. P. HIF-dependent induction of adenosine A2B receptor in hypoxia. Faseb J 20, 2242-50 (2006).
-
(2006)
Faseb J
, vol.20
, pp. 2242-2250
-
-
Kong, T.1
Westerman, K.A.2
Faigle, M.3
Eltzschig, H.K.4
Colgan, S.P.5
-
109
-
-
0024371490
-
Cancer risk in relation to serum copper levels
-
Coates, R. J., Weiss, N. S., Daling, J. R., Rettmer, R. L. & Warnick, G. R. Cancer risk in relation to serum copper levels. Cancer Res 49, 4353-6 (1989).
-
(1989)
Cancer Res
, vol.49
, pp. 4353-4356
-
-
Coates, R.J.1
Weiss, N.S.2
Daling, J.R.3
Rettmer, R.L.4
Warnick, G.R.5
-
110
-
-
20444412608
-
Copper-dependent activation of hypoxia-inducible factor (HIF)-1: Implications for ceruloplasmin regulation
-
Martin, F. et al. Copper-dependent activation of hypoxia-inducible factor (HIF)-1: implications for ceruloplasmin regulation. Blood 105, 4613-9 (2005).
-
(2005)
Blood
, vol.105
, pp. 4613-4619
-
-
Martin, F.1
-
112
-
-
0033566693
-
Reciprocal positive regulation of hypoxia-inducible factor 1alpha and insulin-like growth factor 2
-
Feldser, D. et al. Reciprocal positive regulation of hypoxia-inducible factor 1alpha and insulin-like growth factor 2. Cancer Res 59, 3915-8 (1999).
-
(1999)
Cancer Res
, vol.59
, pp. 3915-3918
-
-
Feldser, D.1
-
113
-
-
33751280734
-
Lysyl oxidase mediates hypoxic control of metastasis
-
Erler, J. T. & Giaccia, A. J. Lysyl oxidase mediates hypoxic control of metastasis. Cancer Res 66, 10238-41 (2006).
-
(2006)
Cancer Res
, vol.66
, pp. 10238-10241
-
-
Erler, J.T.1
Giaccia, A.J.2
-
114
-
-
33646365644
-
Lysyl oxidase is essential for hypoxia-induced metastasis
-
Erler, J. T. et al. Lysyl oxidase is essential for hypoxia-induced metastasis. Nature 440, 1222-6 (2006).
-
(2006)
Nature
, vol.440
, pp. 1222-1226
-
-
Erler, J.T.1
-
115
-
-
7444224685
-
Integrating the anti-VEGF-A humanized monoclonal antibody bevacizumab with chemotherapy in advanced colorectal cancer
-
Hurwitz, H. Integrating the anti-VEGF-A humanized monoclonal antibody bevacizumab with chemotherapy in advanced colorectal cancer. Clin Colorectal Cancer 4 Suppl 2, S62-8 (2004).
-
(2004)
Clin Colorectal Cancer
, vol.4
, Issue.SUPPL. 2
, pp. 62-68
-
-
Hurwitz, H.1
-
116
-
-
2542561964
-
Bevacizumab plus irinotecan, fluorouracil, and leucovorin for metastatic colorectal cancer
-
Hurwitz, H. et al. Bevacizumab plus irinotecan, fluorouracil, and leucovorin for metastatic colorectal cancer. N Engl J Med 350, 2335-42 (2004).
-
(2004)
N Engl J Med
, vol.350
, pp. 2335-2342
-
-
Hurwitz, H.1
-
117
-
-
20744451420
-
Bevacizumab extends survival for patients with nonsquamous non-small-cell lung cancer
-
Belani, C. P. & Ramalingam, S. Bevacizumab extends survival for patients with nonsquamous non-small-cell lung cancer. Clin Lung Cancer 6, 267-8 (2005).
-
(2005)
Clin Lung Cancer
, vol.6
, pp. 267-268
-
-
Belani, C.P.1
Ramalingam, S.2
-
118
-
-
17844379201
-
Bevacizumab and chemotherapy improves survival in NSCLC
-
Kerr, C. Bevacizumab and chemotherapy improves survival in NSCLC. Lancet Oncol 6, 266 (2005).
-
(2005)
Lancet Oncol
, vol.6
, pp. 266
-
-
Kerr, C.1
-
119
-
-
27144531609
-
Technology evaluation: Vegf trap (cancer), regeneron/sanofi-aventis
-
Lau, S. C., Rosa, D. D. & Jayson, G. Technology evaluation: VEGF Trap (cancer), Regeneron/sanofi-aventis. Curr Opin Mol Ther 7, 493-501 (2005).
-
(2005)
Curr Opin Mol Ther
, vol.7
, pp. 493-501
-
-
Lau, S.C.1
Rosa, D.D.2
Jayson, G.3
-
120
-
-
33846260566
-
Sorafenib for the treatment of advanced renal cell carcinoma
-
Kane, R. C. et al. Sorafenib for the treatment of advanced renal cell carcinoma. Clin Cancer Res 12, 7271-8 (2006).
-
(2006)
Clin Cancer Res
, vol.12
, pp. 7271-7278
-
-
Kane, R.C.1
-
121
-
-
0035003528
-
Gene transfer of antisense hypoxia inducible factor-1 alpha enhances the therapeutic efficacy of cancer immunotherapy
-
Sun, X. et al. Gene transfer of antisense hypoxia inducible factor-1 alpha enhances the therapeutic efficacy of cancer immunotherapy. Gene Ther 8, 638-45 (2001).
-
(2001)
Gene Ther
, vol.8
, pp. 638-645
-
-
Sun, X.1
-
122
-
-
33645026059
-
Overexpression of von hippel-lindau tumor suppressor protein and antisense HIF-1alpha eradicates gliomas
-
Sun, X. et al. Overexpression of von Hippel-Lindau tumor suppressor protein and antisense HIF-1alpha eradicates gliomas. Cancer Gene Ther 13, 428-35 (2006).
-
(2006)
Cancer Gene Ther
, vol.13
, pp. 428-435
-
-
Sun, X.1
-
123
-
-
23644453277
-
Pleiotropic effects of HIF-1 blockade on tumor radiosensitivity
-
Moeller, B. J. et al. Pleiotropic effects of HIF-1 blockade on tumor radiosensitivity. Cancer Cell 8, 99-110 (2005).
-
(2005)
Cancer Cell
, vol.8
, pp. 99-110
-
-
Moeller, B.J.1
-
124
-
-
0037414180
-
YC-1: A potential anticancer drug targeting hypoxia-inducible factor 1
-
Yeo, E. J. et al. YC-1: a potential anticancer drug targeting hypoxia-inducible factor 1. J Natl Cancer Inst 95, 516-25 (2003).
-
(2003)
J Natl Cancer Inst
, vol.95
, pp. 516-525
-
-
Yeo, E.J.1
-
125
-
-
33645786505
-
Development of novel therapeutic strategies that target HIF-1
-
Semenza, G. L. Development of novel therapeutic strategies that target HIF-1. Expert Opin Ther Targets 10, 267-80 (2006).
-
(2006)
Expert Opin Ther Targets
, vol.10
, pp. 267-280
-
-
Semenza, G.L.1
|