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Volumn 28, Issue 10, 2013, Pages 1415-1423

NLRP3 inflammasome and host protection against bacterial infection

Author keywords

Bacteria; Host defense; Infection; Inflammation; NLRP3 protein, human; Pathology

Indexed keywords

CARRIER PROTEIN; INFLAMMASOME; INTERLEUKIN 1BETA; INTERLEUKIN 1BETA CONVERTING ENZYME; NLRP3 PROTEIN, HUMAN;

EID: 84885705098     PISSN: 10118934     EISSN: 15986357     Source Type: Journal    
DOI: 10.3346/jkms.2013.28.10.1415     Document Type: Review
Times cited : (92)

References (71)
  • 1
    • 69949105157 scopus 로고    scopus 로고
    • The NLRP3 inflammasome: a sensor of immune danger signals
    • Cassel SL, Joly S, Sutterwala FS. The NLRP3 inflammasome: a sensor of immune danger signals. Semin Immunol 2009; 21: 194-8.
    • (2009) Semin Immunol , vol.21 , pp. 194-198
    • Cassel, S.L.1    Joly, S.2    Sutterwala, F.S.3
  • 2
    • 60749104683 scopus 로고    scopus 로고
    • The inflammasome: a caspase-1-activation platform that regulates immune responses and disease pathogenesis
    • Franchi L, Eigenbrod T, Muñoz-Planillo R, Nuñez G. The inflammasome: a caspase-1-activation platform that regulates immune responses and disease pathogenesis. Nat Immunol 2009; 10: 241-7.
    • (2009) Nat Immunol , vol.10 , pp. 241-247
    • Franchi, L.1    Eigenbrod, T.2    Muñoz-Planillo, R.3    Nuñez, G.4
  • 3
  • 4
    • 77249118801 scopus 로고    scopus 로고
    • The inflammasomes: mechanisms of activation and function
    • Latz E. The inflammasomes: mechanisms of activation and function. Curr Opin Immunol 2010; 22: 28-33.
    • (2010) Curr Opin Immunol , vol.22 , pp. 28-33
    • Latz, E.1
  • 5
    • 1642285783 scopus 로고    scopus 로고
    • NALP3 forms an IL-1beta-processing inflammasome with increased activity in Muckle-Wells autoinflammatory disorder
    • Agostini L, Martinon F, Burns K, McDermott MF, Hawkins PN, Tschopp J. NALP3 forms an IL-1beta-processing inflammasome with increased activity in Muckle-Wells autoinflammatory disorder. Immunity 2004; 20: 319-25.
    • (2004) Immunity , vol.20 , pp. 319-325
    • Agostini, L.1    Martinon, F.2    Burns, K.3    McDermott, M.F.4    Hawkins, P.N.5    Tschopp, J.6
  • 6
    • 58049202273 scopus 로고    scopus 로고
    • Inflammasomes: guardians of cytosolic sanctity
    • LamkanfiM, Dixit VM. Inflammasomes: guardians of cytosolic sanctity. Immunol Rev 2009; 227: 95-105.
    • (2009) Immunol Rev , vol.227 , pp. 95-105
    • Lamkanfi, M.1    Dixit, V.M.2
  • 7
    • 77649179433 scopus 로고    scopus 로고
    • NLRP3 inflammasome activation: the convergence of multiple signalling pathways on ROS production?
    • Tschopp J, Schroder K. NLRP3 inflammasome activation: the convergence of multiple signalling pathways on ROS production? Nat Rev Immunol 2010; 10: 210-5.
    • (2010) Nat Rev Immunol , vol.10 , pp. 210-215
    • Tschopp, J.1    Schroder, K.2
  • 8
    • 65549154784 scopus 로고    scopus 로고
    • An essential role for the NLRP3 inflammasome in host defense against the human fungal pathogen Candida albicans
    • Hise AG, Tomalka J, Ganesan S, Patel K, Hall BA, Brown GD, Fitzgerald KA. An essential role for the NLRP3 inflammasome in host defense against the human fungal pathogen Candida albicans. Cell Host Microbe 2009; 5: 487-97.
    • (2009) Cell Host Microbe , vol.5 , pp. 487-497
    • Hise, A.G.1    Tomalka, J.2    Ganesan, S.3    Patel, K.4    Hall, B.A.5    Brown, G.D.6    Fitzgerald, K.A.7
  • 9
    • 84866907391 scopus 로고    scopus 로고
    • The role of NLR-related protein 3 inflammasome in host defense and inflammatory diseases
    • Yang CS, Shin DM, Jo EK. The role of NLR-related protein 3 inflammasome in host defense and inflammatory diseases. Int Neurourol J 2012; 16: 2-12.
    • (2012) Int Neurourol J , vol.16 , pp. 2-12
    • Yang, C.S.1    Shin, D.M.2    Jo, E.K.3
  • 10
    • 80655144737 scopus 로고    scopus 로고
    • Crystal structure of NALP3 protein pyrin domain (PYD) and its implications in inflammasome assembly
    • Bae JY, Park HH. Crystal structure of NALP3 protein pyrin domain (PYD) and its implications in inflammasome assembly. J Biol Chem 2011; 286: 39528-36.
    • (2011) J Biol Chem , vol.286 , pp. 39528-39536
    • Bae, J.Y.1    Park, H.H.2
  • 11
    • 84871314266 scopus 로고    scopus 로고
    • Multiple binding sites on the pyrin domain of ASC protein allow self-association and interaction with NLRP3 protein
    • Vajjhala PR, Mirams RE, Hill JM. Multiple binding sites on the pyrin domain of ASC protein allow self-association and interaction with NLRP3 protein. J Biol Chem 2012; 287: 41732-43.
    • (2012) J Biol Chem , vol.287 , pp. 41732-41743
    • Vajjhala, P.R.1    Mirams, R.E.2    Hill, J.M.3
  • 12
    • 84874280249 scopus 로고    scopus 로고
    • ATP release and purinergic signaling in NLRP3 inflammasome activation
    • Gombault A, Baron L, Couillin I. ATP release and purinergic signaling in NLRP3 inflammasome activation. Front Immunol 2012; 3: 414.
    • (2012) Front Immunol , vol.3 , pp. 414
    • Gombault, A.1    Baron, L.2    Couillin, I.3
  • 13
    • 34047270416 scopus 로고    scopus 로고
    • Pannexin-1 couples to maitotoxin- and nigericin-induced interleukin-1beta release through a dye uptake-independent pathway
    • Pelegrin P, Surprenant A. Pannexin-1 couples to maitotoxin- and nigericin-induced interleukin-1beta release through a dye uptake-independent pathway. J Biol Chem 2007; 282: 2386-94.
    • (2007) J Biol Chem , vol.282 , pp. 2386-2394
    • Pelegrin, P.1    Surprenant, A.2
  • 19
    • 78651393239 scopus 로고    scopus 로고
    • A role for mitochondria in NLRP3 inflammasome activation
    • Zhou R, Yazdi AS, Menu P, Tschopp J. A role for mitochondria in NLRP3 inflammasome activation. Nature 2011; 469: 221-5.
    • (2011) Nature , vol.469 , pp. 221-225
    • Zhou, R.1    Yazdi, A.S.2    Menu, P.3    Tschopp, J.4
  • 20
    • 84876567161 scopus 로고    scopus 로고
    • Microtubule-driven spatial arrangement of mitochondria promotes activation of the NLRP3 inflammasome
    • Misawa T, Takahama M, Kozaki T, Lee H, Zou J, Saitoh T, Akira S. Microtubule-driven spatial arrangement of mitochondria promotes activation of the NLRP3 inflammasome. Nat Immunol 2013; 14: 454-60.
    • (2013) Nat Immunol , vol.14 , pp. 454-460
    • Misawa, T.1    Takahama, M.2    Kozaki, T.3    Lee, H.4    Zou, J.5    Saitoh, T.6    Akira, S.7
  • 21
    • 84876237736 scopus 로고    scopus 로고
    • The adaptor MAVS promotes NLRP3 mitochondrial localization and inflammasome activation
    • Subramanian N, Natarajan K, Clatworthy MR, Wang Z, Germain RN. The adaptor MAVS promotes NLRP3 mitochondrial localization and inflammasome activation. Cell 2013; 153: 348-61.
    • (2013) Cell , vol.153 , pp. 348-361
    • Subramanian, N.1    Natarajan, K.2    Clatworthy, M.R.3    Wang, Z.4    Germain, R.N.5
  • 23
    • 27144440476 scopus 로고    scopus 로고
    • Cardif is an adaptor protein in the RIG-I antiviral pathway and is targeted by hepatitis C virus
    • Meylan E, Curran J, Hofmann K, Moradpour D, Binder M, Bartenschlager R, Tschopp J. Cardif is an adaptor protein in the RIG-I antiviral pathway and is targeted by hepatitis C virus. Nature 2005; 437: 1167-72.
    • (2005) Nature , vol.437 , pp. 1167-1172
    • Meylan, E.1    Curran, J.2    Hofmann, K.3    Moradpour, D.4    Binder, M.5    Bartenschlager, R.6    Tschopp, J.7
  • 31
    • 84872617996 scopus 로고    scopus 로고
    • Microglial activation of the NLRP3 inflammasome by the priming signals derived from macrophages infected with mycobacteria
    • Lee HM, Kang J, Lee SJ, Jo EK. Microglial activation of the NLRP3 inflammasome by the priming signals derived from macrophages infected with mycobacteria. Glia 2013; 61: 441-52.
    • (2013) Glia , vol.61 , pp. 441-452
    • Lee, H.M.1    Kang, J.2    Lee, S.J.3    Jo, E.K.4
  • 32
    • 84862502510 scopus 로고    scopus 로고
    • Intracellular invasion of Orientia tsutsugamushi activates inflammasome in asc-dependent manner
    • Koo JE, Hong HJ, Dearth A, Kobayashi KS, Koh YS. Intracellular invasion of Orientia tsutsugamushi activates inflammasome in asc-dependent manner. PLoS One 2012; 7: e39042.
    • (2012) PLoS One , vol.7
    • Koo, J.E.1    Hong, H.J.2    Dearth, A.3    Kobayashi, K.S.4    Koh, Y.S.5
  • 33
    • 77954726266 scopus 로고    scopus 로고
    • Inflammation and fibrosis during Chlamydia pneumoniae infection is regulated by IL-1 and the NLRP3/ASC inflammasome
    • He X, Mekasha S, Mavrogiorgos N, Fitzgerald KA, Lien E, Ingalls RR. Inflammation and fibrosis during Chlamydia pneumoniae infection is regulated by IL-1 and the NLRP3/ASC inflammasome. J Immunol 2010; 184: 5743-54.
    • (2010) J Immunol , vol.184 , pp. 5743-5754
    • He, X.1    Mekasha, S.2    Mavrogiorgos, N.3    Fitzgerald, K.A.4    Lien, E.5    Ingalls, R.R.6
  • 34
    • 33748598700 scopus 로고    scopus 로고
    • Caspase-1 activation of lipid metabolic pathways in response to bacterial pore-forming toxins promotes cell survival
    • Gurcel L, Abrami L, Girardin S, Tschopp J, van der Goot FG. Caspase-1 activation of lipid metabolic pathways in response to bacterial pore-forming toxins promotes cell survival. Cell 2006; 126: 1135-45.
    • (2006) Cell , vol.126 , pp. 1135-1145
    • Gurcel, L.1    Abrami, L.2    Girardin, S.3    Tschopp, J.4    van der Goot, F.G.5
  • 39
    • 84861461121 scopus 로고    scopus 로고
    • Integrin a5ß1 activates the NLRP3 inflammasome by direct interaction with a bacterial surface protein
    • Jun HK, Lee SH, Lee HR, Choi BK. Integrin a5ß1 activates the NLRP3 inflammasome by direct interaction with a bacterial surface protein. Immunity 2012; 36: 755-68.
    • (2012) Immunity , vol.36 , pp. 755-768
    • Jun, H.K.1    Lee, S.H.2    Lee, H.R.3    Choi, B.K.4
  • 41
    • 79955776183 scopus 로고    scopus 로고
    • A Yersinia effector with enhanced inhibitory activity on the NF-?B pathway activates the NLRP3/ASC/caspase-1 inflammasome in macrophages
    • Zheng Y, Lilo S, Brodsky IE, Zhang Y, Medzhitov R, Marcu KB, Bliska JB. A Yersinia effector with enhanced inhibitory activity on the NF-?B pathway activates the NLRP3/ASC/caspase-1 inflammasome in macrophages. PLoS Pathog 2011; 7: e1002026.
    • (2011) PLoS Pathog , vol.7
    • Zheng, Y.1    Lilo, S.2    Brodsky, I.E.3    Zhang, Y.4    Medzhitov, R.5    Marcu, K.B.6    Bliska, J.B.7
  • 43
    • 84855272667 scopus 로고    scopus 로고
    • Inflammasome-dependent pyroptosis and IL-18 protect against Burkholderia pseudomallei lung infection while IL-1ß is deleterious
    • Ceballos-Olvera I, Sahoo M, Miller MA, Del Barrio L, Re F. Inflammasome-dependent pyroptosis and IL-18 protect against Burkholderia pseudomallei lung infection while IL-1ß is deleterious. PLoS Pathog 2011; 7: e1002452.
    • (2011) PLoS Pathog , vol.7
    • Ceballos-Olvera, I.1    Sahoo, M.2    Miller, M.A.3    Del Barrio, L.4    Re, F.5
  • 45
    • 77955390094 scopus 로고    scopus 로고
    • Redundant roles for inflammasome receptors NLRP3 and NLRC4 in host defense against Salmonella
    • Broz P, Newton K, LamkanfiM, Mariathasan S, Dixit VM, Monack DM. Redundant roles for inflammasome receptors NLRP3 and NLRC4 in host defense against Salmonella. J Exp Med 2010; 207: 1745-55.
    • (2010) J Exp Med , vol.207 , pp. 1745-1755
    • Broz, P.1    Newton, K.2    Lamkanfi, M.3    Mariathasan, S.4    Dixit, V.M.5    Monack, D.M.6
  • 51
    • 84866345786 scopus 로고    scopus 로고
    • A spatially-organized multicellular innate immune response in lymph nodes limits systemic pathogen spread
    • Kastenmüller W, Torabi-Parizi P, Subramanian N, Lämmermann T, Germain RN. A spatially-organized multicellular innate immune response in lymph nodes limits systemic pathogen spread. Cell 2012; 150: 1235-48.
    • (2012) Cell , vol.150 , pp. 1235-1248
    • Kastenmüller, W.1    Torabi-Parizi, P.2    Subramanian, N.3    Lämmermann, T.4    Germain, R.N.5
  • 52
    • 84873725252 scopus 로고    scopus 로고
    • Effects of differences in lipid A structure on TLR4 pro-inflammatory signaling and inflammasome activation
    • Chilton PM, Embry CA, Mitchell TC. Effects of differences in lipid A structure on TLR4 pro-inflammatory signaling and inflammasome activation. Front Immunol 2012; 3: 154.
    • (2012) Front Immunol , vol.3 , pp. 154
    • Chilton, P.M.1    Embry, C.A.2    Mitchell, T.C.3
  • 55
    • 77954956738 scopus 로고    scopus 로고
    • Chlamydial infection of monocytes stimulates IL-1beta secretion through activation of the NLRP3 inflammasome
    • Abdul-Sater AA, Saïd-Sadier N, Padilla EV, Ojcius DM. Chlamydial infection of monocytes stimulates IL-1beta secretion through activation of the NLRP3 inflammasome. Microbes Infect 2010; 12: 652-61.
    • (2010) Microbes Infect , vol.12 , pp. 652-661
    • Abdul-Sater, A.A.1    Saïd-Sadier, N.2    Padilla, E.V.3    Ojcius, D.M.4
  • 56
    • 84857872597 scopus 로고    scopus 로고
    • Significant role of IL-1 signaling, but limited role of inflammasome activation, in oviduct pathology during Chlamydia muridarum genital infection
    • Nagarajan UM, Sikes JD, Yeruva L, Prantner D. Significant role of IL-1 signaling, but limited role of inflammasome activation, in oviduct pathology during Chlamydia muridarum genital infection. J Immunol 2012; 188: 2866-75.
    • (2012) J Immunol , vol.188 , pp. 2866-2875
    • Nagarajan, U.M.1    Sikes, J.D.2    Yeruva, L.3    Prantner, D.4
  • 57
    • 84860342710 scopus 로고    scopus 로고
    • Caspase-1 has both proinflammatory and regulatory properties in Helicobacter infections, which are differentially mediated by its substrates IL-1ß and IL-18
    • Hitzler I, Sayi A, Kohler E, Engler DB, Koch KN, Hardt WD, Müller A. Caspase-1 has both proinflammatory and regulatory properties in Helicobacter infections, which are differentially mediated by its substrates IL-1ß and IL-18. J Immunol 2012; 188: 3594-602.
    • (2012) J Immunol , vol.188 , pp. 3594-3602
    • Hitzler, I.1    Sayi, A.2    Kohler, E.3    Engler, D.B.4    Koch, K.N.5    Hardt, W.D.6    Müller, A.7
  • 60
    • 67651215923 scopus 로고    scopus 로고
    • The caspase 1 inflammasome is not required for control of murine Lyme borreliosis
    • Liu N, Belperron AA, Booth CJ, Bockenstedt LK. The caspase 1 inflammasome is not required for control of murine Lyme borreliosis. Infect Immun 2009; 77: 3320-7.
    • (2009) Infect Immun , vol.77 , pp. 3320-3327
    • Liu, N.1    Belperron, A.A.2    Booth, C.J.3    Bockenstedt, L.K.4
  • 61
    • 84875850500 scopus 로고    scopus 로고
    • Activation of inflammasome signaling mediates pathology of acute P: aeruginosa pneumonia
    • Cohen TS, Prince AS. Activation of inflammasome signaling mediates pathology of acute P: aeruginosa pneumonia. J Clin Invest 2013; 123: 1630-7.
    • (2013) J Clin Invest , vol.123 , pp. 1630-1637
    • Cohen, T.S.1    Prince, A.S.2
  • 62
    • 11844299050 scopus 로고    scopus 로고
    • Regulation of Pseudomonas aeruginosa corneal infection in IL-1 beta converting enzyme (ICE, caspase-1) deficient mice
    • Thakur A, Barrett RP, McClellan S, Hazlett LD. Regulation of Pseudomonas aeruginosa corneal infection in IL-1 beta converting enzyme (ICE, caspase-1) deficient mice. Curr Eye Res 2004; 29: 225-33.
    • (2004) Curr Eye Res , vol.29 , pp. 225-233
    • Thakur, A.1    Barrett, R.P.2    McClellan, S.3    Hazlett, L.D.4
  • 63
    • 80051810145 scopus 로고    scopus 로고
    • Critical role for NLRP3 in necrotic death triggered by Mycobacterium tuberculosis
    • Wong KW, Jacobs WR Jr. Critical role for NLRP3 in necrotic death triggered by Mycobacterium tuberculosis. Cell Microbiol 2011; 13: 1371-84.
    • (2011) Cell Microbiol , vol.13 , pp. 1371-1384
    • Wong, K.W.1    Jacobs, W.R.2
  • 65
    • 79956187649 scopus 로고    scopus 로고
    • Caspase-1-processed cytokines IL-1beta and IL-18 promote IL-17 production by gammadelta and CD4 T cells that mediate autoimmunity
    • Lalor SJ, Dungan LS, Sutton CE, Basdeo SA, Fletcher JM, Mills KH. Caspase-1-processed cytokines IL-1beta and IL-18 promote IL-17 production by gammadelta and CD4 T cells that mediate autoimmunity. J Immunol 2011; 186: 5738-48.
    • (2011) J Immunol , vol.186 , pp. 5738-5748
    • Lalor, S.J.1    Dungan, L.S.2    Sutton, C.E.3    Basdeo, S.A.4    Fletcher, J.M.5    Mills, K.H.6
  • 67
    • 54049100347 scopus 로고    scopus 로고
    • The Pseudomonas aeruginosa type III secretion system plays a dual role in the regulation of caspase-1 mediated IL-1beta maturation
    • Galle M, Schotte P, Haegman M, Wullaert A, Yang HJ, Jin S, Beyaert R. The Pseudomonas aeruginosa type III secretion system plays a dual role in the regulation of caspase-1 mediated IL-1beta maturation. J Cell Mol Med 2008; 12: 1767-76.
    • (2008) J Cell Mol Med , vol.12 , pp. 1767-1776
    • Galle, M.1    Schotte, P.2    Haegman, M.3    Wullaert, A.4    Yang, H.J.5    Jin, S.6    Beyaert, R.7
  • 68
    • 2942537824 scopus 로고    scopus 로고
    • Targeting Rac1 by the Yersinia effector protein YopE inhibits caspase-1-mediated maturation and release of interleukin-1beta
    • Schotte P, Denecker G, Van Den Broeke A, Vandenabeele P, Cornelis GR, Beyaert R. Targeting Rac1 by the Yersinia effector protein YopE inhibits caspase-1-mediated maturation and release of interleukin-1beta. J Biol Chem 2004; 279: 25134-42.
    • (2004) J Biol Chem , vol.279 , pp. 25134-25142
    • Schotte, P.1    Denecker, G.2    Van Den Broeke, A.3    Vandenabeele, P.4    Cornelis, G.R.5    Beyaert, R.6


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