Granuloma formation and host defense in chronic mycobacterium tuberculosis infection requires PYCARD/ASC but not NLRP3 or caspase-1

PLoS ONE

Volumn 5, Issue 8, 2010, Pages

  McElvania Tekippe, Erin ^a   Allen, Irving C ^b   Hulseberg, Paul D ^c   Sullivan, Jonathan T ^a   McCann, Jessica R ^a   Sandor, Matyas ^c   Braunstein, Miriam ^a   Ting, Jenny P Y ^a,b  

^a UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF NORTH CAROLINA   (United States)

^c UNIVERSITY OF WISCONSIN SCHOOL OF MEDICINE AND PUBLIC HEALTH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADAPTOR PROTEIN; APOPTOTIC SPECK LIKE PROTEIN CONTAINING A CARD DOMAIN PROTEIN; CRYOPYRIN; CYTOKINE; INFLAMMASOME; INTERLEUKIN 1BETA; INTERLEUKIN 1BETA CONVERTING ENZYME; PYCARD PROTEIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BACTERIAL VIRULENCE; CELL CULTURE; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOKINE RELEASE; FEMALE; GRANULOMA; HOST RESISTANCE; IMMUNE RESPONSE; IN VITRO STUDY; IN VIVO STUDY; LUNG TUBERCULOSIS; MACROPHAGE; MOUSE; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; PROTEIN ANALYSIS; PROTEIN FUNCTION; SURVIVAL TIME; WILD TYPE;

ANIMALS; CARRIER PROTEINS; CASPASE 1; CELLS, CULTURED; CHRONIC DISEASE; CYTOSKELETAL PROTEINS; FEMALE; GRANULOMA; HUMANS; INTERLEUKIN-1BETA; MACROPHAGES; MICE; MYCOBACTERIUM TUBERCULOSIS; TUBERCULOSIS;

ANIMALIA; BACTERIA (MICROORGANISMS); MUS; MYCOBACTERIUM TUBERCULOSIS;

EID: 77957908944     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0012320     Document Type: Article

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