Inflammasome-dependent pyroptosis and IL-18 protect against burkholderia pseudomallei lung infection while IL-1β is deleterious

PLoS Pathogens

Volumn 7, Issue 12, 2011, Pages

  Ceballos Olvera, Ivonne ^a   Sahoo, Manoranjan ^a   Miller, Mark A ^a   del Barrio, Laura ^a   Re, Fabio ^a,b  

^a UNIVERSITY OF TENNESSEE HEALTH SCIENCE CENTER   (United States)

^b ROSALIND FRANKLIN UNIVERSITY OF MEDICINE AND SCIENCE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTILEUKINATE; CHEMOKINE RECEPTOR CXCR2 ANTAGONIST; GAMMA INTERFERON; INFLAMMASOME; INTERLEUKIN 1 RECEPTOR BLOCKING AGENT; INTERLEUKIN 18; INTERLEUKIN 1BETA; INTERLEUKIN 1BETA CONVERTING ENZYME; NUCLEOTIDE BINDING OLIGOMERIZATION DOMAIN LIKE RECEPTOR; NUCLEOTIDE BINDING OLIGOMERIZATION DOMAIN LIKE RECEPTOR C4; NUCLEOTIDE BINDING OLIGOMERIZATION DOMAIN LIKE RECEPTOR P3; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BACTERIAL GROWTH; BACTERIAL LOAD; BURKHOLDERIA PSEUDOMALLEI; CELL DEATH; CONTROLLED STUDY; CYTOKINE PRODUCTION; DENDRITIC CELL; HUMAN; HUMAN CELL; IMMUNE DEFICIENCY; IN VITRO STUDY; INFECTION RESISTANCE; INFECTION SENSITIVITY; LETHAL DOSE; LUNG INFECTION; LUNG INFILTRATE; MACROPHAGE; MELIOIDOSIS; MOUSE; NEUTROPHIL; NONHUMAN; PYROPTOSIS; SURVIVAL; WILD TYPE;

ANIMALS; APOPTOSIS REGULATORY PROTEINS; BURKHOLDERIA PSEUDOMALLEI; CALCIUM-BINDING PROTEINS; CARRIER PROTEINS; HUMANS; INFLAMMASOMES; INTERLEUKIN-18; INTERLEUKIN-1BETA; MELIOIDOSIS; MICE; MICE, KNOCKOUT; NEUTROPHILS; PNEUMONIA, BACTERIAL; RECEPTORS, INTERLEUKIN-1 TYPE I; RECEPTORS, INTERLEUKIN-8B;

BACTERIA (MICROORGANISMS); BURKHOLDERIA PSEUDOMALLEI; MUS; NEGIBACTERIA;

EID: 84855272667     PISSN: 15537366     EISSN: 15537374     Source Type: Journal    
DOI: 10.1371/journal.ppat.1002452     Document Type: Article

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